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  • 線虫を利用した腸内細菌研究

    中台(鹿毛) 枝里子 腸内細菌学雑誌 38 (1), 9-19, 2024

    <p>腸内細菌やプロバイオティクスによる疾患や健康の制御に向けたアプローチが盛んに試みられる一方,腸内細菌と宿主間の相互作用の分子的実体には未解明な点も多い.線虫Caenorhabditis elegans (C. elegans)は,3つのノーベル賞研究をはじめとして,さまざまな生命現象の発見において重要な役割を果たしてきたモデル生物の一つであるが,腸内細菌研究においても例外ではない.乳酸桿菌…

    DOI

  • <i>Oscheius</i> sp. KHA501の病原性および昆虫病原性細菌との関係性

    杉山 大樹, 澤之向 大樹, 長江 星八, 長谷川 浩一 日本線虫学会誌 53 (1_2), 1-10, 2023-12-20

    ...自活性の<i>Caenorhabditis elegans</i>は<i>S. marcescens</i> bKHA501を餌として利用できず、<i>S. marcescens</i> bKHA501の感染で死亡したハチノスツヅリガ上でも増殖できなかった。昆虫病原性細菌を利用する<i>Oscheius</i> sp....

    DOI Web Site

  • 蛍光ナノダイヤモンドを用いた量子生体センサー

    鹿野 豊, 藤原 正澄 日本物理学会誌 78 (10), 593-598, 2023-10-05

    <p>計算・通信・暗号といった現代の情報社会の礎として情報理論がある.一方,情報社会を担うハードウェアは物理法則に従うデバイスによって構成されているため,物理法則によって制限された情報理論が必要である.</p><p>中でも,量子力学の法則によって制限された情報理論は量子情報科学と呼ばれ,量子エレクトロニクス技術と融合しながら40~50年かけて発展してきた.</p><p>デジタル社会の情報処理の最…

    DOI

  • タンパク質<i>C</i>-マンノシル化の生理機能と病態における機能

    Nishitsuji Kazuchika, Ikezaki Midori, Manabe Shino, Ihara Yoshito Trends in Glycoscience and Glycotechnology 35 (204), E23-E27, 2023-03-25

    ...<i>Dpy-19</i> was recognized as a gene encoding <i>C</i>-mannosyltransferase in <i>Caenorhabditis elegans</i>. DPY19L1 and DPY19L3 were later confirmed as mammalian <i>C</i>-mannosyltransferases....

    DOI DOI Web Site ほか3件 参考文献37件

  • (1)線虫のゲノム解析について

    三谷 昌平 東京女子医科大学雑誌 93 (1), 1-6, 2023-02-25

    ...<p>Approximately 40% of protein-coding genes in the nematode <i>Caenorhabditis elegans</i> (<i>C. elegans</i>) are orthologous to human protein-coding genes, making this animal a useful model organism....

    DOI

  • Gravitational and mechanical forces drive mitochondrial translation

    Taisei Wakigawa, Yusuke Kimura, Mari Mito, Toshiya Tsubaki, Muhoon Lee, Koki Nakamura, Abdul Haseeb Khan, Hironori Saito, Tohru Yamamori, Tomokazu Yamazaki, Akira Higashibata, Tatsuhisa Tsuboi, Yusuke Hirabayashi, Nono Takeuchi-Tomita, Taku Saito, Atsushi Higashitani, Yuichi Shichino, Shintaro Iwasaki 2023-01-19

    ...Genome-wide ribosome profiling revealed reduced mitochondrial translation in mammalian cells and<jats:italic>Caenorhabditis elegans</jats:italic>under both microgravity at the International Space Station...

    DOI Web Site 参考文献109件

  • The role of nutrition and oxidative stress as aging factors in <i>Caenorhabditis elegans</i>

    Yasuda Kayo, Miyazawa Masaki, Ishii Takamasa, Ishii Naoaki Journal of Clinical Biochemistry and Nutrition 73 (3), 173-177, 2023

    <p>The molecular mechanism of aging, which has been a “black box” for many years, has been elucidated in recent years, and the nematode <i>C. elegans</i>, which is a model animal for aging research, …

    DOI Web Site 参考文献58件

  • 核内のセントロメア空間配置を決める分子メカニズムの解明

    松永 幸大 PLANT MORPHOLOGY 35 (1), 43-48, 2023

    <p>細胞が分裂する際,複製されたDNAは凝縮して,染色分体が二本連なった染色体となり,その後,二つの細胞に等しく分配される.染色分体が等しく分配される時,染色分体の結合部位にあるセントロメアという特別なDNA領域が,紡錘糸に引っ張られて両極に移動する.細胞分裂が終了すると,染色体は脱凝縮して細胞核が再構築される.再構築された細胞核において,分裂面から遠位領域に塊となったセントロメアの分布が変わ…

