Chiral Scandium-catalyzed Highly Stereoselective Ring-opening of meso-Epoxides with Thiols
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The desymmetrization of <I>meso</I>-epoxides with thiols proceeded smoothly in dichloromethane or dichloroethane in the presence of a catalytic amount of a chiral scandium complex consisting of Sc(OTf)<SUB>3</SUB> and chiral bipyridine <B>1</B>, to afford the corresponding sulfides in high yields with high enantioselectivities.
- Chemistry Letters
Chemistry Letters 36(1), 34-35, 2007-01-05
The Chemical Society of Japan