検索結果を絞り込む

本文・本体へのリンク

検索結果 282 件

  • Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

    Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martinez-Fabregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga eLife 10 e66014-, 2021-04-19

    <jats:p>Cytokines elicit pleiotropic and non-redundant activities despite strong overlap in their usage of receptors, JAKs and STATs molecules. We use IL-6 and IL-27 to ask how two cytokines …

    DOI PDF Web Site ほか1件 被引用文献2件

  • Ruthenium(II) and Iridium(III) Complexes as Tested Materials for New Anticancer Agents

    Joanna Masternak, Agnieszka Gilewska, Barbara Barszcz, Iwona Łakomska, Katarzyna Kazimierczuk, Jerzy Sitkowski, Joanna Wietrzyk, Anna Kamecka, Magdalena Milczarek Materials 13 (16), 3491-, 2020-08-07

    ...In this study, we present new complexes, ruthenium(II) [(η6-p-cymene)RuCl(py2CO)]PF6 (1), iridium(III) [(η5-Cp)IrCl(py2CO)]PF6 (2), and NH4[IrCl4(py2CO)]·H2O (3), based on di-2-pyridylketone (py2CO)....

    DOI Web Site 被引用文献1件

  • Kinetics of cytokine receptor trafficking determine signaling and functional selectivity

    Jonathan Martinez-Fabregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga eLife 8 2019-11-27

    <jats:p>Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes. We have …

    DOI PDF Web Site ほか1件 被引用文献1件

  • Transcriptomic Analysis of Breast Cancer Stem Cells and Development of a pALDH1A1:mNeptune Reporter System for Live Tracking

    Nadège Bidan, Justine Bailleul‐Dubois, Jérémy Duval, Marie Winter, Marie Denoulet, Karine Hannebicque, Ihsan Y. El‐Sayed, Christophe Ginestier, Violaine Forissier, Emmanuelle Charafe‐Jauffret, Manon Macario, Yukiko T Matsunaga, Samuel Meignan, François Anquez, Sylvain Julien, Amélie Bonnefond, Mehdi Derhourhi, Xuefen Le Bourhis, Chann Lagadec PROTEOMICS 19 (21-22), 2019-09-08

    <jats:title>Abstract</jats:title><jats:p>Many solid cancers are hierarchically organized with a small number of cancer stem cells (CSCs) able to regrow a tumor, while their progeny lacks this …

    DOI Web Site Web Site 参考文献32件

  • Iridium-Catalyzed Direct Cyclization of Aromatic Amines with Diols

    Maki Minakawa, Kouichi Watanabe, Satoru Toyoda, Yasuhiro Uozumi Synlett 29 (18), 2385-2389, 2018-10-02

    ...Thus, under conditions of 165 °C for 18 hours, the direct cyclization of N-methylanilines with 1,3-propanediol by using an IrCl3 catalyst with rac-BINAP as a ligand in mesitylene afforded the corresponding...

    DOI PDF

  • Heterogeneous Microtesla SABRE Enhancement of <sup>15</sup>N NMR Signals

    Kirill V. Kovtunov, Larisa M. Kovtunova, Max E. Gemeinhardt, Andrey V. Bukhtiyarov, Jonathan Gesiorski, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson Angewandte Chemie 129 (35), 10569-10573, 2017-07-28

    ...Immobilization of [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous...

    DOI Web Site Web Site ほか2件 被引用文献1件

  • Heterogeneous Microtesla SABRE Enhancement of <sup>15</sup>N NMR Signals

    Kirill V. Kovtunov, Larisa M. Kovtunova, Max E. Gemeinhardt, Andrey V. Bukhtiyarov, Jonathan Gesiorski, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson Angewandte Chemie International Edition 56 (35), 10433-10437, 2017-07-28

    ...Immobilization of [IrCl(COD)(IMes)], [IMes=1,3‐bis(2,4,6‐trimethylphenyl), imidazole‐2‐ylidene; COD=cyclooctadiene] catalyst onto silica particles modified with amine linkers engenders an effective heterogeneous...

