比較代謝化学的手法によるPー450機能性人工触媒の創製と薬物代謝研究への応用
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書誌事項
比較代謝化学的手法によるPー450機能性人工触媒の創製と薬物代謝研究への応用
広部雅昭, 1993
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ヒカク タイシャ カガクテキ シュホウ ニ ヨル P-450 キノウセイ ジンコウ ショクバイ ノ ソウセイ ト ヤクブツ タイシャ ケンキュウ エノ オウヨウ
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注記
研究分担者: 長野哲雄, 樋口恒彦, 増野匡彦, 太田茂
平成4年度科学研究費補助金(一般研究B)研究成果報告書(課題番号02453140)
[2+],[18],は上付、[2]は下付文字
収録内容
- Synthesis of a highly stable iron porphyrin coordinated by alkylthiolate anion as a model for cytochrome P-450 and its catalytic activity in O-O bond cleavage
- Sulfide oxidation, amine N-demethylation, and olefin oxidation by heme-undecapeptide, microperoxidase-11, in the presence of hydrogen
- Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo [1,5-a] pyridine
- Comparative study on drug metabolism using cyt. P450 chemical model and liver microsomal systems
- "Metabolic activation" of o-methoxyphenols via O-demethylation with a Cu[2+]-ascorbic acid-O[2] system as a functional model of cytochrome P-450
- Application of chemical cytochrome P-450 model systems to studies on drug metabolism. IV. Mechanism of piperidine metabolism pathways via an iminium intermediate
- Substrate oxidation catalyzed by heme-undecapeptide, microperoxidase-11 in the presence of iodosylbenzene and cumene hydroperoxide
- Highly efficient oxygen transfer reactions from various heteroaromatic N-oxides to olefins, alcohols, and sulfides catalyzed by ruthenium porphyrin
- [18]O incorporation from H[2][18]O[2] in the oxidation of N-methylcarbazole and sulfides catalyzed by microperoxidase-11
- The selectivities and the mechanism on highly efficient epoxidation of olefins with 2,6-disubstituted pyridine N-oxides catalyzed by ruthenium porphyrin