Hypercholesterolemia-reducing Effect of Young Barley Leaf Powder

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  • Koga Ryota
    Asahi Ryokuken Co., Ltd. Energy of Ground (Daichi-no-chikara) Laboratory Co., Ltd. Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
  • Tsubata Masahito
    Toyo Shinyaku Co., Ltd. Energy of Ground (Daichi-no-chikara) Laboratory Co., Ltd.
  • Ikeguchi Motoya
    Toyo Shinyaku Co., Ltd.
  • Takagaki Kinya
    Toyo Shinyaku Co., Ltd.
  • Irino Nobuhito
    Asahi Ryokuken Co., Ltd. Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
  • Kondo Ryuichiro
    Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University

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  • 大麦若葉末の高コレステロール血症改善作用
  • オオムギ ワカハズエ ノ コウコレステロール ケツショウ カイゼン サヨウ

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Abstract

To confirm the effect of Young Barley Leaf Powder (YBLP) on hypercholesterolemia, we performed a pre-clinical study involving diet-induced hypercholesterolemia in rats and a clinical study in healthy subjects. The pre-clinical study used three experimental groups : Wistar rats were fed a normal diet, a high cholesterol diet (HCD), or a HCD with 4% (w/w) YBLP for 4 weeks. In the clinical study, fifteen healthy subjects, with mean total plasma cholesterol of 205.1 mg/dL, were supplemented with a powdered drink containing YBLP for 12 weeks. The clinical study was of a preliminary open-label design. Following treatment, lipid parameters were analyzed in the rat and human plasma. The results indicated that total plasma cholesterol and LDL cholesterol were decreased, in both the pre-clinical and clinical studies, following ingestion of YBLP. Additionally, the ability of YBLP to absorb bile acids was examined. YBLP, and residual substances after hexane extraction, were observed to strongly absorb bile acids. These results suggest that YBLP could improve hypercholesterolemia due to its ability to absorb bile acids.

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