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Li Shi-gang 日本薬理学会年会要旨集 WCP2018 (0), PO3-4-17-, 2018

<p>It has been supposed that mast cells have important participation in the physiopathology of RA,however, the role of mast cells in the pathogenesis of RA remains unclear.</p><p>In this study, we …

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Sylwia A. Mankowska, Pietro Gatti-Lafranconi, Matthieu Chodorge, Sudharsan Sridharan, Ralph R. Minter, Florian Hollfelder Scientific Reports 6 (1), 36391-, 2016-11-07

...This is demonstrated by evolution of an anti-Fas receptor single-chain variable fragment (scFv) that was improved 98-fold <jats:italic>vs</jats:italic> the parental clone....

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土肥, 有理 政治学研究論集 44 1-20, 2016-09-09

Article

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Takeshi Yamamoto, Kanae Fujiwara, Yuma Tsubota, Natsuko Kageyama-Yahara, Shusaku Hayashi, Makoto Kadowaki International Archives of Allergy and Immunology 169 (3), 146-156, 2016

...of Foxp3⁺CD4⁺CD25^- regulatory T cells in the colon as a novel mechanism underlying the therapeutic action of kakkonto could be utilized for the development of a novel anti-FA...

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Kazuhito Honjo, Yoshiki Kubagawa, John F. Kearney, Hiromi Kubagawa The Journal of Immunology 194 (4), 1975-1982, 2015-02-15

...<jats:title>Abstract</jats:title> <jats:p>The IgM Fc receptor (FcμR) is the newest FcR, and coligation of FcμR and Fas/CD95 on Jurkat cells with agonistic IgM anti-Fas mAb was shown to inhibit...

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Anja Förster, Franco H. Falcone, Bernhard F. Gibbs, Liane M. Preussner, Britta S. Fiebig, Hülya Altunok, Jens M. Seeger, Sabine Cerny-Reiterer, Anja Rabenhorst, Kerstin Papenfuss, Peter Valent, Hamid Kashkar, Karin Hartmann Leukemia & Lymphoma 54 (4), 835-842, 2012-10-09

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Ayako Shigeta, Yuji Tada, Ji-Yang Wang, Shunsuke Ishizaki, Junichi Tsuyusaki, Keita Yamauchi, Yasunori Kasahara, Ken Iesato, Nobuhiro Tanabe, Yuichi Takiguchi, Akemi Sakamoto, Takeshi Tokuhisa, Kazutoshi Shibuya, Kenzo Hiroshima, James West, Koichiro Tatsumi American Journal of Physiology-Lung Cellular and Molecular Physiology 303 (2), L141-L151, 2012-07-15

...CD40 stimulation, in combination with anti-Fas Ab, induced significant emphysematous changes and increased alveolar cell apoptosis....

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Cristiane Comparin, Günter Hans Filho, Luiz Carlos Takita, Nayara de Castro Wiziack Costa, Roberta Ayres Ferreira do Nascimento, Lidiane de Oliveira Costa Nanni Anais Brasileiros de Dermatologia 87 (3), 477-481, 2012-06

...Anti-Fas antibodies in intravenous immunoglobulin (IVIG) would block the apoptosis cascade....

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Kina Katsunari, Masuda Hiromi, Nakayama Hitoshi, Iwahara Chihiro, Nagatsuka Yasuko, Hirabayashi Yoshio, Ogawa Hideoki, Takamori Kenji, Iwabuchi Kazuhisa Inflammation and Regeneration 32 (5), 213-221, 2012

...Furthermore, the antagonist anti-Fas antibody ZB4 significantly inhibited DIM21-induced neutrophil apoptosis....

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Katsunari Kina, Hiromi Masuda, Hitoshi Nakayama, Yasuko Nagatsuka, Takuji Nabetani, Yoshio Hirabayashi, Yasue Takahashi, Kazunori Shimada, Hiroyuki Daida, Hideoki Ogawa, Kenji Takamori, Kazuhisa Iwabuchi The Journal of Immunology 186 (9), 5323-5332, 2011-05-01

...Furthermore, the antagonistic anti-Fas Ab ZB4 significantly inhibited DIM21-induced neutrophil apoptosis....

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三澤 いづみ, 河村 円香, CHU Guiyan, 山内 伸彦, 服部 眞彰 日本繁殖生物学会　講演要旨集 104 (0), 1109-1109, 2011

...一方、anti-Fas抗体を用いてアポトーシスを誘導すると、概日リズムのコアループを形成するPer2とBmal1の振動が消滅し、Rev-erbαの位相は後ろにシフトした。また、アポトーシス関連因子であるFas遺伝子は、anti-Fas抗体を添加して約30時間後に発現量が増加した。...

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L. Jiang, J.G. Li, L. Lan, Y.M. Wang, Q. Mao, J.P. You Transplantation Proceedings 42 (9), 3773-3778, 2010-11

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Melissa A. Stern, Chunling Hu, Dyana T. Saenz, Hind J. Fadel, Olivia Sims, Mary Peretz, Eric M. Poeschla Journal of Virology 84 (14), 7378-7395, 2010-07-15

...In an interesting contrast, simian immunodeficiency virus SIVmac Vif had substantial anti-fA3 activities, which were complete against fA3CH and partial against fA3H....

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Shusaku Miyata, Genzou Takemura, Ken-ichiro Kosai, Tomoyuki Takahashi, Masayasu Esaki, Longhu Li, Hiromitsu Kanamori, Rumi Maruyama, Kazuko Goto, Akiko Tsujimoto, Toshiaki Takeyama, Tomonori Kawaguchi, Takamasa Ohno, Kazuhiko Nishigaki, Takako Fujiwara, Hisayoshi Fujiwara, Shinya Minatoguchi The American Journal of Pathology 176 (2), 687-698, 2010-02

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Nodoka Sato, Yoichi Mizutani, Yong Nan Li, Jun Fujiwara, Hirokazu Ishida, Daisuke Toiyama, Koichi Abe, Issei Hayashi, Hiroyuki Nakanishi, Akihiro Kawauchi, Tsuneharu Miki Urologia Internationalis 84 (3), 362-368, 2010

...JTE-522 and anti-Fas monoclonal antibody (CH-11) exhibited a synergistic cytotoxic effect against Caki-1 cells....

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Yong Zou, Tao Chen, Meifang Han, Hongwu Wang, Weiming Yan, Ge Song, Zeguang Wu, Xiaojing Wang, Chuanlong Zhu, Xiaoping Luo, Qin Ning The Journal of Immunology 184 (1), 466-475, 2009-12-14

...Highly activated liver NK cells were cytotoxic to MHV-3-infected hepatocytes and this effect was markedly inhibited by anti-Fas ligand (FasL) plus anti-NKG2D mAbs....

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Hiromi Kubagawa, Satoshi Oka, Yoshiki Kubagawa, Ikuko Torii, Eiji Takayama, Dong-Won Kang, G. Larry Gartland, Luigi F. Bertoli, Hiromi Mori, Hiroyuki Takatsu, Toshio Kitamura, Hiroshi Ohno, Ji-Yang Wang Journal of Experimental Medicine 206 (12), 2779-2793, 2009-10-26

...initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcμR per se has no inhibitory activity in Fas-mediated apoptosis and that such inhibition is only achieved when anti-Fas...

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FUKUMOTO, Kazuhiko, BO, Wang, HIKOSAKA, Keisuke, NORITAKE, Hidenao, SHIBATA, Kiyoshi, INOUE, Hirokazu, SUZUKI, Atsushi, INABA, Keisuke, SAKAGUCHI, Takanori, SUZUKI, Shohachi, KONNO, Hiroyuki, MIURA, Naoyuki 秋田医学 35 (3/4), 231-237, 2009-03-01

...Treatment with anti-Fas antibody plus actinomycin D or cycloheximide induced over 50% apoptosis for primary hepatocytes based on annexin V staining....

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Kim Sung-Su, Won So-Jung, Kim Nam Jae, Yoo Jae Kuk, Bae KiHwan, Lee Kyung-Tae Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 32 (1), 91-98, 2009

...Preincubation with anti-Fas or anti-FasL blocking antibodies completely prevented 3-OA-induced apoptosis....

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ISHIMA Yu, KRAGH-HANSEN Ulrich, MARUYAMA Toru, OTAGIRI Masaki Ｄｒｕｇ　Ｍｅｔａｂｏｌｉｓｍ　ａｎｄ　Ｐｈａｒｍａｃｏｋｉｎｅｔｉｃｓ 24 (4), 308-317, 2009

...The cytoprotective effect of SNO-HSA in a ischemia/reperfusion model and its antiapoptotic effect on HepG2 cells treated with anti-Fas antibody were pronounced and could be enhanced by binding of oleate...

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Nakamura, Hideki, Kawakami, Atsushi, Iwamoto, Naoki, Ida, Hiroaki, Koji, Takehiko, Eguchi, Katsumi Apoptosis : an international journal on programmed cell death 13 (11), 1322-1330, 2008-11

...TRAIL-induced apoptosis in SGEC, which was stronger than that induced by anti-Fas antibody....

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Yeong Seok Kim, Ga Bin Park, Hyun-Kyung Lee, Hyunkeun Song, In-Hak Choi, Wang Jae Lee, Dae Young Hur The Journal of Immunology 181 (9), 6158-6169, 2008-11-01

...ZB4, an antagonistic anti-fas Ab, and NOK-1, an antagonistic anti-fasL Ab, effectively blocked apoptosis without exerting any influence on ROS generation....

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Eddy Himpe, Céline Degaillier, Astrid Coppens, Ron Kooijman Journal of Endocrinology 199 (1), 69-80, 2008-07-24

...IGF1 did not affect Fas expression or activation by anti-Fas of caspase-8, but inhibited the depolarization of the mitochondrial membrane....

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Shruti M. Raja, Shuzhen Chen, Ping Yue, Timothy M. Acker, Benjamin Lefkove, Jack L. Arbiser, Fadlo R. Khuri, Shi-Yong Sun Molecular Cancer Therapeutics 7 (7), 2212-2223, 2008-07-01

...This was also true to Fas-induced apoptosis when combined with Fas ligand or an agonistic anti-Fas antibody....

