検索結果 2,662 件

Zhang Yuan-Bin, Guo Xiu-Quan, Wang Gang-Gang, Pu Hai-Bo The Tohoku Journal of Experimental Medicine advpub (0), 2024

DOI Web Site PubMed

Kitazawa Tadashi, Takai Hideki, Kono Tetsuro, Okada Hiroyuki, Ogata Yorimasa Ｊｏｕｒｎａｌ　ｏｆ　Ｏｒａｌ　Ｓｃｉｅｎｃｅ 66 (1), 15-19, 2024

...At the graft sites, levels of SP7/OSX and BMP2 mRNA were significantly increased....

DOI Web Site PubMed 参考文献21件

Kuramochi Kosei, Matsushima Kiyoshi Journal of Hard Tissue Biology 33 (1), 1-10, 2024

...Additionally, <i>BMP-2</i> mRNA, and BMP-2 and DSPP protein expression levels were examined to confirm hard tissue formation....

DOI Web Site 参考文献33件

GOMYO-FURUYA Natsuko, KAMIO Naoto, WATANABE Takahiro, HAYAMA Tomomi, FUKAI Joji, KURAMOCHI Kosei, NAKANISHI Kento, WATANABE Arata, OKABE Tatsu, MATSUSHIMA Kiyoshi Biomedical Research 44 (6), 257-264, 2023-11-20

...Real-time PCR was used to examine BMP-2 and Osterix mRNA expression. Calcified nodule formation was evaluated with Alizarin red staining....

DOI Web Site PubMed 参考文献15件

山田, 淳一, 出山, 義昭, 吉村, 善隆, 鈴木, 邦明, 八若, 保孝 北海道歯学雑誌 44 26-36, 2023-09-15

...Additionally, ouabain increased phosphorylation of ERK and p38 in response to BMP-2, whereas JNK phosphorylation was suppressed....

HANDLE

Katsumata Shinichi, Matsuzaki Hiroshi Metallomics Research 3 (2), note01-note07, 2023-07-20

...Hemoglobin concentration, serum osteocalcin concentration, femoral bone mineral content and density, and femoral <i>Igf1</i>, <i>Bmp2</i>, <i>Runx2</i>, <i>Sp7</i>, <i>Spp1</i>, <i>Bglap</i>, and <i>Col1a1...

DOI

鈴木 茂樹, 長谷川 龍, 佐藤 瞭子, 大道寺 美乃, 長﨑 果林, 根本 英二, 山田 聡 日本歯科保存学雑誌 66 (3), 179-191, 2023-06-30

<p> 目的：局所クロマチンの「ゆるみ」によるクロマチンアクセシビリティの上昇は，転写複合体の結合を可能にすることで標的遺伝子発現を促すことから，エピジェネティクスな遺伝子発現調節機構の主体である．そこで本研究では，いまだ明らかになっていないヒト歯髄幹細胞（human dental pulp stem …

DOI

Mori, Natsumi, Esaki, Nobutoshi, Shimoyama, Yoshie, Shiraki, Yukihiro, Asai, Naoya, Sakai, Tomohisa, Nishida, Yoshihiro, Takahashi, Masahide, Enomoto, Atsushi, Mii, Shinji Pathology - Research and Practice 245 154443-, 2023-05

...However, enhancement of SMAD1/5/9 phosphorylation was observed in CD109 knockdown cells under bone morphogenetic protein-2 (BMP-2) stimulation....

機関リポジトリ HANDLE

Megumi Yokoyama, Osamu Katsumata-Kato, Junko Fujita-Yoshigaki International Journal of Dentistry 2023 1-7, 2023-03-31

...They also showed higher BMP2 expression than control glands. Primary-cultured parotid acinar cells supplemented with BMP2 showed higher proliferative potential than control cells....

DOI PDF XML 参考文献42件

Shiho Hisaoka, Jin Osawa, Riku Kobashi, Atsuhiko Ishida, Isamu Kameshita, Noriyuki Sueyoshi Biochemical and Biophysical Research Communications 649 16-24, 2023-03

DOI Web Site Web Site 参考文献27件

Ryo Kunimatsu, Kodai Rikitake, Yuki Yoshimi, Nurul Aisyah Rizky Putranti, Yoko Hayashi, Kotaro Tanimoto International Journal of Molecular Sciences 24 (4), 4048-, 2023-02-17

...The expression of ALP stain, Alizarin red stain, ALP, BMP-2, and OCN was the highest in the CD146+ group....

DOI Web Site 参考文献60件

Akiyoshi Kuroda, Ayumi Mineo, Shintaro Shoji, Gen Inoue, Wataru Saito, Hiroyuki Sekiguchi, Masashi Takaso, Kentaro Uchida Bio-Medical Materials and Engineering 34 (1), 67-76, 2023-01-11

...Among these, 12 upregulated genes (Bmp2, Fgf9, Fgf18, Ngf, Pdgfa, Pdgfb, Tgfb1, Vegfa, Vegfc, Wnt4, Wnt5a, Wnt10a) were associated with secretory growth factors....

DOI Web Site 参考文献49件

Hirao Takuya, Kim Beak Gyu, Habuchi Hinako, Kawaguchi Kotoku, Nakahari Takashi, Marunaka Yoshinori, Asano Shinji Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 46 (1), 111-122, 2023-01-01

...The inhibition on the differentiation by FBS was recovered by the TGF-β1 and BMP-2 inhibitors in combination.</p>...

DOI Web Site PubMed ほか1件 参考文献42件

Tang Yulan, Wang Chen, Desamero Mark Joseph M., Kok Mun Keong, Chambers James Kenn, Uchida Kazuyuki, Kominami Yuri, Ushio Hideki, Cervancia Cleofas, Estacio Maria Amelita, Kyuwa Shigeru, Kakuta Shigeru Experimental Animals 72 (1), 132-139, 2023

...The expression of mRNA (<i>Wnt3a, Ctnnb1/β-catenin, Lef1,</i> and <i>Bmp2</i>) and protein (WNT3A and β-catenin) of selected Wnt/β-catenin associated genes explains Philippines stingless bee propolis promoting...

DOI Web Site PubMed 参考文献28件

Liu Xiao-Po, Li Jia-Qi, Li Ruo-Yu, Cao Guo-Long, Feng Yun-Bo, Zhang Wei Experimental Animals 72 (3), 413-424, 2023

...In conclusion, MGAT5 may modulate the osteogenic differentiation of BMSCs via the <i>β</i>-catenin, BMP type 2 (BMP2) and TGF-β signals and involved in the process of OP.</p>...

DOI Web Site PubMed 参考文献59件

山本 まりこ, 大浦 清 日本薬理学会年会要旨集 97 (0), 3-B-P-055-, 2023

...Therefore, we have tried to delivery <i>bmp-2 </i>gene into the target site safely and efficiently....

DOI Web Site

Honami Sugimoto, Shinji Fukuda, Satoru Yokawa, Miki Hori, Hotsuna Ninomiya, Takuma Sato, Ken Miyazawa, Tatsushi Kawai, Tadahide Furuno, Satoshi Inouye, Shigemi Goto, Takahiro Suzuki Biochemical and Biophysical Research Communications 635 203-209, 2022-12

DOI Web Site Web Site 参考文献27件

Yoshikawa, Ryo, 福井, 友章, 大江, 啓介, Kumabe, Yohei, Oda, Takahiro, Sawauchi, Kenichi, Takase, Kyohei, Yamamoto, Yuya, 酒井, 良忠, 黒田, 良祐, 新倉, 隆宏 Current Issues in Molecular Biology 44 (11), 5562-5578, 2022-11

...-2 (E-BMP-2) on them....

HANDLE

Chen, Xutong, Ando, Ryo, Casco-Robles, Roman Martin, Casco-Robles, Martin Miguel, 丸尾, 文昭, Obata, Shuichi, 千葉, 親文 Biomedicines 10 (11), 2772-, 2022-11

...We previously demonstrated that PcNobs in the blastema express an orphan gene, Newtic1, and that they secrete growth factors such as BMP2 and TGFβ1 into the surrounding tissues....

DOI 機関リポジトリ HANDLE ほか1件 参考文献25件

Hongzhou Shen, Yu Zhuang, Chenglong Zhang, Changru Zhang, Yuan Yuan, Hongbo Yu, Jiawen Si, Guofang Shen International Journal of Molecular Sciences 23 (20), 12204-, 2022-10-13

...<jats:p>This bedside-to-bench study aimed to systematically investigate the value of applying BMP2-loaded calcium phosphate cement (BMP2-CPC) in the restoration of large-scale alveolar bone defects....

DOI Web Site 被引用文献1件

Éva Fige, Zsolt Sarang, László Sós, Zsuzsa Szondy Cells 11 (18), 2928-, 2022-09-19

...The effect of retinoids seems to be mediated by bone morphogenetic protein (BMP)-2, and the Smad3 transcription factor....

DOI Web Site 被引用文献1件

Manami Matsumura, Masaru Murakami, Masayuki Funaba Cell Biochemistry and Function 40 (7), 742-749, 2022-09-05

...Responsiveness to MITF‐A on hepcidin transcription decreased when the cells were stimulated with BMP2 or IL‐1β....

DOI Web Site Web Site 参考文献44件

YoungBum Park, Sien Lin, Yan Bai, Seyedsina Moeinzadeh, Sungwoo Kim, Jianping Huang, Uilyong Lee, Ngan Fong Huang, Yunzhi Peter Yang Tissue Engineering Part A 28 (17-18), 760-769, 2022-09-01

DOI Web Site Web Site 被引用文献1件

LiNa Wang, Ming Dong, DongMei Shi, CaiHui Yang, Shuo Liu, Lu Gao, WeiDong Niu BMC Oral Health 22 (1), 2022-08-11

...Meanwhile in osteoblasts, the gene and protein expression of PI3K, BMP-2 and Runx2 were significantly reduced (<jats:italic>P</jats:italic> < 0.05) in the inflammatory microenvironment....

DOI PDF Web Site 被引用文献1件

Masanari Kuwahara, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Takuya Sueishi, Masakazu Toya, Taisuke Uchida, Tomoaki Tsutsui, Ryota Hirose, Hidetoshi Tsushima, Yasuharu Nakashima BMC Pharmacology and Toxicology 23 (1), 2022-08-09

...Several studies have reported that statins, the competitive inhibitors of 3-hydroxy-2-methylglutaryl coenzyme A (HMG-CoA) reductase, induce the expression of BMP2 in multiple cell types as the pleotropic...

DOI PDF Web Site 参考文献41件

Cangyou Xie, Michiko Satake-Ozawa, Fatma Rashed, Masud Khan, Masaomi Ikeda, Shunya Hayashi, Shinichi Sawada, Yoshihiro Sasaki, Tohru Ikeda, Yoshiyuki Mori, Kazunari Akiyoshi, Kazuhiro Aoki International Journal of Molecular Sciences 23 (14), 7768-, 2022-07-14

...In the present study, we investigated the osteoconductive capacity of a newly synthesized CHP nanogel, CHPA using OP3-4 and BMP-2....

