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Keiichi Akahoshi, Junichi Shindoh, Minoru Tanabe, Shuichi Watanabe, Hayato Takamizawa, Susumu Eguchi, Itaru Endo, Shoji Kubo, Akinobu Taketomi, Hiroaki Nagano, Masafumi Nakamura, Kiyoshi Hasegawa, Etsuro Hatano, Tomoharu Yoshizumi, Norihiro Kokudo Journal of Hepato-Biliary-Pancreatic Sciences 31 (3), 143-151, 2023-12-26

...While 64.7% of the respondents considered solitary tumors as being R, irrespective of size, opinions diverged on the upper limit of the number of tumors/tumor size for R: (1) up to three nodules with no...

DOI Web Site 被引用文献1件

Sumi Daigo, Taguchi Hiroki, Takeuchi Kumiko, Fujishiro Hitomi Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 48 (9), 487-494, 2023

...Since CHAC1 is a proapoptotic factor, we examined appearance of apoptotic cells and cleavage of caspase-3 after exposure to As(III) to determine whether As(III)-induced CHAC1 up-regulation was involved...

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SHINOHARA Hiroyuki, HASHIMOTO Takeyuki Ｍｅｄｉｃａｌ　Ｉｍａｇｉｎｇ　Ｔｅｃｈｎｏｌｏｇｙ 40 (5), 261-272, 2022-11-25

...Without regularization, the object-specific modulation transfer function (OMTF), defined as the ratio of power spectrum of original and reconstructed images, was ~1 up to 1.6 cycles/cm, lower than the...

DOI 医中誌

Jean-François Chassagneux, Junchao Chen, Noufel Frikha, Chao Zhou IMA Journal of Numerical Analysis 43 (5), 3109-3168, 2022-11-09

...$ up to some logarithmic factor $|\!...

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岡山 雅信 日本内科学会雑誌 111 (9), 1988-1991, 2022-09-10

DOI Web Site

秋山 真二, 武田 朋大, 榎 宏謙, 本村 優希, 本田 知之, 東條 悟志, 岩坪 昌一 情報通信政策研究 6 (1), 151-179, 2022-08-05

<p>第208回通常国会において成立した「電波法及び放送法の一部を改正する法律」は、電波の公平かつ能率的な利用を促進するため、①電波監理審議会の機能強化、②特定基地局の開設指針の制定に関する制度の整備、③電波利用料制度の見直し等を行うほか、近年の放送を取り巻く環境の変化等を踏まえ、④情報通信分野の外資規制の見直しを行うとともに、⑤日本放送協会の受信料の適正かつ公平な負担を図るための制度の整備等の…

DOI

Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez Hepatology 77 (1), 239-255, 2022-05-15

...</jats:p> </jats:sec> <jats:sec> <jats:title>Approach and Results</jats:title> <jats:p>Intestinal PPARα was activated and fatty acid‐binding protein 1 (FABP1)...

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Zuyi Ma, Zhenchong Li, Shujie Wang, Zixuan Zhou, Chunsheng Liu, Hongkai Zhuang, Qi Zhou, Shanzhou Huang, Chuanzhao Zhang, Baohua Hou Journal of Experimental & Clinical Cancer Research 41 (1), 130-, 2022-04-07

...Mechanistically, ZMAT1 up-regulated p53 expression and inhibition of p53 abrogated the effect of ZMAT1 over-expression on pancreatic cancer cell, indicating the role of ZMAT1 in PDAC was dependent on p53...

DOI PDF Web Site 被引用文献1件

宮崎 康信, 巽 雄二郎, 泰山 正則 溶接学会論文集 40 (4), 249-257, 2022

...up to 6h after welding, indicating that the average hydrogen concentration is a good indicator of the maximum hydrogen concentration....

DOI Web Site 被引用文献1件 参考文献12件

Annalisa Ferino, Julien Marquevielle, Himanshi Choudhary, Giorgio Cinque, Coralie Robert, Anne Bourdoncle, Raffaella Picco, Jean-Louis Mergny, Gilmar F. Salgado, Luigi E. Xodo ACS Omega 6 (49), 34092-34106, 2021-11-30

DOI Web Site 被引用文献1件

Bo Liu, Hui-Yang Jiang, Tao Yuan, Wei-Dong Zhou, Zhen-Dong Xiang, Qi-Quan Jiang, Deng-Long Wu Current Pharmaceutical Design 27 (41), 4261-4269, 2021-11-10

...Finally, we identified that AFAP1-AS1 up-regulated IGF1R expression by competitively binding to miR-15b to de-repress IGF1R....

DOI Web Site Web Site 被引用文献1件

Chuang Li, Lijuan Zhu, Lijun Fu, Mingli Han, Ya Li, Zhaozhong Meng, Xinguang Qiu Diagnostic Pathology 16 (1), 2021-10-25

...Besides, the protein levels of p-p38, p-JAK2 and p-STAT1 were remarkably down-regulated in miR-195-5p overexpressed PTC cells and tumor xenografts, whereas CircRNA NRIP1 up-regulation overturned the impacts...

DOI PDF Web Site 被引用文献1件

Ching-Tien Lee, Cheng-Fang Hsieh, Jiz-Yuh Wang International Journal of Molecular Sciences 22 (20), 10948-, 2021-10-11

...These results suggest that BPA induces N2a neurotoxicity characterized by AIF-dependent apoptosis and p62-related autophagy defects via HO-1 up-regulation and AMPK activation, thereby resulting in neuronal...

DOI Web Site 被引用文献1件

Matteo Cassandri, Silvia Pomella, Alessandra Rossetti, Francesco Petragnano, Luisa Milazzo, Francesca Vulcano, Simona Camero, Silvia Codenotti, Francesca Cicchetti, Roberto Maggio, Claudio Festuccia, Giovanni Luca Gravina, Alessandro Fanzani, Francesca Megiorni, Marialuigia Catanoso, Cinzia Marchese, Vincenzo Tombolini, Franco Locatelli, Rossella Rota, Francesco Marampon International Journal of Molecular Sciences 22 (19), 10671-, 2021-10-01

...MS-275 reversibly hampered cell survival in vitro in FN-RMS RD (RASmut) and irreversibly in FP-RMS RH30 cell lines down-regulating cyclin A, B, and D1, up-regulating p21 and p27 and reducing ERKs activity...

DOI Web Site 被引用文献1件

Yufei Yao, Xin Shen, Maolin Zhou, Boyu Tang Frontiers in Oncology 11 722797-, 2021-09-30

...(up to four times), but it downregulated nuclear factor (NF)-κB, NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3), and IL-1β (less than 0.5 times)....

DOI Web Site 被引用文献1件

Kunii, Hiroki, Kubo, Tomoaki, Asaoka, Natsuki, Balboula, Ahmed Z., Hamaguchi, Yu, Shimasaki, Tomoya, Bai, Hanako, Kawahara, Manabu, Kobayashi, Hisato, Ogawa, Hidehiko, Takahashi, Masashi Biochemical and biophysical research communications 569 179-186, 2021-09-10

...By RNA sequencing of VMM samples, three candidate genes for pregnancy markers (ISG15 and IFIT1: up-regulated, MUC16: down-regulated) were selected....

DOI HANDLE Web Site ほか1件 被引用文献2件 参考文献21件

尾身 頌吾, カストロ ホワン ホセ 日本建築学会計画系論文集 86 (786), 2083-2092, 2021-08-30

...</p><p>　The study considers four construction periods 1) up to 1879 when the Kingdom of the Ryukyus become Okinawa Prefecture, 2) from 1879 up to 1911 when the Japanese government enforced the National...

DOI 機関リポジトリ 機関リポジトリ ほか3件 参考文献2件

Guanning Wang, Masaki Tajima, Tasuku Honjo, Akio Ohta International Immunology 33 (11), 563-572, 2021-08-28

...NFAT1 interaction with this domain revealed substantial potency in PD-1 transcription compared to STAT5A, and STAT5A overexpression could quench NFAT1-dependent PD-1 up-regulation in a sequence-specific...

DOI PDF PDF 被引用文献2件

Joshua A. Hill, Danniel Zamora, Hu Xie, Laurel A. Thur, Colleen Delaney, Ann Dahlberg, Steven A. Pergam, Wendy M. Leisenring, Michael Boeckh, Filippo Milano Blood Advances 5 (16), 3113-3119, 2021-08-17

...Letermovir was administered on day +1 up to day +98. The cumulative incidence of CS-CMVi was significantly lower by day 98 in the letermovir cohort (19% vs 65%)....

DOI PDF 被引用文献1件

Nan Chen, Yi Zheng The Journal of Rheumatology 48 (12), 1876-1882, 2021-08-01

...The sex ratio was 1:1. Up to 70.5% of the patients had airway involvement during the disease course; among them, the larynx was most commonly affected (82.2%)....

DOI Web Site 被引用文献1件

Cuiling Li, Guangchao Liu, Xiaoyu Geng, Chunmei He, Taiyong Quan, Ken‐Ichiro Hayashi, Ive De Smet, Hélène S. Robert, Zhaojun Ding, Zhong‐Bao Yang The Plant Journal 108 (1), 55-66, 2021-07-30

...Al‐induced PIN1 up‐regulation and auxin accumulation in the root‐apex TZ was also regulated by the calossin‐like protein BIG....

DOI Web Site Web Site 参考文献58件

Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei Journal of Cachexia, Sarcopenia and Muscle 12 (6), 1570-1581, 2021-07-16

...The administration of a combination of cisplatin and IGF‐1 significantly suppressed the cisplatin‐induced downregulation of IGF‐1/PI3K/Akt signalling and upregulation of MuRF1 and atrogin‐1 (up to 1.6 ...

DOI Web Site Web Site 被引用文献2件

Mohammed E Hefni, Maria Bergström, Torbjörn Lennqvist, Cecilia Fagerström, Cornelia M Witthöft Analytical and Bioanalytical Chemistry 413 (21), 5349-5360, 2021-07-13

...The assay proved suitable for both clinical and food samples and was linear from ≈ 0.1 up to 200 μmol/L for all methylamines except for TMA and TMAO, which were linear up to 100 μmol/L....

DOI PDF Web Site 被引用文献1件

Asaka Kamiya, Hidenori Terasaki, Tadashi Kondo American Mineralogist 106 (7), 1077-1082, 2021-07-01

...up to at least 2000 K....

DOI PDF 参考文献26件

Qian Li, Zhipeng Zhao, Xiaohan Qin, Mengzhu Zhang, Qian Du, Zhonghao Li, Yuxia Luan Advanced Functional Materials 31 (37), 2104630-, 2021-06-26

...up‐regulation and interferon‐γ stimulation, achieving down‐regulated PD‐L1 expression in both tumor cells and exosomes....

DOI Web Site Web Site 被引用文献1件

西田 昌司, Masashi NISHIDA 神戸女学院大学論集 = KOBE COLLEGE STUDIES 68 (1), 47-55, 2021-06-20

肥満は美容上の問題のみならず様々な生活習慣病の原因となる。日常的な温浴が運動と同様に肥満を解消するか否かを、マウス前駆脂肪細胞 3T3-L1 の温熱刺激モデルを用い、温熱刺激が脂肪細胞の表現型に及ぼす影響から検討した。脂肪細胞に42℃、1時間の温熱負荷を加えて熱ショック蛋白70（HSP70）の発現を検討すると、負荷30分後から発現の亢進が認められ、細胞が負荷を受けていることが確認できた。ミトコン…

DOI 機関リポジトリ Web Site

M. M. Walle-Hansen, A. H. Ranhoff, M. Mellingsæter, M. S. Wang-Hansen, M. Myrstad BMC Geriatrics 21 (1), 199-, 2021-03-22

...up until July 1, 2020....