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Wan-Hua Tsai, Chia-Wen Chang, Yee-Shin Lin, Woei-Jer Chuang, Jiunn-Jong Wu, Ching-Chuan Liu, Pei-Jane Tsai, Ming T. Lin Infection and Immunity 76 (4), 1349-1357, 2008-04

...Anti-Fas antibody inhibited SPE B- and G308S-induced apoptosis in a dose-dependent manner, suggesting that Fas-mediated SPE B-induced apoptosis also occurs RGD independently....

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Kenji Matsumoto, Akihiko Maeda, Bruce S. Bochner, Hiroshi Wakiguchi, Hirohisa Saito International Archives of Allergy and Immunology 146 (Suppl. 1), 40-46, 2008

...Anti-Fas mAb-treated basophils were shrunken and exhibited condensed nuclei, consistent with apoptosis....

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折田 創, Kuhajda Frank, Gabrielson Edward 順天堂医学 54 (1), 10-15, 2008

脂肪酸合成酵素Fatty Acid Synthase (FAS) は, 食道癌, 胃癌, 大腸癌といった消化器癌や乳癌, 肺癌などの多くの癌に高発現している. 現在までにわれわれは, C75という脂肪酸合成酵素阻害剤を用いたとき, この酵素 (FAS) の活性低下が癌細胞をアポトーシスに誘導し腫瘍縮小効果を認めることから, 新しい抗癌剤としての可能性を報告してきた. 残念ながら, …

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MATSUDA Fuko, INOUE Naoko, GOTO Yasufumi, MAEDA Akihisa, CHENG Yuan, SAKAMAKI Kazuhiro, MANABE Noboru Journal of Reproduction and Development 54 (5), 314-320, 2008

...Fas-mediated apoptosis was induced by co-treatment with anti-Fas antibody (CH-11), which acts as an agonist of Fas-ligand, and cycloheximide (CHX)....

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Herbert Fluhr, Stefanie Krenzer, Gerburg M. Stein, Björn Stork, Margarita Deperschmidt, Diethelm Wallwiener, Sebastian Wesselborg, Marek Zygmunt, Peter Licht Journal of Cell Science 120 (23), 4126-4133, 2007-12-01

...Pre-treatment of ESCs with interferon (IFN)-γ and tumor necrosis factor (TNF)-α sensitizes them to become apoptotic upon stimulation of Fas by an agonistic anti-Fas antibody....

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N Koide, A Morikawa, G Tumurkhuu, J Dagvadorj, F Hassan, S Islam, Y Naiki, I Mori, T Yoshida, T Yokochi Clinical and Experimental Immunology 150 (3), 553-560, 2007-09-27

...Anti-Fas agonistic antibody exhibited cytotoxic actions on END-D cells. Fas-mediated cell death was enhanced by LPS or IFN-γ....

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Takashi Izawa, Naozumi Ishimaru, Keiji Moriyama, Masayuki Kohashi, Rieko Arakaki, Yoshio Hayashi Blood 110 (1), 242-250, 2007-07-01

...Furthermore, the expression of FLIPL, an inhibitory molecule against Fas-mediated apoptosis, in normal DCs was significantly decreased by RANKL and anti-Fas mAb....

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Ajaikumar B. Kunnumakkara, Asha S. Nair, Kwang Seok Ahn, Manoj K. Pandey, Zhengfang Yi, Mingyao Liu, Bharat B. Aggarwal Blood 109 (12), 5112-5121, 2007-06-15

...This, in turn, led to the down-regulation of gene products involved in cell survival (IAP2, XIAP, Bcl-2, Bcl-xL, survivin, and antiFas-associated death domain–like interleukin-1β–converting enzyme-inhibitory...

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Daniela Berrrrpohl, Zerong You, Eng H Lo, Hyung-Hwan Kim, Michael J Whalen Journal of Cerebral Blood Flow & Metabolism 27 (11), 1806-1818, 2007-04-04

...Protection in TNFα/Fas—/— mice from histopathological and motor deficits was reversed by reconstitution with recombinant TNFα before CCI, and TNFα—/— mice administered anti-Fas ligand antibodies had improved...

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Shih-Hwa Chiou, Chung-Lan Kao, Yu-Lih Chang, Hung-Hai Ku, Yung-Jen Tsai, Han-Tso Lin, Chih-Ju Yen, Chi-Hsien Peng, Jen-Hwey Chiu, Tung-Hu Tsai Analytical Biochemistry 363 (1), 46-57, 2007-04

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池脇 信直, 大矢 和彦, イケワキ ノブナオ, オオヤ カズヒコ, Nobunao IKEWAKI, Kazuhiko OHYA 九州保健福祉大学研究紀要 = Journal of Kyushu University of Health and Welfare 8 123-131, 2007-03-25

type:P(論文)

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Min Wang, Viviana M. Berthoud, Eric C. Beyer Journal of Cell Science 120 (2), 320-329, 2007-01-15

...Infection of LNCaP (but not PC3) cells with Ad-Cx43 greatly increased their sensitivity to killing by tumor necrosis factor α (TNFα), anti-Fas antibodies, and TRAIL as quantified using an MTS assay....

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Alfons S.K. de Hooge, Dagmar Berghuis, Susy Justo Santos, Esther Mooiman, Salvatore Romeo, J. Alain Kummer, R. Maarten Egeler, Maarten J.D. van Tol, Cornelis J.M. Melief, Pancras C.W. Hogendoorn, Arjan C. Lankester Clinical Cancer Research 13 (1), 206-214, 2007-01-01

...Functional significance was tested by anti-Fas antibody (death receptor pathway) or natural killer cell (perforin/granzyme pathway) treatment....

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Kanno Syu-ichi, Hiura Takako, Shouji Ai, Osanai Yuu, Ujibe Mayuko, Ishikawa Masaaki Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 30 (11), 2069-2074, 2007

...The induction of apoptosis and reduction of cell viability by cytotoxic anti-Fas antibody was more susceptible in resistant cells than parental cells....

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町田 卓郎, 佐藤 勉, 高橋 祥, 荒木 直子, 村瀬 和幸, 井山 諭, 佐藤 康史, 小船 雅義, 瀧本 理修, 松永 卓也, 加藤 淳二, 新津 洋司郎 日本臨床免疫学会総会抄録集 35 (0), 134-134, 2007

...これらをagonistic anti-Fas antibodyで刺激し、propidium iodide染色の後、フローサイトメーターおよび蛍光顕微鏡観察で細胞死を判定した。［結果］rho+には典型的なアポトーシスが誘導されたが、rho0の細胞死はネクローシスであった。...

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Johan Garaude, Seyma Cherni, Sandra Kaminski, Etienne Delepine, Christine Chable-Bessia, Monsef Benkirane, Joana Borges, Atanasio Pandiella, Miguel Angel Iñiguez, Manuel Fresno, Robert A. Hipskind, Martin Villalba The Journal of Immunology 177 (11), 7607-7617, 2006-12-01

...reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas...

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Mantej S. Bharhani, Rajka Borojevic, Shibesh Basak, Edwin Ho, Pengfei Zhou, Kenneth Croitoru American Journal of Physiology-Gastrointestinal and Liver Physiology 291 (5), G820-G829, 2006-11

...Anti-Fas mAb alone did not induce much apoptosis unless cells were pretreated with IFN-γ and TNF-α....

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Mi-Sook Lee, Seung-Ah Yoo, Chul-Soo Cho, Pann-Ghill Suh, Wan-Uk Kim, Sung Ho Ryu The Journal of Immunology 177 (8), 5585-5594, 2006-10-15

...In addition, SAA protects RA FLS against the apoptotic death induced by serum starvation, anti-Fas IgM, and sodium nitroprusside....

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Takemi Otsuki, Yoshie Miura, Yasumitsu Nishimura, Fuminori Hyodoh, Akiko Takata, Masayasu Kusaka, Hironobu Katsuyama, Masafumi Tomita, Ayako Ueki, Takumi Kishimoto Experimental Biology and Medicine 231 (5), 522-533, 2006-05

...In addition, anti-caspase 8 autoantibody and anti-Fas autoantibody were detected in serum specimens from patients with silicosis, and a functional assay showed that anti-Fas antibody stimulated Fas-mediated...

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W-U Kim, S-A Yoo, S-Y Min, S-H Park, H-S Koh, S-W Song, C-S Cho Clinical and Experimental Immunology 144 (3), 503-511, 2006-04-21

...A combined treatment of HCQ and anti-Fas mAb increased FLS apoptosis and caspase-3 activity synergistically, compared with either anti-Fas mAb or HCQ alone....

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K A Slot, M de Boer-Brouwer, M Houweling, A B Vaandrager, J H Dorrington, K J Teerds Journal of Endocrinology 188 (2), 227-239, 2006-02

...Activation of Fas receptor by an agonistic anti-Fas receptor antibody induced apoptosis, as was evaluated by caspase-3 activation, poly(ADP-ribose) polymerase fragmentation, phosphatidylserine externalization...

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Liu Yan-Qiu, Mu Zhen-Qiang, You Song, Tashiro Shin-ichi, Onodera Satoshi, Ikejima Takashi Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (9), 1873-1879, 2006

...In this study, U937 cells showed susceptible to apoptosis induced by 27 μ<small>M</small> oridonin and an agonistic anti-Fas IgM mAb (CH-11) (500 ng/ml) as a Fas-sensitized positive control....

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French Lars E Allergology International 55 (1), 9-16, 2006

...culminating in epidermal detachment in TEN can be inhibited <i>in vitro</i> by antagonistic monoclonal antibodies to Fas, and by intravenous immunoglobulins (IVIG) which have been shown to contain natural anti-Fas...

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Mohammad Saleem, Mee-Hyang Kweon, Jung-Mi Yun, Vaqar Mustafa Adhami, Naghma Khan, Deeba N. Syed, Hasan Mukhtar Cancer Research 65 (23), 11203-11213, 2005-12-01

...The treatment of cells with a combination of anti-Fas monoclonal antibody and Lupeol resulted in higher cell death compared with the additive effect of the two compounds alone, suggesting a synergistic...

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Nomura, Jun, Matsumoto, Ken-Ichi, Iguchi-Ariga, Sanae M M, Ariga, Hiroyoshi Oncology reports 14 (5), 1305-1309, 2005-11

...Fas triggers apoptosis after stimulation by its ligand FasL or the Fas ligand agonist anti-Fas antibody through a mitochondria-dependent or -independent pathway, and MSSP has been identified as a transcription...

