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木庭 茂, 中薗 健一, 斎藤 浩輝, 一原 直昭, 國島 広之, 藤谷 茂樹 The Japanese Journal of Antibiotics 77 (1), 100-106, 2024-03-25

<p>REMAP-CAP（Randomized Embedded Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia）は，COVID-19を含む市中肺炎の最適な治療管理を明らかにするためのプラットフォーム試験である。プラットフォーム試験の有用性は国際的にも今後高まることが期待され，感染症領域で本邦唯一のプ…

DOI

Azumi Hidekazu, Kubo Masayuki, Otani Atsushi, Ochi Shinichi, Kobayashi Shinya, Miyataka Yasumasa, Nakamura Fumihiko, Yagi Hideo Internal Medicine advpub (0), 2024

...Sequential use of antimicrobials, including macrolides, was introduced during intensive chemotherapy, and the patient successfully underwent allogeneic hematopoietic stem cell transplantation (AHSCT)....

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Ito Masashi, Morimoto Kozo, Saotome Mikio, Miyabayashi Akiko, Wakabayashi Keiko, Yamada Hiroyuki, Hijikata Minako, Keicho Naoto, Ohta Ken Internal Medicine advpub (0), 2024

...Despite long-term macrolide therapy, bronchiectasis exacerbations frequently occurred. PCD was suspected because of the low nasal nitric oxide level (20.7 nL/min)....

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TSUYUKI Yuzo, MAEDA Takahiro, TORII Kae, YOSHIDA Haruno, IKEDA Noriaki, YOSHIDA Saki, ITO Masahiko, GOTO Mieko, TAKAHASHI Takashi Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 86 (5), 468-473, 2024

...Resistance to tetracycline-, macrolide-, and lincosamide-classes was mainly associated with possession of <i>tet</i>(O), <i>tet</i>(S), <i>erm</i>(B), <i>linB</i>, and <i>lnuD</i> genes....

DOI PubMed

西野 由香里, 下島 優香子, 福井 理恵, 黒田 寿美代, 山崎 華恵子, 畠山 薫, 横山 敬子, 貞升 健志 食品衛生学雑誌 64 (5), 185-190, 2023-10-25

<p> <i>Campylobacter jejuni</i> および <i>Campylobacter coli</i> の分離状況と薬剤感受性を把握するために，2010 年から2019 年に東京都内で流通した食肉（鶏肉，牛肉，豚肉，鹿肉，猪肉，馬肉，羊肉）を対象として調査を行った．さらに，エリスロマイシン（EM）耐性株の耐性機序の解析を行った．<i>C. jejuni</i> …

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加藤 雄大, 松本 美咲, 杉山 裕衣, 松久保 修, 永田 悠起, 木村 有里, 田中 浩一 医学検査 72 (4), 605-613, 2023-10-25

<p><i>Streptococcus agalactiae</i>（Group B streptococcal; GBS）は高齢者や基礎疾患を有する成人の侵襲性感染症の原因菌として報告が増加しており，死亡率は8.47～11.58%程度と報告されている。中でも菌血症患者は非菌血症患者に比較して致死率が高いことが知られているが，GBS菌血症のみに着目した報告は少ないため，GBS菌血症を後方視的に解…

DOI

福井 健太, 畠山 博充, 市川 輝人, 二宮 啓彰, 大氣 大和, 松本 悠, 桑原 達, 廣田 誠, 折舘 伸彦 日本耳鼻咽喉科頭頸部外科学会会報 126 (9), 1047-1051, 2023-09-20

<p>　歯性上顎洞炎の治療方針は確立されていないが, 当院では歯科治療や低用量マクロライド療法で改善しない症例に内視鏡下鼻副鼻腔手術 (Endscopic Sinus Surgery: ESS) を施行している. 今回われわれは, ESS を必要とした歯性上顎洞炎の臨床因子の検討を行った. 当院で歯性上顎洞炎と診断した109例を対象とした. 副鼻腔 CT で, ① 上顎洞陰影あり, ② …

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砂塚 敏明 有機合成化学協会誌 81 (9), 848-856, 2023-09-01

...meroterpenoids, pyripyropenes (cholesterol lowering agents), arisugacins (acetylcholinesterase inhibitors), 2) indole alkaloids, madindolines (IL-6 modulators), and neoxaline (cell proliferation inhibitor), 3) macrolides...

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Ogata, Ryo, Kido, Takashi, Takeda, Kazuaki, Nemoto, Kazuki, Heima, Riko, Takao, Mami, Miyashita, Ritsuko, Ozasa, Mutsumi, Tokito, Takatomo, Okuno, Daisuke, Ito, Yuya, Yura, Hirokazu, Koga, Tomohiro, Hashimoto, Kunio, Takemoto, Shinnosuke, Takazono, Takahiro, Ishimoto, Hiroshi, Sakamoto, Noriho, Fukuda, Kazumasa, Sasaki, Yuka, Obase, Yasushi, Ishimatsu, Yuji, Yatera, Kazuhiro, Izumikawa, Koichi, Mukae, Hiroshi Microorganisms 11 (9), art. no. 2145-, 2023-08-24

...Genetic analysis confirmed M. genavense isolation, and macrolides were used universally....

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大橋 功, 岸 義人 MEDCHEM NEWS 33 (3), 132-135, 2023-08-01

ハリコンドリン類は、複雑かつユニークな構造を有する海洋産ポリエーテルマクロライドであり、抗がん作用を期待されたが、開発に必要な化合物量の確保が困難であった。近年、ハーバード大学が主導する全合成研究の進展を受けて、ハリコンドリン類からの創薬研究に再挑戦し、全合成を通じて医薬品候補化合物E7130を見出した。ハーバード大学とエーザイの緊密なコラボレーション、タイムリーな情報共有、総力をかけたプロセス…

DOI 医中誌

渡部 真文, 玉村 雪乃, グルゲ キールティ シリ 獣医疫学雑誌 27 (1), 6-8, 2023-07-20

...the selection pressure for antimicrobial resistance were high for tetracyclines and fluoroquinolones, whereas ecotoxicological effects to aquatic organisms were relatively higher for sulfonamides and macrolides...

DOI Web Site 参考文献5件

Wambugu, Peris, Shah, Mohammad-Monir, Nguyen, Hien-Anh, Le, Kim-Anh, Le, Huy-Hoang, Vo, Hien-Minh, Toizumi, Michiko, Bui, Minh-Xuan, Dang, Duc-Anh, Yoshida, Lay-Myint Pathogens 12 (7), art. no. 943-, 2023-07-17

...Vaccine-type pneumococcus and macrolide resistance were commonly detected among hospitalized pediatric ARI cases....

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Matsumoto Hiroyuki, Komiya Kosaku, Ichihara Shogo, Nagaoka Yuhei, Yamanaka Marimu, Nishiyama Yoshiki, Hiramatsu Kazufumi, Kadota Jun-ichi Internal Medicine 62 (14), 2043-2050, 2023-07-15

...</p><p><b>Conclusion </b>A history of cephem and macrolide use can be considered a risk factor for ESBL-producing bacteria isolation from sputum samples....

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Mihaela Ilie, Florica Marinescu, Gina Ghita, Ioana Savin, Georgeta Tudor, Lucian Luminaroiu, Petrache-Ionut Gheorghe, Georgiana Dumitrescu, Norazian Mohamed Noor IOP Conference Series: Earth and Environmental Science 1216 (1), 012009-, 2023-07-01

...In this paper, our aim was to identify, quantify and distribute macrolide antibiotics in the aquatic environment in the river basins of Arges-Vedea, Buzau-Ialomita and Dobrogea-Litoral and of the Danube...

DOI Web Site Web Site 被引用文献1件

Aoi Kimishima, Kazunari Sakai, Masako Honsho, Hidehito Matsui, Paul Wasuwanich, Yoshihiro Watanabe, Masato Iwatsuki, Toshiaki Sunazuka, Naoaki Arima, Kazutoyo Abe, Hideaki Hanaki, Yukihiro Asami The Journal of Antibiotics 76 (8), 499-501, 2023-05-19

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Osaki Megumu, Kobayashi Takehiko, Yoshida Shiomi, Shimizu Shigeki, Tsuyuguchi Kazunari Internal Medicine 62 (8), 1237-1241, 2023-04-15

...Variable number tandem repeat analyses and drug susceptibility testing revealed <i>Mycobacterium avium</i> had acquired macrolide resistance during chemotherapy with rifampicin, ethambutol, and clarithromycin...

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Juri Koizumi, Keisuke Nakase, Nobukazu Hayashi, Chikage Takeo, Hidemasa Nakaminami Microbiology Spectrum 11 (2), 2023-04-13

...Increased prevalence of macrolides-clindamycin resistant <jats:italic>C. acnes</jats:italic> relates to the acquisition of exogenous antimicrobial resistance genes....

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HATA Eiji Japan Agricultural Research Quarterly: JARQ 57 (2), 111-122, 2023-04-01

...After the 2000s, <i>M. bovis</i> strains having low susceptibility to 16-membered macrolides and tetracyclines have spread in Japan....

DOI Web Site 参考文献36件

Aoi Kimishima, Kazunari Sakai, Masako Honsho, Paul Wasuwanich, Hidehito Matsui, Yoshihiro Watanabe, Masato Iwatsuki, Toshiaki Sunazuka, Naoaki Arima, Kazutoyo Abe, Hideaki Hanaki, Yukihiro Asami The Journal of Antibiotics 76 (5), 301-303, 2023-03-24

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Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa British Journal of Cancer 128 (10), 1838-1849, 2023-03-04

...We previously reported that macrolide antibiotics including azithromycin (AZM) inhibit autophagy in various types of cancer cells in vitro....

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林 もも香, 神田 真軌, 吉川 聡一, 中島 崇行, 林 洋, 松島 陽子, 大場 由実, 小池 裕, 永野 智恵子, 大塚 健治, 笹本 剛生 食品衛生学雑誌 64 (1), 53-60, 2023-02-25

<p>食鳥肉，鶏卵および生乳中動物用医薬品の迅速一斉分析法の妥当性評価を行った．LC-MS/MSを用い，サルファ剤，抗コクシジウム剤，マクロライド系抗生物質を含む20種類の動物用医薬品を同時に分析した．試料からアセトニトリルで抽出し，硫酸マグネシウム，クエン酸三ナトリウム，塩化ナトリウムで脱水，塩析した後，定容し試験溶液とした．4種類の畜産食品試料（鶏筋肉，合鴨筋肉，鶏卵，生乳）について，10お…

DOI Web Site Web Site ほか1件 参考文献6件

篠原, 浩, Fujisawa, Takao, Chang, Bin, Ito, Yutaka, Suga, Shigeru, 松村, 康史, 山本, 正樹, 長尾, 美紀, Ohnishi, Makoto, Sugai, Motoyuki, 中野, 哲志 Antimicrobial Agents and Chemotherapy 67 (2), 2023-02-16

...88.5% of the Japanese 35B/D-CC558 and 35B/D-CC2755 isolates were found to harbor the Tn916-like integrative and conjugative elements Tn2009, Tn2010, and Tn6002, associated with multidrug resistance to macrolides...

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Hikaru Tamura, Tomoki Maekawa, Hisanori Domon, Kridtapat Sirisereephap, Toshihito Isono, Satoru Hirayama, Takumi Hiyoshi, Karin Sasagawa, Fumio Takizawa, Takeyasu Maeda, Yutaka Terao, Koichi Tabeta Pharmaceuticals 16 (2), 303-, 2023-02-15

...<jats:p>The macrolide erythromycin (ERM) inhibits excessive neutrophil accumulation and bone resorption in inflammatory tissues....

