3-Isopropylidenemalic Acid: A Mechanism-based Inhibitor of 3-Isopropylmalate Dehydrogenase

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  • Akira Chiba
    Department of Chemistry, Tokyo Institute of TechnologyO-okayama, Meguro-ku, Tokyo
  • Noriko Arai
    Department of Chemistry, Tokyo Institute of TechnologyO-okayama, Meguro-ku, Tokyo
  • Tadashi Eguchi
    Department of Chemistry and Materials Science, Tokyo Institute of TechnologyO-okayama, Meguro-ku, Tokyo
  • Katsumi Kakinuma
    Department of Chemistry, Tokyo Institute of TechnologyO-okayama, Meguro-ku, Tokyo

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Abstract

<jats:title>Abstract</jats:title> <jats:p>3-Isopropylidenemalic acid (1) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, 1 appeared to be a mechanism-based inhibitor (KI = 60.2 μM) for IPMDH as deduced from the time-dependent and kinetic analyses.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 28 (12), 1313-1314, 1999-12-01

    Oxford University Press (OUP)

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