検索結果 261 件

矢野 圭輔, 杉田 光士郎, 武藤 充, 大西 峻, 岩元 祐実子, 緒方 将人, 高田 倫, 祁答院 千寛, 村上 雅一, 松久保 眞, 川野 孝文, 中目 和彦, 加治 建, 家入 里志 小児外科 56 (4), 320-325, 2024-04-25

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薄井 佳子, 馬場 勝尚, 辻 由貴, 關根 沙知, 照井 慶太 小児外科 56 (4), 372-375, 2024-04-25

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東 紗弥, 森井 真也子, 渡部 亮, 山形 健基, 林 海斗, 水野 大 小児外科 56 (4), 384-388, 2024-04-25

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千葉 正博, 唐沢 浩二, 岡本 まとか 小児外科 56 (4), 330-334, 2024-04-25

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小川 祥子, 田中 潔, 高安 肇, 小西 健一郎, 上松 由昌 小児外科 56 (4), 351-355, 2024-04-25

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藤枝 悠希, 大畠 雅之 小児外科 56 (4), 367-371, 2024-04-25

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横井 暁子 小児外科 56 (4), 380-383, 2024-04-25

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松木 杏子, 田附 裕子, 出口 幸一, 正畠 和典, 野村 元成, 渡邊 美穂, 上野 豪久, 神山 雅史, 奥山 宏臣 小児外科 56 (4), 393-397, 2024-04-25

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加治 建 小児外科 56 (4), 317-319, 2024-04-25

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和田 基 小児外科 56 (4), 335-341, 2024-04-25

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佐々木 理人, 増本 幸二 小児外科 56 (4), 346-350, 2024-04-25

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田附 裕子, 上野 豪久, 木村 武司, 奥山 宏臣 小児外科 56 (4), 356-361, 2024-04-25

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池上 満智彰, 宮野 剛, 植田 江莉, 飯田 寿恵, 二階 公貴, 金子 浩太郎, 伊藤 成宜, 岡崎 任晴 小児外科 56 (4), 376-379, 2024-04-25

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柿原 知, 吉田 真理子, 高澤 慎也, 森田 香織, 一瀬 諒紀, 渡辺 栄一郎, 藤代 準 小児外科 56 (4), 398-402, 2024-04-25

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宮本 昌和 小児外科 56 (4), 326-329, 2024-04-25

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鈴木 完, 入江 澄子, 鎌田 悠子, 渡邊 峻, 荻野 恵, 畑中 政博, 藤田 雄治, 長沼 純子 小児外科 56 (4), 342-345, 2024-04-25

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藤雄木 亨真, 小関 元太, 石丸 哲也, 金森 豊, 山岸 徳子, 齋藤 傑, 山本 裕輝, 下島 直樹, 米田 光宏 小児外科 56 (4), 362-366, 2024-04-25

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三宅 啓, 矢本 真也, 野村 明芳, 菅井 佑, 根本 悠里, 西谷 友里, 山城 優太朗, 福本 弘二 小児外科 56 (4), 389-392, 2024-04-25

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安藤 亮, 工藤 博典, 櫻井 毅, 和田 基 小児外科 56 (4), 403-407, 2024-04-25

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加治 　建 外科と代謝・栄養 58 (1), 50-52, 2024-02-15

DOI Web Site 参考文献14件

藤枝 悠希, 大畠 雅之 Journal of the Japanese Society of Pediatric Surgeons 59 (7), 1070-1075, 2023-12-20

...必要になったため，2歳時から中心静脈カテーテル（central venous catheter: CVC）を留置し経口摂取に加え，在宅中心静脈栄養を開始した．何度かカテーテル関連血流感染症（catheter related blood stream infection; CRBSI）を起こし，CVCの入れ替えを行った．2021年に短腸症候群治療薬であるGlucagon-like peptide-2（GLP...

DOI

門久 政司, 岡本 竜弥, 河井 昌彦, 山本 美紀, 上林エレーナ 幸江, 小川 絵里, 岡島 英明, 波多野 悦朗 移植 58 (Supplement), s164_2-s164_2, 2023

...【まとめ】初回大量小腸切除術以後の外科的介入を要さずに完全IVHで成長発達が得られた症例と，複数回の外科的介入を要し，今後の成長発達不良や肝不全への進行も危惧される症例，この２例における今後のGLP-２製剤の導入や小腸移植の適応などを考察する．</p>...

DOI

伊藤 よう子, 山田 洋平, 城崎 浩司, 工藤 裕実, 加藤 源俊, 長谷川 康, 松原 健太郎, 岡林 剛史, 尾原 秀明, 藤野 明浩 移植 58 (Supplement), s265_2-s265_2, 2023

...残存自己腸管はTreitz靭帯から20cmとなり、短腸症に対しGLP-2製剤投与と在宅静脈栄養を含めた腸管リハビリテーションを実施している。【結論】小腸移植患者の予後向上には社会的なサポートも含めた多面的なプローチが必要である。</p>...

DOI 医中誌

城崎 浩司, 山田 洋平, 伊藤 よう子, 工藤 裕実, 金森 洋樹, 加藤 源俊, 筋野 智久, 長谷川 康, 松原 健太郎, 岡林 剛史, 細江 直樹, 尾原 秀明, 藤野 明浩 移植 58 (Supplement), s164_1-s164_1, 2023

...非小腸移植例の24例は0歳から63歳、13例で外科的介入、8例でGLP-2製剤の導入を行った。GLP-2導入症例は全例で排便量・ストマ排液量が減少し、長期例4例は輸液量の減量（26％～100％）を達成した。一方小腸移植例は、移植時10歳から31歳、6例がH類縁、2例がSBSを原疾患とし、いずれも中心静脈アクセス喪失および著しく損なわれたQOLを適応とした。...

DOI

田附 裕子, 木村 武司, 上野 豪久, 森田 隆介, 長井 直子, 松尾 怜奈, 阿部 薫, 北村 真世, 田中 美和, 奥山 宏臣 移植 58 (Supplement), s163_2-s163_2, 2023

...【目的・方法】腸管不全患者において外科的介入の効果、短腸症に対するGLP-2アナログ製剤（GLP-2）の効果をPN依存において検討した。【結果】外科的治療の適応となった患者は、トランジション症例を含む10例で、短腸症5例(3～38歳)、CIPO5例(7～28歳)であった。短腸症ではSTEP治療および腸管延長術が選択され術後排便回数が減少した。...

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Ryuichi Okamoto, Tomohiro Mizutani, Hiromichi Shimizu Digestion 104 (1), 24-29, 2022-11-09

...However, most of these factors did not show clinical benefit, except the recombinant glucagon-like peptide-2 (GLP-2)....

DOI PDF 参考文献30件

GOTO Tomoya, UMEDA Tomoki, HINO Shingo, MORITA Tatsuya, NISHIMURA Naomichi Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 68 (2), 104-111, 2022-04-30

...In particular, this effect of RMD but not IMD could have resulted from increased glucose available as a secretagogue of the trophic hormone GLP-2, in the ileum.</p>...

DOI Web Site Web Site ほか1件 参考文献34件

Johanna Eliasson, Mark K. Hvistendahl, Nanna Freund, Federico Bolognani, Christian Meyer, Palle B. Jeppesen Journal of Parenteral and Enteral Nutrition 46 (7), 1639-1649, 2022-03-28

...<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Apraglutide is a novel long‐acting glucagon‐like peptide‐2 (GLP‐2) analog designed for once‐weekly subcutaneous dosing...

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福森, 理加, 高山, 由美子, 泉, 賢一, 及川, 伸 家畜衛生学雑誌 47 (4), 197-204, 2022-03

...以上の結果から，BHによる食欲増進効果は認められなかったが，インスリンやGLP-2の分泌促進作用を介して代謝機能改善に寄与する可能性が示唆された。...

日本農学文献記事索引

Nadya M. Morrow, Natasha A. Trzaskalski, Antonio A. Hanson, Evgenia Fadzeyeva, Dawn E. Telford, Sanjiv S. Chhoker, Brian G. Sutherland, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill Arteriosclerosis, Thrombosis, and Vascular Biology 42 (2), 127-144, 2022-02

...Treatment with a GLP-2 receptor antagonist, GLP-2(3-33), reduced villus length in HFHC-fed mice but did not impact TRL secretion in any diet group....

DOI Web Site 被引用文献1件

Kewan, Ahmed, Shimatani, Tomohiko, 實安, 隆興, 上曽山, 博, 本田, 和久 Neuroscience Letters 768 136362-, 2022-01-18

...GLP-1 and GLP-2 specifically activate their receptors GLP-1 receptor (GLP1R) and GLP-2 receptor (GLP2R), respectively in chickens....

DOI HANDLE Web Site ほか1件 参考文献31件

Fukumori, Rika, Doi, Kazuya, Mochizuki, Taisei, Oikawa, Shin, Gondaira, Satoshi, Iwasaki, Tomohito, Izumi, Kenichi Animal Science Journal 93 (1), e13791-, 2022

journal article

機関リポジトリ HANDLE

Adam Ramzy, Timothy J. Kieffer Physiological Reviews 102 (1), 155-208, 2022-01-01

...-2)....

DOI Web Site 被引用文献1件

SALAHUDDIN Md, HIRAMATSU Kohzy, NISHIMOTO Iori, KITA Kazumi Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 84 (2), 265-274, 2022

...Paraffin sections were made from the proximal and distal ileum of each animal and subjected to immunohistochemistry for GLP-1 and GLP-2 peptides and <i>in situ</i> hybridization for...