DOI Web Site 参考文献44件

Wen Shi, Takashi Kanamoto, Masaharu Aihara, Shiro Oka, Sanae Kuroda, Tsuyoshi Nakai, Takeo Mazuka, Keisuke Takenaka, Yuji Sato, Masahiro Tsukamoto, Kosuke Ebina, Ken Nakata Scientific Reports 12 (1), 2022-07-13

...The superficial layer of S1 had higher expression of Collagen10, aggrecan, Sox9, and lower expression of Collagen1 and BMP2 than that of S2....

DOI PDF Web Site 参考文献40件

Angelos Kaspiris, Argyris C. Hadjimichael, Elias S. Vasiliadis, Dionysios J. Papachristou, Peter V. Giannoudis, Elias C. Panagiotopoulos Journal of Clinical Medicine 11 (13), 3901-, 2022-07-04

...Conclusion: Administration of BMP-2 and -7, PRP and MSCs were considered effective and safe methods in fracture treatment, increasing bone consolidation, reducing time to repair and being linked to satisfactory...

DOI Web Site 被引用文献1件

Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa Frontiers in Bioengineering and Biotechnology 10 2022-06-21

...Gene analysis of the BMP-Smad signaling pathway-associated molecules revealed that <jats:italic>Epfn</jats:italic> activation decreased follistatin expression at stage 2, but increased <jats:italic>BMP2...

DOI Web Site 被引用文献1件 参考文献40件

Nurul Aisyah Rizky Putranti, Ryo Kunimatsu, Kodai Rikitake, Tomoka Hiraki, Kengo Nakajima, Takaharu Abe, Yuji Tsuka, Shuzo Sakata, Ayaka Nakatani, Hiroki Nikawa, Kotaro Tanimoto Cells 11 (12), 1914-, 2022-06-13

...Histological and immunohistochemical evaluations showed that combining SHEDs and CAP enhanced the expression of BMP-2, VEGF, and CD31, and promoted bone regeneration....

DOI Web Site 参考文献29件

Yanlin Li, Wenduo Jiang, Yue Feng, Lei Wu, Yimin Jia, Ruqian Zhao International Journal of Molecular Sciences 23 (11), 6263-, 2022-06-03

...Similar mitigation effects of betaine were observed for BMP2 and BMP6, the up-stream regulators of hepcidin expression....

DOI Web Site 被引用文献1件

Norika Chiba, Yukie Noguchi, Chang Hwan Seong, Tomokazu Ohnishi, Tetsuya Matsuguchi FEBS Letters 596 (13), 1720-1732, 2022-06

...Here, we found that BMP9 and BMP2 rapidly induced early growth response 1 (EGR1) protein expression in osteoblasts through MEK/ERK pathway‐dependent transcriptional activation....

DOI Web Site Web Site ほか1件 参考文献41件

Akiyoshi Kuroda, Wataru Saito, Gen Inoue, Masayuki Miyagi, Shintaro Shoji, Hiroyuki Sekiguchi, Masashi Takaso, Kentaro Uchida Cureus 2022-05-30

DOI Web Site 参考文献26件

Jianbo Li, Xiuan Zhang, Xiqiong Wang, Congjiao Sun, Jiangxia Zheng, Junying Li, Guoqiang Yi, Ning Yang Journal of Animal Science and Biotechnology 13 (1), 52-, 2022-05-18

...These differential peaks covered 281 and 327 genes, such as <jats:italic>BMP2</jats:italic>, <jats:italic>SMAD2</jats:italic>, <jats:italic>SOX9</jats:italic> and <jats:italic>CYP19A1</jats:italic>, which...

DOI PDF Web Site 被引用文献1件

Shinichi Nakagawa, Rintaro Okada, Junichi Kushioka, Joe Kodama, Hiroyuki Tsukazaki, Zeynep Bal, Daisuke Tateiwa, Yuichiro Ukon, Hiromasa Hirai, Takahiro Makino, Shota Takenaka, Seiji Okada, Takashi Kaito Scientific Reports 12 (1), 7906-, 2022-05-12

...We developed NOVOSIS putty (NP), a novel composite material of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP)/hydrogel, and BMP-2, which can sustainably release BMP-2 over 2 weeks....

DOI PDF Web Site 被引用文献1件 参考文献28件

Coralee E. Tye, Prachi N. Ghule, Jonathan A. R. Gordon, Fleur S. Kabala, Natalie A. Page, Michelle M. Falcone, Kirsten M. Tracy, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein Scientific Reports 12 (1), 2022-05-11

...RNA-seq analysis shows that loss of chromatin-bound MIR181A1HG alters expression and BMP2 responsiveness of skeletal gene networks (e.g., SOX5 and DLX5)....

DOI PDF Web Site 被引用文献1件

Satoh, Akira, Kashimoto, Rena, Ohashi, Ayaka, Furukawa, Saya, Yamamoto, Sakiya, Inoue, Takeshi, Hayashi, Toshinori, Agata, Kiyokazu Zoological Letters 8 (1), 6-, 2022-04-28

...We previously found that BMP2, FGF2, and FGF8 (B2FF) could play sufficient roles in blastema induction in urodele amphibians....

DOI 機関リポジトリ PDF ほか1件 参考文献29件

Atsuko Sato, Gina M. Oba, Nathanael Aubert-Kato, Kei Yura, John Bishop BMC Ecology and Evolution 22 (1), 2022-04-28

...to MDBGs, showing that only four out of 62 CNS developmental genes showed correlation coefficient > 0.9, comparable to the values between MDBGs, and three of these four genes were signaling molecules: BMP2...

DOI PDF Web Site 参考文献46件

Tatjana Bordukalo-Nikšić, Vera Kufner, Slobodan Vukičević Frontiers in Immunology 13 2022-04-26

...Certain BMPs (BMP2 and -7) were approved for clinical use; however, increased bone resorption rather than formation were observed in clinical applications, suggesting the role BMPs have in osteoclast activation...

DOI Web Site 被引用文献1件

Muhammad Subhan Amir, Norika Chiba, Chang Hwan Seong, Joji Kusuyama, Nahoko Eiraku, Tomokazu Ohnishi, Norifumi Nakamura, Tetsuya Matsuguchi Journal of Cellular Physiology 237 (4), 2183-2197, 2022-04

...Here, we have found that BMP9 rapidly increases the protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) in osteoblasts under normoxic conditions more efficiently than BMP2 or BMP4....

DOI Web Site Web Site 参考文献55件

Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin International Journal of Molecular Sciences 23 (7), 3824-, 2022-03-30

...-2)....

DOI Web Site 被引用文献1件

Fabien Kawecki, Jessica Jann, Michel Fortin, François A. Auger, Nathalie Faucheux, Julie Fradette International Journal of Molecular Sciences 23 (6), 3302-, 2022-03-18

...ASCs displayed a better osteogenic response to BMP-9 than to BMP-2 in monolayer cell culture, as shown by higher transcript levels of the osteogenic markers RUNX2, osterix (OSX/SP7), and alkaline phosphatase...

DOI Web Site 被引用文献1件

Daisuke Tateiwa, Takashi Kaito, Kunihiko Hashimoto, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Hiroyuki Tsukazaki, Shinichi Nakagawa, Yuichiro Ukon, Hiromasa Hirai, Hongying Tian, Ivan Alferiev, Michael Chorny, Satoru Otsuru, Seiji Okada, Masahiro Iwamoto Frontiers in Cell and Developmental Biology 10 2022-03-14

...The collagen sponge discs that absorbed recombinant human (rh) BMP-2 were implanted into the dorsal fascia of young adult mice to induce ectopic bone....

DOI Web Site 被引用文献1件

Catharina Marques Sacramento, Rahyza Inácio Freire Assis, Miki Taketomi Saito, Ricardo Della Coletta, Mauricio da Rocha Dourado, Enilson A. Sallum, Francisco H. Nociti, Renato Correa Viana Casarin, Denise Carleto Andia, Karina Gonzales Silvério Differentiation 124 17-27, 2022-03

DOI Web Site Web Site 被引用文献1件

Benedikt Eggers, Anna-Maria Wagenheim, Susanne Jung, Johannes Kleinheinz, Marjan Nokhbehsaim, Franz-Josef Kramer, Sonja Sielker International Journal of Molecular Sciences 23 (5), 2503-, 2022-02-24

...Additionally, RT-qPCR was used to investigate effects on osteogenic markers, such as alkaline phosphatase (ALP), bone morphogenic protein (BMP)2, collagen (COL)1A1, osteonectin (SPARC), osteoprotegerin...

DOI Web Site 被引用文献1件

Kawai, Mariko, Ozasa, Ryosuke, Ishimoto, Takuya, Nakano, Takayoshi, Yamamoto, Hiromitsu, Kashiwagi, Marina, Yamanaka, Shigeki, Nakao, Kazumasa, Maruyama, Hiroki, Bessho, Kazuhisa, Ohura, Kiyoshi Materials 15 (3), 993-, 2022-01-27

Kawai M.Y., Ozasa R., Ishimoto T., et al. Periodontal Tissue as a Biomaterial for Hard-Tissue Regeneration following bmp-2 Gene Transfer. Materials, 15, 3, 993. https://doi.org/10.3390/ma15030993.

DOI HANDLE Web Site 参考文献51件

Sungyub Lee, Minsun Kim, Sooyeon Hong, Eom Ji Kim, Jae-Hyun Kim, Youngjoo Sohn, Hyuk-Sang Jung Frontiers in Pharmacology 12 2022-01-04

...In addition, SR stimulates osteoblast differentiation and increased protein expression of the bone morphogenetic protein 2 (BMP-2)/SMAD signaling pathway....

DOI Web Site 被引用文献1件

于 在強, 大徳 和之, 皆川 正仁, 今泉 忠淳, 元村 成, 古川 賢一, 瀬谷 和彦 日本薬理学会年会要旨集 96 (0), 2-B-P-138-, 2022

...These results suggest that TNF-α-BMP2 signaling mainly contributes to valve ectopic calcification by inhibiting CD34 expression.</p>...

DOI Web Site

Nosho Shuji, Ono Mitsuaki, Komori Taishi, Mikai Akihiro, Tosa Ikue, Ishibashi Kei, Tanaka Yukie, Kimura-Ono Aya, Hara Emilio S, Oohashi Toshitaka, Kuboki Takuo Journal of Prosthodontic Research 66 (1), 124-130, 2022

...However, recombinant human BMP-2 (rhBMP-2) products have not been legally approved in Japan....

DOI Web Site PubMed ほか1件 被引用文献1件 参考文献29件

YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, SUGAYA Tsutomu, SHIMADA Yasushi, OHARA Naoko, YOSHIYAMA Masahiro Journal of Oral Tissue Engineering 20 (2), 41-46, 2022

...<p>This study was designed to examine the effects of bone morphogenetic protein-2 (BMP-2) on bone response at palatal site using gelatin hydrogel in ovariectomized...

