検索結果 69 件

Yoshikazu Takaesu, Masahiro Suzuki, Margaret Moline, Kate Pinner, Kanako Inabe, Yurie Nishi, Kenichi Kuriyama Clinical and Translational Science 16 (4), 581-592, 2023-01-06

...Month 12 was followed by abrupt discontinuation and a 2‐week end‐of‐study follow‐up....

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Takaesu, Yoshikazu, Suzuki, Masahiro, Margaret, Moline, Kate, Pinner, Inabe, Kanako, Nishi, Yurie, Kuriyama, Kenichi Clinical and Translational Science 16 (4), 581-592, 2022-12-23

...Month 12 was followed by abrupt discontinuation and a 2-week end-of- study follow-up....

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Ankur Butala, Kevin Li, Aathman Swaminathan, Susan Dunlop, Yekaterina Salnikova, Bronte Ficek, Brandon Portnoff, Michael Harper, Bailey Vernon, Bela Turk, Zoltan Mari, Alexander Pantelyat Parkinson's Disease 2022 1-14, 2022-09-20

...), corresponding with improved minimal reading volumes at 24 weeks and 30 weeks (end of study)....

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Austin G. Kulasekararaj, Antonio M. Risitano, Jaroslaw P. Maciejewski, Rosario Notaro, Peter Browett, Jong Wook Lee, Mingjun Huang, Michael Geffner, Robert A. Brodsky Blood 138 (20), 1928-1938, 2021-11-18

...End points included hemoglobin (Hgb) change vs baseline at week 24 (primary), reduction in blood transfusions, and patient-reported outcomes....

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Richa Sharma, Lindsey R. Kuohn, Daniel M. Weinberger, Joshua L. Warren, Lauren H. Sansing, Adam Jasne, Guido Falcone, Amar Dhand, Kevin N. Sheth Stroke 52 (2), 563-572, 2021-02

...Excess cerebrovascular mortality occurred nationally from the weeks ending March 28 to May 2, 2020, up to a 7.8% increase above expected levels during the week of April 18....

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Alvina G Lai, Laura Pasea, Amitava Banerjee, Geoff Hall, Spiros Denaxas, Wai Hoong Chang, Michail Katsoulis, Bryan Williams, Deenan Pillay, Mahdad Noursadeghi, David Linch, Derralynn Hughes, Martin D Forster, Clare Turnbull, Natalie K Fitzpatrick, Kathryn Boyd, Graham R Foster, Tariq Enver, Vahe Nafilyan, Ben Humberstone, Richard D Neal, Matt Cooper, Monica Jones, Kathy Pritchard-Jones, Richard Sullivan, Charlie Davie, Mark Lawler, Harry Hemingway BMJ Open 10 (11), e043828-, 2020-11

...The peak RR for all-cause deaths was 2.1 from week ending on 17 April....

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Andrea M. Harriott, David Y. Chung, Aylin Uner, Refik O. Bozdayi, Andreia Morais, Tsubasa Takizawa, Tao Qin, Cenk Ayata Annals of Neurology 89 (1), 99-110, 2020-10-27

...End points, including periorbital and hindpaw mechanical allodynia, mouse grimace, anxiety, and working memory, were examined in male and female mice....

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Luisa Weiner, Fabrice Berna, Nathalie Nourry, François Severac, Pierre Vidailhet, Amaury C. Mengin Trials 21 (1), 2020-10-21

...Assessments are scheduled at pretreatment, mid-treatment (at 4 weeks), end of active treatment (at 8 weeks), and at 3-month and 6-month follow-up....

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Pasquale Longobardi, Valentina Hartwig, Luigi Santarella, Klarida Hoxha, Jhonny Campos, Marco Laurino, Pietro Salvo, Maria Giovanna Trivella, Flavio Coceani, Monica Rocco, Antonio L'Abbate Wound Repair and Regeneration 28 (6), 856-866, 2020-08-24

...This trend continued up to the 6‐week end‐point when a significantly greater area reduction was found with group B (65.5%) and group C (56.8%) compared to group A (29.7%) (<jats:italic>P</jats:italic> ...

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Kenzo Asahi, Eduardo A. Undurraga, Rodrigo Wagner medRxiv 202 2020-05-06

...We found a 10% increase in testing yielded ~9% (95% CI:4.2–3.4%; p<0.001) increase in reported cases across countries, and ~2% (95%CI:0.1-3.4%; p=0.03) increase across US states during the week ending...

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Gupta, Atul, Ikeda, Masanori, Geng, Bob, Azmi, Jay, Price, Robert G., Bradford, Eric S., Yancey, Steven W., Steinfeld, Jonathan Journal of Allergy and Clinical Immunology 144 (5), 1336-1342, 2019-08-16

...End points included the incidence of adverse events (AEs) and immunogenicity (primary), absolute blood eosinophil counts (cells per microliter; secondary), and annualized exacerbation rates and asthma...

機関リポジトリ

Sònia Abilleira, Natalia Pérez de la Ossa, Xavier Jiménez, Pere Cardona, Dolores Cocho, Francisco Purroy, Joaquín Serena, Luis San Román, Xabier Urra, Marta Vilaró, Jordi Cortés, José Antonio González, Ángel Chamorro, Miquel Gallofré, Tudor Jovin, Carlos Molina, Erik Cobo, Antoni Dávalos, Marc Ribó International Journal of Stroke 14 (7), 734-744, 2019-05-29

...Cluster randomization is performed according to a pre-established temporal sequence (temporal cluster design) with three strata: day/night, distance to the endovascular treatment stroke center, and week/week-end...

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Giuseppe Biondi‐Zoccai, Sebastiano Sciarretta, Christopher Bullen, Cristina Nocella, Francesco Violi, Lorenzo Loffredo, Pasquale Pignatelli, Ludovica Perri, Mariangela Peruzzi, Antonino G.M. Marullo, Elena De Falco, Isotta Chimenti, Vittoria Cammisotto, Valentina Valenti, Flaminia Coluzzi, Elena Cavarretta, Albino Carrizzo, Francesco Prati, Roberto Carnevale, Giacomo Frati Journal of the American Heart Association 8 (6), e010455-, 2019-03-19

...All participants used all types of products, with an intercycle washout of 1 week....

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Wilfred R. Bion The Long Week-End 1897-1919 212-217, 2018-05-08

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Michael Hoerger, Joseph A. Greer, Vicki A. Jackson, Elyse R. Park, William F. Pirl, Areej El-Jawahri, Emily R. Gallagher, Teresa Hagan, Juliet Jacobsen, Laura M. Perry, Jennifer S. Temel Journal of Clinical Oncology 36 (11), 1096-1102, 2018-04-10

...End-of-life care data were abstracted from the electronic health record....

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Yi-Yuan Sun, Ming Li, Yue-Yue Li, Li-Xiang Li, Wen-Zhe Zhai, Peng Wang, Xiao-Xiao Yang, Xiang Gu, Li-Jin Song, Zhen Li, Xiu-Li Zuo, Yan-Qing Li Scientific Reports 8 (1), 2964-, 2018-02-14

...End points included change from baseline in IBS symptoms, quality of life, stool consistency and frequency....

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F. Ji, B. Wei, Y. H. Yeo, E. Ogawa, B. Zou, C. D. Stave, Z. Li, S. Dang, N. Furusyo, R. C. Cheung, M. H. Nguyen Alimentary Pharmacology & Therapeutics 47 (5), 550-562, 2018-01-12

...end‐of‐treatment by 31 May 2017....

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小畑 政道, 山岡 功 日本原子力学会誌ATOMOΣ 60 (10), 634-636, 2018

<p>　バックエンド部会は，1985年から夏期セミナーを開催し，また，1994年からはバックエンドに関連するレポートや論文を集めた部会誌を発行し，更に2003年からは週末基礎講座を開催して，技術分野間の交流と世代間の交流とを図ってきた。本稿では，2017年度に実施した夏期セミナーと週末基礎講座での試みと結果を紹介する。</p>

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Komazawa, Makoto, Itao, Kenichi, Lopez, Guillaume, 羅, 志偉 Global Journal of Health Science 9 (9), 52-57, 2017-07-14

...As for in-week fluctuation, the trend of higher heart rate during the week and lower heart rate during week-ends and holidays has been comfirmed....

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川田 順造, KAWADA Junzo 国際日本学 14 203-213, 2017-01-31

...Lʼauteur propose la pratique de riziculture en classe à lʼécole primaire et secondaire, pour que les élèves puissent continuer la riziculture plus tard en tant que “week-end farmers” même sʼils deviennent...

