Sex, gender, and epigenetics : from molecule to bedside
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書誌事項
Sex, gender, and epigenetics : from molecule to bedside
Academic Press, 2023
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内容説明・目次
内容説明
Sex, Gender, and Epigenetics: From Molecule to Bedside explores our expanding knowledge of the science of epigenetics in which gene expression is modified as a consequence of small chemical additions to various components of the genome. The book provides an overview of the field, describing the epigenetic phenomena that unite biological sex and environmental experience to create the unique phenome of each individual. The book also analyzes the impact of ancestors' environmental experience on subsequent generations through the sex-specific transmission of environmentally induced epigenetic modifications. Here, international leaders in the field discuss both sex-specific normal physiology and the experience of disease, with chapters dedicated to fetal programming, the microbiome, cancer, bipolar disorder and schizophrenia, embryogenesis, and oocyte aging, among other topics.
目次
- 1. Exploring how we become what we are 2. A critical view of the revolution of precision medicine. Genetics, epigenetics, sex, and gender 3. Genetic and epigenetic contributions to female-biased lupus disease: X-chromosome inactivation in immune cells 4. Genetic, molecular, and cellular determinations of sex-specific cardiovascular traits 5. Epigenetics and mental and physical health of children born after ART 6. Epigenetic aspects of male infertility treatment 7. Evidence for assisted reproductive technology associated epigenetic variation in humans 8. Deconvoluting the functional role of DNA methylation in trauma
- Implications for epigenetic therapy and prospects of targeted "epigenetic therapy" 9. Antenatal Origins of Health and Disease-A clinician's perspective 10. Maternal anxiety during pregnancy and the lack of fetal DNA methylation in cord blood 11. DNA methylation and other epigenetic modifications mediating the transgenerational impacts of paternal exposures on offspring phenotypes 12. Epigenetics and psychiatry 13. Integrative transcriptomics reveals sexually dimorphic control of the cholinergic/neurokine interface in schizophrenia and bipolar disorder 14. Gender specific neurobehavioral and gene expression changes in a valproic acid (VPA)-induced mouse model of autistic like behavior and correction by S-adenosylmethionine (SAMe) 15. Genetics and epigenetics of the onecarbon metabolism pathway in autism spectrum disorder: Role of a sex-specific brain epigenome 16. Novel mechanisms for gene regulation: Chemical tags on RNA molecules 17. Genes, environments, and epigenetics 18. Epigenetic mechanisms linking poor maternal nutrition during pregnancy to the cardio-metabolic health of offspring 19. Epigenetic aspects of human reproduction and early pregnancy 20. Sex-specific impact of maternal metabolic environment on the development of the offspring, from gametogenesis to infancy and beyond 21. Mitochondria as epigenetic regulators of reproductive aging 22. The fetal programming of telomere biology hypothesis 23. Brain organoids modeling of genetic and environmental impact on neurodevelopmental traits
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