DOI Web Site PubMed ほか1件 被引用文献1件 参考文献37件

Patrizia Proia, Alessandra Amato, Patrik Drid, Darinka Korovljev, Sonya Vasto, Sara Baldassano Frontiers in Endocrinology 12 2021-09-13

...A description of the role of parathyroid hormone (PTH) and gut hormones (gastric inhibitory peptide (GIP), glucagon-like peptide (GLP)-1, and GLP-2) as potential candidates in this interaction to promote...

DOI Web Site 被引用文献1件

Yoshinori Hanawa, Masaaki Higashiyama, Chie Kurihara, Rina Tanemoto, Suguru Ito, Akinori Mizoguchi, Shin Nishii, Akinori Wada, Kenichi Inaba, Nao Sugihara, Kazuki Horiuchi, Yoshikiyo Okada, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Ryota Hokari Journal of Gastroenterology and Hepatology 36 (11), 3140-3148, 2021-08-21

...Intestinal damage was evaluated histologically, and messenger RNA (mRNA) levels of TNF‐α, IFN‐γ, IL1‐β, MAdCAM‐1, GLP1R, and GLP2R were determined with quantitative reverse transcription polymerase chain...

DOI Web Site Web Site 参考文献40件

EGUCHI SUSUMU, HIDAKA MASAAKI, SOYAMA AKIHIKO, HARA TAKANOBU, KUGIYAMA TOTA, HAMADA TAKASHI, TANAKA TAKAYUKI, MATSUSHIMA HAJIME, ADACHI TOMOHIKO, INOUE YUSUKE, ITO SHINICHIRO, KANETAKA KENGO Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ advpub (0), 169-174, 2021-08-06

...We will also attempt to evaluate postoperative small intestinal mucosal atrophy using DAO and GLP-2 activities in the serum, and postoperative nutrient absorption using nutrient assessment indicators....

DOI Web Site PubMed ほか1件 参考文献20件

Xiuting Hu, Wei Cheng, Shengxian Fan, Yuhua Huang, Xi Chen, Zhiwei Jiang, Jian Wang BMC Infectious Diseases 21 (1), 583-, 2021-06-16

...-2 (GLP2.SBS group, <jats:italic>n</jats:italic> = 5)....

DOI PDF Web Site 被引用文献1件

Aoki, Kai, Suzuki, Takuji, Hui, Fang, Nakano, Takuro, Yanazawa, Koki, Yonamine, Masato, Fujita, Shinichiro, 菅澤, 威仁, Yoshida, Yasuko, 麻見, 直美, 川上, 康, 竹越, 一博 Nutrients 13 (5), 1735-, 2021-05

...The levels of plasma GLP-2 and the jejunum expression of the GLP-2 receptor, sucrase-isomaltase (SI), and glucose transporter 2 (GLUT2) were higher in LEx mice....

DOI 機関リポジトリ HANDLE ほか1件 参考文献33件

Rahim Mohammad Naimi, Mark Krogh Hvistendahl, Lise Margrete Thomassen, Hanna Johnsen, Charlotte Bayer Christiansen, Jens Juul Holst, Bolette Hartmann, Palle Bekker Jeppesen BMJ Open Gastroenterology 8 (1), e000604-, 2021-05

...Nevertheless, some patients with SBS with colon in continuity suffer from high-volume faecal excretions and have been shown to benefit from treatment with GLP-2....

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Yudai Inabu, Hiroshi Yamamoto, Haruki Yamano, Yutaka Taguchi, Shunnosuke Okada, Tetsuji Etoh, Yuji Shiotsuka, Ryoichi Fujino, Hideyuki Takahashi Heliyon 7 (5), e07046-, 2021-05

DOI Web Site Web Site 参考文献31件

Priska Stahel, Changting Xiao, Avital Nahmias, Lili Tian, Gary Franklin Lewis Endocrine Reviews 42 (6), 815-838, 2021-03-20

...Hormones and peptides originating from the pancreas (insulin, glucagon), gut [glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), ghrelin, cholecystokinin (CCK), peptide YY], adipose tissue (leptin, adiponectin...

DOI PDF PDF 被引用文献1件

Jenna Elizabeth Hunt, Bolette Hartmann, Kristina Schoonjans, Jens Juul Holst, Hannelouise Kissow Frontiers in Endocrinology 12 2021-02-26

...-5 (TGR5) signaling in the response using GLP-1 receptor, GLP-2 receptor and TGR5 knockout mice....

DOI Web Site 被引用文献1件

中村 志郎, 和田 基, 大毛 宏喜, 宇田川 恵理, 鈴木 瞭介, ミンジョン ユン, アンドリュー グリム, 池内 浩基 日本小腸学会学術集会プログラム・抄録集 5 (0), 40-40, 2021

...<p><b>背景:</b> テデュグルチド(本剤)は、短腸症候群(SBS)の治療薬として既に欧米で承認されているGLP-2アナログ製剤である。腸管不全を伴う日本人成人SBS患者を対象とした第Ⅲ相試験(SHP633-306)において、24週時点での臨床的意義のある静脈栄養サポート(PS)量の減少が確認されている。...

DOI

Kirsa Skov-Jeppesen, Nicola Hepp, Jannika Oeke, Morten Steen Hansen, Abbas Jafari, Maria Saur Svane, Nariman Balenga, John A Olson, Morten Frost, Moustapha Kassem, Sten Madsbad, Jens-Erik Beck Jensen, Jens Juul Holst, Mette Marie Rosenkilde, Bolette Hartmann Journal of Bone and Mineral Research 36 (8), 1448-1458, 2020-12-01

...In contrast, the effect of GLP-2 on bone turnover seems to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland. © 2021 The Authors....

DOI PDF Web Site ほか1件 被引用文献1件

Yaqi Chang, Qiuhong Deng, Zhenyu Zhang, Hua Zhao, Jiayong Tang, Xiaoling Chen, Guangmang Liu, Gang Tian, Jingyi Cai, Gang Jia Journal of Cellular Physiology 236 (4), 3015-3032, 2020-09-22

...‐2; and (iv) LPS + high dose GLP‐2....

DOI Web Site Web Site 被引用文献1件

Johana Norona, Petya Apostolova, Dominik Schmidt, Rebekka Ihlemann, Nadine Reischmann, Gregory Taylor, Natalie Köhler, Jocelyn de Heer, Steffen Heeg, Geoffroy Andrieux, Benjamin A. Siranosian, Annette Schmitt-Graeff, Dietmar Pfeifer, Antonella Catalano, Ian J. Frew, Michele Proietti, Bodo Grimbacher, Alla Bulashevska, Ami S. Bhatt, Tilman Brummer, Till Clauditz, Tatjana Zabelina, Nicolaus Kroeger, Bruce R. Blazar, Melanie Boerries, Francis Ayuk, Robert Zeiser Blood 136 (12), 1442-1455, 2020-09-17

...Glucagon-like-peptide-2 (GLP-2) is an enteroendocrine tissue hormone produced by intestinal L cells. We observed that acute GVHD reduced intestinal GLP-2 levels in mice and patients developing GVHD....

DOI PDF 被引用文献7件

Yasutada Akiba, Koji Maruta, Takeshi Takajo, Kazuyuki Narimatsu, Hyder Said, Ikuo Kato, Atsukazu Kuwahara, Jonathan D. Kaunitz American Journal of Physiology-Gastrointestinal and Liver Physiology 318 (6), G1070-G1087, 2020-06-01

...The gut hormone glucagon-like peptide-2 (GLP-2) inhibited uptake into the PV....

DOI Web Site 参考文献88件

Mirielle L. Pauline, Patrick N. Nation, Pamela R. Wizzard, Tierah Hinchliffe, Tong Wu, Violetta Dimitriadou, Justine M. Turner, Paul W. Wales Journal of Parenteral and Enteral Nutrition 45 (3), 538-545, 2020-05-21

...‐2) analogues....

DOI Web Site Web Site ほか1件 被引用文献1件

Miao Yu, Zhenming Li, Weidong Chen, Gang Wang, Ting Rong, Zhichang Liu, Fengyin Wang, Xianyong Ma Journal of Animal Science 98 (3), skz395-, 2020-03-01

...decreased (P &lt; 0.05, minimum in HI2) with increasing HILM levels, while the mRNA expression of IL-10, barrier function (MUC1, ZO-1, Occludin, and Claudin-2), and development-related genes (IGF-1, GLP...

DOI PDF 被引用文献2件

Koji Maruta, Takeshi Takajo, Yasutada Akiba, Hyder Said, Emi Irie, Ikuo Kato, Atsukazu Kuwahara, Jonathan D. Kaunitz Digestive Diseases and Sciences 65 (9), 2605-2618, 2020-01-31

DOI PDF Web Site 被引用文献1件 参考文献43件

Hiramatsu Kohzy The Journal of Poultry Science 57 (1), 1-6, 2020

...GLP-1 co-localizes with GLP-2 and neurotensin in the same cells of the chicken ileum. Intestinal L cells secrete GLP-1 in response to food ingestion....

DOI Web Site Web Site 被引用文献4件 参考文献66件

塙 芳典, 東山 正明, 種本 理那, 伊東 傑, 西井 慎, 溝口 明範, 因幡 健一, 杉原 奈央, 和田 晃典, 堀内 和樹, 成松 和幸, 渡辺 知佳子, 高本 俊介, 富田 謙吾, 穂苅 量太 日本小腸学会学術集会プログラム・抄録集 4 (0), 36-36, 2020

...またTNF<i>α</i>、IFN<i>γ</i>、IL1<i>β</i>、MAdCAM-1のmRNAの発現は有意に上昇し、GLP-1R、GLP-2Rの発現は有意に低下していた。ACK群で免疫組織学的にMAdCAM-1の有意な発現の増加を認めた。ACK投与により小腸粘膜の透過性は亢進していた。腸内細菌はACKの自由飲水群でdysbiosisを認めた。...

