Molecular neuropathology
著者
書誌事項
Molecular neuropathology
（Postgraduate medical science）
Published in association with the Royal Postgraduate Medical School, University of London, by Cambridge University Press, c1995
- : pbk.
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.
目次
- Part I. Basic Techniques: 1. Brain banks M. C. Royston and M. Stefan
- 2. RNA isolation and analysis M. S. Palmer
- 3. Polymerase chain reaction M. S. Palmer
- 4. Principles and practice of in situ hybridization histochemistry in neuropsychiatric research P. J. Harrison and R. C. A. Pearson
- 5. Immunocytochemistry - a neuropathological perspective S. M. Gentleman and G. W. Roberts
- 6. Autoradiography in brain research M. C. Royston
- Part II. Applications: 7. Human prion disease M. S. Palmer and J. Collinge
- 8. Molecular pathogenesis of the cerebral amyloidosis G. W. Roberts, M. Gentleman and J. McKenzie
- 9. Intracerebral transplantation and functional recovery H. F. Baker and R. Ridley
- 10. Methods of construction of transgenic animals and applications of the technology F. Busfield, K. Duff, C. Lendon and A. Goate
- 11. Neuropathology by numbers: application of image analysis techniques to quantitative neuropathology M. C. Royston.
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