DOI Web Site 参考文献78件

Akira Aoki, Hideto Jinno, Kenji Ogawa, Taku Nakagawa, Takayuki Inagaki, Takeaki Wajima, Yoshinori Okamoto, Kei-ichi Uchiya Microbiology Spectrum 11 (1), 2023-02-14

...Previous studies have reported a correlation between drug susceptibility testing and the mutation of macrolide resistance genes. </jats:p>...

DOI Web Site 参考文献27件

Naoya Itoh, Takanori Kawabata, Nana Akazawa, Daichi Kawamura, Hiromi Murakami, Yuichi Ishibana, Eiichi N. Kodama, Norio Ohmagari PLOS ONE 18 (2), e0281518-, 2023-02-09

...Macrolide DOT showed a decreasing trend in Phases 2 and 4 and decreasing and increased levels in Phases 3 and 4, respectively; no change was observed for quinolones....

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Kazuki Nakazato, Mami Oda, Haruhiko Fuwa Bulletin of the Chemical Society of Japan 96 (3), 257-267, 2023-02-03

...<jats:title>Abstract</jats:title> <jats:p>Total synthesis of (+)-neopeltolide, a potent antiproliferative marine macrolide natural product, was accomplished in 11 steps from a commercially...

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Nahar Lutfun, Hagiya Hideharu, Nada Takahiro, Iio Koji, Gotoh Kazuyoshi, Matsushita Osamu, Otsuka Fumio Acta Medica Okayama 77 (1), 1-9, 2023-02

...Inducible resistance to the macrolide, lincosamide, and streptogramin B (iMLSB) antibiotic family is a latent mechanism for antimicrobial resistance in Staphylococcus aureus....

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小笠原 愛美, 齋藤 泰智, 中河 知里, 作田 泰宏, 髙屋 絵美梨, 高渕 優太朗, 秋田 隆司 医学検査 72 (1), 68-76, 2023-01-25

<p><i>Mycoplasma pneumoniae</i>（<i>M. pneumoniae</i>）によるマイコプラズマ肺炎は，市中肺炎の中で最も多く見られる感染症の一つで，小児の肺炎の10～20%を占める。<i>M. pneumoniae</i>の診断が遅れると，病気の悪化や治療の遷延化につながることから，<i>M. …

DOI

Didik Huswo Utomo, Masaki Kita Bulletin of the Chemical Society of Japan 96 (2), 120-126, 2023-01-13

...<jats:title>Abstract</jats:title> <jats:p>The antitumor macrolide aplyronine A (ApA) disturbs microtubule (MT) dynamics by inducing the protein–protein interaction (PPI) between actin and...

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Wataru Mimura, Daisuke Shinjo, Kensuke Shoji, Kiyohide Fushimi Antimicrobial Stewardship & Healthcare Epidemiology 3 (1), 2023

...</jats:p> </jats:sec> <jats:sec id="S2732494X23000025_as4"> <jats:title>Results:</jats:title> <jats:p>In total, 86,389 patients (19.1%) were prescribed oral antibiotics; amoxicillin, macrolides...

DOI Web Site 参考文献36件

TERASHI Yasuyo, HIRATA Yoshikazu, ASAI Tetsuo Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 85 (10), 1106-1109, 2023

...As for second-line antimicrobials for veterinary treatment, fluoroquinolones, a third-generation cephalosporins, and 15 membered-ring macrolides, accounted for 5.6%, 0.1%, and 0.9% of...

DOI Web Site PubMed 参考文献4件

Ito Masashi, Morimoto Kozo, Ohfuji Takashi, Miyabayashi Akiko, Wakabayashi Keiko, Yamada Hiroyuki, Hijikata Minako, Keicho Naoto Internal Medicine advpub (0), 2023

...Long-term macrolide therapy was remarkably effective. This is the first case report of PCD caused by a <i>FOXJ1</i> variant in Japan. </p>...

DOI Web Site 参考文献22件

浦辺 大志, 立山 香織, 梅本 真吾, 平野 隆, 鈴木 正志 日本鼻科学会会誌 62 (2), 310-316, 2023

<p>線毛機能不全症候群（primary ciliary dyskinesia: PCD）は，先天的な線毛の微細構造異常と線毛運動機能の低下によって難治性反復性の副鼻腔炎や中耳炎，気管支拡張症や肺炎といった耳鼻咽喉科・呼吸器科関連疾患を認める。PCDの鼻副鼻腔病変に対する治療法は確立していない。今回我々は，当科で経験したPCD …

DOI Web Site 医中誌 参考文献10件

Kimishima Aoi, Matsui Hidehito, Sakai Kazunari, Honsho Masako, Honma Sota, Sugamata Miho, Kondo Naozumi, Maruyama Serino, Wasuwanich Paul, Naher Kamrun, Arima Naoaki, Abe Kazutoyo, Hanaki Hideaki, Asami Yukihiro BPB Reports 6 (4), 141-143, 2023

<p>Semi-synthetic antibiotic, azithromycin (AZM) does not show significant bactericidal activity against <i>Pseudomonas aeruginosa</i> (<i>P. aeruginosa</i>). We focused on potential for AZM as a …

DOI Web Site 参考文献27件

Mori, Mayako, Kido, Takashi, Sakamoto, Noriho, Ozasa, Mutsumi, Kido, Kumiko, Noguchi, Yasuko, Tokito, Takatomo, Okuno, Daisuke, Yura, Hirokazu, Hara, Atsuko, Ishimoto, Hiroshi, Suematsu, Takashi, Obase, Yasushi, Tanaka, Yoshimasa, Izumikawa, Koichi, Takeuchi, Kazuhiko, Mukae, Hiroshi Journal of Clinical Medicine 12 (1), 317-, 2022-12-31

...A 39-year-old Japanese woman with sinusitis and bronchiectasis without situs inversus had had upper and lower respiratory symptoms since childhood and had received long-term macrolide therapy without an...

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Mayako Mori, Takashi Kido, Noriho Sakamoto, Mutsumi Ozasa, Kumiko Kido, Yasuko Noguchi, Takatomo Tokito, Daisuke Okuno, Hirokazu Yura, Atsuko Hara, Hiroshi Ishimoto, Takashi Suematsu, Yasushi Obase, Yoshimasa Tanaka, Koichi Izumikawa, Kazuhiko Takeuchi, Hiroshi Mukae Journal of Clinical Medicine 12 (1), 317-, 2022-12-31

...A 39-year-old Japanese woman with sinusitis and bronchiectasis without situs inversus had had upper and lower respiratory symptoms since childhood and had received long-term macrolide therapy without an...

DOI Web Site 参考文献19件

Inga Baranauskaite-Fedorova, Jolanta Dvarioniene Water 15 (1), 10-, 2022-12-21

...<jats:p>Of all the antibiotics used today for human treatment in the world, macrolide antibiotics—erythromycin, clarithromycin and azithromycin—stand out the most for misuse, and they were included as...

DOI Web Site 被引用文献1件

荒井, 梨沙, 窪田, 祥平, 早野, 聡子, 粟生, 耕太 横浜医学 73 (4), 547-551, 2022-12-20

症例は13歳男児．喘鳴ならびに労作時の呼吸困難に対して，近医でサルメテロール/ フルチカゾンプロピオン酸エステル配合剤（SFC）を導入されるも改善せず，当院に紹介となった．ステロイド薬の全身投与ならびにサルブタモール吸入を施行したが喘鳴，呼吸困難は残存したため，CT検査を施行したところ，副鼻腔の液体貯留，右下葉に小葉中心性の粒状影ならびに気管支壁のびまん性肥厚を認めた．びまん性汎細気管支炎（DP…

機関リポジトリ 医中誌

Niwa Hideo, Tanaka Shigeo, Komiya Masamichi, Makiyama Yasuhide ＩＪＯＭＳ 21 (1-2), 8-13, 2022-12-13

DOI Web Site 医中誌 参考文献23件

Shiyang Lu, Tao Zhou, Keisuke Fukaya, Enjuro Harunari, Naoya Oku, Daisuke Urabe, Yasuhiro Igarashi Journal of Natural Products 85 (12), 2796-2803, 2022-12-09

DOI Web Site 参考文献33件

Tomohiro Oishi, Daisuke Yoshioka, Takashi Nakano, Kazunobu Ouchi Microorganisms 10 (12), 2428-, 2022-12-08

...Our observation of 122 M. pneumoniae strains suggested that 76 were macrolide-susceptible M. pneumoniae (MSMP) and 46 were macrolide-resistant....

DOI Web Site 参考文献21件

Ishimoto Hiroshi, Sakamoto Noriho, Hara Atsuko, Kido Takashi, Yamaguchi Hiroyuki, Yamamoto Kazuko, Obase Yasushi, Ishimatsu Yuji, Mukae Hiroshi Internal Medicine 61 (23), 3559-3562, 2022-12-01

...Confirming the presence of HLA-B54 antigen may help determine the indication for long-term macrolide therapy in interstitial pneumonia patients. </p>...

DOI Web Site PubMed ほか1件 参考文献13件

Ui Okada, Satoshi Murakami Microbiology 168 (11), 2022-11-30

...One of the original type VII ABC transporters, which possesses all characteristic features of this class, is the macrolide efflux transporter MacB....

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Keisuke Murata, Hirotoshi Mori, Haruhiko Fuwa Bulletin of the Chemical Society of Japan 95 (12), 1775-1785, 2022-11-26

...<jats:title>Abstract</jats:title> <jats:p>The stereochemical assignment of marine macrolide natural products by quantum chemical calculations is often hampered by the generation of an intractable...

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Rui Guo, Gang Li, Zhao Zhang, Xiaoping Peng Marine Drugs 20 (11), 701-, 2022-11-09

...Marine-derived SMs, especially terpenoids, polyketides, and macrolides compounds, occupy a significant proportion of natural products from T. harzianum, deserving more of our attention.</jats:p>...

DOI Web Site 被引用文献1件

El-Desoky Ahmed H. H., Hitora Yuki, Onodera Keita, Ise Yuji, Losung Fitje, Mangindaan Remy E. P., Tsukamoto Sachiko ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 70 (11), 818-822, 2022-11-01

...The sponge extract exhibited cytotoxicity and the bioassay-guided isolation afforded a dimeric dilactone macrolide, swinholide A, as the cytotoxic compound.</p>...

DOI 機関リポジトリ HANDLE ほか2件 参考文献13件

Timm O Koller, Kathryn J Turnbull, Karolis Vaitkevicius, Caillan Crowe-McAuliffe, Mohammad Roghanian, Ondřej Bulvas, Jose A Nakamoto, Tatsuaki Kurata, Christina Julius, Gemma C Atkinson, Jörgen Johansson, Vasili Hauryliuk, Daniel N Wilson Nucleic Acids Research 50 (19), 11285-11300, 2022-10-27

...Unlike HflX, HflXr confers resistance to macrolide and lincosamide antibiotics by an experimentally unexplored mechanism....

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Kentaro Koide, Takahiro Yamaguchi, Chihiro Katsukawa, Nao Otsuka, Tsuyoshi Kenri, Kazunari Kamachi Microbiology Resource Announcements 11 (10), 2022-10-20

...<jats:p> We report the complete genome sequence of macrolide-resistant <jats:named-content content-type="genus-species">Bordetella pertussis</jats:named-content> BP616...

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今井 彩香, 中島 隆博, 月舘 利治, 石井 正則 耳鼻咽喉科展望 65 (5), 207-215, 2022-10-15

<p>マイコプラズマ感染症は，<i>Mycoplasma pneumoniae</i>による肺炎を主体とした感染症であるが，呼吸器感染症以外にも中枢神経系，血液造血器系，循環器系，消化器系，皮膚関節，筋肉などに臓器病変を起こし，多彩な臨床症状を引き起こすことが知られている。耳鼻咽喉科領域では急性咽喉頭炎や急性中耳炎などを来す。マイコプラズマ肺炎に合併した急性上咽頭炎では咽頭扁桃がいちご状に腫大す…

DOI 医中誌

Tatsuya Yagi, Buster Mannheimer, Johan Reutfors, Johan Ursing, Diego Hernan Giunta, Helle Kieler, Marie Linder British Journal of Clinical Pharmacology 89 (2), 887-897, 2022-10-09

...Codispensation of macrolides in patients on DOACs was not associated with an increased risk of bleeding....

