Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3'-Methanodeoxyuridine

• Moriguchi Tomohisa

  Graduate School of Engineering, Gunma University

• Yamato Fumisada

  Graduate School of Engineering, Gunma University

• Shinozuka Kazuo

  Graduate School of Engineering, Gunma University

Bibliographic Information

Other Title

• Synthesis and Properties of Novel Oligodeoxynucleotides Containing 6,3′-Methanodeoxyuridine

Abstract

This paper deals with the synthesis and properties of novel oligodeoxynucleotide containing 6,3′-methanodeoxyuridine which is connected between C-6 of pyrimidine base and C-3′ of deoxyribose by a methylene group. The modified base was successfully introduced into the oligodeoxynucleotide by the standard method. The modified oligodeoxynucleotide formed the less stable duplex with both complementary DNA and RNA. The CD spectra indicated that the duplex formed the noncanonical duplex structure distinct from the A-form or B-form structure.

Journal

• Chemistry Letters

  Chemistry Letters 37 (5), 548-549, 2008

  The Chemical Society of Japan

Keywords

• General Chemistry

Details

• CRID: 1390282679560810240
• NII Article ID: 10021080653
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2008.548
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/37/5/548/55595715/cl.2008.548.pdf
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed