Discrimination of mobile supramolecular chirality : acylative molecular transformations by organocatalysis
著者
書誌事項
Discrimination of mobile supramolecular chirality : acylative molecular transformations by organocatalysis
（Springer theses : recognizing outstanding Ph. D. research）
Springer, c2022
- : paperback
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注記
"Doctoral thesis accepted by Kyoto University, Kyoto, Japan"
Includes bibliographical references and index
内容説明・目次
内容説明
This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.
目次
Introduction.- Mechanistic Study of Organocatalytic Chemoselective Monoacylation of 1,5-Pentanediol.- Discrimination of Mobile Supramolecular Chirality: Kinetic Resolution of Topologically Chiral Racemic Rotaxanes by Organocatalysis.- Conclusion and Perspective.
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