中田 和人 NAKADA Kazuto

Articles:  1-20 of 30

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  • Cytoplasmic transfer of heritable elements other than mtDNA from SAMP1 mice into mouse tumor cells suppresses their ability to form tumors in C57BL6 mice

    Shimizu Akinori , Tani Haruna , Takibuchi Gaku , Ishikawa Kaori , Sakurazawa Ryota , Inoue Takafumi , Hashimoto Tetsuo , Nakada Kazuto , Takenaga Keizo , Hayashi Jun-Ichi , 石川 香 , 橋本 哲男 , 中田 和人 , 林 純一

    In a previous study, we generated transmitochondrial P29mtSAMP1 cybrids, which had nuclear DNA from the C57BL6 (referred to as B6) mouse strain-derived P29 tumor cells and mitochondrial DNA (mtDNA) ex …

    Biochemical and biophysical research communications 493(1), 252-257, 2017-11

    IR 

  • RLR-mediated antiviral innate immunity requires oxidative phosphorylation activity

    Yoshizumi Takuma , Imamura Hiromi , Taku Tomohiro , Kuroki Takahiro , Kawaguchi Atsushi , Ishikawa Kaori , Nakada Kazuto , Koshiba Takumi , 川口 敦史 , 石川 香 , 中田 和人

    Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an ad …

    Scientific reports (7), 5379, 2017-07

    IR 

  • Model mice carrying pathogenic mutant mtDNAs  [in Japanese]

    小笠原 絵美 , 中田 和人

    医学のあゆみ 260(1), 73-79, 2017-01-07

    Ichushi Web 

  • Pathogeneses of mitochondrial DNA-based disorders  [in Japanese]

    石川 香 , 林 純一 , 中田 和人

    医学のあゆみ 254(5), 452-458, 2015-08-01

    Ichushi Web 

  • G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice

    Shimizu Akinori , Mito Takayuki , Hashizume Osamu , Yonekawa Hiromichi , Ishikawa Kaori , Nakada Kazuto , Hayashi Jun-Ichi , 清水 章文 , 石川 香 , 中田 和人 , 林 純一

    We previously generated mito-mice-tRNALys7731 as a model for primary prevention of mitochondrial diseases. These mice harbour a G7731A mtDNA mutation in the tRNALys gene, but express only muscle weakn …

    Biochemical and biophysical research communications 459(1), 66-70, 2015-03

    IR 

  • A Specific Nuclear DNA Background Is Required for High Frequency Lymphoma Development in Transmitochondrial Mice with G13997A mtDNA

    Hashizume Osamu , Yamanashi Haruka , Taketo Makoto M. , Nakada Kazuto , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    We previously found that mouse mitochondrial DNA (mtDNA) with a G13997A mutation (G13997A mtDNA) controls not only the transformation of cultured lung carcinoma cells from poorly metastatic into highl …

    PLoS ONE 10(3), e0118561, 2015-03

    IR 

  • Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders

    Mito Takayuki , Ishizaki Hikari , Suzuki Michiko , Morishima Hitomi , Ota Azusa , Ishikawa Kaori , Nakada Kazuto , Maeno Akiteru , Shiroishi Toshihiko , Hayashi Jun-Ichi , 石川 香 , 中田 和人 , 林 純一

    The spectra of phenotypes associated with aging and mitochondrial diseases sometimes appear to overlap with each other. We used aged mice and a mouse model of mitochondrial diseases (transmitochondria …

    Biochemical and biophysical research communications 456(4), 933-937, 2015-01

    IR 

  • Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene

    Shimizu Akinori , Mito Takayuki , Hayashi Chisato , Ogasawara Emi , Koba Ryusuke , Negishi Issei , Takenaga Keizo , Nakada Kazuto , Hayashi Jun-Ichi , 清水 章文 , 中田 和人 , 林 純一

    Proceedings of the National Academy of Sciences of the United States of America 111(8), 3104-3109, 2014-01

    IR 

  • Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype

    Takibuchi Gaku , Imanishi Hirotake , Morimoto Mami , Ishikawa Kaori , Nakada Kazuto , Toyama-Sorimachi Noriko , Kikkawa Yoshiaki , Takenaga Keizo , Hayashi Jun-Ichi , 瀧渕 岳 , 中田 和人 , 林 純一

    To examine whether polymorphic mtDNA mutations that do not induce significant respiration defects regulate phenotypes of tumor cells, we used mouse transmitochondrial tumor cells (cybrids) with nuclea …

    Mitochondrion 13(6), 881-887, 2013-11

    IR 

  • Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System

    Imanishi Hirotake , Takibuchi Gaku , Kobayashi Toshihiko , Ishikawa Kaori , Nakada Kazuto , Mori Masayuki , Kikkawa Yoshiaki , Takenaga Keizo , Toyama-Sorimachi Noriko , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    mammalian species, mitochondrial DNA (mtDNA) with pathogenic mutations that induce mitochondrial respiration defects has been proposed to be involved in tumor phenotypes via induction of enhanced glyc …