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Prasanga Madhushani Kumarage, Liyana Arachchilage Dinithi Sandunika De Silva, Gang-Joon Heo Journal of Applied Microbiology 133 (4), 2267-2279, 2022-10-01

...Most of the Vibrio spp. possess resistance towards the commonly used antimicrobials, including β-lactams, aminoglycosides, tetracyclines, sulphonamides, quinolones and macrolides....

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Joon Kee Lee, Youn Young Choi, Young Joo Sohn, Kyung-Min Kim, Ye Kyung Kim, Mi Seon Han, Ji Young Park, Eun Young Cho, Jae Hong Choi, Eun Hwa Choi Journal of Microbiology, Immunology and Infection 55 (5), 910-916, 2022-10

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西田 憲晃, 鹿村 悠子, 礒脇 明治 Ｄｒｕｇ　Ｄｅｌｉｖｅｒｙ　Ｓｙｓｔｅｍ 37 (4), 349-353, 2022-09-25

アジマイシン^Ⓡ点眼液1％は、アジスロマイシン水和物を有効成分とした日本で唯一のマクロライド系抗生物質点眼液である。アジスロマイシンは良好な組織移行性を示し、酸性pHで安定な特徴をもつ薬物である。また、アジマイシン^Ⓡ点眼液1％の製剤技術には、ポリカルボフィル等を配合した眼科用Drug Delivery …

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Farah Al-Marzooq, Akela Ghazawi, Saeed Tariq, Lana Daoud, Timothy Collyns Frontiers in Microbiology 13 2022-09-21

...The combinations worked efficiently in strains carrying <jats:italic>mphA</jats:italic> gene encoding macrolide phosphotransferase which can cause macrolide inactivation....

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ナカザト, カズキ 大学院研究年報 理工学研究科編 52 2022-09-01

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Rambabu N. Reddi, Arumugam Sudalai, Changbum Jo Bulletin of the Korean Chemical Society 43 (10), 1169-1172, 2022-08-18

...<jats:title>Abstract</jats:title><jats:p>This article describes a concise synthesis of two important fragments (tetrahydropyran [THP] and ketone moieties) of the cytotoxic macrolide (+)‐neopeltolide in...

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Inoue Kenji, Kobayashi Seiichi, Sato Keigo, Kanno Hitoshi, Kantou Rina, Naganuma Yuka, Kawamura Naomi, Oike Yasunori, Kobayashi Michio, Yanai Masaru, Suzuki Akira, Kurai Hanako, Miyairi Isao, Kutsuna Satoshi, Gu Yoshiaki Japanese Journal of Infectious Diseases 75 (4), 347-354, 2022-07-31

...The delivery of oral antimicrobial agents across the region in 2020 was 28.7% lower than that in 2013, with delivery of cephalosporins, quinolones, and macrolides decreasing by 34.8%, 46.8%, and 56.0%,...

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鈴木 崇真, 丸岡 真治, 北川 大輔, 古森 円香, 新谷 祐衣, 枡尾 和江, 矢野 寿一, 中村 文彦 医学検査 71 (3), 554-559, 2022-07-25

<p><i>Moraxella nonliquefaciens</i>はヒトの上気道に常在するグラム陰性桿菌で，小児の気管支炎や副鼻腔炎の原因となることが知られているが，角膜材料からの検出例は少ない。今回，<i>M. nonliquefaciens</i>による角膜潰瘍の1例を経験したので報告する。患者は70歳代男性。左眼痛のため受診し，左眼角膜輪部の菲薄化を認め，感染性角膜潰瘍，前房蓄膿，眼内…

DOI Web Site 医中誌

Beata Mlynarczyk-Bonikowska, Cezary Kowalewski, Aneta Krolak-Ulinska, Wojciech Marusza International Journal of Molecular Sciences 23 (15), 8088-, 2022-07-22

...ceftaroline. (3) Resistance to glycopeptides (VRSA, VISA, hVISA strains, vancomycin tolerance). (4) Resistance to oxazolidinones (mutational and enzymatic resistance to linezolid). (5) Resistance to MLS-B (macrolides...

DOI Web Site 被引用文献1件

水戸部 森歌, 三宅 啓文, 高野 弘紀, 久保田 寛顕, 小林 甲斐, 髙野 操, 安藤 尚克, 水島 大輔, 横山 敬子, 貞升 健志 日本性感染症学会誌 32 (1), 39-46, 2022-07-20

東京都内で伝播しているMycoplasma genitaliumのマクロライド耐性、キノロン耐性遺伝子変異の保有状況を把握するため、2019年1月～2020年3月に都内のMSM （men who have sex with men）より得られた54の臨床検体を用いて、23S rRNA遺伝子、gyrAおよびparCにおける一塩基置換の検出を試みた。3領域全てのシークエンスデータが得られた47検体の…

DOI 医中誌

Urszula Łapińska, Margaritis Voliotis, Ka Kiu Lee, Adrian Campey, M Rhia L Stone, Brandon Tuck, Wanida Phetsang, Bing Zhang, Krasimira Tsaneva-Atanasova, Mark AT Blaskovich, Stefano Pagliara eLife 11 2022-06-07

...Crucially, we found that fast growing phenotypic variants avoid macrolide accumulation and survive treatment without genetic mutations....

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Satoru Suzuki, Aya Kadoya, Nagi Masuda, Yuta Sugimoto, Hideshige Takada, Kaoruko Mizukawa, Ayaka Takei, Hsin-Yiu Chou, Jer-Horng Wu Journal of Global Antimicrobial Resistance 29 360-370, 2022-06

DOI Web Site Web Site 参考文献42件

Shuqi Li, Nicholas C. Poulton, Jesseon S. Chang, Zachary A. Azadian, Michael A. DeJesus, Nadine Ruecker, Matthew D. Zimmerman, Kathryn A. Eckartt, Barbara Bosch, Curtis A. Engelhart, Daniel F. Sullivan, Martin Gengenbacher, Véronique A. Dartois, Dirk Schnappinger, Jeremy M. Rock Nature Microbiology 7 (6), 766-779, 2022-05-30

...found that the intrinsic resistance factor <jats:italic>whiB7</jats:italic> was inactivated in an entire Mtb sublineage endemic to Southeast Asia, presenting an opportunity to potentially repurpose the macrolide...

DOI PDF Web Site 被引用文献2件

Juri Koizumi, Keisuke Nakase, Hidemasa Nakaminami Microbiology Resource Announcements 11 (5), 2022-05-19

...Macrolide-clindamycin-resistant <jats:named-content content-type="genus-species">C. acnes</jats:named-content> strains have been reported worldwide....

DOI Web Site 被引用文献1件 参考文献14件

Yuichi Muraki, Masayuki Maeda, Ryo Inose, Koki Yoshimura, Naoki Onizuka, Masao Takahashi, Eiji Kawakami, Yoshiaki Shikamura, Naotaka Son, Makoto Iwashita, Manabu Suzuki, Masayuki Yokoi, Hirokazu Horikoshi, Yasuaki Aoki, Michiyo Kawana, Miwako Kamei, Hajime Hashiba, Choichiro Miyazaki Antibiotics 11 (5), 682-, 2022-05-18

...Use of third-generation cephalosporins, quinolones, and macrolides in pharmacies that received prescriptions primarily from hospitals or clinics decreased from January 2019 to January 2021....

DOI Web Site 被引用文献1件

Philip L. Mar, Piotr Horbal, Mina K. Chung, Jonathan W. Dukes, Michael Ezekowitz, Dhanunjaya Lakkireddy, Gregory Y.H. Lip, Mike Miletello, Peter A. Noseworthy, James A. Reiffel, James E. Tisdale, Brian Olshansky, Rakesh Gopinathannair Circulation: Arrhythmia and Electrophysiology 15 (5), 2022-05

...QT prolongation is an important pharmacodynamic interaction involving mainly Vaughan-Williams class III AAD as many commonly used drug classes, such as macrolide antibiotics, fluoroquinolone antibiotics...

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及川 加奈, 舟橋 恵二, 宮澤 翔吾, 魚住 佑樹, 堀井 洋利, 河内 誠, 西村 直子, 尾崎 隆男 医学検査 71 (2), 193-200, 2022-04-25

<p>2018年5月～2019年4月の1年間に当院小児科において175例（1か月～14歳，中央値4歳10か月）から<i>Streptococcus pyogenes</i> 175株が分離された。分離された<i>S. pyogenes</i>のT血清型，13種抗菌薬（PCG, CDTR, CTX, CTRX, CFPM, MEPM, EM, CAM, AZM, CLDM, TFLX, …

DOI Web Site 医中誌

Mitsunori Yoshida, Hanako Fukano, Masato Suzuki, Yoshihiko Hoshino Microbiology Resource Announcements 11 (4), 2022-04-21

<jats:p> <jats:named-content content-type="genus-species">Mycobacterium fortuitum</jats:named-content> subsp. <jats:italic>fortuitum</jats:italic> is …

DOI Web Site 参考文献15件

Martijn Zwama, Kunihiko Nishino Antimicrobial Agents and Chemotherapy 66 (4), 2022-04-19

...enterica</jats:named-content> spp.) in the <jats:named-content content-type="genus-species">Escherichia coli</jats:named-content> efflux pump AcrB dramatically increase macrolide...

DOI Web Site 参考文献37件

Ichiro Tatsuno, Masanori Isaka, Tadao Hasegawa Microbiology and Immunology 66 (6), 299-306, 2022-04-06

...<jats:title>Abstract</jats:title><jats:p>The <jats:italic>mef</jats:italic>(A)‐ and its subclass <jats:italic>mef</jats:italic>(E) systems had long been considered to constitute one of the primary macrolide‐resistant...

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Takeshi Yamada, Kanoko Yoshida, Takashi Kikuchi, Tomoya Hirano Marine Drugs 20 (4), 226-, 2022-03-25

<jats:p>Two new cytotoxic metabolites, halosmysins B and C, have been isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4 separated from the marine alga Sargassum thunbergii. These chemical …

DOI Web Site 参考文献22件

Tomohiro Oishi, Kazunobu Ouchi Journal of Clinical Medicine 11 (7), 1782-, 2022-03-24

...This affects the treatment of MP infection; that is, some patients with MRMP infections fever cannot be controlled despite macrolide therapy....

DOI Web Site 参考文献51件

Ahmet Furkan Kurt, Bilgul Mete, Fatouma Moustapha Houssein, Yesim Tok, Mert Ahmet Kuskucu, Ebru Yucebag, Seval Urkmez, Fehmi Tabak, Gokhan Aygun Acta Microbiologica et Immunologica Hungarica 2022-03-21

...<jats:sub>MUS-1</jats:sub>, <jats:italic>bla</jats:italic> <jats:sub>EBR-1</jats:sub>), tetracyclines (<jats:italic>tetX</jats:italic>), sulfonamides (<jats:italic>sul2</jats:italic>), macrolides...

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Angela I. Bordin, Laura Huber, Macarena G. Sanz, Noah D. Cohen Equine Veterinary Journal 54 (3), 481-494, 2022-03-21

...A macrolide antimicrobial in combination with rifampin remains the recommended treatment for foals with <jats:italic>R. equi</jats:italic> pneumonia....