DOI

武藤 充, 加治 建, 矢野 圭輔, 大西 峻, 山田 和歌, DW Lim, 長野 綾香, 松井 まゆ, 松久保 眞, JM Turner, PW Wales, 家入 里志 外科と代謝・栄養 54 (6), 229-233, 2020

...GLP‐2とEGFは相乗して粘膜透過性を抑制し, 腸管バリア機能強化に寄与することが分かった. 現在臨床応用されているペプチド成長因子はGLP‐2 analogのみであるが, さらに複数を組み合わせることで, より効果的に残存腸管順応を推進することが可能かもしれない. Ghrelin, EGFはその候補としてあげられる....

DOI Web Site 医中誌 参考文献11件

Yijing Yu, Fitore Raka, Khosrow Adeli Journal of Clinical Medicine 8 (12), 2227-, 2019-12-17

...Microbiota changes also involve altered short chain fatty acid signaling and influence enteroendocrine cell function including GLP-1/GLP-2-producing L-cells which regulate postprandial lipid metabolism...

DOI Web Site 被引用文献1件

Mette Simone Aae Madsen, Jacob Bak Holm, Albert Pallejà, Pernille Wismann, Katrine Fabricius, Kristoffer Rigbolt, Martin Mikkelsen, Morten Sommer, Jacob Jelsing, Henrik Bjørn Nielsen, Niels Vrang, Henrik H. Hansen Scientific Reports 9 (1), 2019-10-30

...DIO mice received treatment with a selective GLP-1 receptor agonist (liraglutide, 0.2 mg/kg, BID) or dual GLP-1/GLP-2 receptor agonist (GUB09–145, 0.04 mg/kg, BID) for 4 weeks....

DOI PDF Web Site 被引用文献2件

Krista Hokkanen, Annakaisa Tirronen, Seppo Ylä-Herttuala Current Opinion in Lipidology 30 (5), 370-376, 2019-10

...-2....

DOI Web Site 被引用文献1件

Machida Maiko, Shiga Saki, Machida Takuji, Ohno Masafumi, Iizuka Kenji, Hirafuji Masahiko Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 42 (10), 1733-1740, 2019-10-01

...In contrast, 5-fluorouracil significantly inhibited proglucagon, GLP-2 receptor, IGF-1, and TGF-β2 mRNA expression as well as the number of anti-GLP-2 antibody-positive cells....

DOI Web Site Web Site ほか2件 参考文献30件

Sachie Sasaki-Hamada, Masaatsu Ikeda, Jun-Ichiro Oka Scientific Reports 9 (1), 2019-09-23

...ability of GLP-2 is due to its potential to reduce oxidative stress....

DOI PDF Web Site 被引用文献1件

Yudai Inabu, Kyotaro Murayama, Katsutoshi Inouchi, Toshihisa Sugino Animal Science Journal 90 (9), 1185-1192, 2019-07-07

...On the other hand, mean plasma GLP‐2 concentration among whole experimental period was higher for TB (0.60 ng/ml) compared with CON (0.41 ng/ml)....

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Fusayo Io, Emi Gunji, Hiroko Koretsune, Koji Kato, Mami Sugisaki-Kitano, Lisa Okumura-Kitajima, Kayo Kimura, Saeko Uchida, Koji Yamamoto European Journal of Pharmacology 853 136-144, 2019-06

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岡 淳一郎 薬学雑誌 139 (5), 783-791, 2019-05-01

...We prepared a GLP-2 derivative containing cell-penetrating peptides (CPPs) and a penetration accelerating sequence (PAS)....

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Patricia D. Finn, David Rodriguez, Jill Kohler, Zhengfeng Jiang, Sindy Wan, Erick Blanco, Andrew J. King, Tao Chen, Noah Bell, Dean Dragoli, Jeffrey W. Jacobs, Rakesh Jain, Michael Leadbetter, Matthew Siegel, Christopher W. Carreras, Samantha Koo-McCoy, Karen Shaw, Cathy Le, Sandra Vanegas, I-Hsin Hsu, Kenji Kozuka, Keiko Okamoto, Jeremy S. Caldwell, Jason G. Lewis American Journal of Physiology-Gastrointestinal and Liver Physiology 316 (3), G412-G424, 2019-03-01

...Our results showed that RDX8940 is minimally systemic, potent, and selective, and induces incretin (GLP-1, GLP-2, and peptide YY) secretion....

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Canxia He, Lei Huang, Peng Lei, Xiaodong Liu, Baolong Li, Yujuan Shan Molecular Nutrition & Food Research 62 (24), 2018-11-22

...also increases butyric acid levels in the mouse colon, and repairs the injury to the mucosal epithelium of the colon and cecum through the upregulation of the expression of tight junction proteins and GLP2...

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Jennifer Taher, Christopher Baker, Danielle Alvares, Laraib Ijaz, Mahmood Hussain, Khosrow Adeli Endocrinology 159 (9), 3340-3350, 2018-07-19

DOI PDF 被引用文献1件

Patricia L. Brubaker Comprehensive Physiology 1185-1210, 2018-06-18

...This comprehensive review covers the biology of GLP‐2, from the control of proglucagon gene expression and the posttranslational processing of proglucagon to liberate GLP‐2 to the regulation of GLP‐2 secretion...

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Vasilis Tsimihodimos, Moses Elisaf Current Medicinal Chemistry 25 (18), 2133-2139, 2018-05-22

...On the other hand, GLP-2 increases the absorption of dietary fat and the production of triglyceride-rich lipoproteins while the role of GIP on lipid metabolism remains indeterminate....

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Marc Schoeler, Thomas Klag, Judith Wendler, Simon Bernhard, Michael Adolph, Andreas Kirschniak, Martin Goetz, Nisar Malek, Jan Wehkamp Therapeutic Advances in Gastroenterology 11 175628481879334-, 2018-01

...Supporting these clinical observations, we found a stronger physiological expression of the GLP-2 receptor in the colon than in the small intestine....

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Shiga Saki, Machida Takuji, Machida Maiko, Hirafuji Masahiko 日本薬理学会年会要旨集 WCP2018 (0), PO2-6-26-, 2018

...tropic effects of GLP-2....

DOI Web Site

天江 新太郎 日本重症心身障害学会誌 43 (1), 63-69, 2018

...その他、骨格筋などの末梢組織へのエネルギー供給、大腸炎の抑制作用、GLP-1を介した糖代謝の改善、GLP-2を介した小腸粘膜上皮細胞の増殖促進作用が確認されている。経腸栄養のみが用いられている重症心身障害児者では、食物繊維が十分に投与できていない場合もあるため、腸管の状態を保全する観点からも配合されている食物繊維の量と質を確認し、積極的に活用すべき栄養素ではあると考えられる。...

DOI Web Site 医中誌

Akiba Yasutada, Kaunitz Jonathan D 日本薬理学会年会要旨集 WCP2018 (0), PO2-6-28-, 2018

...Since glucagon-like peptide-2 (GLP-2) reduces intestinal solute permeability but enhances fat absorption, we also hypothesized that GLP-2 affects LPS transport during fat absorption....

DOI Web Site

Ana Kostic, Thomas Alexander King, Feng Yang, Kuo‐Chen Chan, George D. Yancopoulos, Jesper Gromada, Joyce B. Harp Diabetes, Obesity and Metabolism 20 (2), 283-291, 2017-09-14

...REGN1193 dose‐dependently increased total GLP‐1, GLP‐2 and glucagon, with plasma levels returning to baseline by day 29 in all dose groups....

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Maciej Salaga, Anna Mokrowiecka, Marta Zielinska, Ewa Malecka-Panas, Radzislaw Kordek, Elzbieta Kamysz, Jakub Fichna Journal of Pharmacology and Experimental Therapeutics 363 (1), 92-103, 2017-07-19

