A Comment on the Analysis of Bell-Shaped Dose-Response Curves.

• KASAI Michiki

  Division of Biophysical Engineering, Graduate School of Engineering Science, Osaka University

Bibliographic Information

Other Title

• Comment on the Analysis of Bell-Shaped

Abstract

A problem of the analysis of bell-shaped dose-response curves was theoretically discussed by using the response of ryanodine receptors for Ca²⁺ concentration as a model case. Usually the response curves were analyzed under the assumption that the receptor has a high affinity activation site and a low affinity inhibition site. However, a solution having a low affinity activation site and a high affinity inhibition site can be deduced theoretically from the same data. A method to avoid an erroneous result was proposed.

Journal

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 48 (1), 91-93, 1998

  THE PHYSIOLOGICAL SOCIETY OF JAPAN

Keywords

• bell-shaped dose-response
• ryanodine receptor
• theoretical analysis

Details

• CRID: 1390282680018227840
• NII Article ID: 130004435660
• NII Article ID: 10008304138
• NII Book ID: AA00691224
• DOI: 10.2170/jjphysiol.48.91
• COI: 1:STN:280:DyaK1c3gslSqtQ%3D%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL BIB ID: 4450315
• PubMed: 9538294
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4450315
• Web Site: https://search.jamas.or.jp/link/ui/1998215954
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed