A Novel <scp>l</scp>-Proline Catalyzed Biginelli Reaction: One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1<i>H</i>)-ones under Solvent-Free Conditions

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  • J S Yadav
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • S Praveen Kumar
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • G Kondaji
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • R Srinivasa Rao
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • K Nagaiah
    Division of Organic Chemistry, Indian Institute of Chemical Technology

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Abstract

<jats:title>Abstract</jats:title> <jats:p>A Novel efficient and simple synthetic protocol for the Biginelli reaction has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones in a one-pot three-component condensation of aldehydes, β-dicarbonyl compounds, and urea or thio-urea by using 10 mol % l-proline as the catalyst under solvent free condition.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 33 (9), 1168-1169, 2004-08-14

    Oxford University Press (OUP)

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