Virus Capsid Coating of Gold Nanoparticles via Cysteine–Au Interactions and Their Effective Cellular Uptakes

• Keita Nagakawa

  Department of Chemistry, Graduate School of Science, Hokkaido University

• Kenichi Niikura

  Research Institute for Electronic Science, Hokkaido University

• Tadaki Suzuki

  Research Center for Zoonosis Control and Global COE program, Hokkaido University

• Yasutaka Matsuo

  Research Institute for Electronic Science, Hokkaido University

• Manabu Igarashi

  Research Center for Zoonosis Control and Global COE program, Hokkaido University

• Hirofumi Sawa

  Research Center for Zoonosis Control and Global COE program, Hokkaido University

• Kuniharu Ijiro

  Research Institute for Electronic Science, Hokkaido University

Abstract

This manuscript describes the synthesis of virus capsid protein-coated Au nanoparticle (VP–AuNP) without the use of the inherent self-assembly of virus proteins into virus particles. Covalent binding between Au and cysteines in the virus proteins keep the cell-surface binding sites on the external surface. Based on this method, various sizes of VP–AuNP can be created in a similar manner to native virus particles. We clarified the optimum size of the VP–AuNP for internalization into cells.

Journal

• Chemistry Letters

  Chemistry Letters 41 (1), 113-115, 2011-12-30

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360565169065030528
• NII Article ID: 10030222850
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2012.113
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/41/1/113/55636850/cl.2012.113.pdf
• Data Source:
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  • CiNii Articles
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