メイラード反応を用いたマンナン型多糖修飾により調製した低アレルゲン性ソバ Fag e 1 の腸管免疫調節作用

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  • Intestinal immunomodulatory effects of a hypoallergenic buckwheat Fag e 1 prepared by Maillard-type glycation with a mannan type-polysaccharide

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The 24 kDa protein (Fag e 1) in buckwheat is considered to be one of its major allergens. The purpose of this study is to investigate the immunomodulatory effects of hypoallergenic Fag e 1 prepared by glycation with polysaccharide on mucosal allergenic responses in mice. Mannan-type-polysaccharide such as galactomannan (GalM), konjac glucomannan (KGM), and yeast glucomannan (YGM) showed attenuation of IL-4 and IL-17 production and elevation of IL-10 in cultured Peyer’s patch (PP) cells. The conjugate of Fag e 1 with GalM, KGM, or YGM was prepared using naturally occurring Maillard-type glycosylation. Dietary administration with Fag e 1-YGM conjugate for 8 weeks induced a significant reduction in Fag e 1-specific IgE and IgG1 levels and elevation in IgA level in sera and PP cells. A decrease in IL-4 and IL-17 and increase in IL-10 in PP cells were observed in the group of Fag e 1-YGM conjugate. Differentiation ratio of regulatory T cells (Treg) and T follicular helper cells in PP increased by feeding with Fag e 1-YGM conjugate. These suggest that Fag e 1-YGM conjugate could be contribute to the development of an immunomodulatory hypoallergenic agent for buckwheat allergy.

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