DOI PDF Web Site 被引用文献1件

Jens Stücker, Andreas S Schmidt, Simon D M White, Fabian Schmidt, Oliver Hahn Monthly Notices of the Royal Astronomical Society 503 (1), 1473-1489, 2021-02-18

...We find that the response amplitude does not approach zero on small scales in physical coordinates, but rather a constant value at z = 0, RK ≈ 0.5 for $k \ge 3\, h\, {\rm Mpc}^{-1}$ up to the scale where...

DOI PDF PDF 被引用文献3件

Anna Gregis, Chiara Ghisalberti, Savino Sciascia, Francesco Sottile, Cristiana Peano International Journal of Environmental Research and Public Health 18 (4), 1943-, 2021-02-17

...From the total amount of 7226, 84 selected articles showed that:(1) up to 50% are published by U.S. universities or institutions; (2) up to 44% of the studies considered “community gardens” as the main...

DOI Web Site 被引用文献1件

Zhilei Xu, Grace E. Chesmore, Shunsuke Adachi, Aamir M. Ali, Andrew Bazarko, Gabriele Coppi, Mark Devlin, Tom Devlin, Simon R. Dicker, Patricio A. Gallardo, Joseph E. Golec, Jon E. Gudmundsson, Kathleen Harrington, Makoto Hattori, Anna Kofman, Kenji Kiuchi, Akito Kusaka, Michele Limon, Frederick Matsuda, Jeff McMahon, Federico Nati, Michael D. Niemack, Aritoki Suzuki, Grant P. Teply, Robert J. Thornton, Edward J. Wollack, Mario Zannoni, Ningfeng Zhu Applied Optics 60 (4), 864-, 2021-01-26

...Room temperature optical measurements verify their control of reflectance to less than 1% up to <jats:inline-formula> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline...

DOI Web Site Web Site 被引用文献5件 参考文献20件

岡本 武三, 三田 功二, 丸山 剛, 柴北 健佑, 里本 健輔, 嶋本 敬介, 黒岩 有一 日本毒性学会学術年会 48.1 (0), P-82-, 2021

<p>動物試験において、使用する実験動物の特徴や背景病変を把握することは、試験結果の評価を行ううえで極めて重要である。今回、ICRマウスの偶発死亡の発生状況について調査を行ったため、その結果を報告する。調査対象とした試験は、2009年4月～2020年3月に当施設において実施されたICRマウス（Crl:CD1及びCrlj:CD1）試験（2、4、13及び26週間毒性試験及びがん原性試験の31週齢まで…

DOI

Passos Rocha Eduardo, Bruniera Anchieta Rodolfo, Alexandre da Cunha Melo Regis, Henrique dos Santos Paulo, Gonçalves Assunção Wirley, Isquierdo de Souza Fernando, Paula Martini Ana Journal of Prosthodontic Research 65 (2), 191-197, 2021

...These included G1: up to 2 years since graduation, G2: 2-5 years, G3: 5-10 years, and G4: more than 10 years....

DOI Web Site PubMed ほか1件 被引用文献1件 参考文献33件

Lucy Fallon, Kellon Belfon, Lauren Raguette, Yuzhang Wang, Christopher Corbo, Darya Stepanenko, Abbigayle Cuomo, Jose Guerra, Stephanie Budhan, Sarah Varghese, Robert Rizzo, Carlos Simmerling Biological and Medicinal Chemsitry 1 2020-12-31

...Using an atomistic model of the glycosylated wild-type spike in the closed and 1-up RBD conformations, we identified specific interactions that stabilize the closed RBD, and mapped the free energy landscape...

DOI Web Site 被引用文献1件

Hirotsugu Kenmotsu, Seiji Niho, Masahiro Tsuboi, Masashi Wakabayashi, Genichiro Ishii, Kazuo Nakagawa, Haruko Daga, Hiroshi Tanaka, Haruhiro Saito, Keiju Aokage, Toshiaki Takahashi, Toshi Menju, Takashi Kasai, Ichiro Yoshino, Koichi Minato, Morihito Okada, Junko Eba, Hisao Asamura, Yuichiro Ohe, Shun-ichi Watanabe Journal of Clinical Oncology 38 (36), 4292-4301, 2020-12-20

...up to four cycles....

DOI Web Site 被引用文献4件

Ryoma Morigaki, Jannifer H. Lee, Tomoko Yoshida, Christian Wüthrich, Dan Hu, Jill R. Crittenden, Alexander Friedman, Yasuo Kubota, Ann M. Graybiel Frontiers in Neuroanatomy 14 2020-12-10

...We show that in heterozygous Q175 knock-in model mice [~192 cytosine-adenine-guanine (CAG) repeats], this MOR1 up-regulation progressed with advancing age and disease progression, and was particularly...

DOI Web Site 参考文献69件

Ivana Bjedov, Helena M. Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S. Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C. Regan, Janne M. Toivonen, Michael P. Murphy, Janet Thornton, Kerri J. Kinghorn, Thomas P. Neufeld, Filipe Cabreiro, Linda Partridge PLOS Genetics 16 (11), e1009083-, 2020-11-30

...Interestingly, strong Atg1 up-regulation was detrimental to lifespan. Transcriptomic and metabolomic approaches identified specific signatures mediated by varying levels of autophagy in flies....

DOI Web Site 被引用文献2件

Benjamin Lee, John P. Hanley, Sarah Nowak, Jason H. T. Bates, Laurent Hébert-Dufresne BMC Public Health 20 (1), 2020-11-16

...</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>We find that reopening schools for all children would maintain a post-intervention R<jats:sub>0</jats:sub> < 1 up to a baseline...

DOI PDF Web Site 被引用文献2件

Fei Teng, Ju-Xiang Zhang, Qi-Meng Chang, Xu-Bo Wu, Wei-Guo Tang, Jian-Fa Wang, Jin-Feng Feng, Zi-Ping Zhang, Zhi-Qiu Hu Journal of Experimental & Clinical Cancer Research 39 (1), 235-, 2020-11-09

...</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>MYLK-AS1 up-regulation was detected in the HCC tumor tissues and cell lines associated...

DOI PDF Web Site 被引用文献1件

Marc Delcroix, Salma Sylla, Ricardo Hueso, François Colas, David Baratoux EPSC 14 775-, 2020-10-08

...AL+FvibD4ut9S8HeM9Y0jw7fBdRu7u1nflk1yp/WLK0+aMaNNTgnHlalKtV/dxlNJOU4wWl0rUYtzvOEUoxlFq8oS5qsadm3r7sf3toc0uRuTtTtVf6f/wDCU2IAPnePsE4GPh/4g5/Pwj6lf09eE/4Smy5/fePcAZP/ABb/AMQcDIAPHhI8ZIGc4+ZeckCvm7Xvhz8c1uP2adQvm8O...

DOI 被引用文献1件

Rosemary Killen 2020-10-08

.../kIaejssVyDnnACR5EsQXGG4CSOpvKKrPeqLSuyGMyTJNIbUw+hI5xBYZ1S6drlBuNV90Nog0I6dcA6Mv2ugL+w3jzlPVerqrNeHdtAkR5Xg4jX7EtKiP/LlmUEIbQTgS/Sg064CQjRcddHp85PlCzVqmiTLKiMqu5R7IFpo0FHgxQSqDpJHC11R0WbuqqOHp2jhylwd1uP7QCzVMr97HmAvDq...

DOI 被引用文献1件

Itziar Garate-Lopez, Ricardo Hueso, Yeon Joo Lee, Valeria Mangano, Kandis Lea Jessup, Javier Peralta, Agustin Sanchez-Lavega, Joe Zender, Johannes Benkhoff, Go Murakami, Manuel Scherf 2020-10-08

...E3sC97a2nwNkq+E98LTETpX6Z+GSBROaJGy7UKk0DgMBrFFUUMHJzOZhks6QwgDWuECDBW3xJW0Rg5QNpIfCPQUuyQkVgWkx62jdIzwJSRRak+FL2Dtu3Kn9EvqTiWM+iZG9DrQQlslBsNtFtH0tUw452ArwSevNUq6D4egPSikBrroaH2VwkBGFFRQqY4E3m50FfJqI0by1UP5x3pvQt1SlxFMpddof8RKgY0PwBbGZwWSEiSlGD8cXxxIOZl5FIURuxxHBBMQBDALjJAIOhQ1ZZoY1Rr4aoJLfaE3CLn2jlrWEt2CWanLDX4zNciJkMX8LjK9Y5Q8DzYTi4eJVIPTIBtrW7SRrP7F...

DOI 被引用文献1件

Ryota Nakano, Masatoshi Hirabayashi 2020-10-08

...torhqtlLO8fUo24/YN8/DLk/oh+1/PAJd+oQ0qwz4yVhFoH29LrNZOe873sKHw/POfuPS738Xjh5bhgi0LUMPgWFUJCl8br7Z4DypZvtraEszZ/hbLvRIXff8HwKOPAkMGt+fWYMseAgLWzz0E0NrrLWH3c28ukBs3oerWW/DCgg/wt66jsbHbCCSTBBNruZInTqQ6IQnV3IJw5IF1uP7QOsydNR1JP...

DOI 被引用文献1件

Leindert A. Boogaard, Paul van der Werf, Axel Weiss, Gergö Popping, Roberto Decarli, Fabian Walter, Manuel Aravena, Rychard Bouwens, Dominik Riechers, Jorge González-López, Ian Smail, Chris Carilli, Melanie Kaasinen, Emanuele Daddi, Pierre Cox, Tanio Díaz-Santos, Hanae Inami, Paulo C. Cortes, Jeff Wagg The Astrophysical Journal 902 (2), 109-, 2020-10-01

...up to 8 (and an additional 21 upper limits, up to <jats:italic>J</jats:italic> = 10) and 6 <jats:inline-formula> <jats:tex-math> <?...