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Sheeba Santhini Manoharan-Basil, Natalia González, Jolein Gyonne Elise Laumen, Chris Kenyon Frontiers in Microbiology 13 793612-, 2022-03-17

...jats:italic>Neisseria</jats:italic> act as a reservoir of resistance genes, and horizontal gene transfer (HGT) has been shown to play an important role in the genesis of resistance to cephalosporins and macrolides...

DOI Web Site 被引用文献1件

Louise Hendrikx, Colette L M van Hees, Jurriaan E M de Steenwinkel, Hannelore I Bax, Tom Sprong, Bert Mulder, Arjan Jansz, Arjanne van Griethuysen, Ron Bosboom, Annette Stemerding, Marjolein Koetsier, Marco van Coevorden, Bas C Mourik, Koen D Quint, Alewijn Ott, Dick van Soolingen, Saskia Kuipers, Reinout van Crevel, Jakko van Ingen Open Forum Infectious Diseases 9 (4), 2022-03-16

...Two-drug regimens of ethambutol and a macrolide are effective for moderately severe infections....

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Daichi Mizukami, Kei Iio, Mami Oda, Yu Onodera, Haruhiko Fuwa Angewandte Chemie International Edition 61 (22), e202202549-, 2022-03-16

...A 13‐step synthesis of (−)‐exiguolide, an anticancer marine macrolide, showcased the feasibility of our tandem reaction sequence for macrolactone synthesis and also demonstrated the power of transannular...

DOI Web Site Web Site 被引用文献4件

篠原, 浩, Furubayashi, Keiichi, Kojima, Yoko, Mori, Haruyo, Komano, Jun, Kawahata, Takuya Journal of Infection and Chemotherapy 28 (3), 444-450, 2022-03

...Most of the isolated strains had the A2058G mutation in 23S rDNA, which is responsible for resistance to macrolides....

HANDLE 医中誌

Giorelli Maurizio, Altomare Sergio, Aniello Maria Stella, Leone Ruggiero, Liuzzi Daniele, Plasmati Immacolata, Sardaro Michele, Superbo Maria, Mennea Giuseppe, Fioretto Nicola, Guglielmi Giuseppe, Balzano Rosario, Scarabino Tommaso, Cuccorese Giuseppe, Cialdella Francesca, Campobasso Giuseppe, Barbara Michele Intractable & Rare Diseases Research 11 (1), 37-39, 2022-02-28

...Currently, precise management protocols of LS with CVT complication do not exist although a combination of macrolides and second or third-generation cephalosporins, as well as anti-coagulants represent...

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Emily E. Ricotta, D. Rebecca Prevots, Kenneth N. Olivier ERJ Open Research 8 (2), 00724-2021, 2022-02-24

...modulator usage (any and monotherapy <jats:italic>versus</jats:italic> combination therapy) and NTM sputum culture positivity, controlling for sex, least severe class of CFTR mutation, receipt of chronic macrolides...

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Sung-Hsin Kuo, Kun-Huei Yeh, Chung-Wu Lin, Jyh-Ming Liou, Ming-Shiang Wu, Li-Tzong Chen, Ann-Lii Cheng Cancers 14 (4), 1005-, 2022-02-16

...For antibiotic-unresponsive HP-negative MALT lymphoma, high-dose macrolides and immunomodulatory drugs, such as thalidomide and lenalidomide, have reported sporadic success....

DOI Web Site 被引用文献1件

Takeyoshi Eda, Masayasu Okada, Ryosuke Ogura, Yoshihiro Tsukamoto, Yu Kanemaru, Jun Watanabe, Jotaro On, Hiroshi Aoki, Makoto Oishi, Nobuyuki Takei, Yukihiko Fujii, Manabu Natsumeda Cancers 14 (3), 770-, 2022-02-02

...We assessed the effects of the candidate macrolide on the mTOR pathway through Western blotting. CLD attenuated p70S6K phosphorylation in a dose-dependent manner....

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Juansheng Zhang, Diqiang Zhang, Xiaoqiang Wang, Xiaoguang Wei, Hao Li Journal of International Medical Research 50 (2), 030006052210787-, 2022-02

...between macrolide-resistance and genotypes....

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Alexandrova Alexandra Sashova, Pencheva Daniela Rosenova, Mitov Ivan Gergov, Setchanova Lena Petrova Japanese Journal of Infectious Diseases 75 (1), 92-95, 2022-01-31

...The dual macrolide resistance mechanism was predominant. The most common serotypes were non-PCV10 serotypes 3 (27.1%, <i>n</i> = 13), 19A (25.0%, <i>n</i> = 12), and VT 19F (23.0%, <i>n</i> = 11)....

DOI Web Site Web Site ほか2件 参考文献14件

宮澤 翔吾, 後藤 研誠, 河内 誠, 及川 加奈, 魚住 佑樹, 舟橋 恵二, 西村 直子, 尾崎 隆男 医学検査 71 (1), 101-105, 2022-01-25

<p><i>Mycoplasma pneumoniae</i>（Mp）DNAとそのマクロライド耐性化遺伝子変異を同時かつ迅速に検出できる遺伝子検査法のスマートジーン^® Myco（スマートジーン）について，小児Mp肺炎における有用性を検討した。2019年4月からの1年間に，当院小児科に肺炎で入院した146例（7か月～14歳7か月）から咽頭ぬぐい液を採取し，スマートジーンとlo…

DOI

Johannes Büchler, Sumire Honda Malca, David Patsch, Moritz Voss, Nicholas J. Turner, Uwe T. Bornscheuer, Oliver Allemann, Camille Le Chapelain, Alexandre Lumbroso, Olivier Loiseleur, Rebecca Buller Nature Communications 13 (1), 2022-01-18

...While the wild type enzyme WelO5* does not accept the macrolide substrates, our engineering strategy leads to active halogenase variants and improves upon their apparent<jats:italic>k</jats:italic><jats...

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東郷 威男, 渥實 潤, 下田 清美, 平松 美也子, 白石 裕治 日本呼吸器外科学会雑誌 36 (1), 7-15, 2022-01-15

<p>マクロライド耐性の肺<i>Mycobacterium avium</i> complex症（肺MAC症）は治療に難渋する．当院ではクラリスロマイシン（CAM）耐性肺MAC症症例に対して外科治療を行ってきた．2014年1月～2019年12月にCAM耐性肺MAC症に対して肺切除を行った14例を対象に検討した．CAM耐性判明から手術までの期間の中央値は5.0ヵ月であった．全例で周術期にアミノグリ…

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Willi Quino, Junior Caro-Castro, Verónica Hurtado, Diana Flores-León, Narjol Gonzalez-Escalona, Ronnie G. Gavilan Frontiers in Microbiology 12 2022-01-11

...Genetic markers associated with resistance to quinolones, tetracycline (<jats:italic>tetO, tetW/N/W</jats:italic>), beta-lactamases (<jats:italic>bla<jats:sub>oxa–61</jats:sub></jats:italic>), macrolides...

DOI Web Site 被引用文献1件

Jun Suzuki, Yusuke Sasabuchi, Shuji Hatakeyama, Hiroki Matsui, Teppei Sasahara, Yuji Morisawa, Toshiyuki Yamada, Kiyohide Fushimi, Hideo Yasunaga Pneumonia 14 (1), 2022-01-10

...Although previous studies have suggested that macrolide therapy is beneficial for ARDS, its benefit for severe CAP-associated ARDS remains uncertain....

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幾田, 慧子, 中川, 俊作, 山脇, 千波, 糸原, 光太郎, 平, 大樹, 今井, 哲司, 米澤, 淳, 中川, 貴之, 櫻木, 実, 佐藤, 憲明, 内野, 詠一郎, 柳田, 素子, 寺田, 智祐 BMC Nephrology 23 2022

...We also evaluated the effect of concomitant use of PPIs and macrolide antibiotics on the risk of AKI....

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Kenichi Takeshita, Noriko Takeuchi, Misako Ohkusu, Haruka Hishiki, Yuki Shiko, Yohei Kawasaki, Bin Chang, Naruhiko Ishiwada Epidemiology and Infection 150 2022

...We also conducted a bacterial analysis, and the isolates of serotype 24-IPD had tendencies of PCG-susceptible (24: 100.0%, non-24: 61.3%; <jats:italic>P</jats:italic> < 0.0001) and macrolide-resistance...

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Haruhiko Fuwa HETEROCYCLES 104 (10), 1709-, 2022

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Yuichi Kama, Yoshiyuki Yamada, Takashi Koike, Kazuo Suzuki, Mayumi Enseki, Kota Hirai, Hiroyuki Mochizuki, Masahiko Kato International Archives of Allergy and Immunology 183 (6), 617-627, 2022

...<b><i>Results:</i></b> Antibiotics were used in 50.5% patients with acute asthma exacerbation and included cephalosporin, penicillin, macrolide, and others....

DOI Web Site

Takayuki Ohyoshi, Atsuhiro Takano, Imari Kikuchi, Tomotaka Ogura, Mayu Namiki, Yuto Miyazaki, Takahiro Hirano, Shota Konishi, Yuta Ebihara, Koichi Takeno, Ichiro Hayakawa, Hideo Kigoshi Organic & Biomolecular Chemistry 20 (14), 2922-2938, 2022

<jats:p>Aplyronine A–swinholide A hybrid, a simplified analog of aplyronine A, was designed and synthesized for structure–activity relationship studies.</jats:p>

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大氣 大和, 畠山 博充, 二宮 啓彰, 福井 健太, 松本 悠, 桑原 達, 佐藤 要, 磯野 泰大, 丹羽 一友, 折舘 伸彦 日本鼻科学会会誌 61 (2), 262-267, 2022

<p>放線菌症は嫌気性のグラム陽性桿菌である<i>Actinomyces</i>属によって引き起こされる疾患である。放線菌症は頭頸部に好発するが，副鼻腔における放線菌症は比較的稀である。我々が渉猟しえた範囲で国内の報告例18例全例が外科的処置を併用し治療していた。今回我々は抗菌薬治療のみで治癒しえた副鼻腔放線菌症例を経験したため報告する。</p><p>症例は77歳男性。前立腺癌の経過観察目的に撮…

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吉住 太地, 西村 和彦, 中川 博史 日本毒性学会学術年会 49.1 (0), P-198-, 2022

<p>【目的】近年、腸管モデル細胞のCaco-2細胞に直径0.1 ㎛程度のポリスチレン粒子（PS-NPs）が取り込まれ、その一部がリソソームに蓄積することが報告された。環境中での増加が問題とされ、経口的に摂取する可能性があるマイクロプラスチックが細胞の生存調節機構に影響を与えることが予想されている。一方、マクロライド系の抗生物質のAzithromycin（AZM）は、高用量でリソソームに過剰に蓄…

DOI

OKAMOTO Mariko, FURUYA Hirotaka, SUGIMOTO Ikuko, TAKAMATSU Daisuke Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 84 (11), 1453-1456, 2022

...Honey contains macrolide-resistant bacteria that are a potential source of genes that may confer tylosin resistance to <i>P. larvae</i>....