    DOI Web Site Web Site ほか2件 被引用文献1件

  • 2 ステモアミド系アルカロイドの網羅的全合成 (口頭発表の部)

    佐藤 隆章, 寄立 麻琴, 高橋 芳人, 田島 隼人, 荻原 知里, 横山 貴, 千田 憲孝 天然有機化合物討論会講演要旨集 59 (0), 7-12, 2017

    ...On the other hand, the lactamselective nucleophilic addition was achieved through chemoselective reduction with [IrCl(CO)(PPh<SUB>3</SUB>)<SUB>2</SUB>] and (Me<SUB>2</SUB>HSi)<SUB>2</SUB>O<SUP>5)</SUP>...

    DOI

  • Extended Sandwich Molecules Displaying Direct Metal–Metal Bonds

    Subrat Kumar Barik, Monojit Ghosal Chowdhury, Susmita De, Pattiyil Parameswaran, Sundargopal Ghosh European Journal of Inorganic Chemistry 2016 (28), 4546-4550, 2016-08-30

    ...<jats:p>Treatment of [Cp*IrCl<jats:sub>2</jats:sub>]<jats:sub>2</jats:sub> (Cp* = pentamethylcyclopentadienyl) with Li[BH<jats:sub>3</jats:sub>(SePh)] at room temperature led to the isolation of a dimetala...

    DOI Web Site Web Site ほか1件 被引用文献1件

  • Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B‐cell lymphoma

    Fabrice Jardin, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, Brigitte Sola, Marlène Ochmann, François Lemonnier, Pierre‐Julien Viailly, Philippe Bertrand, Catherine Maingonnat, Alexandra Traverse‐Glehen, Philippe Gaulard, Diane Damotte, Richard Delarue, Corinne Haioun, Christian Argueta, Yosef Landesman, Gilles Salles, Jean‐Philippe Jais, Martin Figeac, Christiane Copie‐Bergman, Thierry Jo Molina, Jean Michel Picquenot, Marie Cornic, Thierry Fest, Noel Milpied, Emilie Lemasle, Aspasia Stamatoullas, Peter Moeller, Martin J.S Dyer, Christer Sundstrom, Christian Bastard, Hervé Tilly, Karen Leroy American Journal of Hematology 91 (9), 923-930, 2016-07-04

    <jats:p>Primary mediastinal B‐cell lymphoma (PMBL) is an entity of B‐cell lymphoma distinct from the other molecular subtypes of diffuse large B‐cell lymphoma (DLBCL). We investigated the …

    DOI Web Site Web Site 被引用文献1件

  • Genomic Landscape of <i>CXCR4</i> Mutations in Waldenström Macroglobulinemia

    Stéphanie Poulain, Christophe Roumier, Aurélie Venet-Caillault, Martin Figeac, Charles Herbaux, Guillemette Marot, Emmanuelle Doye, Elisabeth Bertrand, Sandrine Geffroy, Frédéric Lepretre, Olivier Nibourel, Audrey Decambron, Eileen Mary Boyle, Aline Renneville, Sabine Tricot, Agnès Daudignon, Bruno Quesnel, Patrick Duthilleul, Claude Preudhomme, Xavier Leleu Clinical Cancer Research 22 (6), 1480-1488, 2016-03-14

    <jats:title>Abstract</jats:title> <jats:p>Purpose: Whole-genome sequencing has revealed MYD88 L265P and CXCR4 mutations (CXCR4mut) as the most prevalent somatic mutations in …

    DOI PDF 被引用文献1件

  • Catalytic Asymmetric Hydrogenation of Pyrimidines

    Ryoichi Kuwano, Yuta Hashiguchi, Ryuhei Ikeda, Kentaro Ishizuka Angewandte Chemie International Edition 54 (8), 2393-2396, 2015-01-07

    ...title>Abstract</jats:title><jats:p>The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99 % <jats:italic>ee</jats:italic>) using an iridium catalyst composed of [IrCl...

    DOI Web Site Web Site 被引用文献4件 参考文献61件

  • Catalytic Asymmetric Hydrogenation of Pyrimidines

    Ryoichi Kuwano, Yuta Hashiguchi, Ryuhei Ikeda, Kentaro Ishizuka Angewandte Chemie 127 (8), 2423-2426, 2015-01-07

    ...title>Abstract</jats:title><jats:p>The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99 % <jats:italic>ee</jats:italic>) using an iridium catalyst composed of [IrCl...