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A. Aab, P. Abreu, M. Aglietta, J. M. Albury, I. Allekotte, A. Almela, J. Alvarez-Muñiz, R. Alves Batista, G. A. Anastasi, L. Anchordoqui, B. Andrada, S. Andringa, C. Aramo, P. R. Araújo Ferreira, H. Asorey, P. Assis, G. Avila, A. M. Badescu, A. Bakalova, A. Balaceanu, F. Barbato, R. J. Barreira Luz, K. H. Becker, J. A. Bellido, C. Berat, M. E. Bertaina, X. Bertou, P. L. Biermann, T. Bister, J. Biteau, J. Blazek, C. Bleve, M. Boháčová, D. Boncioli, C. Bonifazi, L. Bonneau Arbeletche, N. Borodai, A. M. Botti, J. Brack, T. Bretz, F. L. Briechle, P. Buchholz, A. Bueno, S. Buitink, M. Buscemi, K. S. Caballero-Mora, L. Caccianiga, L. Calcagni, A. Cancio, F. Canfora, I. Caracas, J. M. Carceller, R. Caruso, A. Castellina, F. Catalani, G. Cataldi, L. Cazon, M. Cerda, J. A. Chinellato, K. Choi, J. Chudoba, L. Chytka, R. W. Clay, A. C. Cobos Cerutti, R. Colalillo, A. Coleman, M. R. Coluccia, R. Conceição, A. Condorelli, G. Consolati, F. Contreras, F. Convenga, C. E. Covault, S. Dasso, K. Daumiller, B. R. Dawson, J. A. Day, R. M. de Almeida, J. de Jesús, S. J. de Jong, G. De Mauro, J. R. T. de Mello Neto, I. De Mitri, J. de Oliveira, D. de Oliveira Franco, V. de Souza, E. De Vito, J. Debatin, M. del Río, O. Deligny, N. Dhital, A. Di Matteo, C. Dobrigkeit, J. C. D’Olivo, Q. Dorosti, R. C. dos Anjos, M. T. Dova, J. Ebr, R. Engel, I. Epicoco, M. Erdmann, C. O. Escobar, A. Etchegoyen, H. Falcke, J. Farmer, G. Farrar, A. C. Fauth, N. Fazzini, F. Feldbusch, F. Fenu, B. Fick, J. M. Figueira, A. Filipčič, T. Fodran, M. M. Freire, T. Fujii, A. Fuster, C. Galea, C. Galelli, B. García, A. L. Garcia Vegas, H. Gemmeke, F. Gesualdi, A. Gherghel-Lascu, P. L. Ghia, U. Giaccari, M. Giammarchi, M. Giller, J. Glombitza, F. Gobbi, F. Gollan, G. Golup, M. Gómez Berisso, P. F. Gómez Vitale, J. P. Gongora, N. González, I. Goos, D. Góra, A. Gorgi, M. Gottowik, T. D. Grubb, F. Guarino, G. P. Guedes, E. Guido, S. Hahn, R. Halliday, M. R. Hampel, P. Hansen, D. Harari, V. M. Harvey, A. Haungs, T. Hebbeker, D. Heck, G. C. Hill, C. Hojvat, J. R. Hörandel, P. Horvath, M. Hrabovský, T. Huege, J. Hulsman, A. Insolia, P. G. Isar, J. A. Johnsen, J. Jurysek, A. Kääpä, K. H. Kampert, B. Keilhauer, J. Kemp, H. O. Klages, M. Kleifges, J. Kleinfeller, M. Köpke, G. Kukec Mezek, B. L. Lago, D. LaHurd, R. G. Lang, N. Langner, M. A. Leigui de Oliveira, V. Lenok, A. Letessier-Selvon, I. Lhenry-Yvon, D. Lo Presti, L. Lopes, R. López, R. Lorek, Q. Luce, A. Lucero, A. Machado Payeras, G. Mancarella, D. Mandat, B. C. Manning, J. Manshanden, P. Mantsch, S. Marafico, A. G. Mariazzi, I. C. Mariş, G. Marsella, D. Martello, H. Martinez, O. Martínez Bravo, M. Mastrodicasa, H. J. Mathes, J. Matthews, G. Matthiae, E. Mayotte, P. O. Mazur, G. Medina-Tanco, D. Melo, A. Menshikov, K.-D. Merenda, S. Michal, M. I. Micheletti, L. Miramonti, D. Mockler, S. Mollerach, F. Montanet, C. Morello, M. Mostafá, A. L. Müller, M. A. Muller, K. Mulrey, R. Mussa, M. Muzio, W. M. Namasaka, L. Nellen, M. Niculescu-Oglinzanu, M. Niechciol, D. Nitz, D. Nosek, V. Novotny, L. Nožka, A Nucita, L. A. Núñez, M. Palatka, J. Pallotta, P. Papenbreer, G. Parente, A. Parra, M. Pech, F. Pedreira, J. Pekala, R. Pelayo, J. Peña-Rodriguez, J. Perez Armand, M. Perlin, L. Perrone, S. Petrera, T. Pierog, M. Pimenta, V. Pirronello, M. Platino, B. Pont, M. Pothast, P. Privitera, M. Prouza, A. Puyleart, S. Querchfeld, J. Rautenberg, D. Ravignani, M. Reininghaus, J. Ridky, F. Riehn, M. Risse, P. Ristori, V. Rizi, W. Rodrigues de Carvalho, J. Rodriguez Rojo, M. J. Roncoroni, M. Roth, E. Roulet, A. C. Rovero, P. Ruehl, S. J. Saffi, A. Saftoiu, F. Salamida, H. Salazar, G. Salina, J. D. Sanabria Gomez, F. Sánchez, E. M. Santos, E. Santos, F. Sarazin, R. Sarmento, C. Sarmiento-Cano, R. Sato, P. Savina, C. M. Schäfer, V. Scherini, H. Schieler, M. Schimassek, M. Schimp, F. Schlüter, D. Schmidt, O. Scholten, P. Schovánek, F. G. Schröder, S. Schröder, J. Schulte, S. J. Sciutto, M. Scornavacche, R. C. Shellard, G. Sigl, G. Silli, O. Sima, R. Šmída, P. Sommers, J. F. Soriano, J. Souchard, R. Squartini, M. Stadelmaier, D. Stanca, S. Stanič, J. Stasielak, P. Stassi, A. Streich, M. Suárez-Durán, T. Sudholz, T. Suomijärvi, A. D. Supanitsky, J. Šupík, Z. Szadkowski, A. Taboada, A. Tapia, C. Timmermans, O. Tkachenko, P. Tobiska, C. J. Todero Peixoto, B. Tomé, A. Travaini, P. Travnicek, C. Trimarelli, M. Trini, M. Tueros, R. Ulrich, M. Unger, L. Vaclavek, M. Vacula, J. F. Valdés Galicia, L. Valore, E. Varela, A. Vásquez-Ramírez, D. Veberič, C. Ventura, I. D. Vergara Quispe, V. Verzi, J. Vicha, J. Vink, S. Vorobiov, H. Wahlberg, A. A. Watson, M. Weber, A. Weindl, L. Wiencke, H. Wilczyński, T. Winchen, M. Wirtz, D. Wittkowski, B. Wundheiler, A. Yushkov, O. Zapparrata, E. Zas, D. Zavrtanik, M. Zavrtanik, L. Zehrer, A. Zepeda, M. Ziolkowski The Astrophysical Journal 902 (2), 105-, 2020-10-01

...up to 2018 August 31, over which the Pierre Auger Observatory has been taking data....

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Linyong Du, Jong-Ho Lee, Hongfei Jiang, Chengde Wang, Silu Wang, Zhihong Zheng, Fei Shao, Daqian Xu, Yan Xia, Jing Li, Yanhua Zheng, Xu Qian, Xinjian Li, Hyung-Ryong Kim, Dongming Xing, Pengyuan Liu, Zhimin Lu, Jianxin Lyu Journal of Experimental Medicine 217 (11), 2020-08-27

...<jats:p>PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells....

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Luis Felipe Campesato, Sadna Budhu, Jeremy Tchaicha, Chien-Huan Weng, Mathieu Gigoux, Ivan Jose Cohen, David Redmond, Levi Mangarin, Stephane Pourpe, Cailian Liu, Roberta Zappasodi, Dmitriy Zamarin, Jill Cavanaugh, Alfredo C. Castro, Mark G. Manfredi, Karen McGovern, Taha Merghoub, Jedd D. Wolchok Nature Communications 11 (1), 4011-, 2020-08-11

...up-regulation in CD8<jats:sup>+</jats:sup> T cells....

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Rehab Alshargabi, Tomomi Sano, Akiko Yamashita, Aiko Takano, Taiki Sanada, Misaki Iwashita, Takanori Shinjo, Takao Fukuda, Terukazu Sanui, Shosei Kishida, Fusanori Nishimura Scientific Reports 10 (1), 9785-, 2020-06-17

...Our study shows that SPOCK1 up-regulation in a noncancerous disease and SPOCK1-induced EMT in gingival overgrowth occurs via cooperation and crosstalk between several potential signaling pathways....

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Yasue Takeuchi, Masataka Tsuge, Ken Tsushima, Yosuke Suehiro, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Tomokazu Kawaoka, Daiki Miki, Michio Imamura, Hiroshi Aikata, C Nelson Hayes, Chise Tateno, Kazuaki Chayama The Journal of Infectious Diseases 222 (12), 2061-2070, 2020-06-09

...</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>SUV39h1 up-regulation was observed in HBV-infected humanized...

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Jéssika D.P. Soares, Scott L. Howell, Filipe J. Teixeira, Gustavo D. Pimentel Current Pharmaceutical Design 26 (9), 970-978, 2020-04-23

...Currently, cancer consensus recommendations suggest a protein intake above 1.0 g/kg.day-1 up to 2.0 g/k.day-1 for cancer patients, although an ideal amount for some amino acids in isolation has yet to...

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Lin Xiaolong, Guo Dongmin, Mihua Liu, Wang Zuo, Hu Huijun, Tan Qiufen, Hu XueMei, Lin Wensheng, Pan Yuping, Lin Jun, Zeng Zhaolin Journal of Cellular and Molecular Medicine 24 (9), 4992-5006, 2020-03-30

<jats:title>Abstract</jats:title><jats:p>Fibroblast growth factor 21 (FGF21) acts as an anti‐atherosclerotic agent. However, the specific mechanisms governing this regulatory activity are unclear. …

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Tetsushi Kataura, Shinji Saiki, Kei‐ichi Ishikawa, Wado Akamatsu, Yukiko Sasazawa, Nobutaka Hattori, Masaya Imoto Journal of Neurochemistry 155 (1), 81-97, 2020-03-20

...Both HO‐1 up‐regulation and bilirubin restoration by BRUP‐1 treatment were significantly abrogated by Nrf2 silencing....

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Wei Hou, Jin Pei, YingPing Wang, Jiao Zhang, HouSheng Zheng, Ranji Cui Journal of Cellular and Molecular Medicine 24 (6), 3751-3755, 2020-02-05

...Therefore, RG significantly prolonged the lifespan of female <jats:italic>D melanogaster</jats:italic> by reducing the expression of Pebp1, up‐regulating ERK and inhibiting the AKT pathway....

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中野, 隆文, Nakano, Takafumi, Tomikawa, Ko Journal of Natural History 54 (19-20), 1279-1292, 2020

...(up to three) and on inner plate with oblique inner row (up to two), pereopod 7 with coxal gill, and distally tapering telson with almost straight lateral margins bearing submarginal setae....

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遠藤 京子, 鬼頭 宏彰, 田中 涼, 梶栗 潤子, 田中 智之, 鈴木 孝禎, 大矢 進 日本薬理学会年会要旨集 93 (0), 2-P-244-, 2020

...However, the underlying mechanism of K_2P5.1 up-regulation in T cells remains to be elucidated....

DOI Web Site

Fu Hui-Zhen, Marian Malek, Enomoto Takuo, Hieno Ayaka, Ina Hidemasa, Suga Haruhisa, Shimizu Masafumi Ｍｉｃｒｏｂｅｓ　ａｎｄ　ｅｎｖｉｒｏｎｍｅｎｔｓ 35 (4), n/a-, 2020

...A quantitative real-time PCR analysis revealed that the foliar spraying of tomato plants with G4L1 up-regulated the expression of <i>PR-1a</i> and <i>LoxD</i> in stem and <i>GluB</i> in roots upon the...

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Yuanyuan Wang, Qian Xing, Xue Chen, Jianbo Wang, Shanghui Guan, Xuan Chen, Peng Sun, Mingxia Wang, Yufeng Cheng Current Cancer Drug Targets 19 (9), 756-763, 2019-12-20

...Kaplan-Meier analysis indicated that LRG1 up-regulation in ESCC was closely correlated to worse clinical survival (overall survival and progression-free survival), all P<0.001....

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Kyoko Endo, Hiroaki Kito, Ryo Tanaka, Junko Kajikuri, Satoshi Tanaka, Elghareeb E. Elboray, Takayoshi Suzuki, Susumu Ohya International Journal of Molecular Sciences 21 (1), 38-, 2019-12-19

...Hypoxia-exposed K2P5.1 up-regulation was also detected in stimulated thymocytes and the mouse T-cell line....

