An Efficient and Facile Synthesis of 2-Amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-Dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile under Solvent-free Conditions

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  • Liangce Rong
    Department of Chemisty, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant
  • Xiaoyue Li
    Department of Chemisty, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant
  • Haiying Wang
    Department of Chemisty, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant
  • Daqing Shi
    Department of Chemisty, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant
  • Shujiang Tu
    Department of Chemisty, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant

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Abstract

<jats:title>Abstract</jats:title> <jats:p>A one-pot three-component condensation of aromatic aldehyde, aromatic ketone, and malononitrile leading to an efficient synthesis of 2-amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile has been carried out in a mortar just by grinding or heating under solvent-free conditions. Compared with the classical reaction conditions, these new synthetic methods have the advantages of excellent yields, shorter reaction time, and mild reaction conditions.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 35 (11), 1314-1315, 2006-10-25

    Oxford University Press (OUP)

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