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Ryosuke TAKAHASHI, Minoru MIYAZATO, Hisae NISHII, Yasuhiro SUMINO, Kazuo TAKAYAMA, Masako ONZUKA, Takuma OSHIRO, Seiichi SAITO, Naohiro FUJIMOTO, Hiromitsu MIMATA, Masatoshi ETO LUTS: Lower Urinary Tract Symptoms 10 (1), 76-83, 2016-11-05

...In addition, uroflowmetry was also performed at baseline, and 12‐week end point visit....

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Hai-Fei Liu, Zeng-Gan Chen, William C. Lineaweaver, Feng Zhang Plastic & Reconstructive Surgery 138 (1), 122-131, 2016-07

...After 8 weeks, end-to-end neurorrhaphy of the peroneal nerve stumps was performed in group A, C, and D during a second-stage procedure....

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江村 実紀, 水野 眞佐夫 北海道大学大学院教育学研究院紀要 126 171-187, 2016-06-30

本研究は小学校高学年児童を対象に，睡眠充足感や睡眠時間の違いがメンタルヘルスと体力に及ぼす影響について明らかにすることを目的とした。対象は札幌市内のA小学校に通う５年生と６年生児童132名とし，2014年６月に実施した。対象者は生活習慣とメンタルヘルスに関するアンケートに解答した。体力の評価には，文部科学省指定の新体力テストの結果を用いた。睡眠習慣の評価には睡眠充足感と睡眠時間を用い，メンタルヘ…

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Takahara Mitsuyoshi, Shiraiwa Toshihiko, Matsuoka Taka-aki, Katakami Naoto, Shimomura Iichiro Endocrine Journal 62 (1), 77-86, 2015

...A 75-g oral glucose tolerance test (OGTT) was performed at 0 (baseline), 4 (end of medication), and 5 weeks (end of washout)....

DOI PubMed 医中誌 被引用文献13件 参考文献33件

横尾 真, 蔡 華溢, 志波 友樹, 岩岡 竜夫 建築歴史・意匠 (2014) 261-262, 2014-09-12

日本建築学会

志波 友樹, 蔡 華溢, 横尾 真, 岩岡 竜夫 建築歴史・意匠 (2014) 265-266, 2014-09-12

日本建築学会

蔡 華溢, 志波 友樹, 横尾 真, 岩岡 竜夫 建築歴史・意匠 (2014) 263-264, 2014-09-12

日本建築学会

Science 344 (6182), 362-362, 2014-04-25

...ending 18 April 2014....

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Katharine D. Currie, Lee M. Rosen, Philip J. Millar, Robert S. McKelvie, Maureen J. MacDonald Applied Physiology, Nutrition, and Metabolism 38 (6), 644-650, 2013-06

...Fourteen males with CAD participated in 12 weeks of END or HIT training, each consisting of 2 supervised exercise sessions per week....

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藤井 晴夫 生活協同組合研究 448 (0), 61-68, 2013-05-05

DOI

V. Köberle, O. Waidmann, B. Kronenberger, A. Andrei, S. Susser, C. Füller, D. Perner, S. Zeuzem, C. Sarrazin, A. Piiper Journal of Viral Hepatitis 20 (8), 530-535, 2013-02-18

..., end of treatment and follow‐up were analysed retrospectively for mi<jats:styled-content style="fixed-case">R</jats:styled-content>‐122 content by quantitative real‐time reverse transcription <jats:styled-content...

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Francisco Jiménez, Carmen Garde, Enrique Poblet, Begoña Jimeno, Jesús Ortiz, María L. Martínez, Araika Gutiérrez‐Rivera, Virginia Pérez‐López, Usue Etxaniz, Corina Naveda, José L. Higuera, Nerea Egüés, Eduardo Escario, Ander Izeta Wound Repair and Regeneration 20 (6), 806-814, 2012-10-30

...At the 18‐week end point, we observed a 27.1% ulcer area reduction in the experimental square as compared with 6.5% in the control square (<jats:italic>p</jats:italic> = 0.046) with a maximum 33.5% vs....