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Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria L. Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutierrez, Gary C. Chamness, Qin Feng, Bert W. O’Malley, Pier Selenica, Britta Weigelt, Jorge S. Reis-Filho, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff Proceedings of the National Academy of Sciences 116 (52), 26823-26834, 2019-12-11

...However, the molecular mechanisms by which FOXA1 up-regulation promotes these processes and the key downstream targets of the FOXA1 oncogenic network remain elusive....

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Anatoly Nikolaev, John B. Fiveash, Eddy S. Yang 2019-12-06

...Up to 80% of DIPG tumors contain a specific K27M mutation in one of two genes encoding histone H3 (H3K27M)....

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Maria Grazia Atzori, Claudia Ceci, Federica Ruffini, Mauro Trapani, Maria Luisa Barbaccia, Lucio Tentori, Stefania D'Atri, Pedro Miguel Lacal, Grazia Graziani Journal of Cellular and Molecular Medicine 24 (1), 465-475, 2019-11-23

...These data suggest that VEGFR‐1 up‐regulation might contribute to melanoma progression and spreading after acquisition of a drug‐resistant phenotype....

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Qian Zhang, Fang Luo, Yu Zhong, Jiajia He, Laigeng Li Journal of Experimental Botany 71 (4), 1449-1458, 2019-11-19

...In the process of inflorescence growth, XND1 was expressed with a similar pattern to NST1. Up-regulation of XND1 in fiber cells repressed SCW formation....

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Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby, Andrew H. Baker Cell Communication and Signaling 17 (1), 143-, 2019-11-08

...up-regulates some that could enhance this effects....

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Yan Xu, Yuan Li, Jiankang Jin, Guangchun Han, Chengcao Sun, Melissa Pool Pizzi, Longfei Huo, Ailing Scott, Ying Wang, Lang Ma, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Christopher Vellano, Liuqing Yang, Chunru Lin, Youngsoo Kim, A. Robert MacLeod, Linghua Wang, Zhenning Wang, Shumei Song, Jaffer A. Ajani Molecular Cancer 18 (1), 141-, 2019-10-10

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Background</jats:title> <jats:p>PVT1 has emerged as an oncogene in many tumor types. However, its role in …

DOI PDF Web Site 被引用文献2件

Zong-Pei Jiang, Wei-Jun Cai, John Lehrter, Baoshan Chen, Zhangxian Ouyang, Chengfeng Le, Brian J. Roberts, Najid Hussain, Michael K. Scaboo, Junxiao Zhang, Yuanyuan Xu Biogeosciences 16 (18), 3507-3525, 2019-09-17

...High NCPO2Ar rates (105.0±59.2 mmol C m−2 d−1, up to 235.4 mmol C m−2 d−1) were observed in the Mississippi and Atchafalaya plumes at intermediate salinities between 15 and 30 where light and nutrients...

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Rui‐Zhi Tan, Chen Wang, Chong Deng, Xia Zhong, Ying Yan, Yi Luo, Hui‐Yao Lan, Tao He, Li Wang Phytotherapy Research 34 (1), 139-152, 2019-09-09

...Furthermore, quercetin down‐regulated protein levels of Mincle, phosphorylated Syk and NF‐κB in kidney macrophages of AKI, as well as inhibited M1, up‐regulated M2 macrophage activity....

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Te-Fu Tsai, Ji-Fan Lin, Yi-Chia Lin, Kuang-Yu Chou, Hung-En Chen, Chao-Yen Ho, Po-Chun Chen, Thomas I-Sheng Hwang Bioscience Reports 39 (9), 2019-09

...The chemotherapy drug such as cisplatin may trigger resistance of BC through PD-L1 up-regulation....

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Takeda S., Kijima-Aoki H., Masumoto H., Suzuki H. Journal of the Magnetics Society of Japan 43 (5), 91-98, 2019-09-01

...This resonance was compensated using the Landau-Lifshitz-Gilbert (LLG) equation, and the net <i>μ</i>-<i>f</i> properties without the bias field (denoted as FMR1) up to 30 GHz successfully extracted....

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Ana‐Luisa Stefanski, Annika Wiedemann, Karin Reiter, Falk Hiepe, Andreia C. Lino, Thomas Dörner Arthritis & Rheumatology 71 (9), 1539-1544, 2019-08-06

...up‐regulation capacity, and reduced proliferation upon stimulation....

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Sokly Siev, Enrico C. Paringit, Chihiro Yoshimura, Seingheng Hul River Research and Applications 35 (9), 1387-1401, 2019-07-26

...up to 0.8....

DOI Web Site Web Site ほか2件 被引用文献1件

Chih-Chung Lin, Li-Der Hsiao, Rou-Ling Cho, Chuen-Mao Yang International Journal of Molecular Sciences 20 (13), 3157-, 2019-06-28

...These results suggested that in HTSMCs, CORM-2 activates PKCα/Pyk2-dependent Nox/ROS/ERK1/2/AP-1, leading to HO-1 up-regulation, which suppresses the lipopolysaccharide (LPS)-induced airway inflammation...

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Ryuta Ichiki, Masayuki Kono, Yuka Kanbara, Takeru Okada, Tatsuro Onomoto, Kosuke Tachibana, Takashi Furuki, Seiji Kanazawa Metals 9 (6), 714-, 2019-06-25

...When the hydrogen fraction in the operating gas of nitrogen/hydrogen gas mixture increased from 1% up to 5%, the nitrogen density of the treated steel surface drastically decreased....

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Hyunsoo Kim, S. Jun Son, Matthew K. Seeley, J. Ty Hopkins Journal of Athletic Training 54 (6), 708-717, 2019-06-01

...</jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Compared with the coper and control groups, the CAI group displayed (1)...

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Weili Yang, Biaoqi Feng, Yuhong Meng, Junpei Wang, Bin Geng, Qinghua Cui, Hongquan Zhang, Yang Yang, Jichun Yang Journal of Cellular and Molecular Medicine 23 (5), 3464-3475, 2019-03-19

...FAM3C overexpression promoted the proliferation and migration of MDA‐MB‐231 cells with YY1 and HSF1 up‐regulation, whereas FAM3C silencing exerted the opposite effects....

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Alastair Copland, Adam Sparrow, Peter Hart, Gil Reynolds Diogo, Mathew Paul, Miyuki Azuma, Rajko Reljic Scientific Reports 9 (1), 2019-03-06

...Here, we sought to unravel the molecular pathways behind PD-L1 up-regulation on antigen-presenting cells (APCs) by BCG....

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Tae-Su Han, Dominic Chih-Cheng Voon, Hiroko Oshima, Mizuho Nakayama, Kanae Echizen, Eri Sakai, Zachary Wei Ern Yong, Kazuhiro Murakami, Liang Yu, Toshinari Minamoto, Chan-Young Ock, Brendan J. Jenkins, Seong-Jin Kim, Han-Kwang Yang, Masanobu Oshima Gastroenterology 156 (4), 1140-1155.e4, 2019-03

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Takafumi Nakano, Yoshihiko Nakamura, Kiyoshi Matsuyama, Keiichi Irie, Mako Yasumura, Yurie Hirata, Motoki Yamasaki, Kanae Misumi, Yuta Yamashita, Takayuki Myose, Koichi Matsuo, Kazunori Sano, Hidetoshi Kamimura, Hiroyasu Ishikura, Takashi Egawa, Kenichi Mishima Thrombosis and Haemostasis 119 (03), 467-478, 2019-01-21

...The results of this study indicated that rhsTM improved functional outcomes via inhibition of HMGB1 up-regulation and M1 microglial activation in the cerebral ischaemic delayed phase. rhsTM may become...

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オウォラビ, イシアカ アラデ, チェンアプラム, マデュー, 関, 千草, 奥山, 祐子, 權, 垠相, 上井, 幸司, 常盤, 峻士, 竹下, 光弘, 中野, 博人 Bulletin of the Chemical Society of Japan 92 (3), 696-701, 2019

application/pdf

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Peiyuan Qiu, Jian Jiang, Zhen Liu, Yijun Cai, Tao Huang, Yan Wang, Qiming Liu, Yanhong Nie, Fang Liu, Jiumu Cheng, Qing Li, Yun-Chi Tang, Mu-ming Poo, Qiang Sun, Hung-Chun Chang National Science Review 6 (1), 87-100, 2019-01-01

...Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging...

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Yue Hao, Xinxin Luo, Xiyuan Ba, Jiali Wang, Shiyang Zhou, Shimin Yang, Changji Fang, Changyu Jiang, Wuping Sun Gene 680 43-50, 2019-01

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高 尚澤, 和気 秀徳, 高 遠, 王 登莉, 劉 克約, 勅使川原 匡, 西堀 正洋 日本薬理学会年会要旨集 92 (0), 1-YIA-06-, 2019

...HMGB1 up-regulated proinflammatory responses by interacting with three pathogen-related pattern recognition receptors: TLR2 and TLR4 and RAGE....

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石塚 はる菜, 渡邊 陽一, 竹山 雅夫 熱処理 59 (4), 215-221, 2019

<p>リチウム添加塩浴軟窒化処理によって形成されるFe-0.4mass%C合金の表面組織とその成長挙動について研究した。アーク溶解により作製したFe-0.4mass%C合金を用い，Li⁺，Na⁺およびK⁺と共にCNO^-およびCN^-からなる823 Kの溶融塩浴にて0.1～10 …

DOI Web Site

Yang Zhang, Jie Zhang, Jinliang Guo, Fanglin Zhou, Somesh Singh, Xuan Xu, Qi Xie, Zhongbao Yang, Chao-Feng Huang Proceedings of the National Academy of Sciences 116 (1), 319-327, 2018-12-17

...We find that STOP1 up-regulates <jats:italic>RAE1</jats:italic> expression by directly binding to the <jats:italic>RAE1</jats:italic> promoter, thus forming...

DOI Web Site 被引用文献5件

Wenjing Liu, Yujia Cui, Jianxun Sun, Linyi Cai, Jing Xie, Xuedong Zhou Bioscience Reports 38 (6), BSR20181678-, 2018-12-14

...Our data indicated that TGF-β1 up-regulated both mRNA and protein expression of Cx43 in osteocytes....

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Yuki Sato, Rena Watanabe, Nozomi Uchiyama, Nana Ozawa, Yui Takahashi, Remina Shirai, Kengo Sato, Yusaku Mori, Takaaki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano, Takuya Watanabe Clinical Science 132 (23), 2493-2507, 2018-12-05

...up-regulation in macrophages....

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Xiyuan Ba, Jiali Wang, Shiyang Zhou, Xinxin Luo, Yun Peng, Shimin Yang, Yue Hao, Guangyi Jin Biomedicine & Pharmacotherapy 108 76-84, 2018-12

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E. Koulouridis, M. Ricci, P. Giles, C. Adami, M. Ramos-Ceja, M. Pierre, M. Plionis, C. Lidman, I. Georgantopoulos, L. Chiappetti, A. Elyiv, S. Ettori, L. Faccioli, S. Fotopoulou, F. Gastaldello, F. Pacaud, S. Paltani, C. Vignali Astronomy & Astrophysics 620 A20-, 2018-11-20

...up to 6<jats:italic>r</jats:italic><jats:sub>500</jats:sub> radius....

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Heng-Ching Wen, Yen Nien Huo, Chih-Ming Chou, Wen-Sen Lee Scientific Reports 8 (1), 2018-11-02

...Treatment with PMA for 32 hours induced Thy-1 up-regulation and inhibited capillary-like tube formation and endothelial cell migration....

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José Alcaraz‐Quiles, Mireia Casulleras, Karl Oettl, Esther Titos, Roger Flores‐Costa, Marta Duran‐Güell, Cristina López‐Vicario, Marco Pavesi, Rudolf E. Stauber, Vicente Arroyo, Joan Clària Hepatology 68 (5), 1937-1952, 2018-10-13

...Moreover, HNA1 up‐regulated the expression of eicosanoid‐generating enzymes (i.e., cyclooxygenase‐2 [COX‐2] and microsomal prostaglandin E [PGE] synthase 1) and the production of inflammatory eicosanoids...

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R. Barchfeld, C. W. Domier, Y. Ren, R. Ellis, P. Riemenschneider, N. Allen, R. Kaita, B. Stratton, J. Dannenberg, Y. Zhu, N. C. Luhmann Review of Scientific Instruments 89 (10), 10C114-, 2018-10-01

...up to &gt;40 cm−1....

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Lindsay J. Celada, Jonathan A. Kropski, Jose D. Herazo-Maya, Weifeng Luo, Amy Creecy, Andrew T. Abad, Ozioma S. Chioma, Grace Lee, Natalie E. Hassell, Guzel I. Shaginurova, Yufen Wang, Joyce E. Johnson, Amy Kerrigan, Wendi R. Mason, Robert P. Baughman, Gregory D. Ayers, Gordon R. Bernard, Daniel A. Culver, Courtney G. Montgomery, Toby M. Maher, Philip L. Molyneaux, Imre Noth, Steven E. Mutsaers, Cecilia M. Prele, R. Stokes Peebles, Dawn C. Newcomb, Naftali Kaminski, Timothy S. Blackwell, Luc Van Kaer, Wonder P. Drake Science Translational Medicine 10 (460), 2018-09-26

<jats:p> PD-1 <jats:sup>+</jats:sup> T <jats:sub>H</jats:sub> 17 cells enhance collagen-1 production from human lung fibroblasts. …

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Yong-Sung Park, Suzie Kang, Hyewon Seo, Cheol-Won Yun Biochemical Journal 475 (17), 2831-2845, 2018-09-11

...Furthermore, mutation of the AfMac1-binding motif of sit1 eliminated AfMac1-mediated sit1 up-regulation....

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Peipei Li, Songsong Wen, Kunlai Sun, Yuqin Zhao, Yin Chen Marine Drugs 16 (8), 281-, 2018-08-15

...UP2-1 also had a small amount of →4)-α-L-Rha(1→ branch at the O-2 position of the →4)-α-L-Rha(1→. UP2-1 exhibited significant anticoagulant and immunomodulating activity in vitro....

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Mariapaola Nitti, Sabrina Piras, Lorenzo Brondolo, Umberto Marinari, Maria Pronzato, Anna Furfaro International Journal of Molecular Sciences 19 (8), 2260-, 2018-08-01

...<jats:p>Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress....

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Daniel Moran-Zuloaga, Florian Ditas, David Walter, Jorge Saturno, Joel Brito, Samara Carbone, Xuguang Chi, Isabella Hrabě de Angelis, Holger Baars, Ricardo H. M. Godoi, Birgit Heese, Bruna A. Holanda, Jošt V. Lavrič, Scot T. Martin, Jing Ming, Mira L. Pöhlker, Nina Ruckteschler, Hang Su, Yaqiang Wang, Qiaoqiao Wang, Zhibin Wang, Bettina Weber, Stefan Wolff, Paulo Artaxo, Ulrich Pöschl, Meinrat O. Andreae, Christopher Pöhlker Atmospheric Chemistry and Physics 18 (13), 10055-10088, 2018-07-16

...These estimates range from few g ha−1 a−1 up to several hundreds of g ha−1 a−1 in the ATTO region.The long-term data presented here provide a statistically solid basis for future studies of the manifold...

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Maria Sumarokova, Jagoba Iturri, Andreas Weber, Maria Maares, Claudia Keil, Hajo Haase, José Luis Toca-Herrera Scientific Reports 8 (1), 9660-, 2018-06-25

...up to 10 µm/s)....

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Michael O’Connor, Helen M. Deeks, Edward Dawn, Oussama Metatla, Anne Roudaut, Matthew Sutton, Lisa May Thomas, Becca Rose Glowacki, Rebecca Sage, Philip Tew, Mark Wonnacott, Phil Bates, Adrian J. Mulholland, David R. Glowacki Science Advances 4 (6), 2018-06

<jats:p>VR combined with cloud computing enables surgical manipulation of real-time molecular simulations, accelerating 3D research tasks.</jats:p>

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Wenchen Pu, Jiao Li, Yuanyuan Zheng, Xianyan Shen, Xin Fan, Jian‐Kang Zhou, Juan He, Yulan Deng, Xuesha Liu, Chun Wang, Shengyong Yang, Qiang Chen, Lunxu Liu, Guolin Zhang, Yu‐Quan Wei, Yong Peng Hepatology 68 (2), 547-560, 2018-05-21

...<jats:italic toggle="yes">Conclusion</jats:italic>: Experimental evidence suggests that Pin1 inhibition by API‐1 up‐regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development...

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Masayuki Utsunomiya Island Arc 27 (4), 2018-05-17

...<jats:title>Abstract</jats:title><jats:p>A mass‐transport deposit named MTD1 (up to 100 m in thickness) is intercalated in the upper Kiwada Formation, a Pleistocene forearc basin fill on the Boso Peninsula...

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Mei Chen, Jiawu Zhao, Imran H.A. Ali, Stephen Marry, Josy Augustine, Mohajeet Bhuckory, Aisling Lynch, Adrien Kissenpfennig, Heping Xu The American Journal of Pathology 188 (4), 1007-1020, 2018-04

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花田, 史彦 京都大学大学院教育学研究科紀要 64 1-13, 2018-03-30

本稿では映画評論家・津村秀夫(1907-85)を対象とし、彼が雑誌『文学界』の企画「近代の超克」(1942年)で行なった議論の戦後における展開を明らかにした。津村に関する先行研究では、彼の戦中期の国策協力や「近代の超克」への参加に関心が集中し、主に批判的な検討がなされてきた。それに対して本稿では、(1)津村が「近代の超克」の段階で、アメリカ映画資本に象徴される「機械文明」「物質文明」からいかに人…

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Qian Han, Guihua Li, Mary SiuMan Ip, Yuelin Zhang, Zhe Zhen, Judith ChoiWo Mak, Nuofu Zhang Journal of Cellular and Molecular Medicine 22 (5), 2717-2726, 2018-03-07

...up‐regulation attenuated <jats:styled-content style="fixed-case">IH</jats:styled-content>‐induced mitochondrial fragmentation and cell apoptosis....

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Ayumi A. Miyakawa, Thais Girão-Silva, Jose E. Krieger, Elazer R. Edelman Clinical Science 132 (4), 437-447, 2018-02-16

...Rapamycin induced SMAD phosphorylation (SMAD1, SMAD2, and SMAD5) and PAI-1 up-regulation, which was specifically abrogated by SMAD2 knockdown....

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Sofia Sklaveniti, Nadine Locoge, Philip S. Stevens, Ezra Wood, Shuvashish Kundu, Sébastien Dusanter Atmospheric Measurement Techniques 11 (2), 741-761, 2018-02-07

...During IRRONIC, changes in ozone production rates ranging from the limit of detection (3σ) of 6.2 ppbv h−1 up to 20 ppbv h−1 were observed when 6 ppbv of NO was added into the flow tubes....

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Xiao-Quan Li, Xiao Ning Li, Jing-Jing Liang, Xin-Bin Cai, Qian Tao, Yu-Xiao Li, Qing Qin, Su-Ping Xu, Ting Rong Luo Molecular Immunology 94 153-165, 2018-02

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LIU Yanli, WU Hongtao, LIU Hairui, CHEN Bai, YAO Jiafeng, WANG Yaoyao Journal of Advanced Mechanical Design, Systems, and Manufacturing 12 (7), JAMDSM0130-JAMDSM0130, 2018

...Then, the analytical solution of the position vector and orientation matrix of the (6+1)-UPS parallel robot are obtained....

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Matsui Miki, Terasawa Kyoko, Kito Hiroaki, Fujii Masanori, Ohya Susumu 日本薬理学会年会要旨集 WCP2018 (0), PO3-4-4-, 2018

...K_Ca3.1 is possible therapeutic target for IBD, however, the mechanism of K_Ca3.1 up-regulation in CD4⁺ T cells remains unclear....

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Genny Del Zotto, Francesca Antonini, Irma Azzari, Claudio Ortolani, Gino Tripodi, Francesca Giacopelli, Serena Cappato, Lorenzo Moretta, Roberto Ravazzolo, Renata Bocciardi Cytometry Part B: Clinical Cytometry 94 (4), 613-622, 2017-11-15

<jats:sec><jats:title>Background</jats:title><jats:p>Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder caused by sporadic heterozygous mutations in …

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Michael E. Rowan, Lorenzo Sironi, Ramesh Narayan The Astrophysical Journal 850 (1), 29-, 2017-11-14

...up to 1), and it asymptotes to <jats:inline-formula> <jats:tex-math> <?...

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Suofeng Sun, Kenji Nakashima, Masahiko Ito, Yuan Li, Takeshi Chida, Hirotaka Takahashi, Koichi Watashi, Tatsuya Sawasaki, Takaji Wakita, Tetsuro Suzuki Scientific Reports 7 (1), 12874-, 2017-10-09

...We demonstrate that PUF60 is involved in: 1) up-regulation of core promoter activity through its interaction with transcription factor TCF7L2, 2) promotion of 3.5 kb RNA degradation and 3) suppression...

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Christoph Burdelski, Rami Shihada, Andrea Hinsch, Alexander Angerer, Cosima Göbel, Emily Friedrich, Claudia Hube‐Magg, Susanne Burdak‐Rothkamm, Martina Kluth, Ronald Simon, Christina Möller‐Koop, Guido Sauter, Franzika Büscheck, Corinna Wittmer, Till S. Clauditz, Till Krech, Maria C. Tsourlakis, Sarah Minner, Markus Graefen, Thorsten Schlomm, Waldemar Wilczak, Frank Jacobsen The Prostate 77 (15), 1528-1538, 2017-09-19

...Comparison of GLO1 staining with several common genomic alterations of prostate cancers revealed a strong link between GLO1 up regulation and <jats:italic>TMPRSS2:ERG</jats:italic> fusion (<jats:italic...

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Kyoko Hayakawa, Anthony M. Formica, Yan Zhou, Daiju Ichikawa, Masanao Asano, Yue-Sheng Li, Susan A. Shinton, Joni Brill-Dashoff, Gabriel Núñez, Richard R. Hardy Journal of Experimental Medicine 214 (10), 3067-3083, 2017-09-06

...In normal adult mice, most mature B cells are enriched for Nod1 up-regulated cells, and signaling through Nod1 promotes competitive survival of mature B cells....

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Jie Qin, Yan Liu, Yongkui Lu, Meiling Liu, Manli Li, Juan Li, Lijuan Wu Scientific Reports 7 (1), 10592-, 2017-09-06

...up-regulation....

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Shuhei Hosomi, Joep Grootjans, Markus Tschurtschenthaler, Niklas Krupka, Juan D. Matute, Magdalena B. Flak, Eduardo Martinez-Naves, Manuel Gomez del Moral, Jonathan N. Glickman, Mizuki Ohira, Lewis L. Lanier, Arthur Kaser, Richard Blumberg Journal of Experimental Medicine 214 (10), 2985-2997, 2017-07-26

<jats:p>Endoplasmic reticulum (ER) stress is commonly observed in intestinal epithelial cells (IECs) and can, if excessive, cause spontaneous intestinal inflammation as shown by mice with …

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Marta Garcia-Contreras, Sanket H. Shah, Alejandro Tamayo, Paul D. Robbins, Ronald B. Golberg, Armando J. Mendez, Camillo Ricordi Scientific Reports 7 (1), 2017-07-20

...We found 7 different miRNAs (1 up-regulated and 6 down-regulated), that were differentially expressed in T1DM....

