パーキンソン病関連内在性脳内アミンをリード化合物とする抗パーキンソン病薬の開発
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Bibliographic Information
パーキンソン病関連内在性脳内アミンをリード化合物とする抗パーキンソン病薬の開発
広部雅昭, 1994
- Title Transcription
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パーキンソンビョウ カンレン ナイザイセイ ノウナイ アミン オ リード カゴウブツ トスル コウパーキンソン ビョウヤク ノ カイハツ
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平成5年度科学研究費補助金(試験研究(B))研究成果報告書
研究課題番号: 03557094
研究分担者: 太田茂, 増野匡彦, 樋口恒彦, 岩澤義郎
[+]は、上付文字
Contents of Works
- Metabolism and penetration through blood-brain barrier of Parkinsonism-related compounds / Kazuya Kikuchi[ほか]
- Amphetamine-antagonistic properties of 4-phenyl-1,2,3,4-tetrahydroisoquinoline : inhibition of spinal reflex-enhancing effects of methamphetamine, phenylethylamine and nomifensine / Hideki Ono[ほか]
- 1-methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents Parkinsonism-like behavior abnormalities / Yoshikazu Tasaki[ほか]
- Fect of MPP[+] and TIQ on cultured rat midbrain dopaminergic neurons / C. Ohsawa[ほか]
- Importance of 1-methyltetrahydroisoquinoline (1MeTIQ) in Parkinson's disease / Shigeru Ohta[ほか]
- Rmation of a novel and neurotoxic tetrahydroisoquinoline derivative, 3-dimethyltetrahydroisoquinoline (1,3DiMeTIQ), a condensation product amphetamines and acetaldehyde in vivo / Yukiko Makino[ほか]
- Relationship between TIQs and Parkinson's disease / S. Ohta[ほか]
- Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes / Tokuji Suzuki[ほか]
- Biosynthesis of 1-methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ), a possible antiparkinsonism agent / Yoshikazu Tasaki[ほか]
- Amphetamine-antagonistic property of 4-phenylterahydroisoquinoline : effect on noradrenaline release in spinal cord slices / Mitsutoshi Satoh[ほか]
- Selective release of serotonin by endogenous alkaloids, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-and (S)salsolinol, in the rat striatum, in vivo microdialysis study / Wakako Maruyama[ほか]
