Synthesis and Transfection Capability of Multi-Functionalized Fullerene Polyamine

DOI PDF 1 Citations 41 References
  • Hiroyuki Isobe
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • Naoki Tomita
    Department of Chemistry, Graduate School of Science, The University of Tokyo
  • Shigeki Jinno
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo
  • Hiroto Okayama
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo
  • Eiichi Nakamura
    Department of Chemistry, Graduate School of Science, The University of Tokyo

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Abstract

<jats:title>Abstract</jats:title> <jats:p>A new fullerene transfection reagent bearing multiple-functional groups has been synthesized by diastereoselective double cycloaddition reaction. The highly oxygenated reagent transfers extra-cellular DNA into mammalian cells with the efficiency comparable to that of a nor-analogue.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 30 (12), 1214-1215, 2001-12-01

    Oxford University Press (OUP)

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