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Yuan Zhang, Chi A. Ma, Monica G. Lawrence, Timothy J. Break, Michael P. O’Connell, Jonathan J. Lyons, Diego B. López, John S. Barber, Yongge Zhao, Daniel L. Barber, Alexandra F. Freeman, Steven M. Holland, Michail S. Lionakis, Joshua D. Milner Journal of Experimental Medicine 214 (9), 2523-2533, 2017-07-14

...Overexpression of SOCS3 strongly inhibited phosphorylation of STAT1 and PD-L1 up-regulation, suggesting that diminished SOCS3 expression may lead to the observed effects....

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Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam, Hong He BMC Cancer 17 (1), 31-, 2017-06-19

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Jing Zheng, Min Hu, Zhuofei Du, Dongjie Shang, Zhaoheng Gong, Yanhong Qin, Jingyao Fang, Fangting Gu, Mengren Li, Jianfei Peng, Jie Li, Yuqia Zhang, Xiaofeng Huang, Lingyan He, Yusheng Wu, Song Guo Atmospheric Chemistry and Physics 17 (11), 6853-6864, 2017-06-12

...The average mass concentration of the submicron particles (PM1) was 5.7 ± 5.4 µg m−3 during the field campaign, ranging from 0.1 up to 33.3 µg m−3....

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Paola Dongiovanni, Marica Meroni, Guido Alessandro Baselli, Giulia Alessandra Bassani, Raffaela Rametta, Alessandro Pietrelli, Marco Maggioni, Federica Facciotti, Valentina Trunzo, Sara Badiali, Silvia Fargion, Stefano Gatti, Luca Valenti Clinical Science 131 (12), 1301-1315, 2017-06-01

...The mechanism entailed FoxO1 up-regulation, as FoxO1 silencing normalized Loxl2 expression reversing fibrosis in InsR+/– MCD-fed mice....

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Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro Journal of Orthopaedic Research 35 (10), 2109-2116, 2017-04-07

...Human MSC encapsulated in PRP/HA/BTX hydrogel were cultured in both growing medium and medium with or without TGF‐β1 up to day 21. The amount of glycosaminoglycan was evaluated....

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B‐F. Wang, P‐P. Cao, Z‐C. Wang, Z‐Y. Li, Z‐Z. Wang, J. Ma, B. Liao, Y‐K. Deng, X‐B. Long, K. Xu, H. Wang, M. Zeng, X. Lu, Z. Liu Allergy 72 (9), 1384-1397, 2017-04-04

...Bafilomycin A1 up‐regulated the levels of <jats:styled-content style="fixed-case">LC</jats:styled-content>3B‐<jats:styled-content style="fixed-case">II</jats:styled-content> and p62 in polyp <jats:styled-content...

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Nakano Masataka, Fukami Tatsuki, Gotoh Saki, Nakajima Miki, 中野 正隆, 深見 達基, 中嶋 美紀 Journal of Biological Chemistry 292 (12), 4873-4884, 2017-03-24

金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系

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池田 潤 実験音声学・言語学研究 9 (0), 27-34, 2017-03-24

...この実験で用いた視覚刺激は、</tt>1 <tt>ユニット母音記号なし（</tt>1U<tt>）、</tt>1 <tt>ユニット母音記号あり（</tt>1UP<tt>）、</tt>2 <tt>ユニット母音記号なし（</tt>2U<tt>）、</tt>2 <tt>ユニット母音記号あり（</tt>2UP<tt>）の</tt>4 <tt>種類に分類されるが、このうち言語的にも視覚的にも異なり、両方の処理が...

DOI

Emmaris Soto, Duilia F. de Mello, Marc Rafelski, Jonathan P. Gardner, Harry I. Teplitz, Anton M. Koekemoer, Swara Ravindranath, Norman A. Grogin, Claudia Scarlata, Peter Kurczynski, Eric Gawiser The Astrophysical Journal 837 (1), 6-, 2017-02-27

...up to 93%....

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Joe Hasei, Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Takuro Horii, Merissa Olmer, Izuho Hatada, Kanji Fukuda, Toshifumi Ozaki, Martin K. Lotz, Hiroshi Asahara Scientific Reports 7 (1), 2017-02-21

...We identified a novel mechanism of catabolic reaction where TWIST1 up-regulates MMP3 expression by enriching 5hmC levels at the MMP3 promoter via TET1 induction....

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Yang Li, Nan Hu, Dan Yang, Gregory Oxenkrug, Qing Yang The FEBS Journal 284 (6), 948-966, 2017-02-20

...up‐regulation....

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Ben‐Xian Xiao, Wei Du, Ying‐Chun Chen Advanced Synthesis & Catalysis 359 (6), 1018-1027, 2017-02-15

...up to 98% <jats:italic>ee</jats:italic>)....

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Hongyan Kang, Jiajia Liu, Anqiang Sun, Xiao Liu, Yubo Fan, Xiaoyan Deng Scientific Reports 7 (1), 42092-, 2017-02-13

...Results showed that the exposure of HUVSMCs to shear stress for 30 min induced cell contraction significantly, which was accompanied by ROCK1 up-regulation, re-distribution, as well as MYPT1 and MLC activation...

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Valentina Audrito, Sara Serra, Aureliano Stingi, Francesca Orso, Federica Gaudino, Cinzia Bologna, Francesco Neri, Giulia Garaffo, Romina Nassini, Gianna Baroni, Eliana Rulli, Daniela Massi, Salvatore Oliviero, Roberto Piva, Daniela Taverna, Mario Mandalà, Silvia Deaglio Oncotarget 8 (9), 15894-15911, 2017-02-09

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Jutiporn Thussagunpanit, Yuko Nagai, Miyu Nagae, Kiyoshi Mashiguchi, Nobutaka Mitsuda, Masaru Ohme-Takagi, Takeshi Nakano, Hidemitsu Nakamura, Tadao Asami Bioscience, Biotechnology, and Biochemistry 81 (2), 292-301, 2017-02-01

...GR24 and KAR1 up-regulate the expression of STH7, encoding a transcription factor belonging to the double B-box zinc finger subfamily....

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Yuan Zhang, Yuan Qu, Tian Niu, Haiyan Wang, Kun Liu Biochemical and Biophysical Research Communications 484 (1), 79-84, 2017-02

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Nadja Engel, Anna Adamus, Nicolas Schauer, Juliane Kühn, Barbara Nebe, Guido Seitz, Karin Kraft PLOS ONE 12 (1), e0169742-, 2017-01-26

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Nami Kim, Miso Nam, Mi Sun Kang, Jung Ok Lee, Yong Woo Lee, Geum-Sook Hwang, Hyeon Soo Kim Scientific Reports 7 (1), 2017-01-24

...Knock-down of AMPK blocked piperine-induced UCP1 up-regulation, demonstrating the required role of AMPK in this effect....

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Takenouchi, Yuta, Kojima, Ryoto, Momma, Riko, Ito, Hajime Synlett 28 (2), 270-274, 2017-01

...This reaction proceeded with high E/Z selectivity and enantioselectivity (E/Z = >99:1, up to 80% yield, up to 99% ee)....

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P. J. Blowey, L. A. Rochford, D. A. Duncan, D. A. Warr, T.-L. Lee, D. P. Woodruff, G. Costantini Faraday Discussions 204 97-110, 2017

...UPS and SXPS data indicate the TCNQ is in a negatively-charged state....

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Kim Sunyoung, Chin Young-Won, Cho Jungsook Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 40 (3), 256-265, 2017

...Treatment with tin protoporphyrin IX, a selective HO-1 inhibitor, abolished neuroprotective and anti-apoptotic effects of luteolin, suggesting a critical role of HO-1 up-regulation....

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Honglei Zhou, Aristeidis Telonis, Yi Jing, Masaya Jimbo, Fernando Blanco, Eric Londin, Jonathan Brody, Isidore Rigoutsos Cancer Research 76 (24_Supplement), A41-A41, 2016-12-14

...</jats:p> <jats:p>We showed that HuR/ELAVL1 up-regulated GPRC5A protein in the first 18 hours following gemcitabine treatment by stabilizing GPRC5A’s mRNA through binding to at least on...

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Joshua B. Bland, William T. Tse Blood 128 (22), 1667-1667, 2016-12-02

...Only a small increase of PD-L1, up to 2-4 fold, was seen on AML cells under this condition....

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Zakaria Ezzoukhry, Elodie Henriet, Léo Piquet, Kevin Boyé, Paulette Bioulac-Sage, Charles Balabaud, Gabrielle Couchy, Jessica Zucman-Rossi, Violaine Moreau, Frédéric Saltel European Journal of Cell Biology 95 (11), 503-512, 2016-11

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Claudia Baumung, Jürgen Rehm, Heike Franke, Dirk W. Lachenmeier Scientific Reports 6 (1), 35577-, 2016-10-19

...Benchmark dose values ranged from 0.004 mg/kg bodyweight for symptoms of intoxication in children to 3 mg/kg bodyweight for mortality in animals; MOEs ranged from below 1 up to 7.6 indicating a considerable...

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Xiaoyong Fu, Rinath Jeselsohn, Resel Pereira, Emporia F. Hollingsworth, Chad J. Creighton, Fugen Li, Martin Shea, Agostina Nardone, Carmine De Angelis, Laura M. Heiser, Pavana Anur, Nicholas Wang, Catherine S. Grasso, Paul T. Spellman, Obi L. Griffith, Anna Tsimelzon, Carolina Gutierrez, Shixia Huang, Dean P. Edwards, Meghana V. Trivedi, Mothaffar F. Rimawi, Dolores Lopez-Terrada, Susan G. Hilsenbeck, Joe W. Gray, Myles Brown, C. Kent Osborne, Rachel Schiff Proceedings of the National Academy of Sciences 113 (43), E6600-, 2016-10-06

...Here we demonstrate that forkhead box protein A1 (FOXA1) up-regulation via gene amplification or overexpression contributes to endocrine resistance and increased invasiveness phenotypes by altering the...

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Shadi Salloum, Jacinta A. Holmes, Rohit Jindal, Shyam S. Bale, Cynthia Brisac, Nadia Alatrakchi, Anna Lidofsky, Annie J. Kruger, Dahlene N. Fusco, Jay Luther, Esperance A. Schaefer, Wenyu Lin, Martin L. Yarmush, Raymond T. Chung Hepatology 64 (6), 1951-1968, 2016-10-05

...<jats:italic toggle="yes">Conclusion:</jats:italic> HIV accentuates an HCV‐driven profibrogenic program in hepatocyte and hepatic stellate cell lines through ROS, NFκB, and TGFβ1 up‐regulation; coculture...

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Jonay Poveda, Ana B. Sanz, Beatriz Fernandez‐Fernandez, Susana Carrasco, Marta Ruiz‐Ortega, Pablo Cannata‐Ortiz, Alberto Ortiz, Maria D. Sanchez‐Niño Journal of Cellular and Molecular Medicine 21 (1), 154-164, 2016-09-06

...The fibrogenic cytokine transforming growth factor‐β1 (<jats:styled-content style="fixed-case">TGF</jats:styled-content>β1) up‐regulated <jats:styled-content style="fixed-case">MXRA</jats:styled-content...