    DOI Web Site

  • α-1,6-Fucosyltransferase Is Essential for Myogenesis in Zebrafish

    Nozomi Hayashiji, Genri Kawahara, Xing Xu, Tomohiko Fukuda, Aurelien Kerever, Jianguo Gu, Yukiko K. Hayashi, Eri Arikawa-Hirasawa Cells 12 (1), 144-, 2022-12-29

    ...Fut8 is widely conserved from Caenorhabditis elegans to humans, and its mutants have been reported in humans, mice, and zebrafish....

    DOI Web Site 参考文献34件

  • ネオニコチノイド(イミダクロプリド、ジノテフラン)暴露による多世代にわたる C. elegans の慢性暴露影響

    坂口 裕子, 高倉 春奈, 福永 夏実, 川添 禎浩, 内田 雅也, 冨永 伸明, 有薗 幸司, 一川 暢宏 日本食品化学学会誌 29 (2), 69-76, 2022-08-30

    ネオニコチノイドは、ニコチン性アセチルコリン受容体の強力なアゴニストとして、神経系を異常興奮させること により殺虫作用を示す。近年、ヒトを含む哺乳類への影響も懸念されている。本研究では、モデル生物である線虫 C. elegans を用いて、二種のネオニコチノイド、イミダクロプリド(IMI)とジノテフラン(DINO)の慢性暴露影響を評価 した。1、10、100、1000 µM の …

    DOI Web Site 医中誌

  • Female meiosis II and pronuclear fusion require the microtubule transport factor Bicaudal D

    Paula Vazquez-Pianzola, Dirk Beuchle, Gabriella Saro, Greco Hernández, Giovanna Maldonado, Dominique Brunßen, Peter Meister, Beat Suter Development 149 (13), dev199944-, 2022-07-01

    ...Furthermore, immediately after the establishment of the female pronucleus, D-TACC and Caenorhabditis elegans BicD, tacc and Chc are also needed for pronuclear fusion, suggesting that the underlying mechanism...

    DOI PDF PDF 被引用文献1件

  • Possible stochastic sex determination in Bursaphelenchus nematodes

    Ryoji Shinya, Simo Sun, Mehmet Dayi, Isheng Jason Tsai, Atsushi Miyama, Anthony Fu Chen, Koichi Hasegawa, Igor Antoshechkin, Taisei Kikuchi, Paul W. Sternberg Nature Communications 13 (1), 2022-05-11

    ...<jats:title>Abstract</jats:title><jats:p>Sex determination mechanisms evolve surprisingly rapidly, yet little is known in the large nematode phylum other than for <jats:italic>Caenorhabditis elegans</jats...

    DOI PDF Web Site 被引用文献1件 参考文献70件

  • Nematode chromosomes

    Carlton, Peter M, Davis, Richard E, Ahmed, Shawn Genetics 221 (1), 2022-05

    ...The nematode Caenorhabditis elegans has shed light on many aspects of eukaryotic biology, including genetics, development, cell biology, and genomics....

    DOI HANDLE PDF ほか1件 被引用文献1件 参考文献273件

  • Insulin and Memory in Invertebrates

    Junko Nakai, Nozomi Chikamoto, Kanta Fujimoto, Yuki Totani, Dai Hatakeyama, Varvara E. Dyakonova, Etsuro Ito Frontiers in Behavioral Neuroscience 16 2022-04-26

    ...In the arthropod <jats:italic>Drosophila melanogaster</jats:italic>, IIS is involved in aversive olfactory memory, and in the nematode <jats:italic>Caenorhabditis elegans</jats:italic>, IIS controls appetitive...

    DOI Web Site 被引用文献3件 参考文献135件

  • Molecular physiology regulating cold tolerance and acclimation of Caenorhabditis elegans

    OKAHATA Misaki, MOTOMURA Haruka, OHTA Akane, KUHARA Atsushi Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 98 (3), 126-139, 2022-03-11

    ...Here, we introduce a molecular physiological mechanism for cold tolerance and acclimation of the nematode <i>Caenorhabditis elegans</i> on the basis of previous reports and a new result....