    PLOS ONE 8(9), UNSP e75981, 2013-09-16

    IR 

  • Mitochondrial DNA with a Large-Scale Deletion Causes Two Distinct Mitochondrial Disease Phenotypes in Mice

    Katada Shun , Mito Takayuki , Ogasawara Emi , Hayashi Jun-Ichi , Nakada Kazuto , 林 純一 , 中田 和人

    Studies in patients have suggested that the clinical phenotypes of some mitochondrial diseases might transit from one disease to another (e.g., Pearson syndrome [PS] to Kearns-Sayre syndrome) in singl …

    G3: Genes, Genomes, Genetics 3(9), 1545-1552, 2013-09

    IR 

  • Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

    Hashizume Osamu , Shimizu Akinori , Yokota Mutsumi , Sugiyama Atsuko , Nakada Kazuto , Miyoshi Hiroyuki , Itami Makiko , Ohira Miki , Nagase Hiroki , Takenaga Keizo , Hayashi Jun-Ichi , 橋爪 脩 , 中田 和人 , 林 純一

    It has been hypothesized that respiration defects caused by accumulation of pathogenic mitochondrial DNA (mtDNA) mutations and the resultant overproduction of reactive oxygen species (ROS) or lactates …

    Proceedings of the National Academy of Sciences of the United States of America 109(26), 10528-10533, 2012-06

    IR 

  • Mitochondrial DNA Mutations Regulate Metastasis of Human Breast Cancer Cells

    Imanishi Hirotake , Hattori Keisuke , Wada Reiko , Ishikawa Kaori , Fukuda Sayaka , Takenaga Keizo , Nakada Kazuto , Hayashi Jun-Ichi , 今西 泰赳 , 中田 和人 , 林 純一

    Mutations in mitochondrial DNA (mtDNA) might contribute to expression of the tumor phenotypes, such as metastatic potential, as well as to aging phenotypes and to clinical phenotypes of mitochondrial …

    PLoS ONE 6(8), e23401, 2011-08

    IR 

  • Mitochondrial diseases  [in Japanese]

    中田 和人 , 林 純一

    医学のあゆみ 238(5), 498-504, 2011-07-30

    Ichushi Web 

  • Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system

    Nishiyama Satoshi , Shitara Hiroshi , Nakada Kazuto , Ono Tomio , Sato Akitsugu , Suzuki Hidenori , Ogawa Tetsuhiro , Masaki Haruhiko , Hayashi Jun-Ichi , Yonekawa Hiromichi , 西山 哲史 , 中田 和人 , 林 純一

    The phenotypes of mitochondrial diseases caused by mutations in mitochondrial DNA (mtDNA) have been proposed to be strictly regulated by the proportion of wild-type and pathogenically mutated mtDNAs. …

    Biochemical and biophysical research communications 401(1), 26-31, 2010-10-08

    IR 

  • The innate immune system in host mice targets cells with allogenic mitochondrial DNA

    Ishikawa Kaori , Toyama-Sorimachi Noriko , Nakada Kazuto , Morimoto Mami , Imanishi Hirotake , Yoshizaki Mariko , Sasawatari Shigemi , Niikura Mamoru , Takenaga Keizo , Yonekawa Hiromichi , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    Mitochondrial DNA (mtDNA) has been proposed to be involved in respiratory function, and mtDNA mutations have been associated with aging, tumors, and various disorders, but the effects of mtDNA importe …

    Journal of experimental medicine 207(11), 2297-2305, 2010-10

    IR 

  • Pathogenesis by failures of mitochondrial central dogma  [in Japanese]

    中田 和人 , 石川 香 , 林 純一

    Cell technology 29(5), 466-473, 2010

  • A model mouse for mitochondrial DNA-based diseases  [in Japanese]

    NAKADA Kazuto , SATO Akitsugu , HAYASHI Jun-Ichi

    Patient studies suggested that accumulation of pathogenic mitochondrial (mt) DNAs having large-scale deletion or point mutation and the resultant mitochondrial respiratory abnormalities are associated …

    Rinsho Shinkeigaku 48(11), 1013-1015, 2008-11-01

    J-STAGE  Ichushi Web  References (10)

  • Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

    Ishikawa Kaori , Hashizume Osamu , Koshikawa Nobuko , Fukuda Sayaka , Nakada Kazuto , Takenaga Keizo , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    We addressed the issue of whether enhanced glycolysis caused by mtDNA mutations independently induces metastasis in tumor cells using mtDNA transfer technology. The resultant trans-mitochondrial cybri …

    FEBS letters 582(23), 3525-3530, 2008-10

    IR 

  • ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

    ISHIKAWA K , Takenaga Keizo , Akimoto Miho , Koshikawa Nobuko , Yamaguchi Aya , Imanishi Hirotake , Nakada Kazuto , Honma Yoshio , Hayashi Jun-Ichi , 中田 和人 , 林 純一

    Mutations in mitochondrial DNA (mtDNA) occur at high frequency in human tumors, but whether these mutations alter tumor cell behavior has been unclear. We used cytoplasmic hybrid (cybrid) technology t …

    Science 320(5876), 661-664, 2008-05

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