Sugiyama Rina

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  • Inhibitory effects of local anesthetics on the proteasome and their biological actions

    Bahrudin Udin , Unno Masaki , Nishio Kazuya , Kita Akiko , Li Peili , Kato Masaru , Inoue Masashi , Tsujitani Shunichi , Murakami Takuto , Sugiyama Rina , Saeki Yasushi , Obara Yuji , Tanaka Keiji , Yamaguchi Hiroshi , Sakane Isao , Kawata Yasushi , Itoh Toshiyuki , Ninomiya Haruaki , Hisatome Ichiro , Morimoto Yukio

    Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind …

    Scientific Reports (7), 2017-07-11

    IR 

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