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Po-Lin Kuo Life Sciences 77 (23), 2964-2976, 2005-10

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Miao-Tzu Huang, Justin C. Mason, Graeme M. Birdsey, Valerie Amsellem, Nicole Gerwin, Dorian O. Haskard, Anne J. Ridley, Anna M. Randi Blood 106 (5), 1636-1643, 2005-09-01

...ICAM-2–deficient cells show defective in vitro migration, as well as increased apoptosis in response to serum deprivation, anti-Fas antibody, or staurosporine....

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Hiroshi Yasui, Teru Hideshima, Noopur Raje, Aldo M. Roccaro, Norihiko Shiraishi, Shaji Kumar, Makoto Hamasaki, Kenji Ishitsuka, Yu-Tzu Tai, Klaus Podar, Laurence Catley, Constantine S. Mitsiades, Paul G. Richardson, Rainer Albert, Volker Brinkmann, Dharminder Chauhan, Kenneth C. Anderson Cancer Research 65 (16), 7478-7484, 2005-08-15

...In combination treatment studies, both dexamethasone and anti-Fas antibodies augment anti–multiple myeloma activity induced by FTY720....

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Torsten Loop, David Dovi-Akue, Michael Frick, Martin Roesslein, Lotti Egger, Matjaz Humar, Alexander Hoetzel, Rene Schmidt, Christoph Borner, Heike L. Pahl, Klaus K. Geiger, Benedikt H. J. Pannen Anesthesiology 102 (6), 1147-1157, 2005-06-01

...Death signaling was not mediated via the Fas/CD95 receptor pathway because neither anti-Fas/CD95 receptor antagonism nor FADD deficiency or caspase-8 deficiency were able to attenuate sevoflurane-mediated...

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Aleksandra Bielawska-Pohl, Claire Crola, Anne Caignard, Catherine Gaudin, Danuta Dus, Claudine Kieda, Salem Chouaib The Journal of Immunology 174 (9), 5573-5582, 2005-05-01

...In addition, although all tested cells were sensitive to the cytotoxic action of TNF, no susceptibility to TRAIL or anti-Fas mAb was observed....

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Robert S. Hauptschein, Kevin E. Sloan, Claudia Torella, Roya Moezzifard, Maryann Giel-Moloney, Carol Zehetmeier, Christine Unger, Leodevico L. Ilag, Daniel G. Jay Cancer Research 65 (5), 1887-1896, 2005-03-01

...FALI of the Fas receptor (Fas/CD95) using a fluorescein-conjugated anti-Fas antibody abrogated Fas ligand–mediated caspase activation....

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Emese Mezosi, Su He Wang, Saho Utsugi, Laszlo Bajnok, James D. Bretz, Paul G. Gauger, Norman W. Thompson, James R. Baker Molecular Endocrinology 19 (3), 804-811, 2005-03-01

...Apoptosis associated with the cleavage of caspases 7, 3, and Bid, and the activation of mitochondria in response to anti-Fas antibody occurred only after cytokine pretreatment....

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Jeong Whun Kim, Eva Wieckowski, Douglas D. Taylor, Torsten E. Reichert, Simon Watkins, Theresa L. Whiteside Clinical Cancer Research 11 (3), 1010-1020, 2005-02-01

...Biological activity of the FasL+ microvesicles was partially blocked by ZB4 anti-Fas monoclonal antibody....

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Alberto Bosque, Julián Pardo, Mª José Martínez-Lorenzo, María Iturralde, Isabel Marzo, Andrés Piñeiro, Mª Angeles Alava, Javier Naval, Alberto Anel Journal of Leukocyte Biology 77 (4), 568-578, 2005-01-14

...In the presence of IL-2, recombinant APO2L/TRAIL or cytotoxic anti-Fas monoclonal antibodies induce rather inhibition of IL-2-dependent growth and not cell death on normal human T cell blasts....

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Shinji Kagaya, Ryoichi Hashida, Naganari Ohkura, Toshihiko Tsukada, Yuji Sugita, Maki Terakawa, Gozoh Tsujimoto, Toshio Katsunuma, Akira Akasawa, Kenji Matsumoto, Hirohisa Saito International Archives of Allergy and Immunology 137 (Suppl. 1), 35-44, 2005

...Rapid expression of the genes for the NR4A receptor family was observed with anti-CD30 Ab treatment but not with anti-Fas Ab....

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小川 法良, 下山 久美子, 河南 崇典 日本臨床免疫学会会誌 28 (1), 10-20, 2005

  シェーグレン症候群（SS）唾液腺において産生されるサイトカインでは浸潤リンパ球由来のIFNγが重要であると考えられ，class II MHC, Fas, CD40など様々な機能分子を上皮細胞に発現誘導する．一部の患者ではIFNγの過剰産生の理由として上皮細胞から産生されるTGFβの産生減少が関与していることが示唆された．またSS唾液腺において産生される主なT細胞遊走性ケモカインはIFNγによ…

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渡邉 寛康 耳鼻と臨床 51 (3), 170-182, 2005

加齢により唾液分泌量が減少することは多くの研究者により報告されており、特に女性において、性ホルモンとの関係が示唆されているが、詳細は不明である。卵巣ホルモンはアポトーシスにより唾液腺細胞数を調節すると仮説をたて、まずラット耳下腺においてアポトーシスの変化を検討した。さらに唾液腺由来の培養細胞を性ホルモン存在下にアポトーシスを誘導しその変化を検討した。造腫瘍性ヒト唾液腺介在部導管上皮細胞 …

DOI

KUSAKABE Ken, OTSUKI Yoshinori, KISO Yasuo Journal of Reproduction and Development 51 (3), 333-340, 2005

...In the experiment of <i>in vitro</i> culture, uNK cells derived from wild-type placenta showed chromatin condensation and DNA fragmentation frequently following the anti-Fas antibody treatment, as compared...

DOI 日本農学文献記事索引 Web Site ほか3件 被引用文献3件 参考文献36件

高田 晶子, 三浦 由恵, 兵藤 文則, 勝山 博信, 植木 絢子, 大槻 剛巳 日本衛生学雑誌 60 (1), 30-37, 2005

...In addition, anti-caspase 8 autoantibody and anti-Fas autoantibody were also detected in the serum from silicosis patients, and a functional assay showed that anti-Fas antibody stimulated Fas-mediated...

DOI Web Site Web Site ほか2件 被引用文献3件 参考文献61件

Alexander K. Nussbaum, J. Lindsay Whitton The Journal of Immunology 173 (11), 6611-6618, 2004-12-01

...absence of effect cannot be attributed to a technical flaw, because identical doses of zVAD were able to rescue mice from hepatocyte apoptosis and lethal intrahepatic hemorrhage, induced by inoculation of anti-Fas...

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V Chopin, C Slomianny, H Hondermarck, X Le Bourhis Experimental Cell Research 298 (2), 560-573, 2004-08

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Sixun Yang, Frank G. Haluska The Journal of Immunology 172 (7), 4599-4608, 2004-04-01

...DTIC treatment, which did not increase FasR expression, also sensitized FasL-mediated killing induced by neutralizing anti-Fas Ab....

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Chang-Goo Huh, Valentina M. Factor, Aránzazu Sánchez, Koichi Uchida, Elizabeth A. Conner, Snorri S. Thorgeirsson Proceedings of the National Academy of Sciences 101 (13), 4477-4482, 2004-03-30

...When injected with a low dose of anti-Fas antibody, the majority of these mice died from massive apoptosis and hemorrhagic necrosis, whereas all wild-type mice survived with signs of minor injury....

DOI Web Site 被引用文献43件

Tomokazu Mitsui, Yasunobu Miyake, Hideaki Kakeya, Hiroyuki Osada, Takao Kataoka The Journal of Immunology 172 (6), 3428-3436, 2004-03-15

...Recently, we have reported that ECH blocks activation of procaspase-8 in the death-inducing signaling complex and thereby prevents apoptosis induced by anti-Fas Ab or soluble FasL....

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Keisuke Ito, Tomonori Nakazato, Akira Murakami, Kenji Yamato, Yoshitaka Miyakawa, Taketo Yamada, Nobumichi Hozumi, Hajime Ohigashi, Yasuo Ikeda, Masahiro Kizaki Clinical Cancer Research 10 (6), 2120-2130, 2004-03-15

...Pretreatment with the thiol antioxidant N-acetyl-l-cysteine (NAC) did not inhibit caspase-8 activation, and the antagonistic anti-Fas antibody ZB4 did not block generation of reactive oxygen species, indicating...

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Salah M. Aouad, Luchino Y. Cohen, Ehsan Sharif-Askari, Elias K. Haddad, Antoine Alam, Rafick-Pierre Sekaly The Journal of Immunology 172 (4), 2316-2323, 2004-02-15

...Caspase-3, caspase-8, and Fas-associated death domain are further recruited to lipid rafts of Jurkat cells following anti-Fas treatment....

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Sang Gyun Kim, Hyun-Soon Jong, Tae-You Kim, Jung Weon Lee, Noe Kyeong Kim, Seung Hwan Hong, Yung-Jue Bang Molecular Biology of the Cell 15 (2), 420-434, 2004-02

...Interestingly, expression of dominant negative FADD and treatment with caspase-8 inhibitor efficiently prevented TGF-β1-induced apoptosis, whereas the treatment with an activating CH11 or a neutralizing ZB4 anti-Fas...

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Do-Young Yoon, Young-Sik Cho, Joo-Won Park, Soo-Hyun Kim, Jong-Wan Kim Clinical Chemistry and Laboratory Medicine (CCLM) 42 (5), 2004-01-10

...However, treatment with agonistic anti-Fas antibody did not induce the apoptosis of C33A/IL-18 receptor transfectants, suggesting that either reactive oxygen species play a key role in resisting the Fas-induced...

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A. Wille, A. Gerber, A. Heimburg, A. Reisenauer, C. Peters, P. Saftig, T. Reinheckel, T. Welte, F. Bühling Biological Chemistry 385 (7), 665-, 2004-01-05

...Finally, we demonstrate that the inhibition of catD activity by pepstatin A decreased the number of apoptotic cells in catLdeficient A549 cells after anti-Fas treatment....

