Koshikawa Nobuko

Articles:  1-1 of 1

  • Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate

    Hiraoka Kiriko , Inoue Takahiro , Taylor Rhys Dylan , Watanabe Takayoshi , Koshikawa Nobuko , Yoda Hiroyuki , Shinohara Ken-ichi , Takatori Atsushi , Sugimoto Hirokazu , Maru Yoshiaki , Denda Tadamichi , Fujiwara Kyoko , Balmain Allan , Ozaki Toshinori , Bando Toshikazu , Sugiyama Hiroshi , Nagase Hiroki

    Despite extensive efforts to target mutated RAS proteins, anticancer agents capable of selectively killing tumour cells harbouring KRAS mutations have remained unavailable. Here we demonstrate the dir …

    Nature Communications (6), 2015-04-27

    IR 

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