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Vedran Lovric, Dong Chen, Yan Yu, Rema A. Oliver, Francois Genin, William R. Walsh The American Journal of Sports Medicine 40 (10), 2365-2374, 2012-09-14

...) end points....

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Yamaguchi Atsuko, Tanaka Nobuko, Eguchi Yoko, Kuno Kazue, Wakikawa Noriko, Sarukura Nobuko, Fukinbara Mina, Yamamoto Shigeru The Journal of Medical Investigation 59 (1,2), 111-115, 2012

...The results suggest that a survey of one weekday is reliable for all weekdays and that of one week-end day is reliable for any weekend day and also indicate the necessity of further studies of EER in rapidly...

DOI 機関リポジトリ Web Site ほか2件 参考文献5件

Jonathan A. Ledermann, Allan Hackshaw, Stan Kaye, Gordon Jayson, Hani Gabra, Iain McNeish, Helena Earl, Tim Perren, Martin Gore, Mojca Persic, Malcolm Adams, Lindsay James, Graham Temple, Michael Merger, Gordon Rustin Journal of Clinical Oncology 29 (28), 3798-3804, 2011-10-01

...End points were progression-free survival (PFS), toxicity, and overall survival....

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M. C. Genovese, F. Van den Bosch, S. A. Roberson, S. Bojin, I. M. Biagini, Peter Ryan, J. Sloan‐Lancaster Arthritis & Rheumatism 62 (4), 929-939, 2010-03-30

...In part B, 77 patients received 1 IV dose of LY2439821 (0.2, 0.6, or 2.0 mg/kg) or placebo every 2 weeks for a total of 5 doses, with a total evaluation period of 16 weeks....

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Gabor D. Kelen, Melissa L. McCarthy, Chadd K. Kraus, Ru Ding, Edbert B. Hsu, Guohua Li, Judy B. Shahan, James J. Scheulen, Gary B. Green Disaster Medicine and Public Health Preparedness 3 (S1), S10-S16, 2009-06

...ending in February 2006....

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Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada Journal of Medical Virology 79 (11), 1686-1695, 2007-09-13

...), end‐of treatment response, and sustained virological response (6 months after end of treatment)....

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E.M. Winter, R.W. Grauss, B. Hogers, J. van Tuyn, R. van der Geest, H. Lie-Venema, R. Vicente Steijn, S. Maas, M.C. DeRuiter, A.A.F. deVries, P. Steendijk, P.A. Doevendans, A. van der Laarse, R.E. Poelmann, M.J. Schalij, D.E. Atsma, A.C. Gittenberger-de Groot Circulation 116 (8), 917-927, 2007-08-21

...End-systolic and end-diastolic volumes were significantly smaller in the EPDC-injected group than in the medium-injected group at all ages evaluated....

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Ajit Sood, Vandana Midha, Syed Hissar, Manoj Kumar, Pothakamuri V Suneetha, Manu Bansal, Nina Sood, Puja Sakhuja, Shiv K Sarin Journal of Gastroenterology and Hepatology 23 (2), 203-207, 2007-07-20

...Patients in both groups were treated for 24 weeks. End of treatment viral response (ETVR) and sustained viral response (SVR) after a 6‐month follow‐up period were assessed....

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Raphael Snir, Dov Zohar Applied Psychology 57 (1), 109-127, 2007-02-27

...travail et les autres en ce qui concerne la probabilité de réaliser des activités relevant du travail pendant les loisirs, ou dans le niveau d’inconfort physique et le poids des affects négatifs pendant le week‐end...

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足立 稔, 笹山 健作, 引原 有輝, 沖嶋 今日太, 水内 秀次, 角南 良幸, 塩見 優子, 西牟田 守, 菊永 茂司, 田中 宏暁, 齋藤 慎一, 吉武 裕 体力科学 56 (3), 347-356, 2007

...WC and LC7-9 each were 13000-18000 counts and 16-32 minutes in week-day, and 8000-12500 counts and 8-18 minutes in week-end....

DOI Web Site Web Site ほか1件 被引用文献19件 参考文献47件

Edward G. Shaw, Robin Rosdhal, Ralph B. D'Agostino, James Lovato, Michelle J. Naughton, Michael E. Robbins, Stephen R. Rapp Journal of Clinical Oncology 24 (9), 1415-1420, 2006-03-20

...Outcomes were assessed at baseline, 12, 24 (end of treatment), and 30 weeks (end of wash-out). All tests were administered by a trained research nurse....

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佐々木 リディア, 小林 浩二 日本地理学会発表要旨集 2006s (0), 70-70, 2006

...On the other hand, Snagov is the typical example of suburban development for the new elites (exclusive recreation facilities, second homes, week-end cottages).Meanwhile, rural communities on the periphery...

DOI

Jianwen Wang, Theodore P. Abraham, Josef Korinek, Stig Urheim, Eileen M. McMahon, Marek Belohlavek Circulation 111 (22), 2943-2950, 2005-06-07

...(end point) in 12 dogs....

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Todd D. Levine Arthritis & Rheumatism 52 (2), 601-607, 2005-02

...Four patients experienced a return of symptoms that coincided with the return of B cells before the 52‐week end point....

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Kume Shinobu, Kobayashi Fuminori, Ishibashi Machiko, Ohno Ryoko, Nakamura Chiharu, Takumi Shigeo Genes & Genetic Systems 80 (3), 185-197, 2005

...After the second up-regulation, the amount of <i>Wcbf2</i> transcript greatly decreased in CS, while it increased again in M808 after 4 weeks until 9 weeks (end of the test period)....

DOI Web Site Web Site ほか1件 被引用文献2件 参考文献42件

金田 勲, 金 昌宣, 井川 正治, 桜井 弘 日本生気象学会雑誌 42 (1), 29-37, 2005

黒米糠抽出物をラットに長期投与させた場合とさらにランニング運動を併用した場合のラットの身体組成と骨密度に及ぼす影響について検討した．20匹の5週齢の雄ウイスター系ラットをコントロール非運動群（CN；n=5），コントロール運動群（CE；n=5），黒米糠摂取非運動群（BN；n=5）および黒米糠摂取運動群（BE；n=5）の計4群に分けた．CN群とCE群は標準食（CE-2，オリエンタル酵母社，日本），B…

DOI Web Site 医中誌 参考文献29件

J.J. Kim, J. Gross, S.J. Potashner, D.K. Morest Journal of Neuroscience Research 77 (6), 798-816, 2004-07-14

...Freshly occurring synaptic degeneration appeared in each period from 1–16 weeks....

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Yutaka Sakakibara, Keiichi Tambara, Fanglin Lu, Takeshi Nishina, Genichi Sakaguchi, Noritoshi Nagaya, Kazunobu Nishimura, Ren-Ke Li, Richard D. Weisel, Masashi Komeda Circulation 106 (12_suppl_1), I193-, 2002-09-24

...At the final week, end-systolic elastance was higher in group IV than in groups I, II, or III (0.61±0.10 versus 0.19±0.03, 0.30±0.09, 0.33±0.07 mm Hg/μL, <jats:italic>P=</jats:italic>...

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Julio Rosenstock, Sharen G. Shen, Marjorie R. Gatlin, James E. Foley Diabetes Care 25 (9), 1529-1533, 2002-09-01

...</jats:p> <jats:p>RESULTS—At the 16-week end point, nateglinide 120 mg, troglitazone 600 mg, and the combination of the agents achieved statistically significant decreases in HbA1c in comparison...

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吉川 邦夫, 瀧谷 知之, 安藤 純之介 動力・エネルギー技術の最前線講演論文集 : シンポジウム 2000.7 (0), 102-107, 2000

...Preliminary experiments of the STAR-MEET system has been done for three months continuously except week ends, where various industrial wastes are tested including waste wood chips, waste plastics, medical...

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D J Margolis, J Kantor, J A Berlin Diabetes Care 22 (5), 692-695, 1999-05-01

...For the six control arms with a 20-week end point, we found a weighted mean healing rate of 30.9% (95% CI 26.6-35.1)....

DOI PDF 被引用文献9件

新田 保次, 神田 忠士 土木計画学研究・論文集 13 695-702, 1996

...<BR>1) The characteristics of parking demand on week-day deffers from it on week-end.<BR>2) Considering the difference, two types of binary logit model have been built....