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鬼頭 典子, 客本 斉子, 帖佐 直幸 Journal of Oral Biosciences 46 (3), 229-242, 2004

本研究では, HSP90の特異的阻害剤であるゲルダナマイシン(GDM)を用いて, ヒト顎下腺由来腺癌細胞株(HSG)へのアポトーシス誘導能を調べるとともに, 抗Fas抗体誘導アポトーシスシグナル伝達経路へのHSP90の関与について検索した。 また, Fasシグナル経路上でのHSP90のターゲットタンパクの同定を試みた。 HSG細胞をGDMで処理すると経時的に細胞死が誘導された。 形態学的所見, …

DOI 医中誌 参考文献78件

Thorsten Kirsch, Wei Wang, David Pfander Journal of Bone and Mineral Research 18 (10), 1872-1881, 2003-10-01

...</jats:p> <jats:p>Methods: To induce mineralization, we treated growth plate chondrocytes with retinoic acid (RA); apoptosis in these cells was induced by treatment with staurosporine, anti-Fas...

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Tone Sandal, Linda Aumo, Lars Hedin, Bjørn T. Gjertsen, Stein O. Døskeland Molecular Biology of the Cell 14 (8), 3292-3304, 2003-08

...Unlike previously described antiapoptotic proteins Irod/Ian5 did not protect against anti-Fas, tumor necrosis factor-α, staurosporine, UV-light, or a number of chemotherapeutic drugs....

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Yuanyuan Xu, Alexander J. Szalai, Tong Zhou, Kurt R. Zinn, Tandra R. Chaudhuri, Xiaoli Li, William J. Koopman, Robert P. Kimberly The Journal of Immunology 171 (2), 562-568, 2003-07-15

...We report here that hepatotoxicity elicited by anti-Fas Ab Jo2 is dependent on FcγRIIB....

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Fumio Yanai, Eiichi Ishii, Kensuke Kojima, Atsuhiko Hasegawa, Taichi Azuma, Shinichi Hirose, Naohiro Suga, Akihisa Mitsudome, Masafumi Zaitsu, Yasushi Ishida, Yuji Shirakata, Koji Sayama, Koji Hashimoto, Masaki Yasukawa The Journal of Immunology 170 (4), 2205-2213, 2003-02-15

...Ab and anti-Fas ligand Ab....

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Toshihiro Okamoto, Toru Kawasaki, Okio Hino Biochemical Pharmacology 65 (4), 677-681, 2003-02

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Reto Asmis, Jim G. Begley Circulation Research 92 (1), 2003-01-10

...To determine if induction of apoptosis in human macrophages also promotes cell lysis, we studied caspase-3 activation by OxLDL and activating anti-Fas antibodies....

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太田 成男 日医大誌 70 (5), 442-446, 2003

...When overexpressed in Jurkat cells, FNK was markedly more potent in prolonging survival following apoptosis-inducing treatment with a kind of cell death cytokines (anti-Fas), a protein kinase inhibitor...

DOI Web Site PubMed

Watanabe Yoshifumi, Haruyama Takahiro, Akaike Toshihiro Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 26 (4), 564-568, 2003

...Liver injury induced MMP-9 expression in the liver 3 to 12 h after intravenous administration of anti-Fas antibody, followed by the expression of the activity and the protein detected by zymography and...

DOI Web Site Web Site ほか2件 参考文献52件

Grazia Maria Spaggiari, Paola Contini, Alessandra Dondero, Roberta Carosio, Francesco Puppo, Francesco Indiveri, Maria Raffaella Zocchi, Alessandro Poggi Blood 100 (12), 4098-4107, 2002-12-01

...Blocking anti-Fas mAb, or anti-FasL mAb, inhibited sHLA-I–mediated apoptosis via activating receptor in NK cell clones....

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Hideki Kitaura, Noriko Nagata, Yuji Fujimura, Hitoshi Hotokezaka, Noriaki Yoshida, Koji Nakayama The Journal of Immunology 169 (9), 4732-4738, 2002-11-01

...Apoptosis of the adherent cells was markedly inhibited by anti-Fas ligand (FasL) Ab....

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Reiko Onuki, Akira Nagasaki, Hiroaki Kawasaki, Tadashi Baba, Taro Q. P. Uyeda, Kazunari Taira Proceedings of the National Academy of Sciences 99 (23), 14716-14721, 2002-10-30

...When YFP-Bid-CFP was cleaved by caspase 8, on activation by anti-Fas Abs but not by Aβ or tunicamycin, no such transfer of energy was detected....

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Yasunari Nakamoto, Shuichi Kaneko, Hong Fan, Takashi Momoi, Hiroko Tsutsui, Kenji Nakanishi, Kenichi Kobayashi, Takashi Suda The Journal of Experimental Medicine 196 (8), 1105-1111, 2002-10-21

<jats:p>A persistent immune response to hepatitis viruses is a well-recognized risk factor for hepatocellular carcinoma. However, the molecular and cellular basis for the procarcinogenic potential …

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Nakamoto Yasunari, Kaneko Shuichi, Fan Hong, Momoi Takashi, Tsutsui Hiroko, Nakanishi Kenji, Kobayashi Kenichi, Suda Takashi, 中本 安成, 金子 周一, 須田 貴司 Journal of Experimental Medicine 196 (8), 1105-1111, 2002-10-21

金沢大学がん研究所がん病態制御

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Nakamoto Yasunari, Kaneko Shuichi, Fan Hong, Momoi Takashi, Tsutsui Hiroko, Nakanishi Kenji, Kobayashi Kenichi, Suda Takashi Journal of Experimental Medicine 196 (8), 1105-1111, 2002-10-21

A persistent immune response to hepatitis viruses is a well-recognized risk factor for hepatocellular carcinoma. However, the molecular and cellular basis for the procarcinogenic potential of the …

機関リポジトリ

S MIHARA, N SUZUKI, Y TAKEBA, K SOEJIMA, S YAMAMOTO Clinical and Experimental Immunology 129 (2), 359-369, 2002-08

...<jats:title>SUMMARY</jats:title><jats:p>We have reported previously that circulating anti-Fas ligand (FasL) autoantibodies able to inhibit Fas/FasL-mediated apoptosis were present in patients with systemic...

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Eun Joo Chung, Sang-Gu Hwang, PhuongMai Nguyen, Sunmin Lee, Jung-Sik Kim, Jin Woo Kim, Pierre A. Henkart, Donald P. Bottaro, Lilian Soon, Paolo Bonvini, Su-Jae Lee, Judith E. Karp, Ho Jung Oh, Jeffrey S. Rubin, Jane B. Trepel Blood 100 (3), 982-990, 2002-08-01

...Incubation of Jurkat cells with anti-Fas induced caspase-dependent limited proteolysis of β-catenin N- and C-terminal regions and rapid redistribution of β-catenin to the detergent-insoluble cytoskeleton...

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Shin Yonehara Cytokine & Growth Factor Reviews 13 (4-5), 393-402, 2002-08

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K TSUBOTA, H FUJITA, K TADANO, N ONODA, K TSUZAKA, T TAKEUCHI Clinical and Experimental Immunology 129 (1), 177-182, 2002-06-28

...Functional assay confirmed the decreased cytotoxicity of lymphocytes in Sjögren's syndrome patients with enlarged exocrine glands, and that it is not affected by anti-Fas ligand antibody....

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Belén Beltrán, Marisol Quintero, Eugenia García-Zaragozá, Enrique O'Connor, Juan V. Esplugues, Salvador Moncada Proceedings of the National Academy of Sciences 99 (13), 8892-8897, 2002-06-19

...Approximately 2 h after stimulation with anti-Fas Ab, a distinct second phase can be detected....

DOI Web Site 被引用文献1件

Naoki Hagimoto, Kazuyoshi Kuwano, Ichiro Inoshima, Michihiro Yoshimi, Norio Nakamura, Masaki Fujita, Takashige Maeyama, Nobuyuki Hara The Journal of Immunology 168 (12), 6470-6478, 2002-06-15

...Concentrations of TGF-β1 that were not sufficient to induce apoptosis alone could enhance agonistic anti-Fas Ab or rFas ligand-mediated apoptosis of cultured bronchiolar epithelial cells....

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Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas, Philippe A. Halban, Marc Y. Donath Proceedings of the National Academy of Sciences 99 (12), 8236-8241, 2002-06-11

...The beneficial effects of FLIP overexpression were blocked by an antagonistic anti-Fas antibody, indicating their dependence on Fas receptor activation....

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Stephen M. Weber, Jian-Min Chen, Stuart M. Levitz The Journal of Immunology 168 (10), 5303-5309, 2002-05-15

...CQ rendered HeLa cells sensitive to anti-Fas treatment in a manner similar to PD98059....

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Maria RUZZENE, Daniele PENZO, Lorenzo A. PINNA Biochemical Journal 364 (1), 41-47, 2002-05-08

...Both effects are also observable if apoptosis is promoted by anti-Fas antibodies and by etoposide....

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Zha O-Quan Shi, Mark J. Fischer, George T. De Sanctis, Mark R. Schuyler, Yohannes Tesfaigzi The Journal of Immunology 168 (9), 4764-4771, 2002-05-01

...IFN-γ but not anti-Fas induced apoptotic cell death in proliferating normal human bronchial epithelial cells and in human bronchial epithelial cells from subjects with asthma....

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Masayuki Fujino, Xiao-Kang Li, Yusuke Kitazawa, Lei Guo, Mikiko Kawasaki, Naoko Funeshima, Takashi Amano, Seiichi Suzuki Journal of Pharmacology and Experimental Therapeutics 300 (3), 939-945, 2002-03-01

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Su He Wang, James D. Bretz, Ellen Phelps, Emese Mezosi, Patricia L. Arscott, Saho Utsugi, James R. Baker The Journal of Immunology 168 (5), 2470-2474, 2002-03-01

...We also analyzed the function of the Fas pathway in vivo in cytokine-treated mice by using an agonist anti-Fas Ab injected directly into the thyroid....

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Mainak Majumder, Asish K Ghosh, Robert Steele, Xiao Yan Zhou, Nancy J Phillips, Ranjit Ray, Ratna B Ray Virology 294 (1), 94-105, 2002-03

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Maryam Ahmed, Martin Lock, Cathie G. Miller, Nigel W. Fraser Journal of Virology 76 (2), 717-729, 2002-01-15

...segment of the LAT, encompassing the LAT exon 1, the stable 2.0-kb intron, and 5′ part of exon 2, we confirmed that this region was able to diminish the onset of programmed cell death initiated by anti-Fas...

