Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides Derived from Wheat Bran in Spontaneously Hypertensive Rats

• Nogata Yoichi

  National Agricultural Research Center for Western Region

• Nagamine Takashi

  National Agricultural Research Center for Western Region

• Sekiya Keizo

  National Agricultural Research Center for Western Region

Bibliographic Information

Other Title

• 小麦ふすま由来アンジオテンシンＩ変換酵素阻害ペプチドの高血圧自然発症ラットに対する血圧降下作用
• 小麦ふすま由来アンジオテンシン1変換酵素阻害ペプチドの高血圧自然発症ラットに対する血圧降下作用
• コムギフス マユライ アンジオテンシン 1 ヘンカン コウソ ソガイ ペプチド ノ コウケツアツ シゼン ハッショウ ラット ニ タイスル ケツアツ コウカ サヨウ

Abstract

In this paper, we report an antihypertensive effect of wheat bran peptides (WBP) in spontaneously hypertensive rats (SHR). Following a single administration of WBP, systolic blood pressure (SBP) was significantly reduced at 2 hours post-administration and the effect lasted for 6 hours at 10mg WBP/kg and 8 hours at 50 and 200mg WBP/kg. When SHR received water containing 0.02% and 0.1% WBP (w/v) ad libitum, SBP was significantly reduced at 10 days post-administration at 0.02% WBP and at 5 days at 0.1% WBP. The effect of both treatments was maintained for 25 days. These results indicate that WBP can exert a potent and long-lasting antihypertensive effect in SHR.

Journal

• Nippon Shokuhin Kagaku Kogaku Kaishi

  Nippon Shokuhin Kagaku Kogaku Kaishi 58 (2), 67-70, 2011

  Japanese Society for Food Science and Technology

Keywords

• bran
• peptide
• angiotensin I-converting enzyme
• spontaneously hypertensive rats
• antihypertensive effect

Details

• CRID: 1390001206409448576
• NII Article ID: 10027868760
• NII Book ID: AN10467499
• DOI: 10.3136/nskkk.58.67
• ISSN: 18816681
• ISSN: 1341027X
• NDL BIB ID: 10969072
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010810619
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10969072
• Text Lang: ja
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed