ミカファンギンとイトラコナゾールの併用にて治療した肺アスペルギルス症の2症例

• 古堅 誠

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 原永 修作

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 當山 真人

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 城間 留奈

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 屋良 さとみ

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 新里 敬

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 比嘉 太

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 健山 正男

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

• 斎藤 厚

  日本赤十字社長崎原爆諌早病院

• 藤田 次郎

  琉球大学大学院医学研究科感染病態制御学講座分子病態感染症学分野 (第一内科)

書誌事項

タイトル別名

• Two Cases of Pulmonary Aspergillosis Successfully Treated with Combinated Micafungin and Itraconazole Therapy
• ミカファンギン ト イトラコナゾール ノ ヘイヨウ ニテ チリョウ シタ ハイ アスペルギルスショウ ノ 2 ショウレイ

抄録

We report 2 cases of pulmonary aspergillosis treated successfully by combining micafungin and traconazole. Case 1: A 51-year-old man with hemoptysis and dyspnea on effort treated for pulmonary tuberculosis and aspergillosis was found on chest CT on admission to have a fungus ball in the left upper lobe and increasing consolidation around the cavity of both lung fields. Bronchoscopy proved positive for aspergillus PCR in bronchial lavage. He was diagnosed with chronic necrotizing pulmonary aspergillosis, based on clinical and radiological findings and the positive reaction for aspergillus PCR. He was treated with micafungin alone at first, this proved ineffective, so itraconazole was added, resulting in improvement. Case 2: A 24-year-old woman with stabilized Hodgkin's disease (mixed). She had suffered from a cough and back pain, and chest CT showed increasing consolidation inside and around a giant bulla. She was diagnosed with chronic necrotizing pulmonary aspergillosis, based on isolation for Aspergillus sp. in sputum culture and a positive reaction for Aspergillus antigen in bronchial lavage and Aspergillus antibody in serum. She was treated with the combined micafungin and itraconazole, which rapidly improved symptoms and radiological findings. Pulmonary aspergillosis therapy is often difficult, because delivery of the drug to the infection site is limited and drug tolerance is poor. We found that combination micafungin and itraconazole therapy is tolerable and effective in these cases.

収録刊行物

• 感染症学雑誌

  感染症学雑誌 79 (12), 951-956, 2005

  一般社団法人 日本感染症学会

キーワード

• aspergillosis
• micafungin
• itraconazole

詳細情報

• CRID: 1390282680025160320
• NII論文ID: 130004331240
• NII論文ID: 10018629426
• NII書誌ID: AN00047715
• DOI: 10.11150/kansenshogakuzasshi1970.79.951
• COI: 1:STN:280:DC%2BD28%2FmtVOrsg%3D%3D
• ISSN: 1884569X
• ISSN: 03875911
• ISSN: http://id.crossref.org/issn/03875911
• NDL書誌ID: 7781606
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7781606
• Web Site: https://search.jamas.or.jp/link/ui/2006104776
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可