sesamin、asarinin (episesamin)の光学純度測定法の確立と細辛sesaminに光学異性体混在の証明

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  • Establishment of a method for analyzing sesamin and asarinin (episesamin) with HPLC-chiral column, and analytical proof that sesamin from Asiasari Radix exists as a <i>d, l</i>-mixture
  • sesamin, asarinin (episesamin)ノ コウガク ジュンド ソクテイホウ ノ カクリツ ト サイシンsesamin ニ コウガク イセイタイ コンザイ ノ ショウメイ

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Asiasari Radix [roots and rhizomes of Asiasarum sieboldii F. Maekawa and Asiasarum heterotropoides F. Maekawa var. mandshuricum F. Maekawa (Aristolochiaceae)] is a traditional medicine. Sesamin and asarinin are important components of Asiasari Radix, and it is reported that their stereochemistry is l-form. On the contrary, the stereochemistry of sesamin and episesamin from sesame are reported as d-form. Therefore, we established a method for analyzing lignans with HPLC-chiral column to invesitigate precise stereochemistry of them from Asiasari Radix and sesame. As a result, we clarified that asarinin from Asiasari Radix existed as only l-form, and sesamin and episesamin from sesame existed as only d-form. In addition, we found that sesamin from Asiasari Radix was a mixture of 96〜95% l-form and 4〜5% d-form.

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