DOI Web Site PubMed 参考文献9件

石川 奈緒, 小林 大晟, 加藤 輔, 野村 咲希, 伊藤 朋子, 岩渕 勝己, 高橋 律久, 笹本 誠, 伊藤 歩 土木学会論文集Ｇ（環境） 78 (7), III_297-III_306, 2022

<p>　下水処理水から検出された5種類の抗菌剤（ロキシスロマイシン(ROX), クラリスロマイシン(CLR), レボフロキサシン/オフロキサシン(LEV), スルファメトキサゾール(SMZ), スルファピリジン(SPD)）について，ゼオライトを用いた抗菌剤の除去処理を検討した．各抗菌剤溶液を1時間処理した場合の除去率はROX, …

DOI Web Site 参考文献26件

清瀬 ますみ, 北井 美穂, 矢野 紘子, 山口 聡 産婦人科の進歩 74 (3), 433-439, 2022

<p>術後のMycoplasma hominis感染症は産婦人科領域での報告が散見される．Mycoplasma hominisはゲノムサイズが最も小さい原核生物で，細胞壁をもたないため，グラム染色で同定することはできず，細胞壁合成阻害薬である<i>β</i>-ラクタム系抗菌薬に耐性を示す．術後感染症の予防のため，術前後にセフェム系抗菌薬を用いることが多いが，Mycoplasma …

DOI Web Site 医中誌

Tetsuya Tsuchida, Satomi Yoshida, Masato Takeuchi, Koji Kawakami Acta Paediatrica 111 (3), 607-613, 2021-12-27

...Other risk factors for AD were macrolides, aminoglycosides, food allergies and histamine H1 receptor antagonists....

DOI Web Site Web Site 被引用文献1件

Sho Nishimura, Kazune Nakamura, Miyako Yamamoto, Daichi Morita, Teruo Kuroda, Takanori Kumagai Microorganisms 10 (1), 37-, 2021-12-26

...Based on HR-ESI-MS spectrometry and a PubChem database search, the compound was predicted to be lucensomycin, which is a tetraene macrolide antibiotic, and this prediction was supported by the results...

DOI Web Site 参考文献27件

Abe, Mizuki, Murakami, Keiji, Hiroshima, Yuka, Amoh, Takashi, Sebe, Mayu, Kataoka, Keiko, Fujii, Hideki Antibiotics 11 (1), 10-, 2021-12-22

...macrolides....

機関リポジトリ

Mizuki Abe, Keiji Murakami, Yuka Hiroshima, Takashi Amoh, Mayu Sebe, Keiko Kataoka, Hideki Fujii Antibiotics 11 (1), 10-, 2021-12-22

...macrolides....

DOI Web Site 被引用文献1件 参考文献29件

Martijn Zwama, Kunihiko Nishino 2021-12-19

...We found that AcrB-Ec harboring Arg717 substitutions were significantly more effective in exporting all tested macrolides, with an up to 8-fold increase in the minimum inhibitory concentration (MIC) values...

DOI Web Site 参考文献36件

Takeshi Akiyoshi, Rina Naitou, Ayuko Imaoka, Mitsue Miyazaki, F. Peter Guengerich, Katsunori Nakamura, Koujiro Yamamoto, Hisakazu Ohtani Int. Journal of Clinical Pharmacology and Therapeutics 59 (12), 745-752, 2021-12-01

DOI

Mathew A. Beale, Michael Marks, Michelle J. Cole, Min-Kuang Lee, Rachel Pitt, Christopher Ruis, Eszter Balla, Tania Crucitti, Michael Ewens, Candela Fernández-Naval, Anna Grankvist, Malcolm Guiver, Chris R. Kenyon, Rafil Khairullin, Ranmini Kularatne, Maider Arando, Barbara J. Molini, Andrey Obukhov, Emma E. Page, Fruzsina Petrovay, Cornelis Rietmeijer, Dominic Rowley, Sandy Shokoples, Erasmus Smit, Emma L. Sweeney, George Taiaroa, Jaime H. Vera, Christine Wennerås, David M. Whiley, Deborah A. Williamson, Gwenda Hughes, Prenilla Naidu, Magnus Unemo, Mel Krajden, Sheila A. Lukehart, Muhammad G. Morshed, Helen Fifer, Nicholas R. Thomson Nature Microbiology 6 (12), 1549-1560, 2021-11-24

...expansion may be linked to changing epidemiology, immune evasion or fitness under antimicrobial selection pressure, since many of the contemporary syphilis lineages we have characterized are resistant to macrolides...

DOI PDF Web Site 被引用文献1件

Xiangning Bai, Flemming Scheutz, Henrik Mellström Dahlgren, Ingela Hedenström, Cecilia Jernberg Microorganisms 9 (11), 2374-, 2021-11-17

...Whole-genome sequencing (WGS) data analysis revealed that the three Stx2m-producing strains harbored additional virulence genes and the macrolide resistance gene mdf (A)....

DOI Web Site 被引用文献1件

Ishida, Tomoharu, Hagiya, Hideharu, Honda, Hiroyuki, Nakano, Yasuhiro, Ogawa, Hiroko, Obika, Mikako, Ueda, Keigo, Kataoka, Hitomi, Hanayama, Yoshihisa, Otsuka, Fumio Plos One 16 (11), e0259633-, 2021-11-12

...We defined broad-spectrum antimicrobials as third-generation cephalosporins, macrolides, fluoroquinolones, and faropenem....

機関リポジトリ

Tomoharu Ishida, Hideharu Hagiya, Hiroyuki Honda, Yasuhiro Nakano, Hiroko Ogawa, Mikako Obika, Keigo Ueda, Hitomi Kataoka, Yoshihisa Hanayama, Fumio Otsuka PLOS ONE 16 (11), e0259633-, 2021-11-12

...We defined broad-spectrum antimicrobials as third-generation cephalosporins, macrolides, fluoroquinolones, and faropenem....

DOI Web Site 参考文献29件

Joohyung Youh, Keisuke Imafuku, Teruki Yanagi, Sho Nakakubo, Yosuke Mai, Hideyuki Kosumi, Takuya Kawamura, Ken Muramatsu, Chihiro Shiiya, Ayame Kimura, Sota Itamoto, Masafumi Yamada, Hideyuki Ujiie Dermatologic Therapy 34 (6), 2021-11

DOI Web Site Web Site 参考文献9件

Hisanori Domon, Toshihito Isono, Takumi Hiyoshi, Hikaru Tamura, Karin Sasagawa, Tomoki Maekawa, Satoru Hirayama, Katsunori Yanagihara, Yutaka Terao Microbiology Spectrum 9 (2), 2021-10-31

...For over 10 years, sub-MICs of macrolides, including clarithromycin, have been recognized to decrease pneumolysin production and release from pneumococcal cells.</jats:p>...

DOI Web Site 被引用文献3件 参考文献57件

Mitsunori Yoshida, Jung-Yien Chien, Kozo Morimoto, Takeshi Kinjo, Akio Aono, Yoshiro Murase, Keiji Fujiwara, Yuta Morishige, Hiroaki Nagano, Ruwen Jou, Naoki Hasegawa, Manabu Ato, Yoshihiko Hoshino, Po-Ren Hsueh, Satoshi Mitarai 2021-10-26

...Known mutations conferring acquired macrolide resistance were rare (1.4%) and not enriched in the predominant clones....

DOI Web Site 被引用文献1件

Nobuhisa Ishiguro, Rikako Sato, Toshihiko Mori, Hiroshi Tanaka, Mitsuo Narita, Takashi Nagano, Masato Owaku, Kensuke Miyajima, Atsushi Manabe PLOS ONE 16 (10), e0258694-, 2021-10-14

...However, macrolide-resistant <jats:italic>M</jats:italic>. <jats:italic>pneumoniae</jats:italic> has been emerging since about 2000....

DOI Web Site 被引用文献1件 参考文献57件

Sheng Han, Xinyue Li, Hongmei Huang, Ting Wang, Zhenglu Wang, Xiaofang Fu, Zilei Zhou, Peng Du, Xiqing Li International Journal of Environmental Research and Public Health 18 (20), 10640-, 2021-10-11

...A stability experiment showed that sulfonamide parents and their metabolites were stable at 4 °C, −20 °C and −80 °C, while macrolides metabolites were more stable than their corresponding parents at 4...

DOI Web Site 被引用文献2件

Jennifer A. Kricker, Clive P. Page, Fridrik Runar Gardarsson, Olafur Baldursson, Thorarinn Gudjonsson, Michael J. Parnham Pharmacological Reviews 73 (4), 1404-1433, 2021-10

DOI Web Site 被引用文献1件

Amemiya Tokunao, Iwakami Shin-ichiro Internal Medicine 60 (19), 3081-3086, 2021-10-01

...macrolide administration group (NEMAG)....

DOI Web Site PubMed ほか1件 参考文献12件

倉田 賢生, 堀内 寿志, 斧沢 京子 日本環境感染学会誌 36 (5), 257-263, 2021-09-25

<p>福岡市民病院外来部門における抗菌薬適正使用支援（AS）の効果を評価した．2011年1月から2020年12月までに外来患者に処方された各系統経口抗菌薬の使用密度（AUD）および治療日数（DOT）ならびに検出微生物の抗菌薬耐性率を求め，ASを開始した2016年前後で比較した．また，薬剤耐性（AMR）対策アクションプランの成果指標との比較を行った．AS開始後，第3世代セファロスポリン系，マクロラ…

DOI Web Site 被引用文献1件 参考文献11件

Yamamoto, Kazuko, Hosogaya, Naoki, Sakamoto, Noriho, Yoshida, Haruo, Ishii, Hiroshi, Yatera, Kazuhiro, Izumikawa, Koichi, Yanagihara, Katsunori, Mukae, Hiroshi BMJ Open 11 (9), e053325-, 2021-09-21

...Clarithromycin is a macrolide antimicrobial agent that has been widely used for bacterial respiratory infectious diseases....

DOI 機関リポジトリ HANDLE ほか1件 参考文献29件

Ohe, Masashi, Furuya, Ken, Goudarzi, Houman Gazi Medical Journal 32 (4), 577-579, 2021-09-09

...Macrolides (MACs) such as clarithromycin (CAM) and erythromycin (EM) have immunomodulatory effects as well as anti-bacterial activity....

HANDLE

Zhijiang Miao, Ruyi Zhang, Peifa Yu, Yang Li, Qiuwei Pan, Yunlong Li International Journal of Antimicrobial Agents 58 (3), 106383-, 2021-09

DOI Web Site Web Site 被引用文献1件

Chih-Hao Chang, Chang-Ku Tsai, Ti-An Tsai, Sui-Ching Wang, Yi-Chen Lee, Chih-Min Tsai, Ta-Yu Liu, Kuang-Che Kuo, Chih-Cheng Chen, Hong-Ren Yu Pediatrics & Neonatology 62 (5), 536-542, 2021-09

DOI Web Site Web Site 被引用文献2件

Takefumi Kuranaga, Miho Tamura, Hiroaki Ikeda, Sakahiro Terada, Yusuke Nakagawa, Hideaki Kakeya Organic Letters 23 (18), 7106-7111, 2021-08-26

DOI Web Site 被引用文献3件

Ryan A. Bronson, Chhavi Gupta, Abigail L. Manson, Jan A. Nguyen, Asli Bahadirli-Talbott, Nicole M. Parrish, Ashlee M. Earl, Keira A. Cohen Nature Communications 12 (1), 2021-08-26

...Identification of multiple evolutionary events within this clade, consistent with regain of wild type, intrinsic macrolide resistance, underscores the critical importance of macrolides in MAB....

DOI PDF Web Site 被引用文献1件

Kang-Yung Peng, Hung-Wei Liao, Jeff S. Chueh, Chien-Yuan Pan, Yen-Hung Lin, Yung-Ming Chen, Peng-Ying Chen, Chun-Lin Huang, Vin-Cent Wu Biomedicines 9 (8), 1026-, 2021-08-17

...The interaction between macrolides and KCNJ5 protein was evaluated via molecular docking and molecular dynamics simulation analysis....

DOI Web Site 被引用文献1件

Huei-Min Hung, Chih-Hsien Chuang, Yi-Yin Chen, Wei-Chao Liao, Shiao-Wen Li, Ian Yi-Feng Chang, Chih-Ho Chen, Ting-Hsuan Li, Ya-Yu Huang, Yi-Chuan Huang, Yi-Ching Chen, Kuo-Chien Tsao, Yhu-Chering Huang, Cheng-Hsun Chiu, Tzou-Yien Lin, Yu-Chia Hsieh Clinical Microbiology and Infection 27 (8), 1169.e1-1169.e6, 2021-08

DOI Web Site Web Site 被引用文献2件

Bertrand Beckert, Elodie C. Leroy, Shanmugapriya Sothiselvam, Lars V. Bock, Maxim S. Svetlov, Michael Graf, Stefan Arenz, Maha Abdelshahid, Britta Seip, Helmut Grubmüller, Alexander S. Mankin, C. Axel Innis, Nora Vázquez-Laslop, Daniel N. Wilson Nature Communications 12 (1), 4466-, 2021-07-22

...Here, we present structures of ribosomes arrested during the synthesis of an Arg-Leu-Arg sequence by the macrolide erythromycin (ERY) and the ketolide telithromycin (TEL)....

DOI PDF Web Site 被引用文献3件

Eftychia Eva Kontou, Tetiana Gren, Francisco Javier Ortiz-López, Emil Thomsen, Daniel Oves-Costales, Caridad Díaz, Mercedes de la Cruz, Xinglin Jiang, Tue Sparholt Jørgensen, Kai Blin, Pep Charusanti, Fernando Reyes, Olga Genilloud, Tilmann Weber ACS Chemical Biology 16 (8), 1456-1468, 2021-07-19

DOI Web Site 被引用文献1件

Takashi Hirama, Lianne G. Singer, Sarah K. Brode, Theodore K. Marras, Shahid Husain Transplant Infectious Disease 23 (4), 2021-07-12

...Ten of 16 patients with post‐transplant NTM‐PD were treated with macrolide‐containing anti‐mycobacterial therapy, leading to clinical improvement in 5/10 (50%), radiological improvement in 5/10 (50%) and...

DOI Web Site Web Site 参考文献27件

Alexandre Castro-Lopes, Sofia Correia, Cátia Leal, Inês Resende, Pedro Soares, Ana Azevedo, José-Artur Paiva Antibiotics 10 (7), 778-, 2021-06-25

...Results: Statistically significant increases occurred in 2020 for total antibacterials, macrolides, cephalosporins, amoxicillin/clavulanic acid, carbapenems, meropenem, and third-generation cephalosporins...

DOI Web Site 被引用文献1件

Kazutoshi Toriyama, Naoharu Takano, Hiroko Kokuba, Hiromi Kazama, Shota Moriya, Masaki Hiramoto, Shinji Abe, Keisuke Miyazawa Cancer Science 112 (8), 3324-3337, 2021-06-24

...Our group previously reported that macrolide antibiotics, especially azithromycin (AZM), have potent autophagy inhibitory effects, and combination treatment with tyrosine kinase inhibitors or proteasome...

DOI Web Site Web Site ほか1件 被引用文献3件 参考文献43件

Toshihiko Kakiuchi, Ippei Miyata, Reiji Kimura, Goh Shimomura, Kunihisa Shimomura, Satoru Yamaguchi, Takato Yokoyama, Kazunobu Ouchi, Muneaki Matsuo Journal of Clinical Microbiology 59 (7), 2021-06-18

...<jats:p> The recent increase in macrolide-resistant <jats:named-content content-type="genus-species">Mycoplasma pneumoniae</jats:named-content> in Asia has become a...

DOI Web Site 被引用文献2件 参考文献26件

Jialiang Sun, Yanan Li Pediatric Research 91 (5), 1036-1042, 2021-06-12

...been reported; however, potential cardiac side effects and macrolide resistance should be clinically noted....

DOI PDF Web Site 被引用文献1件

Warish Ahmed, Pradip Gyawali, Kerry A. Hamilton, Sayalee Joshi, David Aster, Erica Donner, Stuart L. Simpson, Erin M. Symonds Frontiers in Microbiology 12 2021-06-11

...Bacteroides</jats:italic> HF183, <jats:italic>Lachnospiraceae</jats:italic> Lachno3, crAssphage) and ARGs indicating resistance to nine antibiotics (belonging to aminoglycosides, beta-lactams, sulfonamides, macrolides...

DOI Web Site 被引用文献1件

Sayer Al-Azzam, Nizar Mahmoud Mhaidat, Hayaa A. Banat, Mohammad Alfaour, Dana Samih Ahmad, Arno Muller, Adi Al-Nuseirat, Elizabeth A. Lattyak, Barbara R. Conway, Mamoon A. Aldeyab Antibiotics 10 (6), 690-, 2021-06-09

...There was an increase in the use of several antibiotics during 2020 compared with 2019 (third generation cephalosporins (19%), carbapenems (52%), macrolides (57%), and lincosamides (106%))....

DOI Web Site 被引用文献1件

Ishiguro, Nobuhisa, Sato, Rikako, Kikuta, Hideaki, Nakanishi, Masanori, Aoyagi, Hayato, Mori, Toshihiko, Nagano, Naoko, Tabata, Yuichi, Hazama, Kyosuke, Konno, Mutsuko, Yamanaka, Tatsuru, Azuma, Katsumi, Tanaka, Hiroshi, Narita, Mitsuo, Morita, Keisuke, Odagawa, Yasuhisa, Ishizaka, Akihito, Tsuchida, Akira, Sasaki, Satoshi, Horino, Atsuko, Kenri, Tsuyoshi, Togashi, Takehiro, Manabe, Atsushi Journal of medical microbiology 70 (6), 001365-, 2021-06

...In 2013 and 2014, the p1 gene type 1 strain, mostly macrolide-resistant, was dominant and the prevalence of macrolide resistance was over 50 %....

DOI HANDLE Web Site 参考文献14件

Mariana M. Lanata, Huanyu Wang, Kathy Everhart, Melisa Moore-Clingenpeel, Octavio Ramilo, Amy Leber Emerging Infectious Diseases 27 (6), 1588-1597, 2021-06

DOI 被引用文献3件

Matsui Katsuhiko, Nakamura Midori, Obana Noriko Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 44 (6), 798-803, 2021-06-01

...The aim of the present study was to evaluate the effect of topically applied josamycin, a macrolide antibiotic, on the scratching behavior of NC/Nga mice with AD-like skin lesions....

DOI Web Site Web Site ほか2件 被引用文献3件 参考文献23件

Daisuke Urabe, Keisuke Fukaya Heterocycles : an international journal for reviews and communications in heterocyclic chemistry 102 (6), 1061-1082, 2021-06-01

...The new macrolides <jats:bold>2</jats:bold>–<jats:bold>4</jats:bold> displayed potent antimicrobial activity against the Gram-positive bacterium <jats:italic>Kocuria rhizohpila</jats:italic> and the plant...

DOI DOI PDF ほか2件 被引用文献9件 参考文献123件

Mitsuboshi Satoru, Date Junichiro, Tsuruma Naoki, Yamaga Hirokazu, Watanabe Kazuya, Kijima Hiroko, Nakashita Manami, Hosokawa Hiroki, Tsugita Masami Japanese Journal of Infectious Diseases 74 (3), 240-244, 2021-05-31

...Therefore, we evaluated whether blood stream infection caused by quinolone- or macrolide-resistant GBS is associated with high mortality....

DOI Web Site Web Site ほか2件 参考文献13件

Ushino Takumi, Jin Wanchun, Wachino Jun-ichi, Arakawa Yoshichika, Kimura Kouji Japanese Journal of Infectious Diseases 74 (3), 233-235, 2021-05-31

...PRGBS tend to be non-susceptible to macrolides and fluoroquinolones....

DOI Web Site Web Site ほか2件 参考文献10件

Humberto Barrios-Camacho, Josefina Duran-Bedolla, Jesus Silva-Sanchez, Luis Lozano-Aguirre, Fernando Reyna-Flores, Alejandro Sanchez-Perez, Ulises Graza-Ramos 2021-05-28

...The plasmid sequence included genes conferring resistance to β-lactams (<jats:italic>bla</jats:italic>CTX-M-15), macrolides (<jats:italic>mphA</jats:italic>), fluoroquinolones (<jats:italic>qepA1</jats...

DOI Web Site Web Site 被引用文献1件

Yvonne A Kwaffo, Mabel Sarpong-Duah, Kwabena Owusu-Boateng, Winfred SK Gbewonyo, Jonathan P Adjimani, Lydia Mosi Experimental Biology and Medicine 246 (17), 1884-1894, 2021-05-26

...<jats:p> Mycobacterium ulcerans produces a macrolide exotoxin, mycolactone which suppresses immune cells activity, is toxic to most cells and the key virulence factor in the pathogenesis of Buruli ulcer...

DOI Web Site Web Site 被引用文献1件

Genki Minegishi, Yasuhiro Kazuki, Shin-Ichiro Nitta, Atsushi Miyajima, Hidetaka Akita, Kaoru Kobayashi Xenobiotica 51 (7), 764-770, 2021-05-20

DOI Web Site 参考文献31件

Dàmaris Berbel, Jordi Càmara, Aida González-Díaz, Meritxell Cubero, Guillem López de Egea, Sara Martí, Fe Tubau, M Angeles Domínguez, Carmen Ardanuy Journal of Antimicrobial Chemotherapy 76 (8), 1991-2003, 2021-05-20

...Isolates were emm and MLST typed and 55 were whole-genome sequenced to determine the nature of the macrolide resistance (MR) determinants and their larger MGE and chromosomal context....

DOI PDF 被引用文献1件

Maxim S. Svetlov, Timm O. Koller, Sezen Meydan, Vaishnavi Shankar, Dorota Klepacki, Norbert Polacek, Nicholas R. Guydosh, Nora Vázquez-Laslop, Daniel N. Wilson, Alexander S. Mankin Nature Communications 12 (1), 2803-, 2021-05-14

...Context-specific action markedly depends on the macrolide structure. Eliminating macrolide-arrest motifs from a protein renders its translation macrolide-tolerant....

DOI PDF Web Site 被引用文献1件

Bhavin V. Pipaliya, Daria N. Trofimova, Rebecca L. Grange, Madhu Aeluri, Xu Deng, Kavan Shah, Andrew W. Craig, John S. Allingham, P. Andrew Evans Journal of the American Chemical Society 143 (18), 6847-6854, 2021-05-03

DOI Web Site 被引用文献1件

Yamakawa Hideaki, Takemura Tamiko, Sato Shintaro, Nakamura Tomohiko, Nishizawa Tomotaka, Oba Tomohiro, Kawabe Rie, Akasaka Keiichi, Amano Masako, Kuwano Kazuyoshi, Matsushima Hidekazu Internal Medicine 60 (9), 1457-1462, 2021-05-01

...One of the DPB patients had more severe peribronchiolar fibrosis than the other, and the disease course was refractory to macrolide therapy....

DOI Web Site PubMed ほか1件 参考文献14件

Mariko Okamoto, Masahiko Kumagai, Hiroyuki Kanamori, Daisuke Takamatsu Frontiers in Microbiology 12 2021-04-29

...In Japan, a macrolide antibiotic, tylosin, is used as the approved prophylactic for AFB....

DOI Web Site 被引用文献4件

Joon Soo An, Bora Shin, Tae Ho Kim, Sunghoon Hwang, Yern-Hyerk Shin, Jinsheng Cui, Young Eun Du, Jungwoo Yi, Sang-Jip Nam, Suckchang Hong, Jongheon Shin, Jichan Jang, Yeo Joon Yoon, Dong-Chan Oh Organic Letters 23 (9), 3359-3363, 2021-04-22

DOI Web Site 被引用文献1件

Annie Delaunois, Matthew Abernathy, Warren D. Anderson, Kylie A. Beattie, Khuram W. Chaudhary, Julie Coulot, Vitalina Gryshkova, Simon Hebeisen, Mark Holbrook, James Kramer, Yuri Kuryshev, Derek Leishman, Isabel Lushbough, Elisa Passini, Will S. Redfern, Blanca Rodriguez, Eric I. Rossman, Cristian Trovato, Caiyun Wu, Jean‐Pierre Valentin Clinical and Translational Science 14 (3), 1133-1146, 2021-04-09

...Combining CLQ or OH‐CLQ with a macrolide did not aggravate their effects....

