<i>N</i>-Heterocyclic Carbene-catalyzed Difluorocarbene Generation and its Application to Aryl Difluoromethyl Ether Synthesis

DOI PDF 8 Citations 103 References
  • Kohei Fuchibe
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
  • Yuta Koseki
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
  • Hisashi Sasagawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba
  • Junji Ichikawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba

Search this article

Abstract

<jats:title>Abstract</jats:title> <jats:p>NHC-catalyzed generation of difluorocarbene from trimethylsilyl 2,2-difluoro-2-(fluorosulfonyl)acetate (TFDA) enables the synthesis of enol difluoromethyl ethers starting from cyclohexenones and tetralones. The resultant enol difluoromethyl ethers were successively dehydrogenated with DDQ to furnish aryl difluoromethyl ethers in good to high yield.</jats:p>

Journal

  • Chemistry Letters

    Chemistry Letters 40 (10), 1189-1191, 2011-10-01

    Oxford University Press (OUP)

Citations (8)*help

See more

References(103)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top