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Naoki Saita, Eisuke Goto, Taro Yamamoto, Isamu Cho, Kaori Tsumori, Hirotsugu Kohrogi, Keishi Maruo, Tomomichi Ono, Motohiro Takeya, Yumiko Kashio, Kazuhiro Nakamura, Mitsuomi Hirashima International Archives of Allergy and Immunology 128 (1), 42-50, 2002

...In contrast, apoptosis induced by anti-Fas antibody in both N-Eos (p = 0.0431) and E-Eos (p = 0.0431) was enhanced by galectin-9....

DOI Web Site 被引用文献5件

青柳 信好, 植野 茂, 浦 栄吾, 丹羽 慎弥 歯科医学 65 (3_4), 241-247, 2002

4-nitroquinoline 1-oxide(4NQO)の化学的刺激による,舌癌誘発過程における粘膜上皮のFasおよびFas ligand(FasL)の発現の変化を,免疫組織化学的に検索した.さらにこの癌組織からクローニングを行い,得られた培養細胞のFasおよびFasLをWestern blottingで調べた.またこれらの培養細胞に抗Fas抗体を作用させ,apoptosisの発現をDNA断…

DOI 医中誌 参考文献15件

Haruyama Hideyuki, Ito Shuichiro, Miyadai Kenji, Takahashi Tohru, Kawaida Reimi, Takayama Tomoko, Hanzawa Hiroyuki, Hata Tadashi, Yamaguchi Junko, Yoshida-Kato Hiroko, Ichikawa Kimihisa, Ohsumi Jun, Yonehara Shin, Serizawa Nobufusa Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 25 (12), 1537-1545, 2002

...We have previously obtained the mouse anti-Fas antibody HFE7A (m-HFE7A), which specifically induces apoptosis in inflammatory cells....

DOI Web Site Web Site ほか2件 被引用文献1件 参考文献56件

Imanishi Toshio, Hano Takuzo, Sawamura Tatsuya, Takarada Shigeho, Nishio Ichiro Circulation Journal 66 (11), 1060-1064, 2002

...HUVECs were treated with agonistic anti-Fas antibody (CH11) and Ox-LDL and then the degree of apoptosis was determined by cell death ELISA....

DOI Web Site PubMed ほか1件 被引用文献3件 参考文献48件

Saadia Faouzi, Beat E. Burckhardt, Jennifer C. Hanson, Carson B. Campe, Laura W. Schrum, Richard A. Rippe, Jacquelyn J. Maher Journal of Biological Chemistry 276 (52), 49077-49082, 2001-12

DOI Web Site Web Site ほか1件 被引用文献4件

Raffaella Faggioni, Russell C. Cattley, Jane Guo, Silvia Flores, Heather Brown, Meiying Qi, Songmei Yin, David Hill, Sheila Scully, Ching Chen, David Brankow, Jeffrey Lewis, Claudia Baikalov, Harvey Yamane, Tina Meng, Frank Martin, Sylvia Hu, Tom Boone, Giorgio Senaldi The Journal of Immunology 167 (10), 5913-5920, 2001-11-15

...IL-18BP-Fc also prevents Con A-induced liver damage and IFN-γ and Fas ligand expression as well as liver damage induced by Pseudomonas aeruginosa exotoxin A or by anti-Fas agonistic Ab....

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Keishi Adachi, Hiroko Tsutsui, Shin-Ichiro Kashiwamura, Ekihiro Seki, Hiroki Nakano, Osamu Takeuchi, Kazuyoshi Takeda, Ko Okumura, Luc Van Kaer, Haruki Okamura, Shizuo Akira, Kenji Nakanishi The Journal of Immunology 167 (10), 5928-5934, 2001-11-15

...The hepatocytotoxic action of these cells was blocked by a perforin inhibitor but not by a neutralizing anti-Fas ligand Ab and was up-regulated by IL-12....

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Olivier Cuvillier, Thierry Levade Blood 98 (9), 2828-2836, 2001-11-01

...Here it is reported that S-1P prevents apoptosis and executioner caspase-3 activation by inhibiting the translocation of cytochrome c and Smac/DIABLO from mitochondria to the cytosol induced by anti-Fas...

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Andrew L. Snow, Linda J. Chen, Ronald R. Nepomuceno, Sheri M. Krams, Carlos O. Esquivel, Olivia M. Martinez The Journal of Immunology 167 (9), 5404-5411, 2001-11-01

...Treatment with either an agonist anti-Fas mAb or Fas ligand-expressing cells identifies two subsets of SLCL based on their sensitivity or resistance to Fas-driven apoptosis....

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Dylan T. Jones, Kanagasabai Ganeshaguru, Andres E. Virchis, Najeem I. Folarin, Mark W. Lowdell, Atul B. Mehta, H. Grant Prentice, A. Victor Hoffbrand, R. Gitendra Wickremasinghe Blood 98 (9), 2800-2807, 2001-11-01

...An agonistic anti-Fas monoclonal antibody (CH-11) did not significantly augment apoptosis induction by any of the death stimuli....

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H Tsujimoto, S Takeshita, K Nakatani, Y Kawamura, T Tokutomi, I Sekine Clinical and Experimental Immunology 126 (2), 355-364, 2001-11

...Furthermore, the agonistic anti-Fas MoAb (CH-11) induced a significant increase in the proportion of apoptotic PMNs in the patients with a viral infection and healthy children, but not in either the patients...

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Beverly Z. Packard, Akira Komoriya, Tilmann M. Brotz, Pierre A. Henkart The Journal of Immunology 167 (9), 5061-5066, 2001-11-01

...In contrast to anti-Fas, induction of apoptosis in these CTL by IL-2 withdrawal resulted in early IETDase activity in the cytoplasm, with no plasma membrane vesiculation....

DOI PDF 被引用文献1件

David Bryder, Veslemøy Ramsfjell, Ingunn Dybedal, Kim Theilgaard-Mönch, Carl-Magnus Högerkorp, Jörgen Adolfsson, Ole Johan Borge, Sten Eirik W. Jacobsen The Journal of Experimental Medicine 194 (7), 941-952, 2001-10-01

...Here, murine Lin−Sca1+c-kit+ stem cells revealed little or no constitutive expression of Fas and failed to respond to an agonistic anti-Fas antibody....

DOI PDF 被引用文献3件

William S. Chen, Pei-Zhang Xu, Kathrin Gottlob, Mei-Ling Chen, Karen Sokol, Tanya Shiyanova, Igor Roninson, Wei Weng, Ryo Suzuki, Kazuyuki Tobe, Takashi Kadowaki, Nissim Hay Genes & Development 15 (17), 2203-2208, 2001-09-01

...Finally, Akt1<jats:sup>−/−</jats:sup> mouse embryo fibroblasts (MEFs) are more susceptible to apoptosis induced by TNF, anti-Fas, UV irradiation, and serum withdrawal.</jats:p>...

DOI Web Site 被引用文献22件

Byung-S. Youn, Young J. Kim, Charlie Mantel, Kang-Yeol Yu, Hal E. Broxmeyer Blood 98 (4), 925-933, 2001-08-15

...When MOLT4 cells, which expressed Fas as well as CXCR4, were stimulated with cycloheximide (CHX), an agonistic anti-Fas antibody, or a combination of these, the cells rapidly underwent apoptosis....

DOI PDF 被引用文献2件

Kathrin Maedler, Giatgen A. Spinas, Roger Lehmann, Pavel Sergeev, Markus Weber, Adriano Fontana, Nurit Kaiser, Marc Y. Donath Diabetes 50 (8), 1683-1690, 2001-08-01

...The effect of glucose was blocked by an antagonistic anti-Fas antibody, indicating that glucose-induced apoptosis is due to interaction between the constitutively expressed FasL and the upregulated Fas...

DOI PDF PDF 被引用文献7件

Valéria M. Borges, Haroldo Falcão, José H. Leite-Júnior, Luciana Alvim, Gerlinde P. Teixeira, Momtchilo Russo, Alberto F. Nóbrega, Marcela F. Lopes, Patricia M. Rocco, Wendy F. Davidson, Rafael Linden, Hideo Yagita, Walter A. Zin, George A. DosReis The Journal of Experimental Medicine 194 (2), 155-164, 2001-07-16

...Administration of neutralizing anti-Fas ligand antibody in vivo blocked induction of silicosis. Thus, Fas ligand plays a central role in induction of pulmonary silicosis.</jats:p>...

DOI PDF 被引用文献5件

Claire RODRIGUEZ-LAFRASSE, Gersende ALPHONSE, Pierre BROQUET, Marie-Thérèse ALOY, Pierre LOUISOT, Robert ROUSSON Biochemical Journal 357 (2), 407-416, 2001-07-09

...Ceramide levels began to increase 2h after the addition of anti-Fas (with no increase during the first hour), and increased continuously to 640% of control cells at 48h....

DOI PDF 被引用文献1件

Lina Musallam, Chantal Éthier, Pierre S. Haddad, Marc Bilodeau American Journal of Physiology-Gastrointestinal and Liver Physiology 280 (6), G1360-G1369, 2001-06-01

...Cells undergoing apoptosis after treatment with anti-Fas antibody were protected by EGF treatment....

DOI Web Site 被引用文献1件

Yigal Dror, Melvin H. Freedman Blood 97 (10), 3011-3016, 2001-05-15

...Patients showed a more prominent decrease in colony formation and increased apoptosis after preincubation with activating anti-Fas antibody....

DOI PDF 被引用文献4件

N Sera, A Kawakami, T Nakashima, H Nakamura, M Imaizumi, T Koji, Y Abe, T Usa, T Tominaga, E Ejima, K Ashizawa, N Yokoyama, N Ishikawa, K Ito, K Eguchi Clinical and Experimental Immunology 124 (2), 197-207, 2001-05

...IL-1β-stimulated thyrocytes became sensitive to apoptosis by anti-Fas IgM monoclonal antibody (mAb)....

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Masayuki Fujino, Xiao-Kang Li, Yusuke Kitazawa, Naoko Funeshima, Lei Guo, Torayuki Okuyama, Takashi Amano, Hiroshi Amemiya, Seiichi Suzuki Cell Transplantation 10 (4-5), 353-361, 2001-05

...An agonistic anti-Fas antibody (0.15 mg/kg) was administered intravenously 24 h after cell transplantation....

DOI Web Site 被引用文献1件

Martha A. O'Brien, Richard A. Moravec, Terry L. Riss BioTechniques 30 (4), 886-891, 2001-04

...course of PARP cleavage and DNA fragmentation in situ using the PARP p85 fragment antibody and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in Jurkat cells treated with anti-Fas...

DOI Web Site 被引用文献2件

Nathalie Scholler, Martha Hayden-Ledbetter, Karl-Erik Hellström, Ingegerd Hellström, Jeffrey A. Ledbetter The Journal of Immunology 166 (6), 3865-3872, 2001-03-15

...The binding to HPB-ALL cells significantly increased when they were grown at a low pH (pH 6.5), whereas binding to Jurkat cells increased after apoptosis was induced with anti-Fas mAb....

DOI PDF 被引用文献2件

P. J. Frost, L. H. Butterfield, V. B. Dissette, J. S. Economou, B. Bonavida The Journal of Immunology 166 (5), 3564-3573, 2001-03-01

...CDDP (0.1–10 μg/ml) sensitized non-MART-127–35 peptide-pulsed T2 to the CD8+ subset of bulk MART-1-specific CTL, and killing was abolished by neutralizing anti-Fas Ab....

DOI PDF 被引用文献1件

Tomoko Kurita-Ochiai, Kuniyasu Ochiai, Kazuo Fukushima Clinical Diagnostic Laboratory Immunology 8 (2), 325-332, 2001-03

...Although cytotoxic anti-Fas antibody affected butyric acid-induced apoptosis, a synergistic effect was not seen....

DOI Web Site 被引用文献12件

S Kodama, M Suzuki, M Arita, G Mogi Clinical and Experimental Immunology 123 (2), 301-308, 2001-02

...GC B-1 cells and B-2 cells were incubated with agonist anti-Fas MoAb, and apoptosis in GC B-1 cells and B-2 cells was analysed by flow cytometry....

DOI PDF Web Site 被引用文献5件

Karl L. Serrao, James D. Fortenberry, Marilyn L. Owens, Frank L. Harris, Lou Ann S. Brown American Journal of Physiology-Lung Cellular and Molecular Physiology 280 (2), L298-L305, 2001-02-01

...Neutrophil-induced A549 cell apoptosis was blocked by inhibitory anti-Fas (42 ± 6% of control cells; P < 0.05) and anti-FasL monoclonal antibodies (29 ± 3%; P < 0.05)....

DOI Web Site 被引用文献2件

Ken Ohta, Naomi Yamashita, Makoto Tajima, Takashi Miyasaka, Ryuji Kawashima, Junichi Nakano, Hitoshi Arioka, Akira Ishii, Tadashi Horiuchi, Terumasa Miyamoto International Archives of Allergy and Immunology 124 (1-3), 259-261, 2001

...Administration of anti-Fas antibody induced apoptosis in the infiltrated eosinophils and abolished augmentation of airway hyperresponsiveness caused by OA inhalation....

DOI Web Site 被引用文献2件

Jingbo Pan, Ling-Xun Duan, Bill S. Sun, Mark A. Feitelson Journal of General Virology 82 (1), 171-182, 2001-01-01

...Accordingly, when HBxAg was introduced into HepG2 cells, it rendered these cells partially resistant to killing by anti-Fas....

DOI Web Site 被引用文献1件

黒田 昌宏, 王 雅棣, 小松 めぐみ, 浅海 淳一, 渋谷 光一, 川崎 祥二, 奥村 能啓, 赤木 史郎, 金澤 右, 本田 理, 平木 祥夫 日本放射線腫瘍学会誌 13 (2), 119-124, 2001

...<BR>Time-lapse observation of individual Jurkat cells using this system confirmed that anti-Fas antibody-mediated apoptotic cells occurred at first budding and were stained with AV-EGFP alone, and thereafter...

DOI 医中誌

HAMA-INABA HIROKO, CHOI KEUN HEE, WANG BING, HAGINOYA KEIKO, YAMADA TAKESHI, HAYATA ISAMU, OHYAMA HARUMI Journal of Radiation Research 42 (2), 201-215, 2001

...Pretreatment with a neutralizing anti-Fas antibody, ZB4, did not abrogate the UVC-induced apoptosis....

DOI NDLデジタルコレクション PDF ほか3件 被引用文献6件 参考文献69件

岩瀬 正泰, 渡辺 仁資, 大橋 勝, 南雲 正男 頭頸部腫瘍 27 (1), 239-243, 2001

...The enhancement of Fas expression was associated with an increased susceptibility of cancer cells to agonistic anti-Fas antibodies (p<0.01)....

DOI

小林 健彦, 堤 康一朗, 桑原 大輔, 岩武 博也, 高桑 俊文 日本耳鼻咽喉科学会会報 104 (2), 139-146, 2001

...We applied an anti-Fas monoclonal, antibody, CH11, to HLEC16 and HLEC16T, and monitored cell death. HLEC16T was found to be significantly less sensitive to CH11-mediated cell death that HLEC16....

DOI PubMed 医中誌 被引用文献1件 参考文献35件

SUGIYAMA Kimio, NODA Yasuhiro, HE Puming Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (3), 674-677, 2001

...In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis....

DOI Web Site Web Site ほか2件 被引用文献3件 参考文献23件

WU XX Urology 57 993-998, 2001

DOI 被引用文献2件

R. Keaney Rathbun, Tracy A. Christianson, Gregory R. Faulkner, Gary Jones, Winifred Keeble, Michael O'Dwyer, Grover C. Bagby Blood 96 (13), 4204-4211, 2000-12-15

...Lysates from lymphoblasts treated with both agonistic anti-fas antibody and IFN-γ contained activated caspase 3 family members (caspases 3, 6, and 7), as well as caspase 8, whereas activation of caspases...

DOI PDF 被引用文献1件

Maria Rescigno, Vincent Piguet, Barbara Valzasina, Suzanne Lens, Rudolf Zubler, Lars French, Vincent Kindler, Jurg Tschopp, Paola Ricciardi-Castagnoli The Journal of Experimental Medicine 192 (11), 1661-1668, 2000-12-04

...Engagement of Fas on immature DCs by Fas ligand (FasL) or by anti-Fas antibodies induces the phenotypical and functional maturation of primary DCs....

DOI PDF 被引用文献8件

Diane Proudfoot, Jeremy N. Skepper, Laszlo Hegyi, Martin R. Bennett, Catherine M. Shanahan, Peter L. Weissberg Circulation Research 87 (11), 1055-1062, 2000-11-24

...In addition, when apoptosis was stimulated in nodular cultures with anti-Fas IgM, there was a 10-fold increase in calcification....

DOI Web Site 被引用文献15件

Maria C. Leite-de-Moraes, André Herbelin, Christine Gouarin, Yasuhiko Koezuka, Elke Schneider, Michel Dy The Journal of Immunology 165 (8), 4367-4371, 2000-10-15

...This process was preceded by up-regulation of Fas (CD95) and Fas ligand expression in response to IL-12 plus IL-18 and was blocked by zVAD, a large spectrum caspase inhibitor, as well as by anti-Fas ligand...

DOI PDF 被引用文献1件

笠原, 一郎, 斉藤, 澄, 中村, 恭一 Journal of Medical and Dental Sciences = Journal of Medical and Dental Sciences 47 (3), 167-175, 2000-09

...Examinations by the TUNEL method and immunohistochemistry using anti-Fas, -Bax, and -Bcl-2 antibodies were conducted....

機関リポジトリ

Arata Honda, Masahiko Hatano, Michinori Kohara, Yutaka Arai, Tety Hartatik, Takashi Moriyama, Michio Imawari, Katsuro Koike, Osamu Yokosuka, Kunitada Shimotohno, Takeshi Tokuhisa Journal of Hepatology 33 (3), 440-447, 2000-09

DOI Web Site Web Site 被引用文献3件

Alain Pierre Bruno, Dominique Lautier, Aurélie de Thonel d'Orgeix, Guy Laurent, Anne Quillet-Mary Blood 96 (5), 1914-1920, 2000-09-01

...Cellular cytotoxicity required cell-cell contact, was not influenced by anti-tumor necrosis factor α or anti-Fas blocking antibodies, and was abrogated by GrB inhibitors or antisense....

DOI PDF 被引用文献1件

René Rückert, Khusru Asadullah, Martina Seifert, Vadim M. Budagian, Ralf Arnold, Claudia Trombotto, Ralf Paus, Silvia Bulfone-Paus The Journal of Immunology 165 (4), 2240-2250, 2000-08-15

...While IL-15 exerted no significant effect on KC proliferation and IL-6 or IL-8 secretion, IL-15 inhibited both anti-Fas and methylcellulose-induced KC apoptosis in vitro....

DOI PDF 被引用文献2件

Ali Khoshnan, Charles Tindell, Isett Laux, David Bae, Brydon Bennett, Andre E. Nel The Journal of Immunology 165 (4), 1743-1754, 2000-08-15

...HuT-78, a lymphoblastoid T cell line with constitutive NF-κB activity, contained elevated levels of Bcl-xL protein and, similar to proliferating CD4+ T cells, was resistant to apoptotic stimuli such as anti-Fas...

DOI PDF 被引用文献2件

Akira Komoriya, Beverly Z. Packard, Martin J. Brown, Ming-Lei Wu, Pierre A. Henkart The Journal of Experimental Medicine 191 (11), 1819-1828, 2000-05-30

...Caspase activities were then assessed at various times after in vitro treatment of mouse thymocytes with dexamethasone or anti-Fas antibody....

DOI PDF 被引用文献3件

Kozo Yasui, Kazunaga Agematsu, Koji Shinozaki, Sho Hokibara, Haruo Nagumo, Takayuki Nakazawa, Atsushi Komiyama Journal of Leukocyte Biology 67 (4), 529-535, 2000-04-01

...Theophylline demonstrated an additive effect to that of anti-Fas antibody (CH11, 1 μg/mL) in inducing neutrophil apoptosis, but not to that of adenosine deaminase or KF-17837 (a selective A2 receptor antagonist...

DOI PDF Web Site 被引用文献1件

Kai C. Wollert, Jörg Heineke, Jürgen Westermann, Mark Lüdde, Beate Fiedler, Wolfgang Zierhut, Didier Laurent, Manuel K. A. Bauer, Klaus Schulze-Osthoff, Helmut Drexler Circulation 101 (10), 1172-1178, 2000-03-14

...Moreover, injection of mice with an agonistic anti-Fas antibody promoted hepatocyte but not cardiomyocyte apoptosis in vivo....

DOI Web Site 被引用文献4件

Masaru Ohashi, Masayasu Iwase, Masao Nagumo Journal of Leukocyte Biology 67 (3), 374-380, 2000-03-01

...DNA fragmentation, annexin V binding, and caspase activities increased in differentiated HL-60 cells with the addition of anti-Fas Ag antibody....

DOI PDF Web Site 被引用文献1件

Wei Liu, Masashi Kato, Anwaral A, Akhand, Akemi Hayakawa, Haruhiko Suzuki, Toshio Miyata, Kiyoshi Kurokawa, Yoshihiro Hotta, Naohisa Ishikawa, Izumi Nakashima Journal of Cell Science 113 (4), 635-641, 2000-02-15

...Coincubation of Jurkat cells with a blocking anti-Fas antibody prevented Fas-induced but not HNE-induced activation of caspase-3....

DOI PDF 被引用文献7件

Masataka Sata, Toshimitsu Suhara, Kenneth Walsh Arteriosclerosis, Thrombosis, and Vascular Biology 20 (2), 309-316, 2000-02

...In contrast, VSMCs remained viable in the presence of soluble FasL or agonist anti-Fas antibody, but they underwent apoptosis after infection with Adeno-FasL....

DOI Web Site 被引用文献3件

Toshio Imanishi, Takuzo Hano, Ichiro Nishio, W. Conrad Liles, Stephen M. Schwartz, David K.M. Han Journal of Vascular Research 37 (6), 523-531, 2000

...Vascular smooth muscle cells (VSMCs) are resistant to FasL or anti-Fas antibody (Ab) signal, and a number of in vitro studies show that VSMC death can only be induced by anti-Fas Ab or FasL in the presence...

DOI Web Site 被引用文献2件

Melissa Yang, Kevin Chen, Jean Chen Shih The American Journal of Chinese Medicine 28 (03n04), 325-330, 2000-01

...<jats:p> We investigated the protective effect of Yang-Gan-Wan (YGW, Pro-Liver pill), a Chinese herbal remedy, against liver apoptosis (programmed cell death) induced by anti-Fas antibody (Jo2)....

DOI Web Site 被引用文献1件

Toshihiro Okamoto European Journal of Pharmacology 387 (2), 229-232, 2000-01

DOI Web Site Web Site 被引用文献8件

Jong-Keuk Lee, Thomas J. Sayers, Alan D. Brooks, Timothy C. Back, Howard A. Young, Kristin L. Komschlies, Jon M. Wigginton, Robert H. Wiltrout The Journal of Immunology 164 (1), 231-239, 2000-01-01

...Transfected Renca cells overexpressing Fas were efficiently killed in vitro upon exposure to anti-Fas Ab (Jo2)....

DOI PDF 被引用文献2件

尾谷 良博, 桑原 大輔, 堤 康一朗 日本耳鼻咽喉科学会会報 103 (10), 1169-1176, 2000

...We applied an anti-Fas monoclonal antibody (CHll) to HNSCC cell lines and monitored their cell death. All three HNSCC cell lines examined expressed Fas protein but not Fas-ligand mRNA....

DOI PubMed 医中誌 被引用文献3件 参考文献33件

Kasahara Ichiro, Saitoh Kiyoshi, Nakamura Kyoichi Journal of Medical and Dental Sciences 47 (3), 167-175, 2000

...Examinations by the TUNEL method and immunohistochemistry using anti-Fas, -Bax, and -Bcl-2 antibodies were conducted....

DOI 医中誌 被引用文献1件

石丸 直澄, 羽地 則雄, 柳 久美子, 林 良夫 日本化学療法学会雑誌 48 (10), 775-779, 2000

...Furthermore, treatment with FOM suppressed caspase activities (ICE and CPP-32) in salivary gland cells stimulated with anti-Fas mAb....

DOI

KAKIZOE MITSUO Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ 47 (2), 125-134, 2000

...These data suggested that the sensitizing activity of cyclohexamide on anti-Fas mediated cytotoxicity could happen in vitro....

DOI PubMed

YOSHIDA-KATO Hiroko, ICHIKAWA Kimihisa, YAMAGUCHI Junko, WATANABE Kenji, OHSUMI Jun, YONEHARA Shin, SERIZAWA Nobufusa Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 64 (9), 1903-1908, 2000

...However, some anti-Fas antibodies show toxicity, and it is difficult to investigate their therapeutic and toxicological effect using animals because of their species specificity....

DOI Web Site Web Site ほか2件 被引用文献2件 参考文献18件

David C. S. Huang, Michael Hahne, Michael Schroeter, Karl Frei, Adriano Fontana, Andreas Villunger, Kim Newton, Juerg Tschopp, Andreas Strasser Proceedings of the National Academy of Sciences 96 (26), 14871-14876, 1999-12-21

...Studies with anti-Fas antibodies have produced conflicting results on Fas signaling, particularly the role of the Bcl-2 family in this process....

DOI Web Site 被引用文献6件

Rongqi Wang, Alex Zagariya, Edmund Ang, Olivia Ibarra-Sunga, Bruce D. Uhal American Journal of Physiology-Lung Cellular and Molecular Physiology 277 (6), L1245-L1250, 1999-12-01

...Apoptosis was induced in the AEC-derived human lung carcinoma cell line A549 or in primary AECs isolated from adult rats with receptor-activating anti-Fas antibodies or purified recombinant Fas ligand,...

DOI Web Site 被引用文献4件

Cédric Raoul, Christopher E. Henderson, Brigitte Pettmann The Journal of Cell Biology 147 (5), 1049-1062, 1999-11-29

...In the presence of neurotrophic factors, exogenous Fas activators such as soluble FasL or anti-Fas antibodies triggered PCD of 40–50% of purified motoneurons over the following 3–5 d; this treatment led...

DOI PDF 被引用文献1件

Wim Van Molle, Geertrui Denecker, Ivan Rodriguez, Peter Brouckaert, Peter Vandenabeele, Claude Libert The Journal of Immunology 163 (10), 5235-5241, 1999-11-15

...<jats:title>Abstract</jats:title><jats:p>Lethal hepatitis can be induced by an agonistic anti-Fas Ab in normal mice or by TNF in mice sensitized to d-(+)-galactosamine or actinomycin D....

DOI PDF 被引用文献5件

Emira Ayroldi, Francesca D’Adamio, Ornella Zollo, Massimiliano Agostini, Rosalba Moraca, Lorenza Cannarile, Graziella Migliorati, Domenico V. Delfino, Carlo Riccardi Blood 94 (10), 3456-3467, 1999-11-15

...Moreover, FasLs-transfected cells expressed soluble FasLs in the supernatant and became resistant to apoptosis induced by agonist anti-Fas MoAb....

DOI PDF 被引用文献1件

Keith R. Jerome, Richard Fox, Zheng Chen, Amy E. Sears, Hyung-yul Lee, Lawrence Corey Journal of Virology 73 (11), 8950-8957, 1999-11

...HSV-1 isolates inhibited apoptosis induced by UV or anti-Fas antibody....

DOI Web Site 被引用文献2件

Gustavo Matute-Bello, W. Conrad Liles, Kenneth P. Steinberg, Peter A. Kiener, Stephen Mongovin, Emil Y. Chi, Mechthild Jonas, Thomas R. Martin The Journal of Immunology 163 (4), 2217-2225, 1999-08-15

...patients with ARDS induced apoptosis of distal lung epithelial cells, which express Fas, and this effect was inhibited by blocking the Fas/FasL system using three different strategies: anti-FasL mAb, anti-Fas...

DOI PDF 被引用文献7件

Wataru Hashimoto, Tadashi Osaki, Haruki Okamura, Paul D. Robbins, Masashi Kurimoto, Shigekazu Nagata, Michael T. Lotze, Hideaki Tahara The Journal of Immunology 163 (2), 583-589, 1999-07-15

...Lysis of CL8-1 cells induced by anti-Fas agonistic Ab was enhanced about 1.4-fold by IFN-γ, a cytokine that is induced by IL-18 in vitro and in vivo....

DOI PDF 被引用文献3件

Chandra Mohan, Ying Yu, Laurence Morel, Ping Yang, Edward K. Wakeland The Journal of Immunology 162 (11), 6492-6502, 1999-06-01

...In vitro, Sle3-bearing T cells show stronger proliferation, increased expansion of CD4+ T cells, and reduced apoptosis (with or without anti-Fas) following stimulation with anti-CD3....

DOI PDF 被引用文献1件

Takashi Nishimura, Akio Ohta The Journal of Immunology 162 (11), 6503-6509, 1999-06-01

...The liver injury was blocked by anti-IFN-γ mAb and anti-TNF-α mAb, but not by anti-Fas ligand mAb. The Fas/Fas ligand independency was also demonstrated using Fas-deficient lpr mice....

DOI PDF 被引用文献6件

Keiko Miwa, Hideo Hashimoto, Takehiro Yatomi, Norio Nakamura, Shigekazu Nagata, Takashi Suda International Immunology 11 (6), 925-931, 1999-06

DOI PDF 被引用文献2件

Hiroyuki Marusawa, Makoto Hijikata, Tsutomu Chiba, Kunitada Shimotohno Journal of Virology 73 (6), 4713-4720, 1999-06

...Furthermore, the core protein among HCV proteins had a key role in protecting the various cells from apoptosis mediated by not only anti-Fas but also TNF-α....

DOI Web Site 被引用文献10件

Akemi Hayakawa, Itsuo Yokoyama, Hisao Tajiri, Tomomitsu Okamoto, Izumi Nakashima Cancer Letters 140 (1-2), 113-119, 1999-06

DOI Web Site Web Site 被引用文献3件

Takahiro Maeda, Yasuaki Yamada, Ryozou Moriuchi, Kazuyuki Sugahara, Kazuto Tsuruda, Tatsurou Joh, Sunao Atogami, Kunihiro Tsukasaki, Masao Tomonaga, Shimeru Kamihira The Journal of Experimental Medicine 189 (7), 1063-1071, 1999-04-05

...Adult T cell leukemia (ATL) cells express Fas antigen and show apoptosis after treatment with an anti-Fas monoclonal antibody....

