Haloperidol Prolongs Diastolic Phase of Ca2+ Transient in Cardiac Myocytes.

• Ishida Hideyuki

  Department of Physiology, School of Medicine, Tokai University

• Hoshiai Kiyotaka

• Hoshiai Minako

• Genka Chokoh

• Hirota Yuki

• Nakazawa Hiroe

Bibliographic Information

Other Title

• Haloperidol Prolongs Diastolic Phase of Ca〔2+〕Transientin Cardiac Myocytes

Abstract

Haloperidol (HPL), a widely used antipsychotic drug, is known to induce serious ventricular arrhythmias. However, the mechanism underlying their induction is not clear. We therefore examined the effects of HPL on the intracellular Ca²⁺ ([Ca²⁺]_i) transient and on cell motion in cultured cardiac myocytes, as well as the pathways involving the HPL-induced abnormality of Ca²⁺ homeostasis. HPL prolonged the diastolic phase of the Ca²⁺ transient, with a mid-diastolic re-elevation of [Ca²⁺]_i. The re-elevation of [Ca²⁺]_i was shown to be provoked by Ca²⁺ release from sarcoplasmic reticulum (SR), which can trigger delayed afterdepolarization, the major arrhythmogenic factor. The re-elevation of [Ca²⁺]_i coincided with cell re-contraction during diastole. The induction of this abnormality by HPL appears to be independent of the mechanisms of the antipsychotic action.<br>

Journal

• The Japanese Journal of Physiology

  The Japanese Journal of Physiology 49 (6), 479-484, 1999

  THE PHYSIOLOGICAL SOCIETY OF JAPAN

Keywords

• haloperidol
• intracellular Ca²⁺
• sarcoplasmic reticulum
• chlorpromazine

Details

• CRID: 1390282680019223424
• NII Article ID: 10008308164
• NII Book ID: AA00691224
• DOI: 10.2170/jjphysiol.49.479
• COI: 1:CAS:528:DC%2BD3cXhtFygsrg%3D
• ISSN: 18811396
• ISSN: 0021521X
• NDL BIB ID: 4979586
• PubMed: 10603433
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4979586
• Web Site: https://search.jamas.or.jp/link/ui/2000258125
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed