Suppression of Cell Adhesion on Well-defined Concentrated Polymer Brushes of Hydrophilic Polymers

• Chiaki Yoshikawa

  World Premier International Research Center for Materials Nanoarchitectonics, NIMS

• Yoshihide Hashimoto

  Biomaterials Center, NIMS

• Shinya Hattori

  Japan Health Sciences Foundation

• Takako Honda

  Japan Health Sciences Foundation

• Kun Zhang

  World Premier International Research Center for Materials Nanoarchitectonics, NIMS

• Dohiko Terada

  Biomaterials Center, NIMS

• Akio Kishida

  Biomaterials Center, NIMS

• Yoshinobu Tsujii

  Institute for Chemical Research, Kyoto University

• Hisatoshi Kobayashi

  Biomaterials Center, NIMS

Abstract

The cell adhesion was investigated on polymer brushes of poly(2-hydroxyethyl methacrylate) (PHEMA), poly(2-hydroxyethyl acrylate) (PHEA), and poly[poly(ethylene glycol) methyl ether methacrylate] (PPEGMA) with different graft densities (in semidilute and concentrated regimes) and thicknesses. The concentrated polymer brushes (CPBs) of all the three, regardless of differences in chemical structure and hydrophilicity, almost completely suppressed the adhesion of L929 fibroblast cell in contrast to the corresponding semidilute polymer brushes (SDPBs). Along with our previous study on excellent protein repellency of CPB owing to its unique size-exclusion effect (of entropic origin), we concluded that such bioinertness should be commonly found in CPB of neutral and hydrophilic polymers.

Journal

• Chemistry Letters

  Chemistry Letters 39 (2), 142-143, 2010-02

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360002219111382528
• NII Article ID: 10027177391
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2010.142
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/39/2/142/55601044/cl.2010.142.pdf
• Data Source:
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  • CiNii Articles