DOI

Imaeda Yoshihiro, Arakawa Satoshi, Yasuoka Hironobu, Kato Hiroyuki, Nagata Hidetoshi, Asano Yukio, Kawabe Norihiko, Shiogama Kazuya, Urano Makoto, Inada Ken-ichi, Tsukamoto Tetsuya, Horiguchi Akihiko Fujita Medical Journal 8 (4), 134-138, 2022

...This case suggests that BMP-2 transformed fibroblasts and pluripotent stem cells into osteocytes. We conclude that the squamous cell carcinoma-like lesion was squamous metaplasia of adenocarcinoma....

DOI 機関リポジトリ Web Site ほか1件

Tomochika Mayo, Sumie Rena, Miyano Ryotaro, Mochizuki Yasushi, Inoue Hajime, Kajikawa Akiyoshi Journal of St. Marianna University 13 (2), 87-93, 2022

...When we removed the exosomes from the cultured HFK supernatant, we observed decreased expression of WNT5A and FGF2, with increased expression of bone morphogenetic protein-2 (BMP2) and VEGF....

DOI Web Site 参考文献15件

Yam Prasad Aryal, Chang-Yeol Yeon, Tae-Young Kim, Eui-Seon Lee, Shijin Sung, Elina Pokharel, Ji-Youn Kim, So-Young Choi, Hitoshi Yamamoto, Wern-Joo Sohn, Youngkyun Lee, Seo-Young An, Chang-Hyeon An, Jae-Kwang Jung, Jung-Hong Ha, Jae-Young Kim Frontiers in Physiology 12 2021-12-10

...<jats:italic>In vitro</jats:italic> cultivation of hDPSCs with apigenin treatment upregulated bone morphogenetic protein (BMP)- and osteogenesis-related signaling molecules such as BMP2, BMP4, BMP7, bone...

DOI Web Site 被引用文献1件

Toshiyuki Kawai, Chi-Chun Pan, Yaichiro Okuzu, Takayoshi Shimizu, Alexander M. Stahl, Shuich Matsuda, William J. Maloney, Yunzhi P. Yang Tissue Engineering Part A 27 (23-24), 1517-1525, 2021-12-01

DOI Web Site Web Site 参考文献46件

John B. Lees‐Shepard, Kaitlyn Flint, Melanie Fisher, Minoru Omi, Kelsey Richard, Michelle Antony, Po Jung Chen, Sumit Yadav, David Threadgill, Nita J. Maihle, Caroline N. Dealy Developmental Dynamics 251 (1), 193-212, 2021-11-27

...In the reserve and prehypertrophic zones, BMP2 signals unilaterally suppress EGFR activity; in the hypertrophic zone, EGFR and BMP2 signals repress each other....

DOI Web Site Web Site ほか1件 被引用文献1件 参考文献69件

Tanaka, Yukie, Aung, Kyaw Thu, Ono, Mitsuaki, Mikai, Akihiro, Dang, Anh Tuan, Hara, Emilio Satoshi, Tosa, Ikue, Ishibashi, Kei, Ono-Kimura, Aya, Nawachi, Kumiko, Kuboki, Takuo, Oohashi, Toshitaka International Journal Of Molecular Sciences 22 (23), 12823-, 2021-11-26

...In the treatment model, CY/ZA administration was suspended after transplantation of BMP-2/beta-TCP....

DOI 機関リポジトリ Web Site 参考文献53件

Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Aki Yoshida, Takayuki Furumatsu, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Hitoshi Nagatsuka Materials 14 (23), 7225-, 2021-11-26

...The cartilage area in the TCP surface was larger in the group without Matrigel (with BMP-2+TGF-β) than in the group with Matrigel (with BMP-2+TGF-β)....

DOI Web Site 参考文献38件

Tomohiko Fukuda, Risa Fukuda, Daizo Koinuma, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin Cellular Signalling 87 110146-, 2021-11

DOI Web Site Web Site 被引用文献1件

Mariem Achour, Farhana Ferdousi, Kazunori Sasaki, Hiroko Isoda Frontiers in Cell and Developmental Biology 9 2021-11-01

...Additionally, RT-qPCR results showed that luteolin upregulated the expressions of <jats:italic>GFAP</jats:italic>, <jats:italic>BMP2</jats:italic>, and <jats:italic>STAT3</jats:italic>, whereas the expression...

DOI Web Site 被引用文献1件

Tingfang Sun, Chunqing Meng, Qiuyue Ding, Keda Yu, Xianglin Zhang, Wancheng Zhang, Wenqing Tian, Qi Zhang, Xiaodong Guo, Bin Wu, Zekang Xiong Bioactive Materials 6 (11), 4163-4175, 2021-11

DOI Web Site Web Site 被引用文献1件

Takuma Kaibara, Lei Wang, Masumi Tsuda, Takayuki Nonoyama, Takayuki Kurokawa, Norimasa Iwasaki, Jian Ping Gong, Shinya Tanaka, Kazunori Yasuda Journal of Biomedical Materials Research Part A 110 (4), 747-760, 2021-10-28

...‐2</jats:italic>,<jats:italic>Runx2</jats:italic>,<jats:italic>Col‐1, ALP</jats:italic>,<jats:italic>OPN</jats:italic>,<jats:italic>BSP</jats:italic>, and<jats:italic>OCN)</jats:italic>in the cultured...

DOI Web Site Web Site 参考文献45件

Md. Arafat Kabir, Akihiro Hirakawa, Bowen Zhu, Kenji Yokozeki, Mamata Shakya, Bingzhen Huang, Toshiyuki Akazawa, Masahiro Todoh, Masaru Murata International Journal of Molecular Sciences 22 (21), 11331-, 2021-10-20

...Supra-periosteal bone induction was found at 14 days in the CGF/BMP-2, while the CGF alone did not induce bone....

DOI Web Site 参考文献24件

Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias Nanomaterials 11 (10), 2569-, 2021-09-29

...The conjugations of drugs or bioactive molecules such as bone-morphogenetic protein-2 (BMP-2), vancomycin, calcitriol, dexamethasone, and cisplatin were able to enhance the osteogenic property of nHA....

DOI Web Site 被引用文献1件

Shikha T. Ramesh, Kolaparamba V. Navyasree, Sneha Sah, Anjitha B. Ashok, Nishada Qathoon, Suryasikha Mohanty, Rajeeb K. Swain, Perunthottathu K. Umasankar Traffic 22 (11), 377-396, 2021-09-27

...Here, we uncover the role of an uncharacterized kinase (BMP‐2 inducible kinase—BMP2K) in AP‐2 phosphorylation. We demonstrate that BMP2K can phosphorylate AP‐2 in vitro and in vivo....

DOI Web Site Web Site 被引用文献1件

Keita Ipposhi, Atsushi Tomokiyo, Taiga Ono, Kozue Yamashita, Muhammad Anas Alhasan, Daigaku Hasegawa, Sayuri Hamano, Shinichiro Yoshida, Hideki Sugii, Tomohiro Itoyama, Marina Ogawa, Hidefumi Maeda Cells 10 (9), 2491-, 2021-09-21

...Conversely, SFRP1 stimulation enhanced nodule formation and expression of BMP-2....

DOI Web Site 被引用文献2件 参考文献53件

Ying Pang, Lili Liu, Hong Mu, Vishnu Priya Veeraraghavan Saudi Journal of Biological Sciences 28 (9), 4916-4920, 2021-09

DOI Web Site Web Site 被引用文献1件

Daisuke Tateiwa, Shinichi Nakagawa, Hiroyuki Tsukazaki, Rintaro Okada, Joe Kodama, Junichi Kushioka, Zeynep Bal, Yuichiro Ukon, Hiromasa Hirai, Takashi Kaito Scientific Reports 11 (1), 16924-, 2021-08-19

...-2....

DOI PDF Web Site 被引用文献2件

Annika Kengelbach-Weigand, Carolina Thielen, Tobias Bäuerle, Rebekka Götzl, Thomas Gerber, Carolin Körner, Justus P. Beier, Raymund E. Horch, Anja M. Boos npj Regenerative Medicine 6 (1), 49-, 2021-08-19

...In the present study, a bone substitute in combination with mesenchymal stem cells (MSC) and endothelial progenitor cells (EPC) with or without growth factors BMP-2 and VEGF-A was prevascularized by an...

DOI PDF Web Site 被引用文献1件

Tetsutaro Abe, Masashi Miyazaki, Toshinobu Ishihara, Shozo Kanezaki, Yuhta Tsubouchi, Hiroshi Tsumura JOR SPINE 4 (3), 2021-08-18

...Groups II, III, and IV were implanted with a carrier containing 3 μg of recombinant human BMP‐2 (rhBMP‐2)....

DOI Web Site Web Site 参考文献38件

Haibin Mu, Xin Liu, Shuoshuo Geng, Dian Su, Heran Chang, Lili Li, Han Jin, Xiumei Wang, Ying Li, Bin Zhang, Xiaohua Xie Frontiers in Physiology 12 2021-08-16

...<jats:p>The <jats:italic>Bmp2</jats:italic> and <jats:italic>Bmp4</jats:italic> expressed in root mesenchyme were essential for the patterning and cellular differentiation of tooth root....

DOI Web Site 被引用文献1件

Alireza Rajabnejad keleshteri, Fathollah Moztarzadeh, Mehdi Farokhi, Ali Abouei Mehrizi, Hamideh Basiri, Seyed Sepehr Mohseni International Journal of Biological Macromolecules 184 29-41, 2021-08

DOI Web Site Web Site 被引用文献1件

Zewu Zhu, Xiaoqiong Zhang, Yingcheng Jiang, Shuhao Ruan, Fang Huang, Huimin Zeng, Minghui Liu, Weiping Xia, Feng Zeng, Jinbo Chen, Yu Cui, Hequn Chen Epigenomics 13 (15), 1171-1186, 2021-08

...Mechanically, NEAT1 not only induced the nucleolar translocation of EGR1 binding to BMP2 promotor, but also functioned as a sponge of miR-129-5p in the cytoplasm to promote BMP2 expression....

DOI Web Site 被引用文献1件

Tomohiko Fukuda, Risa Fukuda, Kohei Miyazono, Carl-Henrik Heldin International Journal of Molecular Sciences 22 (15), 7882-, 2021-07-23

...Ishikawa cells secreted higher amounts of BMP2 compared with ovarian cancer cell lines. Exogenous BMP2 stimulation enhanced EC cell sphere formation via c-KIT induction....

DOI Web Site 被引用文献3件

Ryota Chijimatsu, Satoshi Miwa, Gensuke Okamura, Junya Miyahara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuji Maenohara, Shinsaku Tsuji, Shin Sameshima, Kentaro Takagi, Keiu Nakazato, Kohei Kawaguchi, Ryota Yamagami, Hiroshi Inui, Shuji Taketomi, Sakae Tanaka, Taku Saito Stem Cell Research & Therapy 12 (1), 2021-07-15

..., whereas chondrogenesis of mouse ASCs and human SSCs was observed with supplementation of BMP2 not TGFβ1....

DOI PDF Web Site 参考文献68件

Eleni K. Tsekoura, Teo Dick, Porntipa Pankongadisak, Daniel Graf, Yaman Boluk, Hasan Uludağ Pharmaceuticals 14 (7), 666-, 2021-07-12

...formulated by using lipid modified polyethylenimine (PEI) polymer and plasmid DNAs (pDNA) like the reporter Green Fluorescent Protein (GFP) and the therapeutically relevant Bone Morphogenetic Protein-2 (BMP...

DOI Web Site 被引用文献1件

Alishba Maryam, Y. Rebecca Chin Frontiers in Molecular Biosciences 8 700973-, 2021-07-01

...We further identify TWIST1 and BMP2 as essential genes that mediate ANLN’s function in stemness but not spheroid growth....

DOI Web Site 被引用文献1件

F. Senatov, A. Maksimkin, A. Chubrik, E. Kolesnikov, P. Orlova, M. Krivozubov, K. Nikitin, A. Gromov, A. Karyagina Journal of the Mechanical Behavior of Biomedical Materials 119 104477-, 2021-07

DOI Web Site Web Site 被引用文献1件

Ishii Takenobu, Sueishi Kenji, Nishii Yasushi ＩＪＯＭＳ 20 (1), 37-49, 2021-06-30

DOI Web Site 医中誌 参考文献39件

Junaidi Khotib, Maria Apriliani Gani, Aniek Setiya Budiatin, Maria Lucia Ardhani Dwi Lestari, Erreza Rahadiansyah, Chrismawan Ardianto Pharmaceuticals 14 (7), 615-, 2021-06-26

...This review summarizes the involvement of extracellular signal-regulated kinase (ERK), p38, Wnt, and bone morphogenetic protein 2 (BMP2) in osteoblastic cellular regulation induced by HA....

DOI Web Site 被引用文献1件

Yao Chen, Bingwei Ma, Xingchun Wang, Xiaojuan Zha, Chunjun Sheng, Peng Yang, Shen Qu Journal of Diabetes Research 2021 1-10, 2021-06-23

...BMP2, BMP4, BMP6, BMP7, and BMP9 have been shown to affect the pathophysiological process of obesity and glucose metabolism beyond bone metabolism....

DOI PDF XML 被引用文献1件

Chia-Ter Chao, Shih-Hua Lin International Journal of Molecular Sciences 22 (12), 6270-, 2021-06-10

...hydrocarbon receptor (AhR)/nuclear factor-κB (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), Runt-related transcription factor 2 (RUNX2), bone morphogenic protein 2 (BMP2...

DOI Web Site 被引用文献1件

Vera Grotheer, Nadine Skrynecki, Lisa Oezel, Joachim Windolf, Jan Grassmann Scientific Reports 11 (1), 11968-, 2021-06-07

...We used inhibitors of BMP and TGF-β signaling, such as SB431542, dorsomorphin and/or a supplemental addition of BMP-2....

DOI PDF Web Site 被引用文献1件

Okada, Rintaro, Yamato, Kai, Kawakami, Minoru, Kodama, Joe, Kushioka, Junichi, Tateiwa, Daisuke, Ukon, Yuichiro, Zeynep, Bal, Ishimoto, Takuya, Nakano, Takayoshi, Yoshikawa, Hideki, Kaito, Takashi Bone Reports 14 100757-, 2021-06-01

...Low magnetic field promotes recombinant human BMP-2-induced bone formation and influences orientation of trabeculae and bone marrow-derived stromal cells....

HANDLE

Katelyn G. Makar, Steven R. Buchman, Christian J. Vercler Plastic and Reconstructive Surgery - Global Open 9 (6), e3611-, 2021-06

...BMP-2 was infused onto a carrier and placed in the fistula, and Grafton DBM was then packed into the defect....

DOI Web Site 被引用文献1件

Lulu Zhao, Shengnan Wang, Hong Liu, Xiaoli Du, Ren Bu, Bing Li, Ruilan Han, Jie Gao, Yang Liu, Jian Hao, Jianrong Zhao, Yan Meng, Gang Li Frontiers in Cell and Developmental Biology 9 2021-04-13

...<jats:italic>In vitro</jats:italic>, the calcium content and ALP activity were measured, and RT-PCR (SM22α, Runx2, BMP-2, and TRAF6) and Western blot (SM22α, Runx2, BMP-2, TRAF6, and NF-κB) were performed...

DOI Web Site 被引用文献1件

Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M. Girisha, Shiro Ikegawa Nature Communications 12 (1), 2021-04-06

...</jats:sup> mice and the <jats:italic>TMEM53</jats:italic> knock-out cell lines indicates that TMEM53 inhibits BMP signaling in osteoblast lineage cells by blocking cytoplasm-nucleus translocation of BMP2...

DOI PDF Web Site 参考文献37件

Peng Chen, Feifei Zhang, Zhexiang Fan, Tianding Shen, Bingcheng Liu, Ruosi Chen, Qian Qu, Jin Wang, Yong Miao, Zhiqi Hu Journal of Nanobiotechnology 19 (1), 94-, 2021-03-31

...Subsequently, BMP2 loaded to the nanocoated layer, as a slow-release signal molecule, activates BMP signaling to regulate HFSCs’ fate in order to obtain a purified CD200<jats:sup>+</jats:sup>α6<jats:sup...

DOI PDF Web Site 被引用文献1件

Shintaro Shoji, Kentaro Uchida, Ryo Tazawa, Wataru Saito, Akiyoshi Kuroda, Hiroyuki Sekiguchi, Daisuke Ishii, Sho Inoue, Gen Inoue, Masashi Takaso Bio-Medical Materials and Engineering 32 1-9, 2021-03-23

..., and IFHG-HA with BMP2....

DOI Web Site 被引用文献1件 参考文献17件

Sebastian Alexis Vishnopolska, Maria Florencia Mercogliano, Maria Andrea Camilletti, Amanda Helen Mortensen, Debora Braslavsky, Ana Keselman, Ignacio Bergadá, Federico Olivieri, Lucas Miranda, Roxana Marino, Pablo Ramírez, Natalia Pérez Garrido, Helen Patiño Mejia, Marta Ciaccio, Maria Isabel Di Palma, Alicia Belgorosky, Marcelo Adrian Martí, Jacob Otto Kitzman, Sally Ann Camper, Maria Ines Pérez-Millán The Journal of Clinical Endocrinology & Metabolism 106 (7), 1956-1976, 2021-03-17

...These variants were identified in known CH causative genes (LHX3, LHX4, GLI2, OTX2, HESX1), in less frequently reported genes (FOXA2, BMP4, FGFR1, PROKR2, PNPLA6) and in new candidate genes (BMP2, HMGA2...

DOI PDF PDF 被引用文献1件

Sajad Chamani, Luca Liberale, Leila Mobasheri, Fabrizio Montecucco, Khalid Al‐Rasadi, Tannaz Jamialahmadi, Amirhossein Sahebkar European Journal of Clinical Investigation 51 (7), 2021-03-11

...</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Statins increase the expression of many mediators involved in bone metabolism including bone morphogenetic protein‐2 (BMP‐2), glucocorticoids...

DOI Web Site Web Site 被引用文献1件

Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Masayuki Shimoda, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura BMC Musculoskeletal Disorders 22 (1), 238-, 2021-03-01

...-2 for 6 days....

DOI PDF Web Site 被引用文献1件 参考文献60件

Shuaitong Yu, Jinqiang Guo, Zheyi Sun, Chujiao Lin, Huangheng Tao, Qian Zhang, Yu Cui, Huanyan Zuo, Yuxiu Lin, Shuo Chen, Huan Liu, Zhi Chen Cell Death & Disease 12 (2), 197-, 2021-02-19

...<jats:italic>Sp7-</jats:italic>Cre<jats:italic>; Bmp2</jats:italic><jats:sup>fx/fx</jats:sup> mice (BMP2-cKO) were generated and exhibited decreased bone density and lower osteoblast number (<jats:italic...

DOI PDF Web Site 被引用文献1件

Tanya Levingstone, Badriah Ali, Cathal Kearney, Nicholas Dunne Journal of Biomedical Materials Research Part B: Applied Biomaterials 109 (10), 1622-1633, 2021-02-18

...Release rates of BSA and BMP‐2 were significantly enhanced in the HA containing hydrogels, confirming for the first time the role of HA as a son sensitizer....

DOI Web Site Web Site 被引用文献2件

Xinwei Liu, Yue Zhou 2021-02-17

...Next, ALP activity and protein levels of BMP2, Osterix, and OCN were reduced to show PDLCs were differentiated....

DOI Web Site Web Site 被引用文献1件

Solomiya Kyyak, Sebastian Blatt, Eik Schiegnitz, Diana Heimes, Henning Staedt, Daniel G. E. Thiem, Keyvan Sagheb, Bilal Al-Nawas, Peer W. Kämmerer Frontiers in Bioengineering and Biotechnology 9 2021-02-17

...At day 3, 7, and 10, cell viability and metabolic activity as well as expression of ALP, OCN, and BMP-2, was examined....

DOI Web Site 被引用文献1件

Zhengyi Fu, Rui Yang, Shengjie Zhou, Zhenhua Ma, Tao Zhang Frontiers in Marine Science 7 1232-, 2021-02-10

...The expression level of BMP2 and BMP4 in golden pompano larvae were not significantly affected by the enhancement products (<jats:italic>P</jats:italic> &gt; 0.05), and the expression level of RXRα decreased...

DOI Web Site 被引用文献1件

Kosei Nakajima, Teruki Kidani, Hiromasa Miura Journal of Orthopaedic Research 39 (7), 1402-1410, 2021-02

...Among BMP1 to BMP15, we found that BMP1, BMP2, BMP4, BMP5, BMP6, and BMP7 were prevalent....

DOI Web Site Web Site 参考文献18件

Komgrit Eawsakul, Salunya Tancharoen, Norased Nasongkla Journal of Drug Delivery Science and Technology 61 102296-, 2021-02

DOI Web Site Web Site 被引用文献1件

Pawornwan Rittipakorn, Nuttawut Thuaksuban, Katanchalee Mai-ngam, Satrawut Charoenla, Warobon Noppakunmongkolchai Polymers 13 (3), 466-, 2021-02-01

...In group B, the cell-scaffold constructs without BMP-2 were cultured in medium containing 10 µg/mL BMP-2. The results showed greater cell proliferation in group A....

DOI Web Site 被引用文献1件

松崎 広志, 盛 喜久江, 勝間田 真一 日本健康医学会雑誌 29 (4), 444-449, 2021-01-28

...また，<i>Bmp2</i>と<i>Spp1</i>のmRNA発現量も正常食群に比し高リン食群で有意に高値を示した。これらの結果から，高リン食は腎臓の<i>Bmp2</i> と<i>Spp1</i>のmRNA発現量を増加させることが示された。</p>...

DOI Web Site 医中誌

SHEN Hongzhou, ZHI Yin, ZHU Fangxing, SI Jiawen, SHI Jun, SHEN Steve GF. Dental Materials Journal 40 (1), 191-201, 2021-01-25

...<p>In this study, we proposed BMP2-incorporated calcium phosphate cement (BMP2-CPC), for application in guided bone regeneration (GBR) and compared the experimental bone restoration performance and clinical...

