Synthesis of a Novel Pyrrolidine-based Peptide Nucleic Acid that Contains Tertiary Amines in the Main Chain and Its Internalization into Cells

• Mizuki Kitamatsu

  Department of Bioscience and Biotechnology, Okayama University

• Tomoko Kashiwagi

  Department of Bioscience and Biotechnology, Okayama University

• Rino Matsuzaki

  Department of Bioscience and Biotechnology, Okayama University

• Masahiko Sisido

  Department of Bioscience and Biotechnology, Okayama University

Abstract

A novel thymine monomer of pyrrolidine-based peptide nucleic acid that contains tertiary amines in the main chain (pyrrolidine-based amino peptide nucleic acid = PAPNA) was synthesized. A mixed oligomer of two PAPNA(T) units and seven units of pyrrolidine-based oxypeptide nucleic acid (POPNA), was synthesized by a solid-phase method. The mixed oligomer was internalized into CHO cells more readily than the previous version of POPNA oligomers.

Journal

• Chemistry Letters

  Chemistry Letters 35 (3), 300-301, 2006-02-11

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360002219110809856
• NII Article ID: 10017273480
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2006.300
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/35/3/300/55590288/cl.2006.300.pdf
• Data Source:
  • Crossref
  • CiNii Articles