Purinergic receptors
著者
書誌事項
Purinergic receptors
（Receptors and recognition, Series B ; v. 12）
Chapman and Hall, 1981
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注記
Includes bibliographies and index
収録内容
- An introduction to purinergic receptors / G. Burnstock and Christine M. Brown
- Purinergic receptors in visceral smooth muscle / M. Helen Maguire and David G. Satchell
- Purinergic receptors in blood vessels / Che Su
- Sites of action and production of adenosine in the heart / J. Schrader
- Brain : intracellular and extracellular purinergic receptor-systems / Henry McIlwain
- Presynatpric [sic] neuromodulation mediated by purinergic receptors / David M. Paton
- Blood platelet receptors for ADP and for adenosine / R.J. Haslam and N.J. Cusak
- Adenosine as a regulator of adenylate cyclase / Constantine Londos, J. Wolff, and Dermot M.F. Cooper
- Photo-affinity labelling of purinergic receptors / Noel J. Cusack and Susanna M.O. Hourani
内容説明・目次
内容説明
Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. Knowledge of the distribution of purinergic receptor sites on the plasma membrane of visceral musculature has grown particularly rapidly since Burnstock and his colleagues (1970) proposed that ATP, or a related adenine derivative, is the inhibitory transmitter released from non cholinergic non-adrenergic nerves present in the gut. Much evidence has been presented favoring the view that ATP is the inhibitory transmitter, and evidence to the contrary has also been put forward. The hypothesis remains controversial primarily because specific blockers of the postsynaptic purinergic site, with which the hypothesis might be tested, have not been found. Nevertheless, the numerous studies designed to investigate the purinergic nerve hypothesis have generated much information concerning the nature of the purinergic receptors in visceral smooth muscle."
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