DOI Web Site 被引用文献1件

Robert A. Scott, Laura J. Scott, Reedik Mägi, Letizia Marullo, Kyle J. Gaulton, Marika Kaakinen, Natalia Pervjakova, Tune H. Pers, Andrew D. Johnson, John D. Eicher, Anne U. Jackson, Teresa Ferreira, Yeji Lee, Clement Ma, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Natalie R. Van Zuydam, Anubha Mahajan, Han Chen, Peter Almgren, Ben F. Voight, Harald Grallert, Martina Müller-Nurasyid, Janina S. Ried, Nigel W. Rayner, Neil Robertson, Lennart C. Karssen, Elisabeth M. van Leeuwen, Sara M. Willems, Christian Fuchsberger, Phoenix Kwan, Tanya M. Teslovich, Pritam Chanda, Man Li, Yingchang Lu, Christian Dina, Dorothee Thuillier, Loic Yengo, Longda Jiang, Thomas Sparso, Hans A. Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Mattias Frånberg, Rona J. Strawbridge, Rafn Benediktsson, Astradur B. Hreidarsson, Augustine Kong, Gunnar Sigurðsson, Nicola D. Kerrison, Jian'an Luan, Liming Liang, Thomas Meitinger, Michael Roden, Barbara Thorand, Tõnu Esko, Evelin Mihailov, Caroline Fox, Ching-Ti Liu, Denis Rybin, Bo Isomaa, Valeriya Lyssenko, Tiinamaija Tuomi, David J. Couper, James S. Pankow, Niels Grarup, Christian T. Have, Marit E. Jørgensen, Torben Jørgensen, Allan Linneberg, Marilyn C. Cornelis, Rob M. van Dam, David J. Hunter, Peter Kraft, Qi Sun, Sarah Edkins, Katharine R. Owen, John R.B. Perry, Andrew R. Wood, Eleftheria Zeggini, Juan Tajes-Fernandes, Goncalo R. Abecasis, Lori L. Bonnycastle, Peter S. Chines, Heather M. Stringham, Heikki A. Koistinen, Leena Kinnunen, Bengt Sennblad, Thomas W. Mühleisen, Markus M. Nöthen, Sonali Pechlivanis, Damiano Baldassarre, Karl Gertow, Steve E. Humphries, Elena Tremoli, Norman Klopp, Julia Meyer, Gerald Steinbach, Roman Wennauer, Johan G. Eriksson, Satu Mӓnnistö, Leena Peltonen, Emmi Tikkanen, Guillaume Charpentier, Elodie Eury, Stéphane Lobbens, Bruna Gigante, Karin Leander, Olga McLeod, Erwin P. Bottinger, Omri Gottesman, Douglas Ruderfer, Matthias Blüher, Peter Kovacs, Anke Tonjes, Nisa M. Maruthur, Chiara Scapoli, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Ulf de Faire, Anders Hamsten, Michael Stumvoll, Panagiotis Deloukas, Peter J. Donnelly, Timothy M. Frayling, Andrew T. Hattersley, Samuli Ripatti, Veikko Salomaa, Nancy L. Pedersen, Bernhard O. Boehm, Richard N. Bergman, Francis S. Collins, Karen L. Mohlke, Jaakko Tuomilehto, Torben Hansen, Oluf Pedersen, Inês Barroso, Lars Lannfelt, Erik Ingelsson, Lars Lind, Cecilia M. Lindgren, Stephane Cauchi, Philippe Froguel, Ruth J.F. Loos, Beverley Balkau, Heiner Boeing, Paul W. Franks, Aurelio Barricarte Gurrea, Domenico Palli, Yvonne T. van der Schouw, David Altshuler, Leif C. Groop, Claudia Langenberg, Nicholas J. Wareham, Eric Sijbrands, Cornelia M. van Duijn, Jose C. Florez, James B. Meigs, Eric Boerwinkle, Christian Gieger, Konstantin Strauch, Andres Metspalu, Andrew D. Morris, Colin N.A. Palmer, Frank B. Hu, Unnur Thorsteinsdottir, Kari Stefansson, Josée Dupuis, Andrew P. Morris, Michael Boehnke, Mark I. McCarthy, Inga Prokopenko Diabetes 66 (11), 2888-2902, 2017-05-31

...We identified 13 novel T2D-associated loci (P &lt; 5 × 10−8), including variants near the GLP2R, GIP, and HLA-DQA1 genes....

DOI PDF PDF 被引用文献9件

Hyder Said, Yasutada Akiba, Kazuyuki Narimatsu, Koji Maruta, Ayaka Kuri, Ken-ichi Iwamoto, Atsukazu Kuwahara, Jonathan D. Kaunitz Digestive Diseases and Sciences 62 (8), 1944-1952, 2017-05-18

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Yongjia Feng, Farok R. Demehri, Weidong Xiao, Yu-Hwai Tsai, Jennifer C. Jones, Constance D. Brindley, David W. Threadgill, Jens J. Holst, Bolette Hartmann, Terrence A. Barrett, Daniel H. Teitelbaum, Peter J. Dempsey Cellular and Molecular Gastroenterology and Hepatology 3 (3), 447-468, 2017-05

DOI Web Site Web Site 被引用文献2件

David W. Lim, Crystal L. Levesque, Donna F. Vine, Mitsuru Muto, Jacob R. Koepke, Patrick N. Nation, Pamela R. Wizzard, Julang Li, David L. Bigam, Patricia L. Brubaker, Justine M. Turner, Paul W. Wales American Journal of Physiology-Gastrointestinal and Liver Physiology 312 (4), G390-G404, 2017-04-01

...Combined treatment with GLP-2 and EGF-cm induced intestinal lengthening and decreased permeability, in addition to the trophic effects of GLP-2 alone....

DOI Web Site 被引用文献3件

Yusuke Nakao, Michiko Horiguchi, Ryuji Nakamura, Sachie Sasaki-Hamada, Chihiro Ozawa, Taichi Funane, Ryo Ozawa, Jun-Ichiro Oka, Chikamasa Yamashita International Journal of Pharmaceutics 515 (1-2), 37-45, 2016-12

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Lonneke M. JanssenDuijghuijsen, Marco Mensink, Kaatje Lenaerts, Ewa Fiedorowicz, Dorien A. M. van Dartel, Jurriaan J. Mes, Yvette C. Luiking, Jaap Keijer, Harry J. Wichers, Renger F. Witkamp, Klaske van Norren Physiological Reports 4 (20), 2016-10

...FABP2, preHP2, and GLP2 were not changed after exercise, whereas calprotectin increased....

DOI Web Site Web Site 被引用文献2件

David W. Lim, Abdoulaye Diané, Mitsuru Muto, Donna F. Vine, Patrick N. Nation, Pamela R. Wizzard, David L. Sigalet, David L. Bigam, Paul B. Pencharz, Justine M. Turner, Paul W. Wales Journal of Parenteral and Enteral Nutrition 41 (2), 156-170, 2016-09-22

...Given JI anatomy, further stimulation by GLP‐2 treatment over innate adaptation and stimulation by EN was modest and restricted to ileum....

DOI Web Site Web Site ほか1件 被引用文献1件

Laura Gillard, Lore Billiauws, Bogdan Stan-Iuga, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Jean-Baptiste Cavin, Françoise Cluzeaud, Camille Mayeur, Muriel Thomas, Jean-Noël Freund, Jean-Marc Lacorte, Maude Le Gall, André Bado, Francisca Joly, Johanne Le Beyec Scientific Reports 6 (1), 28345-, 2016-06-21

...Circulating levels of ghrelin, PYY, GLP-1, and GLP-2 were determined in SBS rat models and patients....

DOI PDF Web Site 被引用文献2件

Kazuhisa Honda Animal Science Journal 87 (9), 1090-1098, 2016-05-06

...There is evidence that OXM and GLP‐2 also induce anorexia in mammals....

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Rune Ehrenreich Kuhre, Nicolai Jacob Wewer Albrechtsen, Carolyn Fiona Deacon, Emilie Balk-Møller, Jens Frederik Rehfeld, Frank Reimann, Fiona Mary Gribble, Jens Juul Holst Journal of Molecular Endocrinology 56 (3), 201-211, 2016-04

...All three cell lines showed basal secretion of GLP-1 and GLP-2, which increased after stimulation....

DOI XML XML 被引用文献3件

Joanne Hsieh, Karin E. Trajcevski, Sarah L. Farr, Christopher L. Baker, Elizabeth J. Lake, Jennifer Taher, Jahangir Iqbal, Mahmood M. Hussain, Khosrow Adeli Endocrinology 156 (10), 3538-3547, 2015-07-01

...Endothelial NOS-deficient mice were resistant to GLP-2 stimulation and secreted fewer large apoB48-particles....

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Changting Xiao, Satya Dash, Cecilia Morgantini, Khosrow Adeli, Gary F. Lewis Diabetes 64 (7), 2310-2318, 2015-06-17

...In contrast, the gut-derived peptide GLP-2, cosecreted from intestinal L cells with GLP-1, has recently been demonstrated to enhance intestinal lipoprotein release....

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Marie-Christine Simon, Klaus Strassburger, Bettina Nowotny, Hubert Kolb, Peter Nowotny, Volker Burkart, Fariba Zivehe, Jong-Hee Hwang, Peter Stehle, Giovanni Pacini, Bolette Hartmann, Jens J. Holst, Colin MacKenzie, Laure B. Bindels, Ines Martinez, Jens Walter, Birgit Henrich, Nanette C. Schloot, Michael Roden Diabetes Care 38 (10), 1827-1834, 2015-06-17

...Oral glucose tolerance and isoglycemic glucose infusion tests were used to assess incretin effect and GLP-1 and GLP-2 secretion, and euglycemic-hyperinsulinemic clamps with [6,6-2H2]glucose were used to...

DOI PDF 被引用文献1件

原田, 範雄, 山根, 俊介, 稲垣, 暢也, Harada, Norio, Yamane, Shunsuke, Kondo, Yaeko, Suzuki, Kazuyo, Nasteska, Daniela, Shibue, Kimitaka, Harada, Takanari, Iwasaki, Kanako, Tsuji, Hidemi, Shide, Kenichiro, Inagaki, Nobuya Journal of Diabetes Investigation 6 (3), 302-308, 2015-05

...Plasma glucose, serum insulin, and plasma total GIP, total GLP-1 and total GLP-2 levels during GFO or glucose loading were determined....

HANDLE 医中誌

Laura S Girão Lopes, Rubens Prado Schwartz, Bruno Ferraz-de-Souza, Maria Elizabeth Rossi da Silva, Pedro Henrique Silveira Corrêa, Márcia Nery Diabetology & Metabolic Syndrome 7 (1), 2015-02-27

DOI PDF Web Site ほか1件 被引用文献1件

Yasutada Akiba, Takuya Inoue, Izumi Kaji, Masaaki Higashiyama, Kazuyuki Narimatsu, Ken‐ichi Iwamoto, Masahiko Watanabe, Paul H. Guth, Eli Engel, Atsukazu Kuwahara, Jonathan D Kaunitz The Journal of Physiology 593 (3), 585-599, 2015-01-30

...By contrast, a selective FFA1 agonist increased DBS accompanied by GLP‐2 release, enhanced by DPPIV inhibition and inhibited by a GLP‐2 receptor antagonist....

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Daniel J. Drucker Diabetes 64 (2), 317-326, 2015-01-13

...GLP-2 plays a key role in the control of energy absorption and in the integrity of the intestinal mucosa, and a GLP-2R agonist, teduglutide, is now used for augmentation of energy absorption in parenteral...

DOI PDF PDF 被引用文献5件

Fujiwara Kaori, Inoue Takuya, Yorifuji Naoki, Iguchi Munetaka, Sakanaka Taisuke, Narabayashi Ken, Kakimoto Kazuki, Nouda Sadaharu, Okada Toshihiko, Ishida Kumi, Abe Yosuke, Masuda Daisuke, Takeuchi Toshihisa, Fukunishi Shinya, Umegaki Eiji, Akiba Yasutada, Kaunitz Jonathan D., Higuchi Kazuhide Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 56 (2), 155-162, 2015

...Treatment with an exogenous GLP-2 analogue increases intestinal villous mass and prevents intestinal injury....

DOI 医中誌 被引用文献4件 参考文献34件

Honda Kazuhisa, Shimatani Tomohiko, Aoki Koji, Yamaguchi Takuya, Kondo Makoto, Saneyasu Takaoki, Kamisoyama Hiroshi The Journal of Poultry Science 52 (3), 183-187, 2015

...However, peripheral roles of chicken GLP-2 have not yet been investigated, although GLP-2 plays important roles both in central and peripheral regulation of food intake in mammals....

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Kaori Austin, Nuvair A. Imam, John E. Pintar, Patricia L. Brubaker Endocrinology 156 (2), 429-436, 2014-12-16

...To determine the role of IGFBP-4 in the tropic effects of GLP-2, IGFBP-4 knockout (KO) and control mice were treated with degradation-resistant GLP-2 or vehicle for 10 days....

DOI PDF 被引用文献1件

David W. Lim, Paul W. Wales, Jessica K. Josephson, Patrick N. Nation, Pamela R. Wizzard, Consolato M. Sergi, Catherine J. Field, David L. Sigalet, Justine M. Turner Journal of Parenteral and Enteral Nutrition 40 (1), 14-21, 2014-10-03

...Although glucagon‐like peptide‐2 (GLP‐2) is being advanced as therapy, the effect of GLP‐2 treatment on PNALD is unknown....

DOI Web Site Web Site ほか1件 被引用文献1件

Xinfu Guan American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 307 (6), R585-R596, 2014-09-15

...GLP-2 activates the PI3K-Akt-FoxO1 signaling pathway in POMC neurons by Glp2r-p85α interaction....

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Ryo Sueyoshi, Kathleen M. Woods Ignatoski, Manabu Okawada, Bolette Hartmann, Jens Holst, Daniel H. Teitelbaum American Journal of Physiology-Gastrointestinal and Liver Physiology 307 (4), G410-G419, 2014-08-15

...-2 receptor, IGF type 1 receptor, and GLP-2 plasma levels....

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Noura El-Jamal, Edmone Erdual, Michel Neunlist, Dine Koriche, Caroline Dubuquoy, Francois Maggiotto, Julien Chevalier, Dominique Berrebi, Laurent Dubuquoy, Eric Boulanger, Antoine Cortot, Pierre Desreumaux American Journal of Physiology-Gastrointestinal and Liver Physiology 307 (3), G274-G285, 2014-08-01

...of GLP-2....

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C. Mo, Y. Zhong, Y. Wang, Z. Yan, J. Li Domestic Animal Endocrinology 48 1-6, 2014-07

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Daniel J. Drucker, Bernardo Yusta Annual Review of Physiology 76 (1), 561-583, 2014-02-10

...GLP-2 circulates at low basal levels in the fasting period, and plasma levels rise rapidly after food ingestion. Renal clearance and enzymatic inactivation control the elimination of bioactive GLP-2....

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Juan P. Valderas, Oslando Padilla, Sandra Solari, Manuel Escalona, Gilberto González The Journal of Clinical Endocrinology & Metabolism 99 (2), 491-497, 2014-02-01

...Insulin and GLP-2 levels were similar during fasting in both groups....

DOI PDF 被引用文献1件

Soraya P. Shirazi-Beechey, Kristian Daly, Miran Al-Rammahi, Andrew W. Moran, David Bravo British Journal of Nutrition 111 (S1), S8-S15, 2014-01-02

...GLP-1 and GIP enhance insulin secretion; GLP-2 increases intestinal growth and glucose absorption....

DOI Web Site 被引用文献6件

Shanshan Xie, Bingrun Liu, Shoupeng Fu, Wei Wang, Yunhou Yin, Nan Li, Wei Chen, Juxiong Liu, Dianfeng Liu Cellular Physiology and Biochemistry 34 (2), 590-602, 2014

DOI Web Site 被引用文献2件

加治 建, 向井 基, 武藤 充, Sigalet David L 外科と代謝・栄養 48 (6), 241-245, 2014

DOI 医中誌 参考文献34件

東本 恭幸 外科と代謝・栄養 48 (6), 233-239, 2014

...濃度は小腸の機能的なサイズを反映するマーカーとして注目され，短腸症候群における静脈栄養離脱の指標となるのみならず，絨毛萎縮を伴う小腸疾患，抗がん剤治療や放射線治療による小腸粘膜傷害，小腸移植後の拒絶反応，新生児壊死性腸炎からの回復過程などのマーカーとして利活用されている．最近では，小児短腸症候群に対する腸管延長術のひとつである serial transverse enteroplasty の術後や，GLP...

DOI 医中誌 参考文献34件

MONIR Mohammad M., HIRAMATSU Kohzy, NISHIMURA Kei, TAKEMOTO Chihiro, WATANABE Takafumi Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 76 (4), 565-568, 2014

...These data indicate that this antigen retrieval method is able to make immunoreactive GLP-2 available for detection and that GLP-2 may act as one of the common hormones secreted by L...

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Ulrike Trautvetter, Gerhard Jahreis British Journal of Nutrition 111 (2), 287-293, 2013-07-22

...The AUC of GLP1 (total and active) and GLP2 increased significantly after the repeated CaP administrations compared with that after placebo administration....

DOI Web Site 被引用文献1件

Xuemei Shi, Fuguo Zhou, Xiaojie Li, Benny Chang, Depei Li, Yi Wang, Qingchun Tong, Yong Xu, Makoto Fukuda, Jean J. Zhao, Defa Li, Douglas G. Burrin, Lawrence Chan, Xinfu Guan Cell Metabolism 18 (1), 86-98, 2013-07

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C Y Shan, J H Yang, Y Kong, X Y Wang, M Y Zheng, Y G Xu, Y Wang, H Z Ren, B C Chang, L M Chen Journal of Endocrinology 218 (3), 255-262, 2013-06-11

...Fasting insulin, insulin resistance index, plasma LPS level, and ZO1 expression were significantly correlated with GLP2 level....

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武藤, 充, 加治, 建, 向井, 基, 中目, 和彦, 義岡, 孝子, 谷本, 昭英, 松藤, 凡 Peptides 43 160-166, 2013-05-01

Table 3, Table 2, Table 1, Figures, Main text, Title page

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Shingo Sato, Ryota Hokari, Chie Kurihara, Hirokazu Sato, Kazuyuki Narimatsu, Hideaki Hozumi, Toshihide Ueda, Masaaki Higashiyama, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura American Journal of Physiology-Gastrointestinal and Liver Physiology 304 (8), G708-G714, 2013-04-15

...Human enteroendocrine NCI-H716 cells were also used to compare the effects of various nutrients on GLP-2 secretion. GLP-2 concentrations were measured by ELISA in vivo and in vitro....

DOI Web Site 被引用文献2件

Xue Ma, Jingru Meng, Min Jia, Long Bi, Ying Zhou, Yukun Wang, Jing Hu, Gonghao He, Xiaoxing Luo Journal of Bone and Mineral Research 28 (7), 1641-1652, 2013-02-20

...Gastrointestinal hormones released after meal ingestion, such as glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide (GLP)-2, have been shown to regulate bone turnover....

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Francesco Russo, Michele Linsalata, Caterina Clemente, Benedetta D’Attoma, Antonella Orlando, Giovanna Campanella, Francesco Giotta, Giuseppe Riezzo BMC Cancer 13 (1), 56-, 2013-02-04

...Zonulin levels were not affected by chemotherapy, whereas GLP-2 and EGF levels decreased significantly....

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Sara Baldassano, Antonella Amato, Francesco Cappello, Francesca Rappa, Flavia Mulè Journal of Endocrinology 217 (1), 11-20, 2013-01-10

...In this view, the murine small intestine adaptive response to a HFD was analyzed and a possible involvement of endogenous GLP2 was verified using GLP2 (3–33) as GLP2 receptor (GLP2R) antagonist....

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Charlotte Pinholt, Sebastian J. Kapp, Jens T. Bukrinsky, Susanne Hostrup, Sven Frokjaer, Willem Norde, Lene Jorgensen International Journal of Pharmaceutics 440 (1), 63-71, 2013-01

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NISHIMURA Kei, HIRAMATSU Kohzy, MONIR Mohammad M., TAKEMOTO Chihiro, WATANABE Takafumi Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 75 (10), 1335-1339, 2013

...L-cells showing immunoreactivity for both GLP-1 and GLP-2 were distributed in the whole ileum....

DOI 機関リポジトリ HANDLE ほか3件 被引用文献10件 参考文献21件

YAMAZAKI Kazuto, KAGAYA Takaki, WATANABE Misako, TERAUCHI Hiroki, IIDA Daisuke, FUKUMOTO Hironori, SUZUKI Shuichi, ARAI Tohru, AOKI Mika, TAKASE Kazuma, SEIKI Takashi, TSUKAHARA Kappei, NAGAKAWA Junichi Biomedical Research 34 (3), 129-136, 2013

...We found that GLP-2(11-33) was the most potent orthosteric GLP-2R antagonist, with binding activity almost equal to those of GLP-2 and GLP-2(3-33) and weaker intrinsic agonistic activity than GLP-2(3-33...

DOI PubMed 医中誌 被引用文献1件 参考文献23件

Meike Körner, Ruth Rehmann, Jean Claude Reubi Molecular and Cellular Endocrinology 364 (1-2), 46-53, 2012-11

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Takuya Inoue, Joon-Ho Wang, Masaaki Higashiyama, Sergiy Rudenkyy, Kazuhide Higuchi, Paul H. Guth, Eli Engel, Jonathan D. Kaunitz, Yasutada Akiba American Journal of Physiology-Gastrointestinal and Liver Physiology 303 (7), G810-G816, 2012-10-01

...Luminal l-glutamate (l-Glu) and 5′-inosine monophosphate (IMP) synergistically increases duodenal HCO<jats:sub>3</jats:sub><jats:sup>−</jats:sup> secretion via GLP-2 release....

DOI Web Site 被引用文献6件

G.W. Moran, C. O'Neill, J.T. McLaughlin Regulatory Peptides 178 (1-3), 95-101, 2012-10

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Xinfu Guan, Xuemei Shi, Xiaojie Li, Benny Chang, Yi Wang, Depei Li, Lawrence Chan American Journal of Physiology-Endocrinology and Metabolism 303 (7), E853-E864, 2012-10-01

...Instead, our laboratory has generated a Glp2r-floxed mouse line to dissect cell-specific GLP-2 receptor GLP-2R) action in the regulation of energy balance....

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Esther Velázquez, Enrique Blázquez, Juan Miguel Ruiz-Albusac Molecular Neurobiology 46 (2), 242-250, 2012-07-18

DOI PDF Web Site ほか1件 被引用文献1件

Kristian Daly, Miran Al-Rammahi, Daleep K. Arora, Andrew W. Moran, Christopher J. Proudman, Yuzo Ninomiya, Soraya P. Shirazi-Beechey American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 303 (2), R199-R208, 2012-07-15

...GLP-2 receptor is expressed in enteric neurons, excluding the direct effect of GLP-2 on enterocytes....

DOI Web Site 被引用文献2件 参考文献45件

Hannelouise Kissow, Niels-Erik Viby, Bolette Hartmann, Jens Juul Holst, Michael Timm, Lars Thim, Steen Seier Poulsen Cancer Chemotherapy and Pharmacology 70 (1), 39-48, 2012-05-22

DOI PDF Web Site ほか1件 被引用文献1件

Sangita G. Murali, Adam S. Brinkman, Patrick Solverson, Wing Pun, John E. Pintar, Denise M. Ney American Journal of Physiology-Gastrointestinal and Liver Physiology 302 (8), G794-G804, 2012-04-15

...WT mice showed jejunal growth with either IGF-I or GLP-2 treatment....

DOI Web Site 被引用文献1件

Sara Baldassano, Anna Lisa Bellanca, Rosa Serio, Flavia Mulè Journal of Endocrinology 213 (3), 277-284, 2012-03-28

...Mice, fasted for 16 h, were injected i.p. with native GLP2 or [Gly<jats:sup>2</jats:sup>]GLP2, stable analog of GLP2, before or after GLP2 (3–33), a GLP2 receptor (GLP2R) antagonist, or exendin (9–39),...

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Seung-Jun Lee, Jennifer Lee, Karen K. Li, Dianne Holland, Heather Maughan, David S. Guttman, Bernardo Yusta, Daniel J. Drucker Endocrinology 153 (3), 1141-1151, 2012-03-01

...However, Glp2r−/− mice failed to up-regulate intestinal epithelial c-fos expression in response to acute GLP-2 administration and do not exhibit changes in small bowel conductance or small or large bowel...

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Ajay Kumar Jain, Barbara Stoll, Douglas G. Burrin, Jens J. Holst, David D. Moore American Journal of Physiology-Gastrointestinal and Liver Physiology 302 (2), G218-G224, 2012-01

...FGF19, GLP-1, and GLP-2 were decreased in plasma of the TPN group compared with the EN group but were all induced by CDCA treatment....

DOI Web Site 被引用文献1件

Yamazaki Kazuto, Takase Kazuma, Watanabe Misako, Kagaya Takaki, Terauchi Hiroki, Iida Daisuke, Fukumoto Hironori, Suzuki Shuichi, Arai Tohru, Aoki Mika, Seiki Takashi, Tsukahara Kappei, Nagakawa Junichi Biomedical Research 33 (6), 337-344, 2012

...responded to GLP-2....

DOI PubMed 医中誌 参考文献13件

HE Parker, K Wallis, CW le Roux, KY Wong, F Reimann, FM Gribble British Journal of Pharmacology 165 (2), 414-423, 2011-12-16

...<jats:p><jats:bold>BACKGROUND AND PURPOSE</jats:bold> The glucagon‐like peptides GLP‐1 and GLP‐2 are secreted from enteroendocrine L‐cells following nutrient ingestion....

DOI Web Site Web Site 被引用文献4件

Viorica Ionut, Richard N. Bergman Journal of Diabetes Science and Technology 5 (5), 1263-1282, 2011-09

...A number of gastrointestinal hormones, including glucagon-like peptide (GLP)-1, peptide YY, oxyntomodulin, GLP-2, glucose-dependent insulinotropic polypeptide, ghrelin, and others, can play roles in energy...

DOI Web Site 被引用文献2件

J. J. Holst, M. Christensen, A. Lund, J. de Heer, B. Svendsen, U. Kielgast, F. K. Knop Diabetes, Obesity and Metabolism 13 (s1), 89-94, 2011-08-08

...Gastrointestinal hormones that are secreted in response to oral glucose include glucagon‐like peptide‐1 (GLP‐1) that strongly inhibits glucagon secretion, and GLP‐2 and GIP, both of which stimulate secretion...

DOI Web Site Web Site 被引用文献8件

Katherine J. Rowland, Patricia L. Brubaker American Journal of Physiology-Gastrointestinal and Liver Physiology 301 (1), G1-G8, 2011-07

...Recent advances in clinical trials involving GLP-2 necessitate elucidation of the exact signaling pathways by which GLP-2 acts....

DOI Web Site 被引用文献3件

Asger Lund, Tina Vilsbøll, Jonatan I. Bagger, Jens J. Holst, Filip K. Knop American Journal of Physiology-Endocrinology and Metabolism 300 (6), E1038-E1046, 2011-06

...IIGI + GLP-2 infusion ( day E) resulted in a glucagon response in the midrange between the glucagon responses to OGTT and IIGI....

DOI Web Site 被引用文献3件

S. P. Shirazi-Beechey, A. W. Moran, D. J. Batchelor, K. Daly, M. Al-Rammahi Proceedings of the Nutrition Society 70 (2), 185-193, 2011-03-30

...GIP and GLP-1 increase insulin secretion, while glucagon-like peptide 2 (GLP-2) modulates intestinal growth, blood flow and expression of SGLT1....

DOI Web Site 被引用文献5件

Fiona M. Keane, Naveed A. Nadvi, Tsun‐Wen Yao, Mark D. Gorrell The FEBS Journal 278 (8), 1316-1332, 2011-03-09

...termId=MI:0194">cleaves</jats:ext-link> <jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.uniprot.org/uniprot/P01275">GLP‐2</jats:ext-link> by <jats:ext-link xmlns:xlink=...

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C.C. Taylor-Edwards, D.G. Burrin, J.J. Holst, K.R. McLeod, D.L. Harmon Journal of Dairy Science 94 (2), 888-898, 2011-02

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松山, 辰男, Tatsuo, Matsuyama, 四條畷学園大学リハビリテーション学部, Shijonawate Gakuen University, Faculty of Rehabilitation 四條畷学園大学リハビリテーション学部紀要 = Annual reports of Faculty of Rehabilitation, Shijonawate Gakuen University 7 1-12, 2011

type:総説

機関リポジトリ Web Site 医中誌

中目 和彦, 松藤 凡, 加治 建, 下野 隆一, 向井 基, 新山 新 Journal of the Japanese Society of Pediatric Surgeons 47 (4), 620-, 2011

DOI 医中誌

佐藤 伸悟, 三浦 総一郎 日本消化器病学会雑誌 108 (4), 564-574, 2011

...粘膜バリアの維持など多彩な作用で腸管機能の恒常性に寄与し，現在，短腸症候群を中心にアナログ製剤の実用化が期待されている．本稿ではGLP-2の生理作用や臨床応用の現況，今後の課題について概説する．...

DOI 医中誌 参考文献77件

Jason L. S. Leen, Angelo Izzo, Chandani Upadhyay, Katherine J. Rowland, Philip E. Dubé, Steven Gu, Scott P. Heximer, Christopher J. Rhodes, Daniel R. Storm, P. Kay Lund, Patricia L. Brubaker Endocrinology 152 (2), 436-446, 2010-12-15

...by the ISEMF cells in the intestinotropic effects of GLP-2....

DOI PDF 被引用文献1件

Grace Flock, Dianne Holland, Yutaka Seino, Daniel J. Drucker Endocrinology 152 (2), 374-383, 2010-11-10

...In contrast, AR231453 inhibits gastric emptying independent of incretin, Y2R, or Glp2 receptors through GPR119-dependent pathways....

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Niels Vrang, Philip Just Larsen Progress in Neurobiology 92 (3), 442-462, 2010-11

DOI Web Site Web Site 被引用文献4件

Giovanni Musso, Roberto Gambino, Maurizio Cassader Diabetes Care 33 (10), 2277-2284, 2010-10-01

...-2....

DOI PDF 被引用文献9件

Bernardo Nuche‐Berenguer, Sergio Portal‐Núñez, Paola Moreno, Nieves González, Alicia Acitores, Ana López‐Herradón, Pedro Esbrit, Isabel Valverde, María L. Villanueva‐Peñacarrillo Journal of Cellular Physiology 225 (2), 585-592, 2010-08-23

...GLP‐1, Ex‐9, insulin or glucagon failed to modify cellular cAMP content, while GLP‐2 and Ex‐4 increased it....