    DOI Web Site Web Site ほか2件 被引用文献2件 参考文献52件

  • Low-dose metformin targets the lysosomal AMPK pathway through PEN2

    Teng Ma, Xiao Tian, Baoding Zhang, Mengqi Li, Yu Wang, Chunyan Yang, Jianfeng Wu, Xiaoyan Wei, Qi Qu, Yaxin Yu, Shating Long, Jin-Wei Feng, Chun Li, Cixiong Zhang, Changchuan Xie, Yaying Wu, Zheni Xu, Junjie Chen, Yong Yu, Xi Huang, Ying He, Luming Yao, Lei Zhang, Mingxia Zhu, Wen Wang, Zhi-Chao Wang, Mingliang Zhang, Yuqian Bao, Weiping Jia, Shu-Yong Lin, Zhiyun Ye, Hai-Long Piao, Xianming Deng, Chen-Song Zhang, Sheng-Cai Lin Nature 603 (7899), 159-165, 2022-02-23

    ...Furthermore, knockdown of <jats:italic>pen-2</jats:italic> in <jats:italic>Caenorhabditis elegans</jats:italic> abrogates metformin-induced extension of lifespan....

    DOI PDF Web Site 被引用文献3件

  • Meta-lens light-sheet fluorescence microscopy for <i>in vivo</i> imaging

    Yuan Luo, Ming Lun Tseng, Sunil Vyas, Ting-Yu Hsieh, Jui-Ching Wu, Shang-Yang Chen, Hsiao-Fang Peng, Vin-Cent Su, Tzu-Ting Huang, Hsin Yu Kuo, Cheng Hung Chu, Mu Ku Chen, Jia-Wern Chen, Yu-Chun Chen, Kuang-Yuh Huang, Chieh-Hsiung Kuan, Xu Shi, Hiroaki Misawa, Din Ping Tsai Nanophotonics 11 (9), 1949-1959, 2022-02-21

    ...The meta-lens is composed of 800-nm-thick GaN nanostructures and is designed for a light-sheet well-adapted to biological specimens such as the nematode <jats:italic>Caenorhabditis elegans</jats:italic...

    DOI Web Site Web Site 参考文献50件

  • Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

    Heyun Guo, Ericca L. Stamper, Aya Sato-Carlton, Masa A. Shimazoe, Xuan Li, Liangyu Zhang, Lewis Stevens, KC Jacky Tam, Abby F. Dernburg, Peter M. Carlton 2022-02-17

    ...Here, we show that in <jats:italic>Caenorhabditis elegans</jats:italic>, meiotic DSB levels are controlled by the phosphoregulation of DSB-1, a homolog of the yeast Spo11 cofactor Rec114, by the opposing...

    DOI Web Site 参考文献80件

  • WormBase in 2022—data, processes, and tools for analyzing <i>Caenorhabditis elegans</i>

    Paul Davis, Magdalena Zarowiecki, Valerio Arnaboldi, Andrés Becerra, Scott Cain, Juancarlos Chan, Wen J Chen, Jaehyoung Cho, Eduardo da Veiga Beltrame, Stavros Diamantakis, Sibyl Gao, Dionysis Grigoriadis, Christian A Grove, Todd W Harris, Ranjana Kishore, Tuan Le, Raymond Y N Lee, Manuel Luypaert, Hans-Michael Müller, Cecilia Nakamura, Paulo Nuin, Michael Paulini, Mark Quinton-Tulloch, Daniela Raciti, Faye H Rodgers, Matthew Russell, Gary Schindelman, Archana Singh, Tim Stickland, Kimberly Van Auken, Qinghua Wang, Gary Williams, Adam J Wright, Karen Yook, Matt Berriman, Kevin L Howe, Tim Schedl, Lincoln Stein, Paul W Sternberg Genetics 220 (4), 2022-02-04

    ...<jats:title>Abstract</jats:title> <jats:p>WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans....

    DOI PDF PDF 被引用文献3件

  • Computable early Caenorhabditis elegans embryo with a phase field model

    Xiangyu Kuang, Guoye Guan, Ming-Kin Wong, Lu-Yan Chan, Zhongying Zhao, Chao Tang, Lei Zhang PLOS Computational Biology 18 (1), e1009755-, 2022-01-14

    ...Using <jats:italic>Caenorhabditis elegans</jats:italic> as the model animal, we present a phase field model to compute early embryonic morphogenesis within a confined eggshell....

