CeO2-catalyzed Transformations of Nitriles and Amides

• Masazumi Tamura

  Department of Applied Chemistry, School of Engineering, Tohoku University

• Ken-ichi Shimizu

  Catalysis Research Center, Hokkaido University

• Atsushi Satsuma

  Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University

Abstract

Recently, cerium oxides have been extensively used as heterogeneous catalysts for green organic reactions. This review describes recent progress in such reactions, with a focus on our studies on pure CeO2-catalyzed reactions of nitriles and amides with nucleophiles (H2O, alcohols, and amines). Hydration of nitriles to amides in water, one-pot ester synthesis from nitriles and alcohols, one-pot synthesis of N-alkylamides from nitriles with amines, and synthesis of N-alkylamides from amides and amines (transamidation) are selectively catalyzed by CeO2 under aqueous or solvent-free conditions. Mechanistic studies suggest that a cooperation of Lewis acid site (Ce4+ cation) and acid–base (Ce–O) pair site plays essential roles in the catalytic reactions.

Journal

• Chemistry Letters

  Chemistry Letters 41 (11), 1397-1405, 2012-11

  Oxford University Press (OUP)

Keywords

• General Chemistry

Details

• CRID: 1360565169065054464
• NII Article ID: 10031126543
• NII Book ID: AA00603318
• DOI: 10.1246/cl.2012.1397
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/41/11/1397/55634796/cl.2012.1397.pdf
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