    DOI Web Site Web Site 被引用文献3件

  • <i><scp>MYD</scp>88</i> L265P mutation contributes to the diagnosis of Bing Neel syndrome

    Stéphanie Poulain, Eileen M. Boyle, Christophe Roumier, Hélène Demarquette, Mathieu Wemeau, Sandrine Geffroy, Charles Herbaux, Elisabeth Bertrand, Bénédicte Hivert, Louis Terriou, Albert Verrier, Jean Paul Pollet, Claude Alain Maurage, Brigitte Onraed, Franck Morschhauser, Bruno Quesnel, Patrick Duthilleul, Claude Preudhomme, Xavier Leleu British Journal of Haematology 167 (4), 506-513, 2014-08-27

    <jats:title>Summary</jats:title><jats:p>Bing‐Neel syndrome (BNS), a rare neurological syndrome associated with Waldenström macroglobulinaemia (WM), is a direct involvement of the central nervous …

    DOI Web Site Web Site 被引用文献4件

  • New Promising Iridium Catalyst for Toluene Hydrogenation

    Michał Zieliński, Mariusz Pietrowski, Maria Wojciechowska ChemCatChem 3 (10), 1653-1658, 2011-08-17

    ...The nature of iridium precursors [H<jats:sub>2</jats:sub>IrCl<jats:sub>6</jats:sub> or Ir<jats:sub>4</jats:sub>(CO)<jats:sub>12</jats:sub>] and catalyst pretreatment conditions (reduction or oxidation/...

    DOI Web Site Web Site 被引用文献2件

  • Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells

    Anne-Frédérique Dessein, Laurence Stechly, Nicolas Jonckheere, Patrick Dumont, Didier Monté, Emmanuelle Leteurtre, Stéphanie Truant, François-René Pruvot, Martin Figeac, Mohamed Hebbar, Charles-Henri Lecellier, Thécla Lesuffleur, Rodrigue Dessein, Georges Grard, Marie-José Dejonghe, Yvan de Launoit, Yasuhiro Furuichi, Grégoire Prévost, Nicole Porchet, Christian Gespach, Guillemette Huet Cancer Research 70 (11), 4644-4654, 2010-06-01

    <jats:title>Abstract</jats:title> <jats:p>Metastasis and drug resistance are major problems in cancer chemotherapy. The purpose of this work was to analyze the molecular mechanisms …

    DOI PDF 被引用文献2件

  • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)

    Olivier Kosmider, Véronique Gelsi-Boyer, Meyling Cheok, Sophie Grabar, Véronique Della-Valle, Françoise Picard, Franck Viguié, Bruno Quesnel, Odile Beyne-Rauzy, Eric Solary, Norbert Vey, Mathilde Hunault-Berger, Pierre Fenaux, Véronique Mansat-De Mas, Eric Delabesse, Philippe Guardiola, Catherine Lacombe, William Vainchenker, Claude Preudhomme, François Dreyfus, Olivier A. Bernard, Daniel Birnbaum, Michaëla Fontenay Blood 114 (15), 3285-3291, 2009-10-08

    <jats:title>Abstract</jats:title> <jats:p>Oncogenic pathways underlying in the development of myelodysplastic syndromes (MDS) remain poorly characterized, but mutations of the …

    DOI PDF 被引用文献7件

  • Isolation of Dendritic Cells

    Kayo Inaba, William J. Swiggard, Ralph M. Steinman, Nikolaus Romani, Gerold Schuler, Carine Brinster Current Protocols in Immunology 86 (1), 3.7.1-, 2009-08

    <jats:title>Abstract</jats:title><jats:p>This unit presents two methods for preparing dendritic cells (DCs), a highly specialized type of antigen‐presenting cell (APC). The first method involves the …

    DOI Web Site Web Site ほか1件 被引用文献8件

  • 3つのスルフィド部位を有する新規シリル配位子を用いた遷移金属錯体の合成とその構造

    渡辺 大亮, 武田 亘弘, 海野 雅史 基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集) 2009 (0), 111-111, 2009

    近年、多座配位子を用いることにより,小分子の活性化などの特異な反応性を持つ遷移金属錯体が合成され,その化学に興味が持たれている。そこで、本研究では一つのシリル部位と三つのスルフィド部位を有する新規四座配位子[(RSCH2)C6H4]3SiH (1)を合成し、Ir(_III_)、Pt(_II_)に関する錯体を合成した。現在、Pd、Rh錯体の合成を検討している。

    DOI

  • Rhodium and Iridium Amino, Amido, and Aminyl Radical Complexes

    Nicola Donati, Daniel Stein, Torsten Büttner, Hartmut Schönberg, Jeffrey Harmer, Sreekanth Anadaram, Hansjörg Grützmacher European Journal of Inorganic Chemistry 2008 (30), 4691-4703, 2008-10

    ...)amine] or the acetonitrile complexes [Rh(trop<jats:sub>2</jats:sub>NH)(MeCN)<jats:sub>2</jats:sub>]<jats:sup>+</jats:sup>(CF<jats:sub>3</jats:sub>SO<jats:sub>3</jats:sub><jats:sup>–</jats:sup>) and [IrCl...