    DOI Web Site 被引用文献1件

  • Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER

    Alexandre Toulmay, Fawn B. Whittle, Jerry Yang, Xiaofei Bai, Jessica Diarra, Subhrajit Banerjee, Tim P. Levine, Andy Golden, William A. Prinz Journal of Cell Biology 221 (3), 2022-01-11

    ...CSF1 has orthologues in Caenorhabditis elegans (lpd-3) and humans (KIAA1109/TWEEK); mutations in KIAA1109 cause the autosomal recessive neurodevelopmental disorder Alkuraya-Kučinskas syndrome....

    DOI PDF 被引用文献1件

  • Two-step screening method to identify α-synuclein aggregation inhibitors for Parkinson’s disease

    Makoto Hideshima, Yasuyoshi Kimura, César Aguirre, Keita Kakuda, Toshihide Takeuchi, Chi-Jing Choong, Junko Doi, Kei Nabekura, Keiichi Yamaguchi, Kichitaro Nakajima, Kousuke Baba, Seiichi Nagano, Yuji Goto, Yoshitaka Nagai, Hideki Mochizuki, Kensuke Ikenaka Scientific Reports 12 (1), 351-, 2022-01-10

    ...The robustness of our screening method was validated by a primary neuronal cell model and a <jats:italic>Caenorhabditis elegans</jats:italic> model, which demonstrated the effect of tannic acid against...

    DOI PDF Web Site 被引用文献1件 参考文献30件

  • Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

    Guo, Heyun, Stamper, Ericca L, 佐藤-カールトン, 綾, 島添, 將誠, Li, Xuan, Zhang, Liangyu, Stevens, Lewis, Tam, KC Jacky, Dernburg, Abby F, Carlton, Peter M eLife 11 2022

    ...Here, we show that in Caenorhabditis elegans, meiotic DSB levels are controlled by the phosphoregulation of DSB-1, a homolog of the yeast Spo11 cofactor Rec114, by the opposing activities of PP4[PPH-4.1...

    DOI HANDLE PDF ほか2件 参考文献100件

  • エクスポソーム研究における無脊椎動物モデル活用の可能性

    丹羽 隆介 日本毒性学会学術年会 49.1 (0), W4-5-, 2022

    ...従来の生命科学においては、ショウジョウバエDrosophila melanogasterや線虫Caenorhabditis elegansに代表される無脊椎動物モデルが、発生や生理の分子メカニズムの解明に大きく貢献してきた。よって、これらの無脊椎動物モデルおよびこれらのモデルで発達した遺伝学的ツールは、エクスポソーム研究においても大いに有効と思われる。...

    DOI

  • Maintenance of quiescent oocytes by noradrenergic signals

    Jeongho Kim, Moonjung Hyun, Masahiko Hibi, Young-Jai You Nature Communications 12 (1), 2021-11-26

    ...Here, we report that in four different species – <jats:italic>Caenorhabditis elegans</jats:italic>, <jats:italic>Caenorhabditis remanei</jats:italic>, <jats:italic>Drosophila melanogaster</jats:italic>...

    DOI PDF Web Site 参考文献69件

  • Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

    Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia, Lorraine V. Kalia Molecular Neurodegeneration 16 (1), 2021-11-12

    ...Invertebrate organisms, such as the nematode worm <jats:italic>Caenorhabditis elegans</jats:italic>, provide in vivo models of human disease processes that can be instrumental for initial pharmacological...

    DOI PDF Web Site 参考文献76件

  • WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing

    Ana R.G. De-Castro, Diogo R.M. Rodrigues, Maria J.G. De-Castro, Neide Vieira, Cármen Vieira, Ana X. Carvalho, Reto Gassmann, Carla M.C. Abreu, Tiago J. Dantas Journal of Cell Biology 221 (1), e202010178-, 2021-11-05

    ...Here, we identify the Caenorhabditis elegans WDR60 homologue, WDR-60, and dissect the roles of this intermediate chain using genome editing and live imaging of endogenous dynein-2/IFT components....

    DOI PDF 被引用文献4件

  • NGLY1: insights from Caenorhabditis elegans

    Nicolas John Lehrbach The Journal of Biochemistry 2021-10-26

    ...In this review, I highlight insights into peptide:N-glycanase biology gained by studies in the highly tractable genetic model animal Caenorhabditis elegans....

    DOI PDF

  • High-Dose Irradiation Inhibits Motility and Induces Autophagy in Caenorhabditis elegans

    Akira Yamasaki, Michiyo Suzuki, Tomoo Funayama, Takahito Moriwaki, Tetsuya Sakashita, Yasuhiko Kobayashi, Qiu-Mei Zhang-Akiyama International Journal of Molecular Sciences 22 (18), 9810-, 2021-09-10

    ...<jats:p>Radiation damages many cellular components and disrupts cellular functions, and was previously reported to impair locomotion in the model organism Caenorhabditis elegans....

    DOI Web Site 被引用文献1件 参考文献54件

  • Nuclear lipid droplets and nuclear damage in Caenorhabditis elegans

    Jose Verdezoto Mosquera, Meghan C. Bacher, James R. Priess PLOS Genetics 17 (6), e1009602-, 2021-06-16

    <jats:p>Fat stored in the form of lipid droplets has long been considered a defining characteristic of cytoplasm. However, recent studies have shown that nuclear lipid droplets occur in multiple …

    DOI Web Site 被引用文献1件

  • Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans

    Komura, Tomomi, Yamanaka, Mikihiro, Nishimura, Kohji, Hara, Keita, Nishikawa, Yoshikazu npj Aging and Mechanisms of Disease 7 (1), 12-, 2021-06-07

    研究グループは、老化研究のモデル動物としてよく用いられる『線虫』を用いて、生体内で特定の蛍光を発する物質が加齢に伴い増加することを見出しました。その蛍光は最終糖化産物(advanced glycation end products: AGEs)に由来するもので、線虫の余命とも相関していることがわかりました。本モデルの測定技術は、今後、抗糖化素材の探索・評価への活用が期待されます。

    DOI 機関リポジトリ PDF ほか1件 被引用文献2件 参考文献40件

  • SYP-5 regulates meiotic thermotolerance in <i>Caenorhabditis elegans</i>

    Yuanyuan Liu, Qiuchen Zhao, Hui Nie, Fengguo Zhang, Tingting Fu, Zhenguo Zhang, Feifei Qi, Ruoxi Wang, Jun Zhou, Jinmin Gao Journal of Molecular Cell Biology 13 (9), 662-675, 2021-06-03

    ...Using the model organism Caenorhabditis elegans, here, we identified the synaptonemal complex (SC) protein SYP-5 as a critical regulator of meiotic thermotolerance. syp-5-null mutants maintained a high...

    DOI PDF PDF 被引用文献1件

  • A hydraulic instability drives the cell death decision in the nematode germline

    Nicolas T. Chartier, Arghyadip Mukherjee, Julia Pfanzelter, Sebastian Fürthauer, Ben T. Larson, Anatol W. Fritsch, Rana Amini, Moritz Kreysing, Frank Jülicher, Stephan W. Grill Nature Physics 17 (8), 920-925, 2021-05-20

    ...We present evidence that in the nematode <jats:italic>Caenorhabditis elegans</jats:italic>, this cell-fate decision is mechanical and related to tissue hydraulics....

    DOI PDF Web Site 被引用文献1件

  • Alternative Animal Models of Aging Research

    Susanne Holtze, Ekaterina Gorshkova, Stan Braude, Alessandro Cellerino, Philip Dammann, Thomas B. Hildebrandt, Andreas Hoeflich, Steve Hoffmann, Philipp Koch, Eva Terzibasi Tozzini, Maxim Skulachev, Vladimir P. Skulachev, Arne Sahm Frontiers in Molecular Biosciences 8 660959-, 2021-05-17

    ...elegans</jats:italic>)....

    DOI Web Site 被引用文献2件

  • Nematode-NOSE(N-NOSE)による消化器系がん検出能の検討

    西川 稿, 土屋 昭彦, 高森 頼雪, 原田 容治, 堀部 俊哉, 広津 崇亮 日本消化器がん検診学会雑誌 59 (3), 237-245, 2021-05-15

    <p>【背景】がんの早期発見は重要であり,簡便で高精度ながん検査が求められている。広津らによって開発されたNematode-NOSE(以後N-NOSE)は,尿を検体として線虫<i>Caenorhabditis elegans</i>(以後<i>C. elegans</i>)の優れた嗅覚を利用した簡便ながん検査であり,先行研究では95.0%の特異度と95.8%の感度が報告されている。</p><p>…

    DOI 医中誌

  • The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1

    Sabrina Dietz, Miguel Vasconcelos Almeida, Emily Nischwitz, Jan Schreier, Nikenza Viceconte, Albert Fradera-Sola, Christian Renz, Alejandro Ceron-Noriega, Helle D. Ulrich, Dennis Kappei, René F. Ketting, Falk Butter Nature Communications 12 (1), 2668-, 2021-05-11

    ...In the nematode <jats:italic>Caenorhabditis elegans</jats:italic>, a comprehensive understanding of the proteins interacting with the telomere sequence is lacking....

    DOI PDF Web Site 被引用文献1件

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