DOI Web Site Web Site ほか1件 被引用文献1件

Yamada, Natsumi, Murata, Wakae, Yamaguchi, Yoshihiro, Fujita, Ken-ichi, Ogita, Akira, Tanaka, Toshio Letters in Applied Microbiology 72 (4), 390-398, 2021-04

...Amphotericin B (AmB), a typical polyene macrolide antifungal agent, is widely used to treat systemic mycoses....

DOI 機関リポジトリ Web Site ほか1件 参考文献34件

Saori Takeda, Masamitsu Kono, Gen Sugita, Jun Arai, David E. Briles, Muneki Hotomi Microbial Pathogenesis 153 104787-, 2021-04

DOI Web Site Web Site 被引用文献2件 参考文献31件

George G Zhanel, Heather J Adam, Melanie Baxter, Philippe R S Lagace-Wiens, James A Karlowsky Journal of Antimicrobial Chemotherapy 76 (7), 1808-1814, 2021-04-01

...Ozenoxacin is active versus SSTI pathogens including MRSA resistant to fluoroquinolones, macrolides, clindamycin, fusidic acid and mupirocin.</jats:p> </jats:sec>...

DOI PDF 被引用文献1件

Hairong Zhang, Jiabin Zou, Xiaoxue Yan, Junlong Chen, Xiujiao Cao, Jialing Wu, Yinghui Liu, Tingting Wang Marine Drugs 19 (4), 180-, 2021-03-25

...Sponges, fungi and dinoflagellates are the main producers of macrolides....

DOI Web Site 被引用文献1件

奥本 穣, 坂本 信二郎, 堀益 靖, 益田 武, 宮本 真太郎, 中島 拓, 岩本 博志, 藤高 一慶, 濱田 泰伸, 服部 登 気管支学 43 (2), 117-122, 2021-03-25

<p><b>背景．</b>びまん性汎細気管支炎（diffuse panbronchiolitis：DPB）は，特徴的な画像所見と他疾患の除外により臨床診断され，14員環マクロライドの長期投与療法が有効な症例が多いが，少数ながら本治療が無効な難治例も存在する．<b>症例．</b>68歳女性．40歳から気管支喘息に対し吸入ステロイドにより治療されていた．7か月前に湿性咳嗽と後鼻漏症状が悪化し，CTで…

DOI 医中誌

Lobna A. Elsadek, James H. Matthews, Shinichi Nishimura, Takahiro Nakatani, Airi Ito, Tongjun Gu, Danmeng Luo, Lilibeth A. Salvador‐Reyes, Valerie J. Paul, Hideaki Kakeya, Hendrik Luesch ChemBioChem 22 (10), 1790-1799, 2021-03-23

...<jats:title>Abstract</jats:title><jats:p>Amantelide A, a polyhydroxylated macrolide isolated from a marine cyanobacterium, displays broad‐spectrum activity against mammalian cells, bacterial pathogens,...

DOI Web Site Web Site 参考文献50件

小泉 龍士, 日馬 由貴, 石金 正裕, 田中 知佳, 大野 茜子, 具 芳明, 金子 明寛, 大曲 貴夫 感染症学雑誌 95 (2), 122-128, 2021-03-20

<p>歯科では医科の約10% の抗菌薬が使用されており，薬剤耐性対策のためには歯科における抗菌薬適正使用も重要である．歯科領域における抗菌薬処方の問題について薬剤耐性（AMR）の視点から評価し，解決方法を模索するため，我々は歯科医に対してAMR への意識，抗菌薬処方，採用抗菌薬などについてアンケート調査を行った．著者一名が講師として参加した「歯科における抗菌薬の使い方」講習会参加者のうち，同意が…

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Ioannis Kyriakidis, Eleni Vasileiou, Zoi Dorothea Pana, Athanasios Tragiannidis Pathogens 10 (3), 373-, 2021-03-19

...baumannii resistance mechanisms in humans as regards beta-lactams (penicillins, cephalosporins, carbapenems, monobactams, and beta-lactamase inhibitors), aminoglycosides, tetracyclines, fluoroquinolones, macrolides...

DOI Web Site 被引用文献1件

Rong Wang, Jin Wang, Abdirahman Hassan, Chia-Hsueh Lee, Xiao-Song Xie, Xiaochun Li Nature Communications 12 (1), 1782-, 2021-03-19

...Bafilomycin A1, a member of macrolide antibiotics and an autophagy inhibitor, serves as a specific and potent V-ATPases inhibitor....

DOI PDF Web Site 被引用文献3件

Hikaru Tamura, Tomoki Maekawa, Hisanori Domon, Takumi Hiyoshi, Satoru Hirayama, Toshihito Isono, Karin Sasagawa, Daisuke Yonezawa, Naoki Takahashi, Masataka Oda, Takeyasu Maeda, Koichi Tabeta, Yutaka Terao Antibiotics 10 (3), 312-, 2021-03-17

...<jats:p>Macrolides are used to treat various infectious diseases, including periodontitis....

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Jia-Qi Hu, Jing-Jing Wang, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen, Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li, Changsheng Wu Organic Letters 23 (6), 2114-2119, 2021-03-10

DOI Web Site 被引用文献1件

Soichiro Hoshino, Ryohei Kanemura, Daisuke Kurita, Yukihiro Soutome, Hyouta Himeno, Masak Takaine, Masakatsu Watanabe, Nobukazu Nameki Communications Biology 4 (1), 300-, 2021-03-08

.../jats:italic> than that of the <jats:italic>ICT1</jats:italic> homolog <jats:italic>PTH4</jats:italic> in the presence of antibiotics that inhibit mitochondrial translation, such as tetracyclines and macrolides...

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Mariko Naito, B. Ross Belvin, Mikio Shoji, Qin Gui, Janina P. Lewis Microorganisms 9 (3), 551-, 2021-03-07

...The mutation is an allelic exchange replacement of the sequences coding for a putative OxyR regulator with ermF sequences coding for the macrolide–lincosamide resistance in anaerobic bacteria....

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Małgorzata Gbylik-Sikorska, Anna Gajda, Ewelina Nowacka-Kozak, Beata Łebkowska-Wieruszewska, Andrzej Posyniak Molecules 26 (5), 1373-, 2021-03-04

...Chromatography–Tandem Mass Spectrometry (UHPLC–MS/MS) method was developed for qualitative and quantitative analysis of veterinary antibiotics (cephalosporins, diaminopyrimidines, fluoro(quinolones), lincosamides, macrolides...

DOI Web Site 被引用文献1件

Keisuke Kamada, Atsushi Yoshida, Shigekazu Iguchi, Yuko Arai, Yutaka Uzawa, Satoshi Konno, Masahiro Shimojima, Ken Kikuchi Scientific Reports 11 (1), 2021-03-02

...<jats:italic>abscessus</jats:italic> (MAB) infections are refractory to macrolides....

DOI PDF Web Site 参考文献24件

Ye Feng, Cheng-Hsun Chiu, Ulrich Heininger, Daniela Flavia Hozbor, Tina Quanbee Tan, Carl-Heinz Wirsing von König The Lancet Regional Health - Western Pacific 8 100098-, 2021-03

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Ana María Sánchez-Baena, Luz Dary Caicedo-Bejarano, Mónica Chávez-Vivas International Journal of Environmental Research and Public Health 18 (5), 2348-, 2021-02-27

...The ARGs mainly reported were those that confer resistance to β-lactam antibiotics, aminoglycosides, fluoroquinolones, macrolides and tetracycline....

DOI Web Site 被引用文献1件

Doriane Calmes, Pascale Huynen, Virginie Paulus, Monique Henket, Françoise Guissard, Catherine Moermans, Renaud Louis, Florence Schleich Respiratory Research 22 (1), 2021-02-26

...In a subpopulation of 14 neutrophilic asthmatics with <jats:italic>Chlamydia pneumoniae</jats:italic> IgA + /IgG + treated with macrolides, we found a significant decrease in blood neutrophils and normalization...

DOI PDF Web Site 被引用文献1件

Cédric Tresse, Marc François‐Heude, Vincent Servajean, Rubal Ravinder, Clémence Lesieur, Lucie Geiben, Louis Jeanne‐Julien, Vincent Steinmetz, Pascal Retailleau, Emmanuel Roulland, Jean‐Marie Beau, Stéphanie Norsikian Chemistry – A European Journal 27 (16), 5230-5239, 2021-02-18

...<jats:title>Abstract</jats:title><jats:p>We give a full account of the total synthesis of tiacumicin B (Tcn‐B), a natural glycosylated macrolide with remarkable antibiotic properties....

DOI Web Site Web Site 被引用文献1件

Meiji Soe Aung, Noriko Urushibara, Mitsuyo Kawaguchiya, Mina Hirose, Miyo Ike, Masahiko Ito, Nobumichi Kobayashi Pathogens 10 (2), 163-, 2021-02-03

...Although most of S. argenteus isolates were susceptible to antimicrobials examined, ST2198 showed higher resistance rates to penicillin, macrolides, and aminoglycosides than other STs, and it harbored...

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幾田, 慧子, 中川, 俊作, Momo, Kenji, 米澤, 淳, 糸原, 光太郎, 佐藤, 夕紀, 今井, 哲司, 中川, 貴之, 松原, 和夫 BMJ Open 11 (2), e041543-, 2021-02

...OBJECTIVES: This study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins...

DOI HANDLE Web Site 被引用文献3件 参考文献38件

Yoshitaka Nakamura, Tomohiro Oishi, Kazunari Kaneko, Tsuyoshi Kenri, Takaaki Tanaka, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Eisuke Kondo, Yuhei Tanaka, Hideto Teranishi, Hiroto Akaike, Ippei Miyata, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kazunobu Ouchi Journal of Infection and Chemotherapy 27 (2), 271-276, 2021-02

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Mitsunori Yoshida, Sotaro Sano, Jung-Yien Chien, Hanako Fukano, Masato Suzuki, Takanori Asakura, Kozo Morimoto, Yoshiro Murase, Shigehiko Miyamoto, Atsuyuki Kurashima, Naoki Hasegawa, Po-Ren Hsueh, Satoshi Mitarai, Manabu Ato, Yoshihiko Hoshino EBioMedicine 64 103187-, 2021-02

DOI Web Site Web Site 被引用文献5件 参考文献56件

Muto Taichiro, Nakamura Nami, Masuda Yu, Numoto Shingo, Kodama Shunsuke, Miyamoto Ryosuke, Hayakawa Tomohito, Mori Hiromitsu, Iwayama Hideyuki, Kurahashi Hirokazu, Agata Hiroatsu, Okumura Akihisa Japanese Journal of Infectious Diseases 75 (1), 89-91, 2021-01-31

...The rate of macrolide-resistant MP was 66.7%....

DOI Web Site Web Site ほか2件 参考文献4件

Michel Baez, Ivette Espinosa, Alexandra Collaud, Iliana Miranda, Damarys de las Nieves Montano, Angel L. Feria, Rosa Elena Hernández-Fillor, Dasiel Obregón, Pastor Alfonso, Vincent Perreten Antibiotics 10 (2), 107-, 2021-01-22

...susceptibility to sulfonamides (sul1, sul2, sul3), trimethoprim (dfrA1, dfrA7, dfrA12, dfrA14, dfrA17), tetracyclines (tet(A), tet(B)), aminoglycosides (aac(6′)-Ib-cr, strA, strB), chloramphenicol (cmlA1, floR), macrolides...

