Quantitative physiology : systems approach
著者
書誌事項
Quantitative physiology : systems approach
Springer , Huazhong University of Science and Technology Press, c2020
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注記
Includes bibliographical references
"This Springer imprint is published by the registered company Springer Natuer Singapore Pre Ltd."--t.p. verso
内容説明・目次
内容説明
Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states.
Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology.
This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics.
Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc.
To benefit from this book, the readers are expected to have a background in general physiology and mathematics
目次
Introduction of Quantitative Physiology.- Systems and Modelling.- Relevant Resources.- Modelling Gene Expression.- Bone and Body Mechanics.- Blood Dynamics.- Metabolic Network.- Systems pharmacology.- Calcium Signalling.- Modelling Neural Activity.- Cortical Spreading Depression (CSD).- Heart Physiome.- Constructing genetic intelligence.- Brain Project
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