Shirai Makoto SHIRAI Makoto


Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd. (2011年 CiNii収録論文より)

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Articles:  1-5 of 5

  • Mixed Type of Malignant Mesothelioma in an Aged Male ICR Mouse

    SHIRAI Makoto , MAEJIMA Takanori , TANIMOTO Tomoe , KUMAGAI Kazuyoshi , MAKINO Toshihiko , KAI Kiyonori , TERANISHI Munehiro , SANBUISSHO Atsushi

    Multiple whitish nodules in the thoracic cavity at the site of the thymus were observed in a 101-week-old male ICR mouse. In a histopathological examination, the neoplastic cells were predominantly fu …

    Journal of Toxicologic Pathology 24(3), 169-172, 2011-09-01

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  • Two- or four-week repeated-dose studies and fertility study of Anastrozole in female rats

    SHIRAI Makoto , SAKURAI Ken , SAITOH Wataru , MATSUYAMA Takuya , TERANISHI Munehiro , FURUKAWA Tadashi , SANBUISSHO Atsushi , MANABE Sunao

    The main focus of this study was to determine the optimal administration period concerning the toxic effects on ovarian morphological changes in the repeated dose toxicity study. In order to assess th …

    The Journal of Toxicological Sciences 34, SP91-SP99, 2009-02-28

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  • Decrease in protein binding and its effect on toxicokinetics (TK) / toxicodynamics (TD) of diclofenac and propranolol in pregnant rats

    MIIDA Hiroaki , NORITAKE Yumiko , SHIMODA Hitomi , HONDA Kumi , MATSUOKA Toshiki , SAKURAI Ken , SHIRAI Makoto , MANABE Sunao , TAKASAKI Wataru , UENO Koichi

    Plasma protein binding is an important factor for the kinetics of drugs and how they act since it is the first step in drug distribution. Physiological changes in pregnancy, which include plasma compo …

    The Journal of Toxicological Sciences 33(5), 525-536, 2008-12-01

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  • Bronchioloalveolar Carcinoma in an Aged Beagle Dog

    MAKINO Toshihiko , SHIRAI Makoto , KUMAGAI Kazuyoshi , MAEJIMA Takanori , SEHATA Shinya , MANABE Sunao , TERANISHI Munehiro

    A pulmonary mass was observed in a 16-year-old beagle dog. In the histopathology, a well-circumscribed mass composed of cuboidal to low or tall columnar neoplastic cells proliferating in a papillary, …

    Journal of Toxicologic Pathology 21(2), 109-113, 2008-06-30

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  • Immunohistochemical Staining Methods for Connexin32 on Formalin-Fixed Paraffin-Embedded Sections

    IGARASHI Isao , SHIRAI Makoto , SUZUKI Yoko , ATSUMI Fusako , SEHATA Shinya , MAEJIMA Takanori , MANABE Sunao , TERANISHI Munehiro

    Connexin32 (Cx32), one of the components of gap junction intercellular communication, is commonly detected by the fluorescent antibody method, although this method has some defects when conducting det …

    Journal of Toxicologic Pathology 19(3), 151-154, 2006-09-30

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