CeCl3·7H2O/NaI-promoted Efficient Alkylation of Activated Quinoline and Isoquinoline

  • J S Yadav
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • B V S Reddy
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • K Sathaiah
    Division of Organic Chemistry, Indian Institute of Chemical Technology
  • P Narayana Reddy
    Division of Organic Chemistry, Indian Institute of Chemical Technology

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Active methylene compounds undergo smooth addition to quinolines and isoquinolines activated by chloroformate in the presence of CeCl3·7H2O/NaI to afford 2-alkyl-1,2-dihydroquinoline and 1-alkyl-1,2-dihydroisoquinoline, respectively in excellent yields with high selectivity.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 35 (4), 448-449, 2006-03-25

    Oxford University Press (OUP)

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