DOI Web Site PubMed ほか1件 参考文献37件

KHANIJOU Manop, ZHANG Rui, BOONSIRISETH Kiatanant, SRISATJALUK Ratchapin LAOVANITCH, SUPHANGUL Suphachai, PAIRUCHVEJ Verasak, WONGSIRICHAT Natthamet, SERIWATANACHAI Dutmanee Dental Materials Journal 40 (1), 173-183, 2021-01-25

...BMP2 released from TDBS was measured by ELISA. TDBS had high crystallinity similar to BoneCeramic while it had a broad pattern to ramus bone, OraGRAFT, and Bio-Oss....

DOI Web Site PubMed ほか1件 参考文献52件

Hideki Ueyama, Yoichi Ohta, Yuuki Imai, Akinobu Suzuki, Ryo Sugama, Yukihide Minoda, Kunio Takaoka, Hiroaki Nakamura BMC Musculoskeletal Disorders 22 (1), 2021-01-20

...The present study aimed to induce and maintain new bone formation using the topical co-administration of recombinant human BMP-2 (rh-BMP-2) and zoledronate (ZOL) on beta-tricalcium phosphate (β-TCP) composite...

DOI PDF Web Site 参考文献26件

Masaru Murata, Jun Hino, Md. Arafat Kabir, Kenji Yokozeki, Michiko Sakamoto, Takehiko Nakajima, Toshiyuki Akazawa Materials 14 (1), 196-, 2021-01-03

...Young rats were divided into the PDP-HAp alone group and the PDP-HAp/BMP-2 group for a long-term observation....

DOI Web Site 被引用文献1件 参考文献33件

YAMAJI Kozo, YOKOYAMA Akihito, MATSUZAKI Kumiko, OHARA Naoko, SUGAYA Tsutomu, YOSHIYAMA Masahiro Journal of Oral Tissue Engineering 19 (1), 10-14, 2021

...The experimental sites of both age groups were divided into two implants: Gel containing BMP-2 (BMP site) and Gel only (Gel site)....

DOI 医中誌

Eessa Ben Abdulrazzaq, Nakata Hidemi, Maung Myo Wai, Kuroda Shinji バイオインテグレーション学会誌 11 (1), 38-47, 2021

...Conclusively, GRR, especially PGRR, enhanced osteoblast proliferation and upregulated gene expression of ALP, BMP-2, OSX, and OCN....

DOI 医中誌

松本 泰治 理学療法学Supplement 48S1 (0), A-55-A-55, 2021

...定期的運動療法がASを予防した機序として，弁内皮細胞障害にひきつづく，炎症細胞浸潤や硬化病変における酸化ストレス産生減少，BMP‒2やrunx-2といった石灰化シグナル伝達抑制など，多面的な影響が考えられた。ヒトにおける検討が必要であるが，運動療法はASの一次予防として重要な役割を担う可能性が示唆された。...

DOI

寺奥 大貴, 齋藤 裕, 池本 哲也, 宮崎 克己, 山田 眞一郎, 森根 裕二, 三宅 雅人, 親泊 政一, 島田 光生 移植 56 (Supplement), s65-s65, 2021

...</p><p>【方法】ヒトADSCから、3Step（GSK-3阻害剤による胚葉転換、FGF4, BMP2による肝芽細胞誘導、HGF, OSM, DexによるHLCへの誘導）でHLCを分化誘導した。...

DOI 医中誌

Keiko Onji, Md. Arafat Kabir, Bowen Zhu, Kenji Yokozeki, Takashi Saito, Toshiyuki Akazawa, Masaru Murata Materials 14 (1), 150-, 2020-12-31

...Collagen materials combined with recombinant human BMP-2 have been commercially available for clinical use....

DOI Web Site 被引用文献2件 参考文献40件

Sandra Gromolak, Agnieszka Krawczenko, Agnieszka Antończyk, Krzysztof Buczak, Zdzisław Kiełbowicz, Aleksandra Klimczak International Journal of Molecular Sciences 21 (24), 9726-, 2020-12-20

...osteocalcin and collagen type I and upregulation of osteogenic-related gene markers BMP-2, Runx2, osterix, collagen type I, osteocalcin, and osteopontin....

DOI Web Site 被引用文献1件

小林 真左子, 河野 通秀, 永井 孝宏, 片桐 浩樹, 飯塚 建行 日本口腔外科学会雑誌 66 (12), 586-595, 2020-12-20

...DBBM adsorbed a higher amount of BMP-2 when compared with the other materials while the DFDBA released BMP-2 faster....

DOI Web Site Web Site ほか1件 参考文献23件

Mara H. O’Brien, Eliane H. Dutra, Shivam Mehta, Po-Jung Chen, Sumit Yadav CARTILAGE 13 (2_suppl), 734S-743S, 2020-12-14

...Cells from the mandibular condyle of mice were treated with recombinant human BMP2 (rhBMP2) or rhNoggin (inhibitor of BMP2 signaling)....

DOI Web Site Web Site 被引用文献1件

Hantao Cai, Ji Zou, Wei Wang, Aofei Yang Molecular Medicine Reports 23 (2), 2020-12-08

DOI 被引用文献1件

Tomohiko Fukuda, Risa Fukuda, Ryo Tanabe, Daizo Koinuma, Hiroo Koyama, Yoshinobu Hashizume, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin Cell Death Discovery 6 (1), 139-, 2020-12-05

...BMP2 also augmented sphere formation, migration, and invasion of OC cells, and induced EMT. High BMP2 expression was observed after chemotherapy of OC patients in the GSE109934 dataset....

DOI PDF Web Site 被引用文献2件

Dan Wang, Jing Cai, Zhaobin Zeng, Xue Gao, Xi Shao, Yuanjun Ding, Xue Feng, Da Jing Journal of Cellular Physiology 236 (6), 4592-4603, 2020-12-02

...We herein found that mechanical stretch (10% elongation at six cycles/min) significantly promoted the expression of osteoblast differentiation‐related markers (including ALP, BMP2, Col1α, OCN, and Runx2...

DOI Web Site Web Site 被引用文献1件

Philipp Kobbe, Markus Laubach, Dietmar W. Hutmacher, Hatem Alabdulrahman, Richard M. Sellei, Frank Hildebrand European Journal of Medical Research 25 (1), 70-, 2020-12

...Further, its synergistic effects when combined with ABG and BMP-2 show the potential of mPCL–TCP scaffolds to support new bone formation in segmental long bone defects....

DOI PDF Web Site 被引用文献1件

Jianmao Zheng, Yuanyuan Kong, Xiaoli Hu, Zhishan Li, Yaoyin Li, Yingqun Zhong, Xi Wei, Junqi Ling Stem Cell Research & Therapy 11 (1), 2020-11-30

...Interestingly, DPSCs-sEV and the encapsulated miR-125a-3p enhanced BMP2 release in macrophages, promoting odontogenesis in DPSCs through BMP2 pathway activation....

DOI PDF Web Site 被引用文献1件

WU Chengzhong, SHAO Xia, LIN Xianglin, GAO Weijin, FANG Yiming, WANG Jingxiao Dental Materials Journal 39 (6), 1072-1079, 2020-11-27

...and BMP7 BMP2/7....

DOI Web Site PubMed ほか1件 参考文献35件

Nakagiri, Ryoko, Watanabe, Satoko, Takabatake, Kiyofumi, Tsujigiwa, Hidetsugu, Watanabe, Toshiyuki, Matsumoto, Hiroshi, Kimata, Yoshihiro Materials 13 (23), 5374-, 2020-11-26

...Bone morphogenic protein (BMP)-2-free honeycomb beta-TCP (TCP group) and honeycomb beta-TCP with BMP-2 (BMP group) were implanted in the zygomatic bone of rats....

機関リポジトリ

Ryoko Nakagiri, Satoko Watanabe, Kiyofumi Takabatake, Hidetsugu Tsujigiwa, Toshiyuki Watanabe, Hiroshi Matsumoto, Yoshihiro Kimata Materials 13 (23), 5374-, 2020-11-26

...Bone morphogenic protein (BMP)-2-free honeycomb β-TCP (TCP group) and honeycomb β-TCP with BMP-2 (BMP group) were implanted in the zygomatic bone of rats....

DOI Web Site 被引用文献2件 参考文献32件

Julius Sundermann, Holger Zagst, Judith Kuntsche, Hermann Wätzig, Heike Bunjes Pharmaceutics 12 (12), 1143-, 2020-11-25

...Imaged capillary isoelectric focusing and the simulation of the surface charges of BMP-2 were used to find a possible explanation for the unusually low solubility of BMP-2 at physiological pH....

DOI Web Site 被引用文献1件

Masami Ito, Osamu Yoshino, Yosuke Ono, Akemi Yamaki‐Ushijima, Tomoko Tanaka, Tomoko Shima, Makoto Orisaka, Akira Iwase, Akitoshi Nakashima, Shigeru Saito American Journal of Reproductive Immunology 85 (5), e13374-, 2020-11-25

...This BMP‐2‐induced cell proliferation was completely blocked by verteporfin....

DOI Web Site Web Site 被引用文献1件 参考文献51件

Matthew Dickinson, Anna E. Kliszczak, Eleni Giannoulatou, Dimitra Peppa, Pierre Pellegrino, Ian Williams, Hal Drakesmith, Persephone Borrow Frontiers in Immunology 11 596841-, 2020-11-24

...Contrastingly, no substantial systemic upregulation of activins A and B or BMP-2 was observed during acute infection, although plasma activin levels trended to be elevated during chronic infection....

DOI Web Site 被引用文献1件

Junichi Kushioka, Takashi Kaito, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Ryota Chijimatsu, Melanie Pye, Masahiro Narimatsu, Jeffrey L. Wrana, Yasumichi Inoue, Hiroko Ninomiya, Shin Yamamoto, Takashi Saitou, Hideki Yoshikawa, Takeshi Imamura Bone Research 8 (1), 41-, 2020-11-23

...Absorbable collagen sponges containing 3 μg of recombinant human BMP2 (rhBMP2) were implanted in the dorsal muscle pouches of wild type (WT) and <jats:italic>Smurf2</jats:italic><jats:sup><jats:italic>...

DOI PDF Web Site 被引用文献1件 参考文献45件

Xingnan Lin, Jiping Chen, Ying Liao, Janak Lal Pathak, Huang Li, Yuelian Liu Coatings 10 (11), 1118-, 2020-11-20

...Slow and sustained delivery of a low dose of BMP-2 promotes bone defect healing....

DOI Web Site 被引用文献1件

Benjamin Gantenbein, Shirley Tang, Julien Guerrero, Natalia Higuita-Castro, Ana I. Salazar-Puerta, Andreas S. Croft, Amiq Gazdhar, Devina Purmessur Frontiers in Bioengineering and Biotechnology 8 2020-11-19

...Recent studies will be summarized that aimed to improve regeneration of these tissues, involving the delivery of bone morphogenic proteins (BMPs), such as BMP2 for improvement of bone healing....

DOI Web Site 被引用文献1件

Nosho, Shuji, Tosa, Ikue, Ono, Mitsuaki, Hara, Emilio Satoshi, Ishibashi, Kei, Mikai, Akihiro, Tanaka, Yukie, Kimura-Ono, Aya, Komori, Taishi, Maekawa, Kenji, Kuboki, Takuo, Oohashi, Toshitaka International Journal of Molecular Sciences 21 (21), 7967-, 2020-10-27

...On the other hand, FGF-2 showed opposite effects compared to those of BMP-2....

DOI 機関リポジトリ Web Site 参考文献47件

Watanabe, Toshiyuki, Takabatake, Kiyofumi, Tsujigiwa, Hidetsugu, Watanabe, Satoko, Nakagiri, Ryoko, Nakano, Keisuke, Nagatsuka, Hitoshi, Kimata, Yoshihiro Materials 13 (21), 4761-, 2020-10-25

...The osteogenic area was larger in the Matrigel groups (with and without BMP-2) than in the Collagen group (with and without BMP-2) in both vertical beta-TCP and horizontal beta-TCP....

DOI 機関リポジトリ Web Site 被引用文献3件 参考文献39件

Seo-Young Kim, Yu-Kyoung Kim, Seong-Woo Chong, Kwang-Bok Lee, Min-ho Lee ACS Biomaterials Science & Engineering 6 (11), 6173-6185, 2020-10-16

DOI Web Site 被引用文献1件

Michael B. Berger, Kyla B. Bosh, Thomas W. Jacobs, D. Joshua Cohen, Zvi Schwartz, Barbara D. Boyan Journal of Orthopaedic Research 39 (9), 1908-1920, 2020-10-12

...that biomimetic Ti6Al4V surface properties induce MSCs to produce factors within 7 days of culture that stimulate MSCs not in contact with the surface to exhibit an osteoblast phenotype via endogenous BMP2...

DOI Web Site Web Site 被引用文献1件

Tao Hu, Zhiwen Luo, Kai Li, Shanjin Wang, Desheng Wu Bioscience Reports 40 (10), 2020-10

...Moreover, the inhibited expression intercellular tight junction protein VE-cadherin and Occludin caused by BMP-2 was blocked by ZN....

DOI PDF 被引用文献1件

Mikai, Akihiro, Ono, Mitsuaki, Tosa, Ikue, Ha Thi Thu, Nguyen, Hara, Emilio Satoshi, Nosho, Shuji, Kimura-Ono, Aya, Nawachi, Kumiko, Takarada, Takeshi, Kuboki, Takuo, Oohashi, Toshitaka International Journal of Molecular Sciences 21 (19), 7028-, 2020-09-24

...These data suggest that the combination of BMP-2/beta-TCP could become a suitable therapy for the management of MRONJ....

機関リポジトリ

Akihiro Mikai, Mitsuaki Ono, Ikue Tosa, Ha Thi Thu Nguyen, Emilio Satoshi Hara, Shuji Nosho, Aya Kimura-Ono, Kumiko Nawachi, Takeshi Takarada, Takuo Kuboki, Toshitaka Oohashi International Journal of Molecular Sciences 21 (19), 7028-, 2020-09-24

...These data suggest that the combination of BMP-2/β-TCP could become a suitable therapy for the management of MRONJ.</jats:p>...

DOI Web Site 被引用文献3件 参考文献37件

Seiko Min, Taewan Kim, Oksu Kim, Carames Goncalo, Tadahiko Utsunomiya, Takashi Matsumoto, Kayo Kuyama, Nikola Angelov BioMed Research International 2020 1-11, 2020-09-23

...The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group)....

DOI PDF XML 被引用文献1件

Shintaro Shoji, Kentaro Uchida, Wataru Satio, Hiroyuki Sekiguchi, Gen Inoue, Masayuki Miyagi, Ken Takata, Yuji Yokozeki, Masashi Takaso Journal of Orthopaedic Surgery and Research 15 (1), 2020-09-18

...-2 (IFH-HA/BMP-2) into the fracture site (<jats:italic>n</jats:italic> = 16, each treatment)....

DOI PDF Web Site 被引用文献1件 参考文献35件

Yu Zhang, Hua Zhu, Hsun-Ming Chang, Peter C. K. Leung Frontiers in Cell and Developmental Biology 8 573028-, 2020-09-15

DOI Web Site 被引用文献1件

Shiau-Ting Shiu, Wei-Zhen Lew, Sheng-Yang Lee, Sheng-Wei Feng, Haw-Ming Huang Materials 13 (18), 4063-, 2020-09-13

...In addition, real-time PCR was performed to examine the gene expression of ALP, BMP-2 and DMP-1. Finally, extracellular matrix vesicle secretion was detected via scanning electron microscopy....

DOI Web Site 被引用文献1件

Daniel Halloran, Hilary W. Durbano, Anja Nohe Journal of Developmental Biology 8 (3), 19-, 2020-09-13

...We then focus on the structure of BMP-2, its activation and regulation signaling pathways, BMP-2 clinical applications, and limitations of using BMP-2 as a therapeutic....

DOI Web Site 被引用文献4件

Xiaoling Song, Maolan Li, Wenguang Wu, Wei Dang, Yuan Gao, Rui Bian, Runfa Bao, Yunping Hu, Defei Hong, Jun Gu, Yingbin Liu Signal Transduction and Targeted Therapy 5 (1), 2-, 2020-08-13

DOI PDF Web Site 被引用文献1件

Joseph K. Kendal, Arvind Singla, Asmaa Affan, Kurt Hildebrand, Abdullah Al-Ani, Mark Ungrin, Douglas J. Mahoney, Doha Itani, Frank R. Jirik, Michael J. Monument Clinical Orthopaedics & Related Research 478 (12), 2921-2933, 2020-08-10

.... (2) To characterize degree of osteosarcoma cell line osteoblastic differentiation in response to BMP-2. (3) To assess if BMP-2 signaling has a consistent effect on local or systemic tumor burden in various...

DOI Web Site 被引用文献1件

Fei Huang, Yaqiang Cao, Gui Wu, Junying Chen, CaihongWang, Wanzun Lin, Ruilong Lan, Bing Wu, Xianhe Xie, Jinsheng Hong, Lengxi Fu Journal of Cellular and Molecular Medicine 24 (18), 10768-10784, 2020-08-04

...It has been reported that high expression of BMP2 in NSCLC correlates with poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown....

DOI Web Site Web Site 被引用文献1件

Asmaa A. M. Rady, Soha M. Hamdy, Mohamed A. Abdel-Hamid, Marwa G. A. Hegazy, Shadia A. Fathy, Amany A. Mostafa Bulletin of the National Research Centre 44 (1), 2020-08-04

...VEGF and BMP-2 were evaluated during fracture healing....

DOI PDF Web Site 被引用文献1件

Min Soo Kim, Wook Jin Cancers 12 (8), 2095-, 2020-07-28

...In addition, the knockdown of TrkB restored the tumor-inhibitory effect of BMP-2 via the activation of SMAD1. Moreover, the TrkB kinase activity was required for its effect on BMP signaling....

DOI Web Site 被引用文献1件

Chang-Meng Wu, Lei Zheng, Qian Wang, Yan-Wei Hu Clinical Chemistry and Laboratory Medicine (CCLM) 59 (1), 27-38, 2020-07-21

...angiotensin II and monocyte chemoattractant protein-1 (MCP-1), senescent human vascular smooth muscle cells-mediated plaque instability and vascular calcification via regulating the expression level of BMP...

DOI Web Site Web Site ほか1件 被引用文献1件

Pei-ying Lv, Peng-fei Gao, Guang-jie Tian, Yan-yan Yang, Fei-fei Mo, Zi-hui Wang, Lu Sun, Ming-jie Kuang, Yong-lan Wang Stem Cell Research & Therapy 11 (1), 215-, 2020-07-17

...<jats:p>This study concluded that exosomes induced by mechanical strain promote HPDLSC proliferation via the miR-181b-5p/PTEN/AKT signaling pathway and promote HPDLSC osteogenic differentiation by BMP2...

DOI PDF Web Site 被引用文献4件

Shangsi Chen, Yufei Shi, Xin Zhang, Jun Ma Materials Science and Engineering: C 112 110893-, 2020-07

DOI Web Site Web Site 被引用文献2件

Yusi Guo, Xiaopei Chi, Yifan Wang, Boon Chin Heng, Yan Wei, Xuehui Zhang, Han Zhao, Ying Yin, Xuliang Deng Stem Cell Research & Therapy 11 (1), 245-, 2020-06-25

...Alkaline phosphatase (ALP) staining, Alizarin Red staining, and combined with qPCR and Western blot analyses of Runx2 and BMP2 were performed to elucidate the effects of mitochondria transfer on the osteogenic...

DOI PDF Web Site 被引用文献1件

Pamela Uribe, Anders Johansson, Ravin Jugdaohsingh, Jonathan J. Powell, Catarina Magnusson, Marcela Davila, Anna Westerlund, Maria Ransjö Scientific Reports 10 (1), 9923-, 2020-06-18

...<jats:italic>OSX, RUNX2, BMP2, ALP, OCN, BSP</jats:italic> and <jats:italic>CX43</jats:italic> genes were expressed in hDFC cultured for 1, 7, 14 and 21 days....

DOI PDF Web Site 被引用文献1件

Eoin P. McNeill, Suzanne Zeitouni, Simin Pan, Andrew Haskell, Michael Cesarek, Daniel Tahan, Bret H. Clough, Ulf Krause, Lauren K. Dobson, Mayra Garcia, Christopher Kung, Qingguo Zhao, W. Brian Saunders, Fei Liu, Roland Kaunas, Carl A. Gregory Nature Communications 11 (1), 3025-, 2020-06-15

...In mice, the intrinsic osteogenic activity of ihOCM surpasses bone morphogenic protein 2 (BMP2) driving healing of calvarial defects in 4 weeks by a mechanism mediated in part by collagen VI and XII....

DOI PDF Web Site 被引用文献2件

Yoshihiko Sugita, Juri Saruta, Takashi Taniyama, Hiroaki Kitajima, Makoto Hirota, Takayuki Ikeda, Takahiro Ogawa International Journal of Molecular Sciences 21 (12), 4194-, 2020-06-12

...Bone morphogenetic protein-2 (BMP-2) adsorption on UV-treated titanium was 4.5-fold greater than that on control titanium after 1-min incubation, resulting in a 4-fold increase in osteoblast attachment...

DOI Web Site 被引用文献8件 参考文献43件

Kobayashi, F, Uehara, O, Ito, C, Furusawa, M, Abiko, Y, Muramatsu, T International endodontic journal 53 (6), 804-811, 2020-06

機関リポジトリ

Joo-Young Park, Chan Ho Park, TacGhee Yi, Si-na Kim, Takanori Iwata, Jeong-Ho Yun International Journal of Molecular Sciences 21 (11), 3767-, 2020-05-26

...In this study, we tried to control the regeneration of cementum and PDL by using a human PDL stem cell (hPDLSC) sheet engineering technology with the pretreatment of recombinant human BMP-2 (rhBMP-2)....

DOI Web Site 参考文献44件

Alberto Azzalin, Francesca Brambilla, Eloisa Arbustini, Katia Basello, Attilio Speciani, Pierluigi Mauri, Paola Bezzi, Lorenzo Magrassi Cells 9 (5), 1249-, 2020-05-18

...We found that the effects on vesicle trafficking are mediated by SHC3 interactions with adaptor protein complex 1 and 2 (AP), BMP-2-inducible protein kinase and a fraction of poly ADP-ribose polymerase...

DOI Web Site 被引用文献2件

Leela Raghava Jaidev Chakka, Jered Vislisel, Cristina de Mattos Pimenta Vidal, Michelle Tillmann Biz, Aliasger K. Salem, Bruno Neves Cavalcanti Clinical Oral Investigations 24 (12), 4427-4437, 2020-05-15

DOI PDF Web Site 被引用文献1件

Shruthy Kuttappan, Jun-ichiro Jo, Chinchu K. Sabu, Deepthy Menon, Yasuhiko Tabata, Manitha B. Nair Materials Science and Engineering: C 110 110591-, 2020-05

DOI Web Site Web Site 参考文献35件

Pinpin Wang, Delphine Logeart-Avramoglou, Hervé Petite, Cristine Goncalves, Patrick Midoux, Federico Perche, Chantal Pichon Acta Biomaterialia 108 337-346, 2020-05

DOI Web Site Web Site 被引用文献1件

Xiao-Hui Wu, Ben Dou, Nan-Yang Sun, Juan Gao, Xiao-Lan Liu Acta Histochemica 122 (4), 151549-, 2020-05

DOI Web Site Web Site 被引用文献1件

Motoki Okamoto, Sayako Matsumoto, Ayato Sugiyama, Kei Kanie, Masakatsu Watanabe, Hailing Huang, Manahil Ali, Yuki Ito, Jiro Miura, Yujiro Hirose, Koichiro Uto, Mitsuhiro Ebara, Ryuji Kato, Aika Yamawaki-Ogata, Yuji Narita, Shigetada Kawabata, Yusuke Takahashi, Mikako Hayashi Polymers 12 (4), 937-, 2020-04-17

...The BMP-2 composite upregulated wound healing-related gene expression compared to the novel polymer composite alone....

DOI Web Site 被引用文献2件 参考文献36件

Manman Wang, Tan Zhang, Xuechun Zhang, Zhou Jiang, Min Peng, Zan Huang Cell & Bioscience 10 (1), 1-, 2020-04-15

...Although bone morphology protein 2-inducible kinase (BMP2K) has been implied to be a potential target for fasudil, a potent polyploidy-inducing compound, the function of BMP2K in megakaryopoiesis and AMKL...

DOI PDF Web Site 被引用文献1件

Zhuang Qian, Ying Zhang, Xiaomin Kang, Huixia Li, Yan Zhang, Xinxin Jin, Xin Gao, Mao Xu, Zhengmin Ma, Liting Zhao, Zhuanmin Zhang, Hongzhi Sun, Shufang Wu Journal of Bone and Mineral Research 35 (8), 1481-1493, 2020-04-14

...The results revealed that <jats:italic>Bmal1</jats:italic> was a transcriptional silencer of <jats:italic>Bmp2</jats:italic> by targeting the <jats:italic>Bmp2</jats:italic> promoter....

DOI Web Site Web Site ほか1件 被引用文献1件

Dewi Sartika, Chih-Hsin Wang, Ding-Han Wang, Juin-Hong Cherng, Shu-Jen Chang, Gang-Yi Fan, Yi-Wen Wang, Chian-Her Lee, Po-Da Hong, Chih-Chien Wang Polymers 12 (4), 853-, 2020-04-07

...Immunohistochemical staining confirmed this result; expression of osteoblast-related genes (BMP-2, COL1a1, and OCN) with the SF-hASCs scaffold treatment was remarkably positive, indicating their ability...

DOI Web Site 被引用文献1件

Kuronuma, Kana, Yokoi, Aya, 福岡, 知也, 宮田, 宗明, Maekawa, Akio, Tanaka, Satowa, Matsubara, Leo, Goto, Chie, Matsuo, Miki, Han, Hao-Wei, Tsuruta, Mai, Murata, Haruka, Okamoto, Hikari, 長谷川, 菜摘, Asano, Shigetaka, 伊藤, 光宏 Heliyon 6 (4), e03743-e03743, 2020-04

...Aberrant MGP by leukemic cells and selective induction of BMP-4 relative to BMP-2 in stromal cells might specify malignant niche....

DOI HANDLE Web Site ほか1件 参考文献35件

Solomiya Kyyak, Sebastian Blatt, Andreas Pabst, Daniel Thiem, Bilal Al-Nawas, Peer W Kämmerer Journal of Biomaterials Applications 35 (1), 83-96, 2020-04-01

...The highest BMP-2 expression was seen in ABSM-i-PRF whereas OCN expression showed higher levels in ABSM-i-PRF/XBSM-i-PRF at days 3 and 7 with lowest expression for ABSM....

DOI Web Site Web Site 被引用文献1件

Heeseog Kang, Smita Jha, Aleksandra Ivovic, Nadja Fratzl-Zelman, Zuoming Deng, Apratim Mitra, Wayne A. Cabral, Eric P. Hanson, Eileen Lange, Edward W. Cowen, James Katz, Paul Roschger, Klaus Klaushofer, Ryan K. Dale, Richard M. Siegel, Timothy Bhattacharyya, Joan C. Marini Journal of Experimental Medicine 217 (5), 2020-03-31

...Conversely, osteoblast differentiation and mineralization were inhibited when osteogenesis of affected osteoblasts was driven in the presence of BMP2....

DOI PDF 被引用文献1件

Helen H N Yan, Hoi Cheong Siu, Siu Lun Ho, Sarah S K Yue, Yang Gao, Wai Yin Tsui, Dessy Chan, April S Chan, Jason W H Wong, Alice H Y Man, Bernard C H Lee, Annie S Y Chan, Anthony K W Chan, Ho Sang Hui, Arthur K L Cheung, Wai Lun Law, Oswens S H Lo, Siu Tsan Yuen, Hans Clevers, Suet Yi Leung Gut 69 (12), 2165-2179, 2020-03-26

...Transcriptionally, <jats:italic>RSPO</jats:italic> fusion organoids resembled normal colon organoids and were distinct from <jats:italic>APC</jats:italic> mutant organoids, with high <jats:italic>BMP2<...

DOI Web Site 被引用文献2件

Preksa Keo, Yoshiro Matsumoto, Yasuhiro Shimizu, Shigeki Nagahiro, Masaomi Ikeda, Kazuhiro Aoki, Takashi Ono European Journal of Orthodontics 43 (1), 86-93, 2020-03-23

...Some mice received submucosal co-injections of anabolic peptide and BMP-2 just in front of the maxillary first molar. Screw insertion was then performed 4 weeks after injection....

DOI PDF 被引用文献1件 参考文献39件

Yubei Qiu, Xiaodong Xu, Weizhong Guo, Yong Zhao, Jiehua Su, Jiang Chen ACS Biomaterials Science & Engineering 6 (4), 2323-2335, 2020-03-19

DOI Web Site 被引用文献1件

Hashimoto, Kunihiko, Kaito, Takashi, Furuya, Masayuki, Seno, Shigeto, Okuzaki, Daisuke, Kikuta, Junichi, Tsukazaki, Hiroyuki, Matsuda, Hideo, Yoshikawa, Hideki, Ishii, Masaru Scientific Reports 10 (1), 4751-, 2020-03-16

Hashimoto K., Kaito T., Furuya M., et al. In vivo dynamic analysis of BMP-2-induced ectopic bone formation. Scientific Reports 10, 4751 (2020); https://doi.org/10.1038/s41598-020-61825-2.

DOI HANDLE PDF ほか1件 被引用文献3件 参考文献46件

Yang-Hee Kim, Xia Yang, Liyang Shi, Stuart A. Lanham, Jons Hilborn, Richard O. C. Oreffo, Dmitri Ossipov, Jonathan I. Dawson Nature Communications 11 (1), 2020-03-13

...-2....

DOI PDF Web Site 被引用文献1件

Shuichi Hamamoto, Ryota Chijimatsu, Kazunori Shimomura, Masato Kobayashi, George Jacob, Fumiko Yano, Taku Saito, Ung-il Chung, Sakae Tanaka, Norimasa Nakamura Journal of Experimental Orthopaedics 7 (1), 10-, 2020-03-07

...TD198946 and BMP-2 combination cultures showed higher chondrogenic differentiation than TD198946 or BMP-2 alone....

DOI PDF Web Site 被引用文献2件 参考文献20件

Yukihiko Hidaka, Risako Chiba-Ohkuma, Takeo Karakida, Kazuo Onuma, Ryuji Yamamoto, Keiko Fujii-Abe, Mari M. Saito, Yasuo Yamakoshi, Hiroshi Kawahara Pharmaceutics 12 (3), 218-, 2020-03-02

...An immortalized mouse myoblast cell line (C2C12 cell) was cultured in the combination of BMP-2 and MDZ (BMP-2+MDZ)....

DOI Web Site 被引用文献3件 参考文献38件

Yeri Alice Rim, Yoojun Nam, Narae Park, Hyerin Jung, Kijun Lee, Jennifer Lee, Ji Hyeon Ju Cells 9 (3), 582-, 2020-03-01

...We generated minicircle vectors containing bone morphogenetic protein 2 (BMP2) and transforming growth factor beta 3 (TGFβ3) and delivered them to mesenchymal stem cell-like, hiPSC-derived outgrowth (OG...

DOI Web Site 被引用文献1件

Chiquita Prahasanti, Alexander Patera Nugraha, Tania Saskianti, Ketut Suardita, Wibi Riawan, Diah Savitri Ernawati Clinical, Cosmetic and Investigational Dentistry Volume 12 79-85, 2020-03

DOI Web Site 被引用文献1件

Xiuli Zhang, Yining Li, Pingzhen Yang, Xiaoyu Liu, Lihe Lu, Yanting Chen, Xinglong Zhong, Zehua Li, Hailin Liu, Caiwen Ou, Jianyun Yan, Minsheng Chen Arteriosclerosis, Thrombosis, and Vascular Biology 40 (3), 751-765, 2020-03

...Similarly, TMAO upregulated the expression of bone-related molecules including Runx2 (Runt-related transcription factor 2) and BMP2 (bone morphogenetic protein-2), suggesting that TMAO promoted osteogenic...

DOI Web Site 被引用文献1件

Sahitya Injamuri, Mohamed N. Rahaman, Youqu Shen, Yue‐Wern Huang Journal of Biomedical Materials Research Part A 108 (5), 1231-1242, 2020-02-24

...When compared with BMP‐2 alone (1 μg per defect), a 50% reduction in the BMP‐2 dose was achieved with the addition of 0.05, 0.1, or 0.25 μg of relaxin per defect....

DOI Web Site Web Site 被引用文献1件

Qiang Ao, Shilin Wang, Qing He, Hirotomo Ten, Kenichi Oyama, Akihiro Ito, Jing He, Rabia Javed, Aijun Wang, Akira Matsuno ACS Applied Materials & Interfaces 12 (11), 13400-13410, 2020-02-24

DOI Web Site 被引用文献1件 参考文献62件

Mahetab Abdal‐Wahab, Khaled A. Abdel Ghaffar, Ola M. Ezzatt, Ahmed Abdel Aziz Hassan, Mervat Mohamed S. El Ansary, Ahmed Y. Gamal Journal of Periodontal Research 55 (3), 441-452, 2020-02-21

...Gingival crevicular fluid (GCF) samples were collected directly from the test sites for the quantitative measurement of PDGF‐BB and BMP‐2 using the ELISA kit at 1, 7, 14, and 21 days after surgery....

DOI Web Site Web Site ほか1件 被引用文献1件

Taiki Kusano, Masashi Nakatani, Naoki Ishiguro, Kinji Ohno, Naoki Yamamoto, Mitsuhiro Morita, Harumoto Yamada, Akiyoshi Uezumi, Kunihiro Tsuchida Journal of Orthopaedic Research 39 (6), 1297-1304, 2020-02-21

...Desloratadine suppressed phosphorylation of Smad1/5/8 induced by BMP2 in PDGFRα+ cells....

DOI Web Site Web Site ほか1件 被引用文献1件 参考文献30件

Xiaozhuan Liu, Xue Li, Yuchang Tao, Ning Li, Mengmeng Ji, Xiuli Zhang, Yao Chen, Zhidong He, Kailun Yu, Zengli Yu Toxicology 431 152353-, 2020-02

DOI Web Site Web Site 被引用文献1件

Sheng-Nan Li, Jia-Fa Wu Stem Cell Research & Therapy 11 (1), 2020-01-29

...The roles of BMP2, TGF-β, and myostatin signaling in this process are unclear....

DOI PDF Web Site 被引用文献1件

Lu Zhang, Guangjun Jiao, Shanwu Ren, Xiaoqian Zhang, Ci Li, Wenliang Wu, Hongliang Wang, Haichun Liu, Hongming Zhou, Yunzhen Chen Stem Cell Research & Therapy 11 (1), 2020-01-28

...Finally, experiments with BMP2 inhibitors confirmed that the BMP-2/Smad1/RUNX2 signalling pathway played an important role in the pro-osteogenesis induced by BMMSC-Exos and enhanced fracture healing of...

DOI PDF Web Site 被引用文献1件

Robert Owen, Hossein Bahmaee, Frederik Claeyssens, Gwendolen C. Reilly Bioengineering 7 (1), 12-, 2020-01-21

...-2)....

DOI Web Site 被引用文献1件

Zhuo Wang, Yuanliang Huang, Luanjun Tan BMC Developmental Biology 20 (1), 2020-01-14

...And the expressions of osteogenic differentiation marker genes Runt-related transcription factor 2 (Runx2), osteocalcin (OCN) and bone morphogenetic protein (BMP-2) were significantly increased in the...

DOI PDF Web Site 被引用文献1件

Marian H. Hettiaratchi, Laxminarayanan Krishnan, Tel Rouse, Catherine Chou, Todd C. McDevitt, Robert E. Guldberg Science Advances 6 (1), eaay1240-, 2020-01-03

...<jats:p>Heparin-based microparticles improve spatial localization of BMP-2 delivery, decreasing bone formation outside of the injury site.</jats:p>...

DOI Web Site 被引用文献4件

Ye Zhang, Ming-wei Liu, Yun He, Ning Deng, Yan Chen, Jiecong Huang, Wei Xie International Journal of Immunopathology and Pharmacology 34 205873842094176-, 2020-01

...After 12 weeks of treatment, we used real-time quantitative polymerase chain reaction (PCR) and Western blot analysis to measure the gene and protein expression of miR-92b-3p, Nox4, NF-κBp65, IκB, BMP2...

DOI Web Site Web Site 被引用文献1件

Zhuo Liang, Yue Luo, Yonggang Lv Journal of Materials Chemistry B 8 (30), 6378-6389, 2020

<p>Microvesicles–polyethyleneimine/pDNA formed <italic>via</italic> layer-by-layer self-assembly increase the delivery of hBMP2 plasmids and enhance bone repair.</p>

DOI Web Site 被引用文献1件

Marta R. Casanova, Catarina Oliveira, Emanuel M. Fernandes, Rui L. Reis, Tiago H. Silva, Albino Martins, Nuno M. Neves Biomaterials Science 8 (9), 2577-2589, 2020

...<p>An engineered biofunctional system comprises endogenous BMP-2 and VEGF bound in a parallel pattern....

DOI Web Site 被引用文献1件

Shigeki Nagahiro, Tomoki Uehara, Mariko Yamamoto Kawai, Preksa Keo, Toshimi Sato, Hiroki Ochi, Shingo Sato, Shinji Kuroda, Takashi Ono, Michiyo Miyashin, Kazuhiro Aoki Dental, Oral and Maxillofacial Research 6 (1), 2020

DOI

高橋 達雄, 阿部 史葉, 打江 佳菜, 篠田 佳奈, 山崎 京介, 安田 紗奈子, 松尾 由理, 野村 政明 日本薬理学会年会要旨集 93 (0), 2-O-029-, 2020

...EphrinB2 increased the expression of BMP2 in osteoclast progenitor cells, RAW264.7, suggesting the possibility that BMP2 is involved in the action of EphrinB2 to promote osteoblast differentiation....

DOI Web Site

劉 旭, 于 在強, 楊 薇, 大徳 和之, 元村 成, 今泉 忠淳, 福田 幾夫, 古川 賢一, 瀬谷 和彦 日本薬理学会年会要旨集 93 (0), 2-P-211-, 2020

...Gene expression of BMP2 and ALP activity as typical calcification markers, were significantly increased in response to TNF-α....

DOI Web Site

渡辺 美咲 ファルマシア 56 (2), 163-163, 2020

超高齢社会を迎えた我が国では，骨粗しょう症患者が急増している．2015年に発行されたガイドラインでは患者数は約1,300万人と推定されており，寝たきり状態のリスクを増大させることから社会問題となっている．骨粗しょう症は，骨吸収と骨形成の均衡が崩れ，骨強度の低下を招く疾患である．中国では古くから民間薬として，タデ科<i>Polygonum</i> <i>amplexicaule</i> var. …

DOI

瀬谷 和彦, 楊 薇, 于 在強, 千代谷 真理, 大徳 和之, 元村 成, 今泉 忠淳, 福田 幾夫, 古川 賢一 日本薬理学会年会要旨集 93 (0), 3-P-323-, 2020

...So, the involvement of PXR in MK-4-induced calcification of HAVICs and BMP2 gene expression was investigated....

DOI Web Site

劉 旭, 于 在強, 瀬谷 和彦, 楊 薇, 大徳 和之, 今泉 忠淳, 古川 賢一, 福田 幾夫 弘前医学 70 (2-4), 179-179, 2020

...黄蓮解毒湯は TNF-α による BMP2 遺伝子発現の亢進および ALP 活性の上昇を有意に抑制した。以上の結果は、黄蓮解毒湯が弁異所性石灰化の薬物治療候補のひとつとなる可能性を示唆している。黄蓮解毒湯はオウゴン、サンシシ、オウレンとオウバクの４種の生薬を含んでおり、高血圧や動悸などに使用されている。今後は、活性の本体を明らかにするため、これらの生薬を用いてさらに検討を進めていく。...

DOI 機関リポジトリ HANDLE ほか1件

Bien Nguyen Dien, Miura Kei-ichiro, Sumita Yoshinori, Nakatani Yuya, Shido Rena, Kajii Fumihiko, Kamakura Shinji, Asahina Izumi Journal of Hard Tissue Biology 29 (2), 123-130, 2020

...<p>Bone morphogenetic protein-2 (BMP-2) has diverse functions and is especially important in bone and cartilage development....

DOI Web Site Web Site ほか1件 被引用文献3件 参考文献21件

Yamamoto Rina, Takabe Wakako, Yagi Masayuki, Yonei Yoshikazu Glycative Stress Research 7 (2), 142-151, 2020

...Methods: For osteoblstgenesis, mouse myoblast C2C12 cells were stimulated with bone morphogenetic protein 2 (BMP2)....

DOI Web Site 医中誌

Hiraoka Kotaro, Inada Hitoshi, Yanai Kazuhiko, Osumi Noriko The Tohoku Journal of Experimental Medicine 252 (3), 199-208, 2020

...To examine whether activation of the pathway affects ciliogenesis, we investigated the effects of two BMPs, BMP2 and BMP4, on the ependymal differentiation of the primary cultured cells prepared from the...

DOI Web Site PubMed ほか1件 被引用文献2件 参考文献6件

荒木 亮, 浅利 亨, 工藤 整, 和田 簡一郎, 熊谷 玄太郎, 佐々木 綾子, 古川 賢一, 石橋 恭之 弘前医学 71 (1), 97-97, 2020

...非 骨分化誘導培地のTPD 非投与下で培養したCSM 患者由来MSCs をコントールとして、 ΔΔCT 法を用いてTPD 各濃度おける骨化関連遺伝子(OCN、OSX、OCN、RUNX2、 BMP2)の相対的発現量を測定した。TPD の各濃度間での比較をFriedman 検定で、CSM とOPLL の 2 群間の比較にはMann-Whitney U 検定を用いて比較した。...

DOI 機関リポジトリ HANDLE ほか1件

Ryo Tazawa, Hiroaki Minehara, Terumasa Matsuura, Tadashi Kawamura, Kentaro Uchida, Gen Inoue, Wataru Saito, Masashi Takaso BioMed Research International 2019 1-7, 2019-12-24

...Group 1.0/BMP-2 had higher bone volume and bone mineral content compared to Group 1.0, and all mice achieved bone union at the bone defect and docking sites....

DOI PDF XML 参考文献17件

Eijiro Jimi, Fei Huang, Chihiro Nakatomi International Journal of Molecular Sciences 20 (24), 6275-, 2019-12-12

...Inhibiting the classical NF-κB signaling pathway blocks growth hormone (GH) or insulin-like growth factor (IGF-1) signaling, suppresses cell proliferation, and suppresses bone morphogenetic protein 2 (BMP2...

DOI Web Site 被引用文献3件

Saqib Umer, Abdul Sammad, Huiying Zou, Adnan Khan, Bahlibi Weldegebriall Sahlu, Haisheng Hao, Xueming Zhao, Yachun Wang, Shanjiang Zhao, Huabin Zhu Genes 10 (12), 1038-, 2019-12-12

...We found an optimum level of FSH (25 ng/mL) which can significantly enhance AMH and BMP2 abundance (p < 0.05)....

DOI Web Site 被引用文献1件