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Xiaosheng Yang, Shiting Li, Jun Zhong, Wenchuan Zhang, Xuming Hua, Bin Li, Hui Sun Journal of Cellular and Molecular Medicine 21 (1), 72-80, 2016-08-25

...Netrin‐1 up‐regulated CD151 and VEGF concomitant with the activation of focal adhesion kinase (FAK), Src and Paxillin <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> and the...

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M. Ajello, G. Ghisellini, V. S. Paliya, D. Kocevski, G. Tagliaferri, G. Madejski, A. Rau, P. Schady, J. Greiner, F. Massaro, M. Baloković, R. Bühler, M. Giomi, L. Marcotulli, F. D’Ammando, D. Stern, S. E. Boggs, F. E. Christensen, W. W. Craig, C. J. Hailey, F. A. Harrison, W. W. Zhang The Astrophysical Journal 826 (1), 76-, 2016-07-20

...Its very hard <jats:italic>NuSTAR</jats:italic> spectrum (power-law photon index of ∼1 up to ∼80 keV) indicates that the emission is produced via inverse Compton scattering off of photons coming from outside...

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Yonghong Liu, Ruitao Lu, Junlian Gu, Yanxuan Chen, Xueyan Zhang, Lan Zhang, Hao Wu, Wenfeng Hua, Jun Zeng Environmental Toxicology and Pharmacology 45 241-250, 2016-07

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Till T. Meiling, Piotr J. Cywiński, Ilko Bald Scientific Reports 6 (1), 2016-06-23

...Depending on starting material, CNDs with PL quantum yield (PLQY) ranging from less than 1% up to 28% are obtained....

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Woo Young Jang, Jain Jeong, Seonggon Kim, Min-cheol Kang, Yong Hun Sung, Minjee Choi, Si Jun Park, Myoung Ok Kim, Sung Hyun Kim, Zae Young Ryoo Applied Physiology, Nutrition, and Metabolism 41 (6), 640-648, 2016-06

...Furthermore, in several recent studies of transgenic (TG) mice overexpressing SAA1 that were fed a high-fat diet (HFD) for a relatively short period, no relationship was found between SAA1 up-regulation...

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Chunshuai Wu, Zhiming Cui, Yonghua Liu, Jinlong Zhang, Wensen Ding, Song Wang, Guofeng Bao, Guanhua Xu, Yuyu Sun, Jiajia Chen International Journal of Developmental Neuroscience 52 (1), 24-32, 2016-05-20

...EHD1 up‐regulated the expression of TrkA in the glutamate stimulated primary neurons....

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Shih-Wein Li, Ching-Ying Wang, Yu-Jen Jou, Tsuey-Ching Yang, Su-Hua Huang, Lei Wan, Ying-Ju Lin, Cheng-Wen Lin Scientific Reports 6 (1), 25754-, 2016-05-13

...<jats:title>Abstract</jats:title><jats:p>SARS coronavirus (SARS-CoV) papain-like protease (PLpro) has been identified in TGF-β1 up-regulation in human promonocytes (Proteomics 2012, 12: 3193-205)....

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Li, Wenzhao, Itou, Junji, Tanaka, Sunao, Nishimura, Tomomi, Sato, Fumiaki, Toi, Masakazu Experimental Cell Research 343 (2), 177-189, 2016-05-01

Among breast cancer subtypes, basal-like breast cancer is particularly aggressive, and research on the molecules involved in its pathology might contribute to therapy. In this study, we found that …

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Wenzhao Li, Junji Itou, Sunao Tanaka, Tomomi Nishimura, Fumiaki Sato, Masakazu Toi Experimental Cell Research 343 (2), 177-189, 2016-05

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Jiankai Zhang, Zhangyou He, Jinhua Guo, Zhe Li, Xiaohong Wang, Chun Yang, Xiaojun Cui Bioscience Reports 36 (2), 2016-04-01

...Moreover, Srx-1 protected H9c2 cells from SI/R-injured injury as the evidences that Srx-1 up-regulation attenuated the inhibitory effects on cell viability, lactate dehydrogenase (LDH) and cell apoptosis...

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Claire Jenkinson, Victoria L. Elliott, Anthony Evans, Lucy Oldfield, Rosalind E. Jenkins, Darragh P. O'Brien, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Evangelia-O Fourkala, Ian J. Jacobs, Usha Menon, Trevor Cox, Fiona Campbell, Stephen P. Pereira, David A. Tuveson, B. Kevin Park, William Greenhalf, Robert Sutton, John F. Timms, John P. Neoptolemos, Eithne Costello Clinical Cancer Research 22 (7), 1734-1743, 2016-03-31

...MRM confirmed significant reduction in levels of TSP-1 up to 24 months prior to diagnosis....

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山下 友子 言語科学 51 9-15, 2016-03-31

...Pauses ranging from 0.1 up to 3 s, at the turn transition from the current speaker to the next, were extracted....

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Peter E. Carlson, Brendan G. McKie, Leonard Sandin, Richard K. Johnson Freshwater Biology 61 (6), 848-861, 2016-03-18

...Flying insects were sampled alongside eight streams (four agricultural, four forested) in central Sweden using sticky traps, placed from 1 up to 100 m from the stream edge....

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Nan Zhao, Huizhi Sun, Baocun Sun, Dongwang Zhu, Xiulan Zhao, Yong Wang, Qiang Gu, Xueyi Dong, Fang Liu, Yanhui Zhang, Xiao Li Scientific Reports 6 (1), 23091-, 2016-03-16

...Conclusions: Twist-1 up-regulation in HepG2 cells resulted in the differential expression of 18 miRNAs. Among them, miR-27a-3p deregulation contributed to VM and metastasis....

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A. Luque, H. C. Stenbaek‐Nielsen, M. G. McHarg, R. K. Haaland Journal of Geophysical Research: Space Physics 121 (3), 2431-2449, 2016-03

...After the passage of a streamer head, the ionized channel established in its wake develops intricate luminous patterns that evolve on timescales from 1 up to 100 ms....

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Nikolaos Papagiannopoulos, Lucia Mona, Lucas Alados-Arboledas, Vassilis Amiridis, Holger Baars, Ioannis Binietoglou, Daniele Bortoli, Giuseppe D'Amico, Aldo Giunta, Juan Luis Guerrero-Rascado, Anja Schwarz, Sergio Pereira, Nicola Spinelli, Ulla Wandinger, Xuan Wang, Gelsomina Pappalardo Atmospheric Chemistry and Physics 16 (4), 2341-2357, 2016-02-29

...We find good agreement on the aerosol extinction coefficient, yet in most of the cases a small CALIPSO underestimation is observed with an average bias of 0.02 km−1 up to 4 km and 0.003 km−1 higher above...

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Li Liu, Qingzhu Sun, Rujuan Bao, Michael Roth, Bo Zhong, Xi Lan, Jia Tian, Qirui He, Dongmin Li, Jian Sun, Xudong Yang, Shemin Lu Scientific Reports 6 (1), 21810-, 2016-02-25

...The NF-kB inhibitor protein RKIP was highly expressed in epithelial cells and blocked IL-1β induced PRMT1 up-regulation; while the STAT6 inhibitor protein PIAS1 was expressed in fibroblasts and suppressed...

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Min Zhang, Jian-Xue Gong, Jia-Lei Wang, Meng-Yang Jiang, Li Li, Yu-Yan Hu, Jie Qi, Ling-Yan Zhang, Hang Zhao, Xin Cui, Xiao-Hui Xian, Wen-Bin Li Molecular Neurobiology 54 (1), 58-71, 2016-01-05

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Shinya Endo, Masayuki Amano, Nao Nishimura, Niina Ueno, Shikiko Ueno, Hiromichi Yuki, Shiho Fujiwara, Naoko Wada, Shinya Hirata, Hiroyuki Hata, Hiroaki Mitsuya, Yutaka Okuno Biochemical and Biophysical Research Communications 469 (2), 236-242, 2016-01

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Guangyuan Zhang, Xiangyu Zou, Yeqing Huang, Feng Wang, Shuai Miao, Guohua Liu, Ming Chen, Yingjian Zhu Kidney and Blood Pressure Research 41 (2), 119-128, 2016

...Nrf2/antioxidant response element (ARE) enhancement and HO-1 up-regulation were further observed after MSC-EV treatment both <i>in vivo</i> and <i>in vitro</i>....

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森井 雄史, 岡田 敬一, 白石 理人, 杉本 浩一, 寺田 岳彦, 佐藤 俊明, 飛田 潤 日本建築学会構造系論文集 81 (730), 2045-2055, 2016

...<br> 1) Up to 0.03 radian in the maximum story drift angle, results estimated from 5 points of sensors (1, 4, 10, 15 and RFL) correspond approximately to the observed results in the 18 story steel high-rise...

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丸山 修, 川上 滉貴, 迫田 大輔, 小阪 亮, 西田 正浩, 山根 隆志 バイオエンジニアリング講演会講演論文集 2016.28 (0), _1A21-1_-_1A21-3_, 2016

...The intrinsic system was promoted while the extrinsic system was inhibited in vitro under shear field at 2,880 s^<-1> up to 3 hours, after measured reaction velocity of blood coagulation factors....

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G. Teyssedre, T. T. N. Vu, C. Laurent Applied Physics Letters 107 (25), 2015-12-21

<jats:p>Among features observed in polyethylene materials under relatively high field, space charge packets, consisting in a pulse of net charge that remains in the form of a pulse as it crosses the …

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Chun‐Ming Wong, Lai Wei, Cheuk‐Ting Law, Daniel Wai‐Hung Ho, Felice Ho‐Ching Tsang, Sandy Leung‐Kuen Au, Karen Man‐Fong Sze, Joyce Man‐Fong Lee, Carmen Chak‐Lui Wong, Irene Oi‐Lin Ng Hepatology 63 (2), 474-487, 2015-12-14

...Down‐regulation of miR‐29 expression in human HCC contributed to SETDB1 up‐regulation by relieving its post‐transcriptional regulation....

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Yasuhiko Kizuka, Miyako Nakano, Shinobu Kitazume, Takashi Saito, Takaomi C. Saido, Naoyuki Taniguchi Biochemical Journal 473 (1), 21-30, 2015-12-09

...Finally, we show that traumatic brain injury-induced BACE1 up-regulation is significantly suppressed in the Mgat3−/− brain....

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C. Hauri, S. C. Doney, T. Takahashi, M. Erickson, G. Jiang, H. W. Ducklow Biogeosciences 12 (22), 6761-6779, 2015-11-26

...Surface total alkalinity and dissolved inorganic carbon data showed large spatial gradients, with a concomitant wide range of Ωarag (< 1 up to 3.9)....

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Wenjing Zeng, Wen Shan, Lili Gao, Dongyan Gao, Yan Hu, Guangzhi Wang, Ning Zhang, Zhenlu Li, Xiaofeng Tian, Wei Xu, Jinyong Peng, Xiaochi Ma, Jihong Yao Scientific Reports 5 (1), 2015-11-03

<jats:title>Abstract</jats:title><jats:p>The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, …

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Yoh Zen, David Britton, Vikram Mitra, Ian Pike, Nigel Heaton, Alberto Quaglia Histopathology 68 (6), 796-809, 2015-11-02

...On immunostaining, two immunological markers (<jats:styled-content style="fixed-case">FYN</jats:styled-content>‐binding protein and allograft inflammatory factor‐1) up‐regulated in <jats:styled-content...

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Jung Jin Kim, Seung Baek Lee, Jinsung Jang, Sang-Yeop Yi, Sun-Hyun Kim, Sang-Ah Han, Jong-Min Lee, Seo-Yun Tong, Nicole D. Vincelette, Bowen Gao, Ping Yin, Debra Evans, Dong Wook Choi, Bo Qin, Tongzheng Liu, Haoxing Zhang, Min Deng, Jin Jen, Jun Zhang, Liewei Wang, Zhenkun Lou Genes & Development 29 (21), 2244-2257, 2015-11-01

...As a consequence, WSB1 up-regulates the expression of HIF-1α’s target genes and promotes cancer invasion and metastasis through its effect on pVHL....

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Shenbin Liu, Wen-Li Mi, Qian Li, Meng-Ting Zhang, Ping Han, Shan Hu, Qi-Liang Mao-Ying, Yan-Qing Wang Anesthesiology 123 (5), 1154-1169, 2015-11-01

...Moreover, intrathecal pretreatment with the CaMKII inhibitor KN-93 or the JAK2–STAT3 cascade inhibitor AG490 attenuated recombinant IL-33-induced nociceptive behaviors and NMDA subunit 1 up-regulation...

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F. H. Zhang, M.-J. Thoraval, S. T. Thoroddsen, P. Taborek Journal of Fluid Mechanics 782 209-239, 2015-10-07

...To understand this difference, we have conducted a set of coalescence experiments using xenon bubbles inside a pressure chamber, where we can continuously raise the pressure from 1 up to 85 atm and thereby...

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Michael P. Grams, Jon M. Gustafson, Kenneth M. Long, Luis E. Fong de los Santos Medical Physics 42 (10), 5782-5786, 2015-09-14

...EBT‐XD film exhibited minimal LRA (<1%) up to 3000 cGy....

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Baek Kim, Sam L. Stephen, Andrew M. Hanby, Kieran Horgan, Sarah L. Perry, Julie Richardson, Elizabeth A. Roundhill, Elizabeth M. A. Valleley, Eldo T. Verghese, Bethany J. Williams, James L. Thorne, Thomas A. Hughes BMC Cancer 15 (1), 2015-09-11

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Xinxin Chen, Yanan Wang, Jun Tao, Yuzhuo Shi, Xiaochen Gai, Fuqiang Huang, Qian Ma, Zhenzhen Zhou, Hongyu Chen, Haihong Zhang, Zhibo Liu, Qian Sun, Haiyong Peng, Rongrong Chen, Yanling Jing, Huayu Yang, Yilei Mao, Hongbing Zhang Gastroenterology 149 (3), 741-752.e14, 2015-09

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Tomomi Fujii, Keiji Shimada, Yoshihiro Tatsumi, Nobumichi Tanaka, Kiyohide Fujimoto, Noboru Konishi Molecular Carcinogenesis 55 (9), 1378-1386, 2015-08-10

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Denise Zwanziger, Julia Badziong, Saskia Ting, Lars Christian Moeller, Kurt Werner Schmid, Udo Siebolts, Claudia Wickenhauser, Henning Dralle, Dagmar Fuehrer Endocrine-Related Cancer 22 (5), 819-830, 2015-07-28

...Moreover, activation and inhibition of PKC resulted in CLAUDIN-1 up- and downregulation in FTC cells respectively....

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Yuhao Zhang, Geoffroy Laumet, Shao-Rui Chen, Walter N. Hittelman, Hui-Lin Pan Journal of Biological Chemistry 290 (23), 14647-14655, 2015-06

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Konstantinos E. Farsalinos, Vassilis Voudris, Konstantinos Poulas Addiction 110 (8), 1352-1356, 2015-05-20

...Minimal amounts of aldehydes per 10 puffs were found at all power levels with A1 (up to 11.3 µg for formaldehyde, 4.5 µg for acetaldehyde and 1.0 µg for acrolein) and at 6.5 W and 7.5 W with A2 (up to...

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Jung-Chien Cheng, Hsun-Ming Chang, Lanlan Fang, Ying-Pu Sun, Peter C. K. Leung PLOS ONE 10 (5), e0126532-, 2015-05-08

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Lutz Bornmann, Rüdiger Mutz Journal of the Association for Information Science and Technology 66 (11), 2215-2222, 2015-04-29

...up to the middle of the 18th century, to 2 to 3% up to the period between the two world wars, and 8 to 9% to 2010....

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Andreas Güldner, Thomas Kiss, Thomas Bluth, Christopher Uhlig, Anja Braune, Nadja Carvalho, Theresa Quast, Ines Rentzsch, Robert Huhle, Peter Spieth, Torsten Richter, Felipe Saddy, Patricia R. M. Rocco, Michael Kasper, Thea Koch, Paolo Pelosi, Marcelo Gama de Abreu Anesthesiology 122 (3), 631-646, 2015-03-01

...</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>The authors found that: (1) UP-MVcontr reduced diffuse alveolar...

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María L. Bacigalupo, Malena Manzi, María V. Espelt, Lucas D. Gentilini, Daniel Compagno, Diego J. Laderach, Carlota Wolfenstein‐Todel, Gabriel A. Rabinovich, María F. Troncoso Journal of Cellular Physiology 230 (6), 1298-1309, 2015-02-25

...Gal1 up‐regulation in HepG2 cells induced down‐regulation of the adherens junction protein E‐cadherin and increased expression of the transcription factor Snail, one of the main inducers of EMT in HCC....

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C. Bazioti, E. Papadomanolaki, Th. Kehagias, M. Androulidaki, G. P. Dimitrakopulos, E. Iliopoulos physica status solidi (b) 252 (5), 1155-1162, 2015-02-25

...<jats:sec><jats:label /><jats:p>We have considered the structural properties of InGaN thin interlayers with thicknesses from 1 up to 40 nm, grown by plasma assisted molecular beam epitaxy (PAMBE) at substrate...

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François Sicard, Nicolas Destainville, Manoel Manghi The Journal of Chemical Physics 142 (3), 2015-01-16

<jats:p>The issue of the nucleation and slow closure mechanisms of non-superhelical stress-induced denaturation bubbles in DNA is tackled using coarse-grained MetaDynamics and Brownian simulations. …

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Wan Chen, Hong Tang, Xiangzhou Liu, Mei Zhou, Jiqiang Zhang, Kanglai Tang Cellular Physiology and Biochemistry 37 (5), 1738-1749, 2015

<jats:p>Background/Aims: Dexamethasone (Dex)-induced spontaneous tendon rupture and decreased self-repair capability is very common in clinical practice. The metaplasia of adipose tissue in the …

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Soojin Lee, Se Min Bang, Yoon Ki Hong, Jang Ho Lee, Haemin Jeong, Seung Hwan Park, Quan Feng Liu, Im-Soon Lee, Kyoung Sang Cho Disease Models & Mechanisms 2015-01-01

...Taken together, our results demonstrating that sra overexpression augments Aβ42 cytotoxicity in Drosophila suggest that DSCR1 up-regulation or calcineurin down-regulation in the brain may exacerbate Aβ42...

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Saitoh Aya, Takase Tomoyuki, Kitaki Hiroyuki, Kiyosue Tomohiro Ｐｌａｎｔ　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ 32 (3), 257-261, 2015

ZEITLUPE (ZTL) is a blue-light photoreceptor with an F-box motif in <i>Arabidopsis thaliana</i>. The molecular mechanisms underlying the ZTL-dependent control of the circadian rhythm and repression …

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Honda Yuichiro, Sakamoto Junya, Nakano Jiro, Kataoka Hideki, Sasabe Ryo, Goto Kyo, Tanaka Miho, Okita Minoru 理学療法学Supplement 2014 (0), 0103-, 2015

【Purpose】This investigation was conducted to determine the molecular mechanism underlying muscle contracture in immobilized rat soleus muscle.【Methods】Wistar rats were divided randomly into …

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大坂 英樹 BINOS 22 (0), 25-35, 2015

<p>神奈川県大磯町丘陵で一年間（2014年07月~2015年06月）にわたり週毎に45週、日の出時刻の前後30分を含む夜明け時間帯に出現する鳥を定点で聞き取りまたは録音により記録し鳥相がどう変化するかを調べた。分析は鳴き声データのみ用いた。観察した鳥類は外来種を含み55種、一日平均17種が観察され、4月後半が最多の27種、9月が最少の5種が観察された。</p><p>鳴き出しの時間帯別では</p…

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Jose‐Andres C. Portillo, Jennifer A. Greene, Isaac Schwartz, Maria Cecilia Subauste, Carlos S. Subauste Immunology 144 (1), 21-33, 2014-12-08

...Although both mutations impaired ICAM‐1 up‐regulation in monocytic cells, only expression of CD40 ΔT6 reduced MCP‐1 and tissue factor up‐regulation in these cells....

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Maëva Elzaiat, Luc Jouneau, Dominique Thépot, Christophe Klopp, Aurélie Allais-Bonnet, Cédric Cabau, Marjolaine André, Stéphane Chaffaux, Edmond-Paul Cribiu, Eric Pailhoux, Maëlle Pannetier Biology of Reproduction 91 (6), 153-, 2014-12-01

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Jung‐Ah Kang, Woo‐Seok Kim, Sung‐Gyoo Park Immunology 143 (4), 550-559, 2014-11-10

...In addition, Notch1 up‐regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1‐mediated further B‐cell activation....

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Hongzhan Fei, Michael Wiedenbeck, Daisuke Yamazaki, Tomoo Katsura Journal of Geophysical Research: Solid Earth 119 (10), 7598-7606, 2014-10

...up to ~800 weight ppm....

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Romain Gosmini, Van Loc Nguyen, Jérôme Toum, Christophe Simon, Jean-Marie G. Brusq, Gael Krysa, Olivier Mirguet, Alizon M. Riou-Eymard, Eric V. Boursier, Lionel Trottet, Paul Bamborough, Hugh Clark, Chun-wa Chung, Leanne Cutler, Emmanuel H. Demont, Rejbinder Kaur, Antonia J. Lewis, Mark B. Schilling, Peter E. Soden, Simon Taylor, Ann L. Walker, Matthew D. Walker, Rab K. Prinjha, Edwige Nicodème Journal of Medicinal Chemistry 57 (19), 8111-8131, 2014-09-24

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Masatoshi Ohnishi, Ayaka Monda, Ryoko Takemoto, Yukina Fujimoto, Mitsumasa Sugitani, Takahiro Iwamura, Takashi Hiroyasu, Atsuko Inoue Neurochemistry International 75 32-38, 2014-09

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Zhenlong Zheng, Hye‐Young Kang, Sunha Lee, Shin‐Wook Kang, Boncheol Goo, Sung Bin Cho Wound Repair and Regeneration 22 (5), 660-665, 2014-09

...Our data indicated that <jats:styled-content style="fixed-case">rhFGF</jats:styled-content>9 and/or <jats:styled-content style="fixed-case">rhTGF</jats:styled-content>‐β1 up‐regulate <jats:styled-content...

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XiaoWei Qian, Tomohiro Numata, Kai Zhang, CaiXia Li, JinChao Hou, Yasuo Mori, XiangMing Fang Anesthesiology 121 (2), 336-351, 2014-08-01

...HO-1 up-regulation decreased bacterial burden both in wild-type bone marrow–derived macrophages and in cecal ligation and puncture–induced septic wild-type mice....

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M. R. Bionta, N. Hartmann, M. Weaver, D. French, D. J. Nicholson, J. P. Cryan, J. M. Glownia, K. Baker, C. Bostedt, M. Chollet, Y. Ding, D. M. Fritz, A. R. Fry, D. J. Kane, J. Krzywinski, H. T. Lemke, M. Messerschmidt, S. Schorb, D. Zhu, W. E. White, R. N. Coffee Review of Scientific Instruments 85 (8), 083116-, 2014-08-01

<jats:p>The advent of few femtosecond x-ray light sources brings promise of x-ray/optical pump-probe experiments that can measure chemical and structural changes in the 10–100 fs time regime. Widely …

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