黒ショウガ（<i>Kaempferia parviflora</i> ）の成分の一酸化窒素産生抑制効果について

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  • 渕野 裕之
    国立研究開発法人医薬基盤・健康・栄養研究所 薬用植物資源研究センター
  • 福井 ななみ
    東京理科大学薬学部
  • 飯田 修
    国立研究開発法人医薬基盤・健康・栄養研究所 薬用植物資源研究センター
  • 和田 浩志
    東京理科大学薬学部
  • 川原 信夫
    国立研究開発法人医薬基盤・健康・栄養研究所 薬用植物資源研究センター

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  • Inhibitory effect of black ginger (<i>Kaempferia parviflora</i> ) constituents on nitric oxide production
  • Inhibitory effect of black ginger (Kaempferia parviflora) constituents on nitric oxide production

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The inhibitory effect of Kaempferia parviflora (black ginger) constituents on nitric oxide (NO) production was examined. From the methanolic extract of K. parviflora rhizome, 16 flavones, 14 flavanones, 2 diarylheptanoids, 2 chalcones and a stilbene were isolated and their inhibitory activities toward NO production were examined. As a result, two methoxyflavones, 5,7,3’,4’-tetramethylluteolin and 5,7-dimethoxyflavone showed significant activities. Most of the flavanone constituents, except for 5,7,3’-trimethoxy-4’-hydroxyflavanone, showed lower activities. The most potent active constituent of Black ginger was the chalcone flavokavin B; its derivative, flavokavin A, also showed significant activity. The curcumin and its derivative, 1-(4-hydroxyphenyl)-7-phenyl-1,6-heptadiene-3,5-dione, showed significant activity. Only one stilbene was isolated, and it showed low activity.

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