DOI PDF 被引用文献19件

K Yamada, F Ichikawa, S Ishiyama-Shigemoto, X Yuan, K Nonaka Diabetes 48 (3), 478-483, 1999-03-01

...The cross-linking of Fas by anti-Fas resulted in the elevation of caspase-3-like, but not caspase-1-like, protease activity 2-12 h after the addition of the anti-Fas....

DOI PDF PDF 被引用文献2件

Takamasa Sawa, Fusanori Nishimura, Hideki Ohyama, Keiso Takahashi, Shogo Takashiba, Yoji Murayama Infection and Immunity 67 (3), 1450-1454, 1999-03

...indicated that lymphocytes in the lesions might be susceptible to Fas-mediated apoptosis but lack the death signal, we next investigated if these lymphocytes actually undergo apoptosis by the addition of anti-Fas...

DOI Web Site 被引用文献1件

I TSUGE, T MORISHIMA, M MORITA, H KIMURA, K KUZUSHIMA, H MATSUOKA Clinical and Experimental Immunology 115 (3), 385-392, 1999-03

...However, KAI3 cells as well as the NK cells from patients were not protected from apoptosis induced by either an anti-Fas antibody or NK-sensitive K562 cells....

DOI PDF Web Site 被引用文献22件

Chulhee Choi, Joo Young Park, Jeonggi Lee, Jung-Hee Lim, Eui-Cheol Shin, Young Soo Ahn, Chul-Hoon Kim, Se-Jong Kim, Joo-Deuk Kim, Il Saing Choi, In-Hong Choi The Journal of Immunology 162 (4), 1889-1895, 1999-02-15

...constitutively and is up-regulated by IL-1, IL-6, or TNF-α in which the pretreatment of IFN-γ triggers astrocytes to express more Fas; 4) apoptosis occurs when fetal astrocytes are treated with agonistic anti-Fas...

DOI PDF 被引用文献1件

小笠原, 勝則 東京女子医科大学雑誌 69 (1), 21-28, 1999-01-25

...The Fas sensitivities of peripheral T cells to anti-Fas monoclonal antibody were evaluated by cell counting and trypan blue exclusion....

機関リポジトリ HANDLE 医中誌

Okamoto Toshihiro, Hitomi Yuji, Hara Atsuko Jpn.J.Pharmacol. 79 (4), 485-488, 1999

...The effect of cyclosporine A (CsA) on anti-Fas antibody-induced hepatitis was studied....

DOI Web Site Web Site ほか4件 被引用文献1件 参考文献14件

Inazawa Yuko, Yonehara Shin Cell Structure and Function 24 (3), 151-159, 1999

...A single administration of agonistic anti-Fas mAb RK8 into mice decreased the number of bone marrow cells especially Mac1⁺ and Gr1⁺ Cells of myeloid lineage....

DOI Web Site Web Site ほか2件 被引用文献2件 参考文献35件

Hashimoto Sachiko, Xu Man, Masuda Yutaka, Aiuchi Toshihiro, Nakajo Shigeo, Cao Judong, Miyakoshi Masazumi, Ida Yoshiteru, Nakaya Kazuyasu The Journal of Biochemistry 125 (1), 17-23, 1999

...These results indicate that β-HIVS induces apoptosis in HL-60 cells through a mechanism unlike those reported for anti-Fas antibodies and etoposide....

DOI PDF PubMed 被引用文献6件

Yamamura Taisei, Nakamura Hiroshi, Yamamoto Takuo, Umemoto Seiji, Fujii Takashi, Kobayashi Nobuyuki, Matsuzaki Masunori JAPANESE CIRCULATION JOURNAL 63 (3), 149-154, 1999

...Samples from the DCM patients stained more intensely with anti-Fas antibody than those from control patients (p<0.05)....

DOI Web Site PubMed 被引用文献1件 参考文献25件

YOSHIKAWA Masahide, TOYOHARA Masahisa, UEDA Sigehiko, SHIROI Akira, TAKEUCHI Hiroshi, NISHIYAMA Toshimasa, YAMADA Takatsugu, FUKUI Hiroshi, ISHIZAKA Shigeaki Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 22 (9), 951-955, 1999

...The HepG2 cells were resistant to TNF-α and anti-Fas antibody, but were rendered susceptible to TNF-α and anti-Fas antibody in the presence of antinomycin D (Act D), an inhibitor of RNA synthesis....

DOI Web Site Web Site ほか2件 被引用文献3件 参考文献33件

ISHIWATA Shunji, NAKASHITA Kei, OZAWA Yasuko, NIIZEKI Masahiro, NOZAKI Seishiro, TOMIOKA Yoshihisa, MIZUGAKI Michinao Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 22 (11), 1163-1166, 1999

...Anti-Fas antibody elicited caspase-3-like activity. However caspase-3-like activity with co-treatment of GL and anti-Fas antibody was the same level as the antibody alone....

DOI Web Site Web Site ほか2件 参考文献30件

岡本 和義, 藤澤 幸史, 西岡 久寿樹 日本臨床免疫学会会誌 22 (6), 439-443, 1999

DOI Web Site PubMed ほか1件 参考文献18件

NOSE,Masato Connective tissue 30 (4), 297-300, 1998-12-25

...The treatment of MRL / gld mice with anti-Fas antibodies was successful in the prevention and amelioration of these diseases....

NDLデジタルコレクション 医中誌 参考文献24件

Shugo Ueda, Hajime Nakamura, Hiroshi Masutani, Tetsuro Sasada, Shin Yonehara, Arimichi Takabayashi, Yoshio Yamaoka, Junji Yodoi The Journal of Immunology 161 (12), 6689-6695, 1998-12-15

...Caspase-3 activity in cell lysate precultured with anti-Fas Ab was suppressed dose dependently by diamide and restored by thiol-reducing agents, DTT or TRX....

DOI PDF 被引用文献3件

Bengt Fadeel, Anders Åhlin, Jan-Inge Henter, Sten Orrenius, Mark B. Hampton Blood 92 (12), 4808-4818, 1998-12-15

...The treatment of neutrophils with agonistic anti-Fas monoclonal antibodies (MoAbs) significantly accelerated this process....

DOI PDF 被引用文献2件

Susan M. Quirk, Dale A. Porter, Sarah C. Huber, Robert G. Cowan Endocrinology 139 (12), 4860-4869, 1998-12-01

...At 48 h, cells were treated with 2 μg/ml control IgG, 2 μg/ml anti-Fas antigen antibody (Fas mAb), 10 ng/ml TNF, or Fas mAb and TNF....

DOI PDF 被引用文献1件

Shigeru Ishiyama, Michiaki Hiroe, Toshio Nishikawa, Takashi Shimojo, Shinji Abe, Hiroyuki Fujisaki, Hiroshi Ito, Katsutoshi Yamakawa, Nobuyuki Kobayashi, Takeshi Kasajima, Fumiaki Marumo The Journal of Immunology 161 (9), 4695-4701, 1998-11-01

...Some rats were injected with anti-Fas Ab (0.1 mg/kg) or anti-FasL Ab (0.1 mg/kg), and subsequently, inflammatory lesions exhibited less severe than did untreated rats with myocarditis....

DOI PDF 被引用文献2件

Ken-ichiro Seino, Kazuhisa Iwabuchi, Nobuhiko Kayagaki, Ryukou Miyata, Isao Nagaoka, Akio Matsuzawa, Katashi Fukao, Hideo Yagita, Ko Okumura The Journal of Immunology 161 (9), 4484-4488, 1998-11-01

...Ligation of Fas by either IgM- or IgG-type anti-Fas mAb also induced PMN migration. PMN derived from lpr mice that express few Fas molecules did not respond to sFasL....

DOI PDF 被引用文献3件

Jessica K. Booker, Elizabeth A. Reap, Philip L. Cohen The Journal of Immunology 161 (9), 4536-4541, 1998-11-01

...The addition of anti-Fas Ab to in vitro cultures resulted in an increase in apoptosis in both B6 and B6/lpr cells....

DOI PDF 被引用文献1件

Bruce D. Uhal, Claudia Gidea, Raed Bargout, Antonio Bifero, Olivia Ibarra-Sunga, Michael Papp, Kevin Flynn, Gerasimos Filippatos American Journal of Physiology-Lung Cellular and Molecular Physiology 275 (5), L1013-L1017, 1998-11-01

...Apoptosis was not induced by isotype-matched nonimmune mouse immunoglobulins or nonactivating anti-Fas monoclonal antibodies....

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Ji Ping Xu, Xiang Li, Etsuko Mori, Mao Wu Guo, Tsuneatsu Mori Zygote 6 (4), 359-367, 1998-11

...However, indirect immunofluorescence (IIF) staining with anti-Fas monoclonal antibody (mAb) on the membrane of follicle and egg of MRL/lpr mice was significantly weaker than that of MRL/+ mice....

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Thomas J. Sayers, Alan D. Brooks, Jong-Keuk Lee, Robert G. Fenton, Kristin L. Komschlies, Jon M. Wigginton, Robin Winkler-Pickett, Robert H. Wiltrout The Journal of Immunology 161 (8), 3957-3965, 1998-10-15

...In addition, cells pretreated with IFN-γ and TNF-α are sensitive to lysis mediated by Fas ligand (FasL)-expressing hybridomas (dllS), cross-linking of anti-Fas Abs or soluble Fas (FasL)....

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Nagendra K. A. Prasad, Giuliana Papoff, Ann Zeuner, Emmanuelle Bonnin, Michel D. Kazatchkine, Giovina Ruberti, Srini V. Kaveri The Journal of Immunology 161 (7), 3781-3790, 1998-10-01

...Affinity-purified anti-Fas Abs from IVIg induced apoptosis of CEM T cells at a 120-fold lower concentration than unfractionated IVIg....

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S Wakisaka, N Suzuki, Y Takeba, Y Shimoyama, H Nagafuchi, M Takeno, N Saito, T Yokoe, A Kaneko, T Asai, T Sakane Clinical and Experimental Immunology 114 (1), 119-128, 1998-10

...Anti-Fas MoAb induced apoptosis of RA synovial cells in vitro, and proinflammatory cytokines tumour necrosis factor-alpha (TNF-α) and IL-1β, but not IL-6 or IL-8, inhibited the anti-Fas-induced apoptosis...

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