CiNii Books - 比較代謝化学的手法によるPー450機能性人工触媒の創製と薬物代謝研究への応用

Author(s)

比較代謝化学的手法によるPー450機能性人工触媒の創製と薬物代謝研究への応用

研究代表者広部雅昭

広部雅昭, 1993

Title Transcription: ヒカクタイシャカガクテキシュホウニヨル P-450 キノウセイジンコウショクバイノソウセイトヤクブツタイシャケンキュウエノオウヨウ

研究分担者: 長野哲雄, 樋口恒彦, 増野匡彦, 太田茂

平成4年度科学研究費補助金(一般研究B)研究成果報告書(課題番号02453140)

[2+],[18],は上付、[2]は下付文字

Synthesis of a highly stable iron porphyrin coordinated by alkylthiolate anion as a model for cytochrome P-450 and its catalytic activity in O-O bond cleavage
Sulfide oxidation, amine N-demethylation, and olefin oxidation by heme-undecapeptide, microperoxidase-11, in the presence of hydrogen
Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo [1,5-a] pyridine
Comparative study on drug metabolism using cyt. P450 chemical model and liver microsomal systems
"Metabolic activation" of o-methoxyphenols via O-demethylation with a Cu[2+]-ascorbic acid-O[2] system as a functional model of cytochrome P-450
Application of chemical cytochrome P-450 model systems to studies on drug metabolism. IV. Mechanism of piperidine metabolism pathways via an iminium intermediate
Substrate oxidation catalyzed by heme-undecapeptide, microperoxidase-11 in the presence of iodosylbenzene and cumene hydroperoxide
Highly efficient oxygen transfer reactions from various heteroaromatic N-oxides to olefins, alcohols, and sulfides catalyzed by ruthenium porphyrin
[18]O incorporation from H[2][18]O[2] in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11
The selectivities and the mechanism on highly efficient epoxidation of olefins with 2,6-disubstituted pyridine N-oxides catalyzed by ruthenium porphyrin