DOI Web Site 被引用文献1件

Tania S. Darphorn, Keshia Bel, Belinda B. Koenders-van Sint Anneland, Stanley Brul, Benno H. Ter Kuile Scientific Reports 11 (1), 2021-01-22

...Tetracycline and (extended spectrum) beta-lactamase resistance genes were each situated in separate clusters, but sulphonamide, macrolide and aminoglycoside formed one cluster and lincosamide and aminoglycoside...

DOI PDF Web Site 被引用文献1件

Tang-Chang Xu, Yi-Han Lu, Jun-Fei Wang, Zhi-Qiang Song, Ya-Ge Hou, Si-Si Liu, Chuan-Sheng Liu, Shao-Hua Wu Microorganisms 9 (2), 217-, 2021-01-21

...They are classified into polyketides, terpenoids, steroids, macrolides, ten-membered lactones, alkaloids, flavonoids, and fatty acids....

DOI Web Site 被引用文献2件

Takuya Yoshioka, Yasuhiro Igarashi, Takushi Namba, Shohei Ueda, Ivy Grace Umadhay Pait, Takuya Nihira, Shigeru Kitani The Journal of Antibiotics 74 (5), 359-362, 2021-01-19

DOI PDF Web Site ほか1件 参考文献8件

Tanimoto Tetsuya, Takahashi Kenzo, Crump Andy Internal Medicine 60 (2), 173-180, 2021-01-15

...The first choices for chemotherapy are fluoroquinolone and macrolide antibiotic drugs....

DOI Web Site PubMed ほか1件 参考文献35件

Kiyoharu Fukushima, Seigo Kitada, Sho Komukai, Tomoki Kuge, Takanori Matsuki, Hiroyuki Kagawa, Kazuyuki Tsujino, Mari Miki, Keisuke Miki, Hiroshi Kida Scientific Reports 11 (1), 1178-, 2021-01-13

...<jats:title>Abstract</jats:title><jats:p>The combination of rifamycin (RFP), ethambutol (EB), and macrolides is currently the standard regimen for treatment of <jats:italic>Mycobacterium avium</jats:italic...

DOI PDF Web Site 被引用文献2件

Clare S. Murray, Sarah J. Lucas, John Blakey, Alan Kaplan, Alberto Papi, James Paton, Wanda Phipatanakul, David Price, Oon Hoe Teoh, Mike Thomas, Steve Turner, Nikolaos G. Papadopoulos European Respiratory Journal 58 (1), 2003599-, 2021-01-08

...Penicillins, but not macrolides, were associated with a reduction in the odds of a subsequent asthma/wheeze consultation compared to OCS alone, in both adults and children....

DOI Web Site 被引用文献1件

楠元, 順哉, Uda, Atsushi, Kimura, Takeshi, 古土井, 春吾, Yoshii, Ryosuke, Matsumura, Megumi, 宮良, 高維, 明石, 昌也 BMC Oral Health 21 (1), 20-20, 2021-01-07

...There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population....

HANDLE

Junya Kusumoto, Atsushi Uda, Takeshi Kimura, Shungo Furudoi, Ryosuke Yoshii, Megumi Matsumura, Takayuki Miyara, Masaya Akashi BMC Oral Health 21 (1), 2021-01-07

...There was reduced use of macrolides and quinolones in outpatients. Although a similar trend was seen for inpatients, the use of quinolones increased in this population....

DOI PDF Web Site 被引用文献1件

小林, 大晟, 奥村, 颯吾, 斎藤, 晴天, 石川, 奈緒, 笹本, 誠, 伊藤, 歩 土木学会論文集G（環境） 77 (7), III_83-III_91, 2021

家畜へ投与された抗菌剤の一部は排泄物中に排出される．そのため抗菌剤が畜産廃水と共に周辺の水環境に流出し，水域生態系に悪影響を及ぼす可能性がある．本研究では，イライトまたはゼオライトを主要粘土鉱物とする2種類の鉱物試料（Y-illite, M-Zeolite）との接触による溶液中及び養豚廃水中に添加した3種類の抗菌剤の除去処理試験を行った．さらに処理水の安全性について，藻類R.subcapitat…

機関リポジトリ

Venugopal Rao Challa, Daniel Kwon, Matthew Taron, Hope Fan, Baldip Kang, Darryl Wilson, F. P. Jake Haeckl, Sandra Keerthisinghe, Roger G. Linington, Robert Britton Chemical Science 12 (15), 5534-5543, 2021

...<p>A total synthesis of the marine macrolide biselide A is described that relies on an enantiomerically enriched α-chloroaldehyde as the sole chiral building block.</p>...

DOI Web Site 被引用文献1件

Naoki Kawakami, Ho Namkoong, Fumitake Saito, Masami Ishizaki, Masahiko Yamazaki, Keiko Mitamura Journal of Infection and Chemotherapy 27 (1), 45-48, 2021-01

DOI Web Site Web Site 被引用文献2件

Didik Huswo Utomo, Akari Fujieda, Kentaro Tanaka, Momoko Takahashi, Kentaro Futaki, Kenta Tanabe, Hideo Kigoshi, Masaki Kita Chemical Communications 57 (81), 10540-10543, 2021

...<jats:p>We developed versatile actin-affinity tags from the side-chain analogs of aplyronine A, an antitumor marine macrolide.</jats:p>...

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Haruhiko Fuwa Organic Chemistry Frontiers 8 (14), 3990-4023, 2021

...<p>Integration of chemical synthesis, NMR spectroscopy, and various analytical means is key to success in the structure elucidation of stereochemically complex marine macrolide natural products.</p>...

DOI Web Site 被引用文献1件

KOMATSU Tetsuya, YOSHIDA Erina, SHIGENAGA Ayumi, YASUIE Nozomi, UCHIYAMA Shintaro, TAKAMURA Yuji, SUGIE Kennosuke, KIMURA Kumiko, HARITANI Makoto, SHIBAHARA Tomoyuki Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 83 (7), 1113-1119, 2021

...The No. 1 isolate showed multidrug resistance against penicillin antibiotics, fosfomycin, streptomycin, macrolide antibiotics, tetracycline antibiotics, and clindamycin....

DOI Web Site PubMed ほか1件

爲政 萌子, 田中 文, 菊澤 千秋, 中野 仁夫 皮膚の科学 20 (4), 332-337, 2021

<p><b>77</b>歳女性。当科初診約 <b>1 </b>年半前より肺腺癌に対してペムブロリズマブを投与されていた。<b>24</b>クール目頃から軽度の瘙痒感を伴う紅斑が四肢に出現し，次第に範囲が拡大してきたため，皮疹発症から約 <b>1 </b>ヶ月後に当科を紹介受診した。原発巣と転移巣の増大がみられたため，当科初診までにペムブロリズマブはすでに終了されていた。初診時，四肢の末端優位に粟…

DOI 医中誌

渡邉 央美 日本毒性学会学術年会 48.1 (0), S11-4-, 2021

<p>感染症の治療は母親と胎児両者の健康のために重要であり、感染症治療薬は妊娠中にもよく使用される。多くの妊婦がB群溶血性連鎖球菌（GBS）感染症や前期破水後の子宮内感染の予防や治療、帝王切開前の感染予防の目的で抗菌薬を投与される。また、妊娠中にも非妊娠時と同様に尿路感染症や上気道感染症等の治療が必要になることがある。</p><p> …

DOI

Tsuda Masashi, Akakabe Mai, Minamida Mika, Kumagai Keiko, Tsuda Masayuki, Konishi Yuko, Tominaga Akira, Fukushi Eri, Kawabata Jun ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 69 (1), 141-149, 2021-01-01

...<p>Two highly potent cytotoxic 26-membered macrolides, isocaribenolide-I (<b>1</b>) and a chlorohydrin <b>2</b>, together with known amphidinolide N (<b>3</b>), have been isolated from a free-swimming...

DOI Web Site Web Site ほか2件 参考文献26件

田端 克彦, 植田 穣, 岡田 慶介, 清水 貴寛, 小川 俊一, 古賀 健史, 盛田 英司, 板澤 寿子, 徳山 研一 アレルギー 70 (4), 310-314, 2021

<p>12歳男児．慢性咳嗽と呼吸困難で受診．胸部X線にて両肺野びまん性散布性粒状影を，胸部単純CTにて両肺野の“Tree-in-bud appearance”を認めた．また，副鼻腔炎も存在し，呼吸機能上，拘束性優位の呼吸機能障害を認めた．びまん性汎細気管支炎（DPB）と診断しクラリスロマイシンの少量長期療法を開始したところ，治療開始1カ月以内に臨床症状は著明に改善し，2カ月以内に呼吸機能所見は正…

DOI Web Site PubMed ほか1件

亀山 雅之, 福地 有吾, 小倉 寛敬, 成松 拓馬, 藤倉 大介, VISWAMOHANAN Savithra, 眞下 大夢 小山工業高等専門学校研究紀要 54 (0), 30-38, 2021

...Enantioselective aldol reaction is one of the most useful methods in order to synthesize the family of macrolides and ionophore antibodies which have a deoxypolypropionate skelton....

DOI

小林 大晟, 奥村 颯吾, 斎藤 晴天, 石川 奈緒, 笹本 誠, 伊藤 歩 土木学会論文集Ｇ（環境） 77 (7), III_83-III_91, 2021

<p>　家畜へ投与された抗菌剤の一部は排泄物中に排出される．そのため抗菌剤が畜産廃水と共に周辺の水環境に流出し，水域生態系に悪影響を及ぼす可能性がある．本研究では，イライトまたはゼオライトを主要粘土鉱物とする2種類の鉱物試料（Y-illite, M-Zeolite）との接触による溶液中及び養豚廃水中に添加した3種類の抗菌剤の除去処理試験を行った．さらに処理水の安全性について，藻類<i>R.sub…

DOI Web Site 参考文献13件

MORITA Satoshi, SATO Shingo, MARUYAMA Soichi, NAGASAKA Mariko, MURAKAMI Kou, INADA Kazuya, UCHIUMI Masako, YOKOYAMA Eiji, ASAKURA Hiroshi, SUGIYAMA Hiromu, TAKAI Shinji, MAEDA Ken, KABEYA Hidenori Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 83 (12), 1860-1868, 2021

...Whole-genome sequence (WGS) analysis indicated that all the strains carried <i>mdfA,</i> a drug resistance gene for macrolide antibiotics, and also pathogenicity-related genes similar to those in the Sakai...

DOI Web Site PubMed ほか1件 被引用文献1件 参考文献54件

MIYATA Ippei Kawasaki Medical Journal 47 7-11, 2021

type:Others

DOI 機関リポジトリ 医中誌

Ohe Masashi, Furuya Ken, Goudarzi Houman BioScience Trends 14 (6), 467-468, 2020-12-31

...A combination of tetracyclines and macrolides may be a potential treatment for COVID-19 because there are some differences in the mechanism of action of tetracyclines and macrolides.</p>...

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Takatoshi Nagano, Takao Yamaguchi, Sohtaro Kajiyama, Takuma Suzuki, Yuji Matsushima, Akihiro Yashima, Satoshi Shirakawa, Kazuhiro Gomi Journal of Clinical Medicine 10 (1), 99-, 2020-12-30

...<jats:p>Previous reports have shown that azithromycin (AZM), a macrolide antibiotic, affects collagen synthesis and cytokine production in human gingival fibroblasts (hGFs)....

DOI Web Site 被引用文献1件

Takayuki Ohyoshi, Hideo Kigoshi Chemistry Letters 50 (4), 580-584, 2020-12-23

...<jats:title>Abstract</jats:title> <jats:p>Aplyronine A, an antitumor marine macrolide, has a novel mode of action, inducing the protein-protein interaction between two major cytoskeletons...

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