Double Strand DNA Cleavage by a Dinuclear Cu(II) Complex

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  • Jung Hee Kim
    Department of Chemistry, Sun Moon University#100 Kalsan, Tangjeong, Asan-si, Chungnam, 336-840 , Korea
  • Soo Hyun Kim
    Department of Chemistry, Sun Moon University#100 Kalsan, Tangjeong, Asan-si, Chungnam, 336-840 , Korea

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Abstract

<jats:title>Abstract</jats:title> <jats:p>A dinuclear Cu(II) complex with 1,3-bis(1,4,7-triaza-1-cyclononyl)propane cleaved plasmid DNA to relaxed circular and linear forms at pH 7.3 and 30 °C. Under the same conditions, double strand cleavage by the corresponding mononuclear Cu(II)([9]aneN3) complex was negligible.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 32 (6), 490-491, 2003-05-06

    Oxford University Press (OUP)

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