YOSHIDA Kazuhiko

Articles:  1-10 of 10

  • Prevention of experimental autoimmune uveoretinitis by blockade of osteopontin with small interfering RNA

    Iwata Daiju , Kitamura Mizuki , Kitaichi Nobuyoshi , Saito Yoshinari , Kon Shigeyuki , Namba Kenichi , Morimoto Junko , Ebihara Akiko , Kitamei Hirokuni , Yoshida Kazuhiko , Ishida Susumu , Ohno Shigeaki , Uede Toshimitsu , Onoé Kazunori , Iwabuchi Kazuya

    Osteopontin (OPN) is elevated during the progression of experimental autoimmune uveoretinitis (EAU) in C57BL/6 (B6) mice. Furthermore, EAU symptoms are ameliorated in OPN knockout mice or in B6 mice t …

    Experimental Eye Research 90(1), 41-48, 2010-01

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  • Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients

    Horie Yukihiro , Kitaichi Nobuyoshi , Katsuyama Yoshihiko , Yoshida Kazuhiko , Miura Toshie , Ota Masao , Asukata Yuri , Inoko Hidetoshi , Mizuki Nobuhisa , Ishida Susumu , Ohno Shigeaki

    Purpose: Vogt-Koyanagi-Harada (VKH) disease is an autoimmune disorder against melanocytes. Polymorphisms of the protein tyrosine phosphatase non-receptor 22 gene (PTPN22) have recently been reported t …

    Molecular Vision (15), 1115-1119, 2009-06-03

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  • Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.

    Horie Yukihiro , Kitaichi Nobuyoshi , Takemoto Yuko , Namba Kenichi , Yoshida Kazuhiko , Hirose Shigeto , Hasumi Yukiko , Ota Masao , Inoko Hidetoshi , Mizuki Nobuhisa , Ohno Shigeaki

    PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanag …

    Molecular Vision (13), 2334-2338, 2007-12-21

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  • Inhibition of nuclear factor-kappa B activation attenuates hydrogen peroxide-induced cytotoxicity in human lens epithelial cells

    Jin Xue-Hai , Ohgami Kazuhiro , Shiratori Kenji , Koyama Yoshikazu , Yoshida Kazuhiko , Kase Satoru , Ohno Shigeaki

    Aims: Hydrogen peroxide (H2O2) is the major oxidant involved in cataract formation. Lens epithelial cells have been suggested to be the first site of oxidative damage. The authors investigated the rel …

    British Journal of Ophthalmology 91(3), 369-371, 2007-03

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  • Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients.

    Horie Yukihiro , Takemoto Yuko , Miyazaki Akiko , Namba Kenichi , Kase Satoru , Yoshida Kazuhiko , Ota Masao , Hasumi Yukiko , Inoko Hidetoshi , Mizuki Nobuhisa , Ohno Shigeaki

    PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopa …

    Molecular Vision (12), 1601-1605, 2006-12-20

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  • Captopril suppresses inflammation in endotoxin-induced uveitis in rats

    Ilieva Iliyana , Ohgami Kazuhiro , Jin Xue-Hai , Suzuki Yukari , Shiratori Kenji , Yoshida Kazuhiko , Kase Satoru , Ohno Shigeaki

    Captopril is an inhibitor of angiotensin-converting enzyme (ACE) that is largely used in the treatment of cardiovascular diseases. Several previous studies have demonstrated that captopril exhibits a …

    Experimental Eye Research 83(3), 651-657, 2006-09

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  • Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice

    Kase Satoru , Yoshida Kazuhiko , Sakai Masaharu , Ohgami Kazuhiro , Shiratori Kenji , Kitaichi Nobuyoshi , Suzuki Yukari , Harada Takayuki , Ohno Shigeaki

    The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf fami …

    Acta Histochemica 107(6), 469-472, 2006-02-20

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  • Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-κB signaling pathway

    Suzuki Yukari , Ohgami Kazuhiro , Shiratori Kenji , Jin Xue-Hai , Ilieva Iliyana , Koyama Yoshikazu , Yazawa Kazunaga , Yoshida Kazuhiko , Kase Satoru , Ohno Shigeaki

    We investigated the effects of astxanthin (AST), a carotenoid, on endotoxin-induced uveitis (EIU), and measured the expression of inflammatory cytokines and chemokines in the presence or absence of AS …

    Experimental Eye Research 82(2), 275-281, 2006-02

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  • Expression of erythropoietin receptor in human Merkel cell carcinoma of the eyelid

    Kase Satoru , Yoshida Kazuhiko , Osaki Mitsuhiko , Adachi Hironobu , Ito Hisao , Ohno Shigeaki

    Background: Merkel cell carcinoma (MCC) of the eyelid is a rare malignant solid tumor of the elderly, which demonstrates a large, firm, reddish nodule mimicking an angiomatous lesion. The expression o …

    Anticancer Research 26(6), 4535-4537, 2006

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  • Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma

    KASE Satoru , SAITO Wataru , YOSHIDA Kazuhiko , NAMBA Kenichi , OSAKI Mitsuhiko , OHGAMI Kazuhiro , SHIRATORI Kenji , KITAICHI Nobuyoshi , ADACHI Hironobu , ITO Hisao , OHNO Shigeaki

    Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (N …

    Pathology International 55(9), 569-573, 2005-09-01

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