Chiral Scandium-catalyzed Highly Stereoselective Ring-opening of meso-Epoxides with Thiols
The desymmetrization of <I>meso</I>-epoxides with thiols proceeded smoothly in dichloromethane or dichloroethane in the presence of a catalytic amount of a chiral scandium complex consisting of Sc(OTf)<SUB>3</SUB> and chiral bipyridine <B>1</B>, to afford the corresponding sulfides in high yields with high enantioselectivities.
- Chemistry letters
Chemistry letters 36(1), 34-35, 2007-01-05
The Chemical Society of Japan