Analysis of human genetic linkage
著者
書誌事項
Analysis of human genetic linkage
Johns Hopkins University Press, c1999
3rd ed
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注記
Includes bibliographical references (p. 345-375) and index
内容説明・目次
内容説明
The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book. New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the book's primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
目次
List of Illustrations
List of Tables
Preface
List of Symbols and Abbreviations
1. Introduction and Basic Genetic Principles
2. Genetic Loci and Genetic Polymorphisms
3. Aspects of Statistical Inference
4. Basics of Linkage Analysis
5. The Informativeness of Family Data
6. Multipoint Linkage Analysis
7. Penetrance
8. Quantitative Phenotypes
9. Numerical and Computerized Methods
10. Variability of the Recombination Fraction
11. Inconsistencies
12. Linkage Analysis with Mendelian Disease Loci
13. Nonparametric Methods
14. Two-Locus Inheritance
15. Complex Traits
Solutions to Study Problems
References
Index
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