Efficient Synthesis of Enantiopure 1,2-Bis(hydroxymethyl)-3,3-difluorocyclopropane Derivatives through Lipase-Catalyzed Reaction

• Toshiyuki Itoh

  Department of Chemistry, Faculty of Education, Okayama University

• Koichi Mitsukura

  Department of Chemistry, Faculty of Education, Okayama University

• Miyuki Furutani

  Department of Chemistry, Faculty of Education, Okayama University

Abstract

Efficient synthesis of chiral difluorocyclopropane building block has been accomplished; prochiral diacetate of 1,2-bis(hydroxymethyl)-3,3-difluorocyclopropane was converted to the corresponding monoacetate through Alcaligenes sp. lipase-catalyzed hydrolysis with >99% enantiomeric excess.

Journal

• Chemistry Letters

  Chemistry Letters 27 (9), 903-904, 1998-09-01

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360846644039701504
• NII Article ID: 10004485319
• NII Book ID: AA00603318
• DOI: 10.1246/cl.1998.903
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/27/9/903/56072598/cl.1998.903.pdf
• Data Source:
  • Crossref
  • CiNii Articles