    DOI Web Site Web Site ほか1件 被引用文献1件

  • Facile Three-Component Synthesis of Substituted Quinolines Catalyzed by Iridium(III) Complex

    Takayuki Nakajima, Takashi Inada, Takeyuki Igarashi, Tadashi Sekioka, Isao Shimizu Bulletin of the Chemical Society of Japan 79 (12), 1941-1949, 2006-12-01

    ...convenient and efficient synthesis of substituted quinolines via a simple one-pot reaction of an aniline, an aromatic aldehyde, and an enolizable aliphatic aldehyde in the presence of the iridium catalyst [IrCl2H...

    DOI PDF 被引用文献2件 参考文献46件

  • 反転配位構造を有するN-混乱ポルフィリンイリジウム錯体

    小名川 丈, 戸叶 基樹, 古田 弘幸 基礎有機化学討論会要旨集(基礎有機化学連合討論会予稿集) 18 (0), 108-108, 2006

    ポルフィリンの構造異性体であるN-混乱ポルフィリン(N-Confused Porphyrin : NCP)は、通常ポルフィリンには見られない金属錯化挙動や特異な物性を示すため、新規機能性分子としての応用展開が期待されている。我々はこれまで、NCPが環内部の配位のみならず、環外周部窒素も利用する金属配位が可能であることを、ロジウムを始めとする種々の金属との錯形成の検討により明らかにしてきた。今回、…

    DOI

  • Iridium Complexes of 2,2′‐Bidipyrrins

    Martin Bröring, Carsten D. Brandt, Esther Cónsul Tejero Zeitschrift für anorganische und allgemeine Chemie 631 (10), 1793-1798, 2005-07-26

    ...jats:sub>2</jats:sub>(μ‐Cl)}<jats:sub>2</jats:sub>] with H<jats:sub>2</jats:sub>BDP proceeds differently and yields the macrocyclic [4e<jats:sup>−</jats:sup>,2H<jats:sup>+</jats:sup>]‐oxidized product [IrCl...

    DOI Web Site Web Site 被引用文献1件

  • DNA amplification method tolerant to sample degradation

    Gang Wang, Elizabeth Maher, Cameron Brennan, Lynda Chin, Christopher Leo, Manjit Kaur, Penny Zhu, Martha Rook, Jia Liu Wolfe, G. Mike Makrigiorgos Genome Research 14 (11), 2357-2366, 2004-11

    ...underline>R</jats:underline>estriction and <jats:underline>C</jats:underline>ircularization-<jats:underline>A</jats:underline>ided <jats:underline>R</jats:underline>olling <jats:underline>C</jats:underline>ircle...

    DOI Web Site 被引用文献2件

  • A Novel Catalysis of [{IrCl(cod)}2] Complex in Organic Syntheses

    Yasutaka Ishii, Satoshi Sakaguchi Bulletin of the Chemical Society of Japan 77 (5), 909-920, 2004-05-01

    ...Aziridines were also synthesized by three-component couplings of aldehydes, amines, and ethyl diazoacetate in the presence of a catalytic amount of [{IrCl(cod)}2]....

    DOI PDF 被引用文献5件 参考文献127件

  • イリジウム錯体触媒を用いる水素移動型酸化反応と応用

    鈴木 健之, 森田 兼司, 土田 美香, 広井 邦雄, 加藤 正 反応と合成の進歩シンポジウム 発表要旨概要 30 (0), 62-63, 2004

    ...The reaction was found to be catalyzed by 0.5 mol % of a chiral Ir complex prepared from [Cp*IrCl<sub>2</sub>]<sub>2</sub>, chiral amino alcohol and <i>t</i>-C<sub>4</sub>H<sub>9</sub>OK at 30 °C, giving...

    DOI

ページトップへ