肝ＵＤＰ‐ｇｌｕｃｕｒｏｎｙｌ　ｔｒａｎｓｆｅｒａｓｅ活性におよぼすグルカゴンの効果

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タイトル別名
  • Effect of glucagon on UDP-glucuronyl transferase activity
  • カン UDP glucuronyl transferase カッセイ ニ オヨ

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抄録

We obserbed that uridine diphosphate glucuronyl transferase (UDP-GT) activity was a significant functional marker of hepatic reserve mass and that was a similar response between UDPGT activity and cyclic AMP by glucagon injection, glucagon tolerance test, in rats treated with alpha-naphthyl isothiocyanate (ANIT). Augmentation of UDP-GT activity was obtained by glucagon and dibutyryl cyclic AMP proportional to amount of liver cell injury and was inhibited by Actinomycin D, a known inhibitor of protein synthesis. There was indicated that cyclic AMP mediated glucuronyl transferase synthesis.

収録刊行物

  • 肝臓

    肝臓 23 (11), 1270-1276, 1982

    一般社団法人　日本肝臓学会

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