Haloperidol Prolongs Diastolic Phase of Ca2+ Transient in Cardiac Myocytes.
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- Ishida Hideyuki
- Department of Physiology, School of Medicine, Tokai University
Bibliographic Information
- Other Title
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- Haloperidol Prolongs Diastolic Phase of Ca〔2+〕Transientin Cardiac Myocytes
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Abstract
Haloperidol (HPL), a widely used antipsychotic drug, is known to induce serious ventricular arrhythmias. However, the mechanism underlying their induction is not clear. We therefore examined the effects of HPL on the intracellular Ca2+ ([Ca2+]i) transient and on cell motion in cultured cardiac myocytes, as well as the pathways involving the HPL-induced abnormality of Ca2+ homeostasis. HPL prolonged the diastolic phase of the Ca2+ transient, with a mid-diastolic re-elevation of [Ca2+]i. The re-elevation of [Ca2+]i was shown to be provoked by Ca2+ release from sarcoplasmic reticulum (SR), which can trigger delayed afterdepolarization, the major arrhythmogenic factor. The re-elevation of [Ca2+]i coincided with cell re-contraction during diastole. The induction of this abnormality by HPL appears to be independent of the mechanisms of the antipsychotic action.<br>
Journal
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- The Japanese Journal of Physiology
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The Japanese Journal of Physiology 49 (6), 479-484, 1999
THE PHYSIOLOGICAL SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390282680019223424
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- NII Article ID
- 10008308164
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- NII Book ID
- AA00691224
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- COI
- 1:CAS:528:DC%2BD3cXhtFygsrg%3D
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- ISSN
- 18811396
- 0021521X
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- NDL BIB ID
- 4979586
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- PubMed
- 10603433
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed