Application of FITC-labeled Ternatin on Its Cellular Localization in 3T3-L1 Murine Preadipocytes

• Kenichiro Shimokawa

  Department of Chemistry, Graduate School of Science, Nagoya University

• Osamu Ohno

  Department of Chemistry, Graduate School of Science, Nagoya University

• Kaoru Yamada

  Department of Chemistry, Graduate School of Science, Nagoya University

• Yuichi Oba

  Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University

• Daisuke Uemura

  Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University

Abstract

The cellular localization of a potent fat-accumulation inhibitor (−)-ternatin was investigated. FITC-labeled ternatin, a chemical probe for current study, was synthesized from a highly bioactive ternatin analogue using Click Chemistry, which was found to be bioactive. The treatment of 3T3-L1 murine preadipocytes with synthetic probe revealed that (−)-ternatin is localized in a specific organelle of 3T3-L1 cells.

Journal

• Chemistry Letters

  Chemistry Letters 38 (2), 150-151, 2009-01-10

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360846644041373696
• NII Article ID: 10025119199
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2009.150
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/38/2/150/55597986/cl.2009.150.pdf
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