DOI Web Site Web Site 被引用文献3件

Alan L. Buchman, Seymour Katz, John C. Fang, Charles N. Bernstein, Souheil G. Abou-Assi Inflammatory Bowel Diseases 16 (6), 962-973, 2010-06

DOI 被引用文献8件

Andrew W. Moran, Miran A. Al-Rammahi, Daleep K. Arora, Daniel J. Batchelor, Erin A. Coulter, Kristian Daly, Catherine Ionescu, David Bravo, Soraya P. Shirazi-Beechey British Journal of Nutrition 104 (5), 637-646, 2010-03-26

...Furthermore, gut hormones secreted by the endocrine cells in response to dietary carbohydrates, glucagon-like peptides (GLP)-1, GLP-2 and glucose-dependent insulinotrophic peptide (GIP), are co-expressed...

DOI Web Site 被引用文献3件

K. Aaboe, F. K. Knop, T. Vilsbøll, C. F. Deacon, J. J. Holst, S. Madsbad, T. Krarup Diabetes, Obesity and Metabolism 12 (4), 323-333, 2010-02-25

...</jats:p><jats:p> <jats:bold>Conclusion:</jats:bold> The postprandial responses of total GLP‐1 and GIP and intact GLP‐2 were unaltered. PYY degradation was prevented....

DOI Web Site Web Site 被引用文献8件

Beverley A. Moore, Nancy Peffer, Allison Pirone, Ashlyn Bassiri, Sarah Sague, Jeffrey M. Palmer, Dana L. Johnson, Tom Nesspor, Connie Kliwinski, Pamela J. Hornby Journal of Pharmacology and Experimental Therapeutics 333 (2), 574-583, 2010-02-18

DOI Web Site 被引用文献2件

Yi Wang, Xinfu Guan American Journal of Physiology-Endocrinology and Metabolism 298 (2), E156-E166, 2010-02

...Since the GLP-2 receptor mRNA and protein were highly expressed in the mouse hippocampus, we further characterized that human <jats:sup>125</jats:sup>I-labeled GLP-2<jats:sub>1–33</jats:sub> specifically...

DOI Web Site 被引用文献2件

Jean‐Francois Marier, Mohamad‐Samer Mouksassi, Nathalie H. Gosselin, Martin Beliveau, Jane Cyran, John Wallens The Journal of Clinical Pharmacology 50 (1), 36-49, 2010-01

...<jats:p>Teduglutide is a GLP‐2 analog currently evaluated for the treatment of short bowel syndrome, Crohn's disease, and other gastrointestinal disorders....

DOI Web Site Web Site 被引用文献1件

加治 建, 松藤 凡, 向井 基, 川野 孝文, 松久保 眞, 右田 美里, 高松 英夫, Wallace Laurie E, Tanaka Hiroaki, Sigalet Davud L Journal of the Japanese Society of Pediatric Surgeons 46 (3), 506-, 2010

DOI 医中誌

中目 和彦, 松藤 凡, 加治 建, 向井 基, 新山 新 Journal of the Japanese Society of Pediatric Surgeons 46 (3), 413-, 2010

DOI 医中誌

Sara Baldassano, Sumei Liu, Mei-Hu Qu, Flavia Mulè, Jackie D. Wood American Journal of Physiology-Gastrointestinal and Liver Physiology 297 (4), G800-G805, 2009-10

...The GLP-2R antagonist GLP-2-(3-33) significantly reversed suppression of the EFS-evoked responses by GLP-2....

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Katharina Wallis, Julian RF Walters, Simon Gabe Current Opinion in Clinical Nutrition & Metabolic Care 12 (5), 526-532, 2009-09

DOI Web Site 被引用文献2件

Bernardo Yusta, Dianne Holland, Jacqueline A. Koehler, Marlena Maziarz, Jennifer L. Estall, Rachel Higgins, Daniel J. Drucker Gastroenterology 137 (3), 986-996, 2009-09

DOI Web Site Web Site 被引用文献1件

Esther Velázquez, Enrique Blázquez, Juan Miguel Ruiz-Albusac Molecular Neurobiology 40 (2), 183-193, 2009-08-13

DOI PDF Web Site ほか1件 被引用文献2件

V. Bucinskaite, T. Tolessa, J. Pedersen, B. Rydqvist, L. Zerihun, J. J. Holst, P. M. Hellström Neurogastroenterology & Motility 21 (9), 978-, 2009-08-05

...However, the GLP‐2 receptor was also expressed....

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Roman Iakoubov, Lina M. Lauffer, Shivangi Trivedi, Young-In J. Kim, Patricia L. Brubaker Endocrinology 150 (9), 4033-4043, 2009-06-04

...To assess the intestinotropic effects of exogenous and endogenous GLP-2, C57BL6/J mice were injected with 1μg h(Gly2)GLP-2[1-33]; 30 or 60 ng hGLP-2[3-33], a GLP-2 receptor antagonist; or PBS (4 wk, twice...

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Antonella Amato, Sara Baldassano, Rosa Serio, Flavia Mulè American Journal of Physiology-Gastrointestinal and Liver Physiology 296 (3), G678-G684, 2009-03

...This effect was virtually abolished by desensitization of GLP-2 receptors or by α-chymotrypsin....

DOI Web Site 被引用文献2件

P. D. Cani, S. Possemiers, T. Van de Wiele, Y. Guiot, A. Everard, O. Rottier, L. Geurts, D. Naslain, A. Neyrinck, D. M. Lambert, G. G. Muccioli, N. M. Delzenne Gut 58 (8), 1091-1103, 2009-02-24

DOI Web Site 被引用文献35件

Irene Hadjiyanni, Kunmin Karen Li, Daniel J. Drucker Endocrinology 150 (2), 592-599, 2009-02-01

...Treatment of NOD mice with a glucagon-like peptide 2 (GLP-2) analog, synthetic human [Gly2] glucagon-like peptide-2 (h[Gly2]GLP-2, increased the length and weight of the small bowel and significantly improved...

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Ishizuka Satoshi, Inafune Ayako, Hira Tohru, Izumi Hirohisa, Ozawa Kazuhiro, Takase Mitsunori, Hara Hiroshi Biomedical Research 30 (4), 259-261, 2009

...We investigated the effects of endogenous glucagon-like peptide-2 (GLP-2) on the development of intestinal mucosa in weanling rats....

DOI PubMed 医中誌 参考文献11件

Catherine P. A. Ivory, Laurie E. Wallace, Donna-Marie McCafferty, David L. Sigalet American Journal of Physiology-Gastrointestinal and Liver Physiology 295 (6), G1202-G1210, 2008-12

...This study shows that the anti-inflammatory effects of GLP-2 are IL-10 independent and that GLP-2 alters the mucosal response of inflamed intestinal epithelial cells and macrophages....

DOI Web Site 被引用文献1件

Xiaowen Liu, Sangita G. Murali, Jens J. Holst, Denise M. Ney American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295 (6), R1794-R1802, 2008-12

...GLP-2 is thought to act through indirect mediators, such as IGF-I....

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George L. Kellett, Edith Brot-Laroche, Oliver J. Mace, Armelle Leturque Annual Review of Nutrition 28 (1), 35-54, 2008-08-01

...-2, and stress....

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Tianru Jin Journal of Endocrinology 198 (1), 17-28, 2008-04-03

...More importantly, the major hormone generated in the pancreas (i.e. glucagon) exerts opposite effects to the ones that are produced in the intestines (i.e. glucagon-like peptide-1 (GLP-1) and GLP-2)....

DOI XML XML 被引用文献3件

David W. Nelson, Sangita G. Murali, Xiaowen Liu, Matthew C. Koopmann, Jens J. Holst, Denise M. Ney American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 294 (4), R1175-R1184, 2008-04

...levels; however, plasma GLP-2 and jejunal IGF-I mRNA were restored to fed levels....

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Rhonda D. Wideman, Scott D. Covey, Gene C. Webb, Daniel J. Drucker, Timothy J. Kieffer Diabetes 56 (11), 2744-2752, 2007-11-01

...In contrast, PC1/3-expressing α-cells increased plasma GLP-1/GLP-2 levels, improved glucose tolerance, and promoted β-cell proliferation....

DOI PDF PDF 被引用文献1件

Kristine Juul Hare, Bolette Hartmann, Hannelouise Kissow, Jens Juul Holst, Steen Seier Poulsen Clinical Cancer Research 13 (17), 5170-5175, 2007-09-01

...The same parameters were increased by GLP-2 treatment alone, and when GLP-2 was combined with the gefitinib treatment, the parameters remained unchanged....

DOI PDF 被引用文献1件

廣谷 芳彦, 池田 卓也, 池田 賢二, 山本 薫, 恩田 光子, 荒川 行生, 李 軍, 北村 和之, 黒川 信夫 薬学雑誌 127 (9), 1509-1513, 2007-09-01

...The plasma GLP-2 levels significantly increased in the STZ-treated rats, whereas HJ decreased the plasma GLP-2 levels....

DOI Web Site Web Site ほか1件 参考文献35件

Sean C. McDonagh, Jenny Lee, Angelo Izzo, Patricia L. Brubaker American Journal of Physiology-Gastrointestinal and Liver Physiology 293 (2), G461-G468, 2007-08

...<jats:p> The intestinal glucagon-like peptides GLP-1 and GLP-2 inhibit intestinal motility, whereas GLP-2 also stimulates growth of the intestinal mucosa....

DOI Web Site 被引用文献1件

Philip E. Dubé, Patricia L. Brubaker American Journal of Physiology-Endocrinology and Metabolism 293 (2), E460-E465, 2007-08

...Expression of the GLP-2R in discrete sets of intestinal cells, including endocrine cells, subepithelial myofibroblasts, and enteric neurons, has led to the hypothesis that GLP-2 acts indirectly through...

DOI Web Site 被引用文献3件

David L. Sigalet, Laurie E. Wallace, Jens J. Holst, Gary R. Martin, Tatsuru Kaji, Hiroaki Tanaka, Keith A. Sharkey American Journal of Physiology-Gastrointestinal and Liver Physiology 293 (1), G211-G221, 2007-07

...These effects were abolished with coadministration of GLP-2 and the VIP antagonist....

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David W. Nelson, James W. Sharp, Mark S. Brownfield, Helen E. Raybould, Denise M. Ney Endocrinology 148 (5), 1954-1962, 2007-05-01

...Our aims were to determine whether 1) the GLP-2 receptor (GLP-2R) is expressed on vagal afferents by localizing it to the nodose ganglia; 2) exogenous GLP-2 stimulates the vagal afferent pathway by determining...

DOI PDF 被引用文献5件

K. WALLIS, J. R. F. WALTERS, A. FORBES Alimentary Pharmacology & Therapeutics 25 (4), 365-372, 2007-01-08

...In Crohn's disease, GLP‐2 is superior to placebo in the induction of remission....

DOI Web Site Web Site 被引用文献2件

Douglas G. Burrin, Barbara Stoll, Xinfu Guan, Liwei Cui, Xiaoyan Chang, Darryl Hadsell American Journal of Physiology-Endocrinology and Metabolism 292 (1), E281-E291, 2007-01

...Before the morphological and cellular kinetic changes, GLP-2 rapidly activated putative GLP-2 receptor downstream signals within 1–4 h, including phosphorylation of protein kinase A, protein kinase B,...

DOI Web Site 被引用文献1件

P.T. Sangild, K.A. Tappenden, C. Malo, Y.M. Petersen, J. Elnif, A.L. Bartholome, R.K. Buddington Journal of Pediatric Gastroenterology and Nutrition 43 (2), 160-167, 2006-08

...:sup> · d<jats:sup>−1</jats:sup>; GLP‐2; n = 8) or were fed sow milk enterally (n = 7)....

DOI Web Site 被引用文献1件

Jennifer L. Estall, Daniel J. Drucker Annual Review of Nutrition 26 (1), 391-411, 2006-08-01

...Current research has focused on determining the physiological mechanisms contributing to the effects of GLP-2 and factors regulating its biological mechanisms of action....

DOI Web Site 被引用文献3件

Kate L. Feltrin, Michael Patterson, Mohammad A. Ghatei, Stephen R. Bloom, James H. Meyer, Michael Horowitz, Christine Feinle-Bisset Peptides 27 (7), 1638-1643, 2006-07

DOI Web Site Web Site 被引用文献2件

PATRICIA L. BRUBAKER Annals of the New York Academy of Sciences 1070 (1), 10-26, 2006-07

...<jats:p><jats:bold><jats:sc>Abstract: </jats:sc></jats:bold> <jats:bold>The glucagon‐like peptides, GLP‐1 and GLP‐2, are cosecreted by intestinal L cells in response to nutrient ingestion....

DOI Web Site Web Site 被引用文献3件

Prue M Pereira, Julie E Bines Journal of Gastroenterology and Hepatology 21 (6), 932-940, 2006-05-24

...The best‐described growth factors are reviewed: glucagon‐like peptide‐2 (GLP‐2), epidermal growth factor (EGF), and growth hormone (GH)....

DOI Web Site Web Site 被引用文献1件

J. J. Cottrell, B. Stoll, R. K. Buddington, J. E. Stephens, L. Cui, X. Chang, D. G. Burrin American Journal of Physiology-Gastrointestinal and Liver Physiology 290 (2), G293-G300, 2006-02

...These endpoints were similar in ENT and GLP-2 pigs except for a lower intestinal weight and net glucose absorption in GLP-2 compared with ENT pigs....

DOI Web Site 被引用文献1件

Xinfu Guan, Heidi E. Karpen, John Stephens, John T. Bukowski, Sanyong Niu, Guangcheng Zhang, Barbara Stoll, Milton J. Finegold, Jens J. Holst, Darry L. Hadsell, Buford L. Nichols, Douglas G. Burrin Gastroenterology 130 (1), 150-164, 2006-01

DOI Web Site Web Site 被引用文献11件

Hirotani Yoshihiko, Yamamoto Kaoru, Ikeda Kenji, Arakawa Yukio, Li Jun, Kitamura Kazuyuki, Kurokawa Nobuo, Tanaka Kazuhiko Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 29 (11), 2327-2330, 2006

...Correlations were found between plasma GLP-2 levels and mucosal weight, DNA and protein content....

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Patrice D. Cani, Audrey M. Neyrinck, Nicole Maton, Nathalie M. Delzenne Obesity Research 13 (6), 1000-1007, 2005-06

...On day 50, rats were food‐deprived 8 hours and anesthetized for blood and intestinal tissue sampling for further proglucagon mRNA, glucagon‐like peptide (GLP)‐1, and GLP‐2 quantification....

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Mark S. Geier, Danik Tenikoff, Roger Yazbeck, Geoffrey W. McCaughan, Catherine A. Abbott, Gordon S. Howarth Journal of Cellular Physiology 204 (2), 687-692, 2005-03-07

...<jats:title>Abstract</jats:title><jats:p>Glucagon‐like peptide‐2 (GLP‐2) is a potent intestinotrophic growth factor that enhances repair of damaged intestinal tissue....

DOI Web Site Web Site 被引用文献1件

G. R. Martin, L. E. Wallace, B. Hartmann, J. J. Holst, L. Demchyshyn, K. Toney, D. L. Sigalet American Journal of Physiology-Gastrointestinal and Liver Physiology 288 (3), G431-G438, 2005-03

...These features suggest GLP-2 may be important in controlling intestinal adaptation....

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Douglas G. Burrin, Barbara Stoll, Xinfu Guan, Liwei Cui, Xiaoyan Chang, Jens J. Holst Endocrinology 146 (1), 22-32, 2005-01-01

...3-kinase was unaffected by GLP-2....

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Cathrine Ørskov, Bolette Hartmann, Steen Seier Poulsen, Jesper Thulesen, Kristine Juul Hare, Jens Juul Holst Regulatory Peptides 124 (1-3), 105-112, 2005-01

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C. Booth, D. Booth, S. Williamson, L. L. Demchyshyn, C. S. Potten Cell Proliferation 37 (6), 385-400, 2004-11-17

...In BDF1 mice, subcutaneous injection of GLP‐2 or teduglutide (0.2 mg/kg/day, b.i.d.) for 14 days increased intestinal weight by 28% and resulted in comparable increases in crypt size, villus height and...

DOI Web Site Web Site 被引用文献2件

Robert A. Goodlad, Julian R.F. Walters, Alison Howard, Dianne Ford, Barry H. Hirst The Journal of Nutrition 134 (11), 2957-2964, 2004-11

DOI PDF Web Site ほか1件 被引用文献4件

Anthony P. Ramsanahie, Urs V. Berger, Michael J. Zinner, Edward E. Whang, David B. Rhoads, Stanley W. Ashley Digestive Diseases and Sciences 49 (11-12), 1731-1737, 2004-11

DOI PDF Web Site ほか1件 被引用文献1件

Lene Hansen, Sarah Lampert, Hitoshi Mineo, Jens J. Holst American Journal of Physiology-Endocrinology and Metabolism 287 (5), E939-E947, 2004-11

...In chloralose-anesthetized pigs, however, electrical stimulation of the vagal trunks at the level of the diaphragm had no effect on GLP-1 or GLP-2 and weak effects on glucose-dependent insulinotropic peptide...

DOI Web Site 被引用文献3件

Monique C. Paris, Peter J. Fuller, Bendix Carstensen, Eva Nagy, Russell G. Taylor, Magdy Sourial, Jens J. Holst, Bolette Hartmann, Julie E. Binesm Digestive Diseases and Sciences 49 (10), 1688-1695, 2004-10

DOI 被引用文献2件

David L Sigalet, Gary Martin, Jon Meddings, Bolette Hartman, Jens J Holst Pediatric Research 56 (3), 371-376, 2004-09

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Jennifer L. Estall, Bernardo Yusta, Daniel J. Drucker Molecular Biology of the Cell 15 (8), 3673-3687, 2004-08

...<jats:p>The intestinotrophic and cytoprotective actions of glucagon-like peptide-2 (GLP-2) are mediated by the GLP-2 receptor (GLP-2R), a member of the class II glucagon-secretin G protein-coupled receptor...

DOI 被引用文献1件

J Thulesen Gut 53 (8), 1145-1150, 2004-08-01

DOI Web Site 被引用文献3件

AL Bartholome, DM Albin, DH Baker, JJ Holst, KA Tappenden Journal of Parenteral and Enteral Nutrition 28 (4), 210-222, 2004-07

...The intestinotrophic mechanism(s) underlying butyrate's effects may involve GLP‐2....

DOI Web Site 被引用文献2件

J. A. Lovshin, Q. Huang, R. Seaberg, P. L. Brubaker, D. J. Drucker Endocrinology 145 (7), 3495-3506, 2004-07-01

...The bioactive form of GLP-2, GLP-2-(1–33) was detected by RIA and HPLC analysis in the fetal and adult brainstem and hypothalamus....

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Gary R. Martin, Laurie E. Wallace, David L. Sigalet American Journal of Physiology-Gastrointestinal and Liver Physiology 286 (6), G964-G972, 2004-06

...GLP-2 treatment induced increases in serum GLP-2 levels and intestinal SGLT-1 expression ( P < 0.01) compared with either TPN or enteral groups....

DOI Web Site 被引用文献6件