DOI

岡本 耕平 Geographical Review of Japa,. Ser. A, Chirigaku Hyoron 68 (1), 1-26, 1995

近代社会において発生した時間規律と空間規律は,生活時間を労働時間とそれ以外の時間に分化させる一方で,職住の空間の分離を促した.その結果,大都市圏においては,昼間に入口が都心部に集中し,夜間は郊外に分散するという都市のデイリー・リズムが形成された.郊外住民は,自らの日常活動を都市のデイリー・リズムに同調させることによって,この時空間システムを強化する一方で,このシステムから強い制約を受けている.本…

DOI Web Site Web Site 被引用文献18件 参考文献38件

山城 迪, Asher Ferix, 内山 敏之, 中村 陽一, 本間 武, 先崎 照治 電気学会論文誌Ｂ（電力・エネルギー部門誌） 114 (12), 1236-1242, 1994

...But, as the week end load pattern is different from that of week-day, daily unit commitment method is not directly applicable to the weekly unit commitment problem....

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M Kambayashi, T Miura, B H Oh, K Murata, H A Rockman, G Parra, J Ross Circulation 86 (6), 1935-1944, 1992-12

...PT systolic wall thickening showed dyskinesia during occlusion but recovered after reperfusion to 48% of control at 1 week and 67% at 3 weeks....

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前場 和吉, 永島 規雄, 小瀬 明男, 井上 正之 日本レーザー医学会誌 13 (Supplement), 313-316, 1992

...end....

DOI

長谷川 元治, 荒井 親雄, 斉藤 光代, 竹内 光吉, 安部 信行, 川崎 健, 高山 吉隆, 駒沢 勉 The Journal of Japan Atherosclerosis Society 11 (5), 1019-1029, 1983

...Ultimately at 22 weeks (end of the study) the mean PWV value stood at 7.58±0.2m/sec for the healthy group, while it was 8.76±0.43m/sec (p<0.001) for the arteriosclerotic group.<br>3....

DOI Web Site 医中誌 被引用文献1件

長谷川 元治, 荒井 親雄, 斉藤 光代, 竹内 光吉, 安部 信行, 川崎 健, 高山 吉隆, 駒沢 勉 動脈硬化 11 (5), 1019-1029, 1983

...Ultimately at 22 weeks (end of the study) the mean PWV value stood at 7.58±0.2m/sec for the healthy group, while it was 8.76±0.43m/sec (p<0.001) for the arteriosclerotic group.<br>3....

J-STAGE

桑田 百代, 伊藤 セツ, 大竹 美登利 家政学雑誌 28 (6), 422-428, 1977

...These were generally decreased for holidays and week-ends.<BR>3) For homemaking hours, non-employed wives decreased in both weekdays and holidays and week-ends, but employed wives increased....

DOI

志水 暎子 家政学雑誌 25 (4), 308-314, 1974

...Passive leisure activities are week-end carpentering and gardening; active forms are travelling and engaging in hobbies.<BR>2. Men prefer sports, while women wish to engage in hobbies....

DOI

Medical Journal of Australia 1 (23), 1167-1167, 1973-06

DOI Web Site 被引用文献1件

阿部 一郎, 桜井 実, 渡辺 照彦, 五十嵐 俊光, 国井 光雄, 大東 章 医療 22 (12), 1398-1402, 1968

...Their ergograms were checked on every week-end and they verified that the increased proportions of the 1 R....

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牧野 礼一郎, 三好 三七夫, 安田 収一 医療 19 (7), 541-548, 1965

...<br>Auro-thioglucose treatment was started from No. 1 (0.01g) oncs a week, and increased their concentration on every 5 to 10 weeks, ended at No. 4 (0.1g) or 5 (0.15g)....

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吉田 鉄也 産業医学 4 (4), 262-280, 1962

...Lesions in the axis cylinder were found at the third week end by in the nitrobenzene group and at the third week end by in the nitrobenzene group and at the forth week end in the aniline group....

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J. C. Fisher Physics Today 13 (2), 32-36, 1960-02-01

...On Labor Day week end, most of these visitors fade away, not to return until the following summer....

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千葉 裕典 民族衛生 24 (3), 112-128,A10, 1958

...Regarding meal-time of evening school students, it was observed that the neareg to the week end, the later is the suopertime,...

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沖永 喜代太 九州歯科学会雑誌 11 (5), 587-615, 1958

...But the difference of it between at the begin ring and the end of work increases towards week end, especially so in the third shift....

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