Reductive Ti-crossed Claisen Condensation between Methyl α-Bromocarboxylates and Acid Chlorides Utilizing a TiCl4–PPh3–<i>N</i>-Methylimidazole Reagent

• Akira Iida

  Department of Chemistry, School of Science and Technology, Kwansei Gakuin University

• Syogo Nakazawa

  Department of Chemistry, School of Science and Technology, Kwansei Gakuin University

• Hidefumi Nakatsuji

  Department of Chemistry, School of Science and Technology, Kwansei Gakuin University

• Tomonori Misaki

  Department of Chemistry, School of Science and Technology, Kwansei Gakuin University

• Yoo Tanabe

  Department of Chemistry, School of Science and Technology, Kwansei Gakuin University

Abstract

Reductive Ti-crossed Claisen condensation between methyl α-bromocarboxylates and acid chlorides utilizing a TiCl4–PPh3–N-methylimidazole reagent proceeded smoothly to give the α-monosubstituted and thermodynamically unfavorable α,α-disubstituted β-keto methyl esters in good to excellent yields (33 examples; 73–96% yield).

Journal

• Chemistry Letters

  Chemistry Letters 36 (1), 48-49, 2006-12-16

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360846644041137408
• NII Article ID: 10018662727
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2007.48
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/36/1/48/55593770/cl.2007.48.pdf
• Data Source:
  • Crossref
  • CiNii Articles