免疫システムの新たな実体:基本免疫と獲得免疫

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タイトル別名
  • New Aspect of Immune System: Innate Immunity and Acquired Immunity
  • 第79回日本感染症学会総会 特別講演1 免疫システムの新たな実体:基本免疫と獲得免疫
  • ダイ79カイ ニホン カンセンショウ ガッカイ ソウカイ トクベツ コウエン 1 メンエキ システム ノ アラタ ナ ジッタイ キホン メンエキ ト カクトク メンエキ

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Recently, it has been turned out that our internal defense system is composed of two distinct components; innate/natural immune system and acquired/adaptive immune system. The former innate immunity is principally located at the surface area such as skin and mucosal compartment, while the latter acquired immunity is observed mainly in the circulating blood and lymphoid organs. The critical difference between those two systems exists in the receptors as well as their ligands. Rearranged gene-derived receptors like immunoglobulin (lg) and MHC molecule-restricted ctp-type of T-cell receptors (TCR) with high specificities and memories are used to recognize peptide antigens in the acquired immunity, whereas non-rearranged invaliant receptors such as toll-like receptors (TLR), γσTCR and CD1 molecule-restricted αβ TCR are employed to detect lipid/glycolipid or nucleic acid-related antigens in the innate immunity. Based on such new findings, the actual roles of immunity are discussed.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 80 (5), 463-468, 2006

    一般社団法人 日本感染症学会

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