Cycloamylose-based Biomaterial: Nanogel of Cholesterol-bearing Cationic Cycloamylose for siRNA Delivery

• Sayaka Toita

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Yuki Soma

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Nobuyuki Morimoto

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Kazunari Akiyoshi

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

Abstract

A new siRNA delivery system made of a functional cycloamylose nanogel is reported. Cholesterol-bearing cationic cycloamylose formed nanogels by self-assembly in water. The nanogels formed 20–40 nm nanoparticles that bound to 21 bp siRNA. The complexes exerted an RNAi effect on SCC7-GL3 cells that stably express the luciferase gene.

Journal

• Chemistry Letters

  Chemistry Letters 38 (11), 1114-1115, 2009-10-31

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360283694087936896
• NII Article ID: 10025548461
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2009.1114
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/38/11/1114/55600370/cl.2009.1114.pdf
• Data Source:
  • Crossref
  • CiNii Articles
  • KAKEN